Jane Endicott - Publications, H-index & Citations

Jane Endicott

newcastle university

79H指数

455论文数

2.4W被引数

收录论文 25

发表时间

Diversity in CDK structural mechanisms of regulation and drug discovery opportunities CDK结构调控机制的多样性及药物发现机遇

Trends in Biochemical Sciences

IF11

2026-02-19

OAAI

Rhianna J. Rowland; Martin E.M. Noble; Jane A. Endicott

Nanobodies restore stability to cancer-associated mutants of tumor suppressor protein p16INK4a 纳米抗体恢复了肿瘤抑制蛋白p16INK4a的癌症相关突变体的稳定性

Structure

IF4.3

2025-08-14

OAAI

Owen Burbidge; Martyna W. Pastok; Diana Papini; Samantha L. Hodder; Grasilda Zenkevičiūtė; Kenneth Z.J. Tan; Shannon Turberville; Martin E.M. Noble; Jane A. Endicott; Laura Itzhaki

Crystallographic fragment screening of CDK2-cyclin A: FragLites map sites of protein-protein interaction CDK2-细胞周期蛋白A的晶体学片段筛选：FragLites绘制蛋白质-蛋白质相互作用位点

Structure

IF4.3

2025-08-14

PREAI

Ian Hope; Mathew P. Martin; Ziwei Jiang; Michael J. Waring; Martin E.M. Noble; Jane A. Endicott; Natalie J. Tatum

Cryo-EM structure of the CDK2-cyclin A-CDC25A complex

NATURE COMMUNICATIONS

IF15.7

2024-08-09

OAAI

Rowland, Rhianna J.; Korolchuk, Svitlana; Salamina, Marco; Tatum, Natalie J.; Ault, James R.; Hart, Sam; Turkenburg, Johan P.; Blaza, James N.; Noble, Martin E. M.; Endicott, Jane A.

Cyclin A and Cks1 promote kinase consensus switching to non-proline-directed CDK1 phosphorylation

CELL REPORTS

IF6.9

2023-03-01

OAAI

al-Rawi, Aymen; Kaye, Edward; Korolchuk, Svitlana; Endicott, Jane A.; Ly, Tony

Emerging approaches to CDK inhibitor development, a structural perspective

RSC CHEMICAL BIOLOGY

IF3.1

2023-01-01

OAAI

Hope, Ian; Endicott, Jane A.; Watt, Jessica E.

Mapping Ligand Interactions of Bromodomains BRD4 and ATAD2 with FragLites and PepLites_ Halogenated Probes of Druglike and Peptide-like Molecular Interactions

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2022-11-11

OAAI

Davison, Gemma; Martin, Mathew P.; Turberville, Shannon; Dormen, Selma; Heath, Richard; Heptinstall, Amy B.; Lawson, Marie; Miller, Duncan C.; Ng, Yi Min; Sanderson, James N.; Hope, Ian; Wood, Daniel J.; Cano, Celine; Endicott, Jane A.; Hardcastle, Ian R.; Noble, Martin E. M.; Waring, Michael J.

Parallel Optimization of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Kinase Domain Inhibitor

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2022-04-25

OAAI

Miller, Duncan C.; Reuillon, Tristan; Molyneux, Lauren; Blackburn, Timothy; Cook, Simon J.; Edwards, Noel; Endicott, Jane A.; Golding, Bernard T.; Griffin, Roger J.; Hardcastle, Ian; Harnor, Suzannah J.; Heptinstall, Amy; Lochhead, Pamela; Martin, Mathew P.; Martin, Nick C.; Myers, Stephanie; Newell, David R.; Noble, Richard A.; Phillips, Nicole; Rigoreau, Laurent; Thomas, Huw; Tucker, Julie A.; Wang, Lan-Zhen; Waring, Michael J.; Wong, Ai-Ching; Wedge, Stephen R.; Noble, Martin E. M.; Cano, Celine

An Alkynylpyrimidine-Based Covalent Inhibitor That Targets a Unique Cysteine in NF-κB-Inducing Kinase

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2021-07-02

OAAI

Al-Khawaldeh, Islam; Al Yasiri, Mohammed J.; Aldred, Gregory G.; Basmadjian, Christine; Bordoni, Cinzia; Harnor, Suzannah J.; Heptinstall, Amy B.; Hobson, Stephen J.; Jennings, Claire E.; Khalifa, Shaimaa; Lebraud, Honorine; Martin, Mathew P.; Miller, Duncan C.; Shrives, Harry J.; de Souza, Joao, V; Stewart, Hannah L.; Temple, Max; Thomas, Huw D.; Totobenazara, Jane; Tucker, Julie A.; Tudhope, Susan J.; Wang, Lan Z.; Bronowska, Agnieszka K.; Cano, Celine; Endicott, Jane A.; Golding, Bernard T.; Hardcastle, Ian R.; Hickson, Ian; Wedge, Stephen R.; Willmore, Elaine; Noble, Martin E. M.; Waring, Michael J.

Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein-Protein Interaction

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2021-03-24

OAAI

Chessari, Gianni; Hardcastle, Ian R.; Ahn, Jong Sook; Anil, Burcu; Anscombe, Elizabeth; Bawn, Ruth H.; Bevan, Luke D.; Blackburn, Timothy J.; Buck, Ildiko; Cano, Celine; Carbain, Benoit; Castro, Juan; Cons, Ben; Cully, Sarah J.; Endicott, Jane A.; Fazal, Lynsey; Golding, Bernard T.; Griffin, Roger J.; Haggerty, Karen; Harnor, Suzannah J.; Hearn, Keisha; Hobson, Stephen; Holvey, Rhian S.; Howard, Steven; Jennings, Claire E.; Johnson, Christopher N.; Lunec, John; Miller, Duncan C.; Newell, David R.; Noble, Martin E. M.; Reeks, Judith; Revill, Charlotte H.; Riedinger, Christiane; St Denis, Jeffrey D.; Tamanini, Emiliano; Thomas, Huw; Thompson, Neil T.; Vinkovic, Mladen; Wedge, Stephen R.; Williams, Pamela A.; Wilsher, Nicola E.; Zhang, Bian; Zhao, Yan

Identification of a novel orally bioavailable ERK5 inhibitor with selectivity over p38α and BRD4

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2019-09-01

OAAI

Myers, Stephanie M.; Miller, Duncan C.; Molyneux, Lauren; Arasta, Mercedes; Bawn, Ruth H.; Blackburn, Timothy J.; Cook, Simon J.; Edwards, Noel; Endicott, Jane A.; Golding, Bernard T.; Griffin, Roger J.; Hammonds, Tim; Hardcastle, Ian R.; Harnor, Suzannah J.; Heptinstall, Amy B.; Lochhead, Pamela A.; Martin, Mathew P.; Martin, Nick C.; Newell, David R.; Owen, Paul J.; Pang, Leon C.; Reuillo, Tristan; Rigoreau, Laurent J. M.; Thomas, Huw D.; Tucker, Julie A.; Wang, Lan-Zhen; Wong, Ai-Ching; Noble, Martin E. M.; Wedge, Stephen R.; Cano, Celine

FragLites-Minimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2019-03-12

PREAI

Wood, Daniel J.; Lopez-Fernandez, J. Daniel; Knight, Leanne E.; Al-Khawaldeh, Islam; Gai, Conghao; Lin, Shengying; Martin, Mathew P.; Miller, Duncan C.; Cano, Celine; Endicott, Jane A.; Hardcastle, Ian R.; Noble, Martin E. M.; Waring, Michael J.

Differences in the Conformational Energy Landscape of CDK1 and CDK2 Suggest a Mechanism for Achieving Selective CDK Inhibition

CELL CHEMICAL BIOLOGY

IF7.2

2019-01-01

OAAI

Wood, Daniel J.; Korolchuk, Svitlana; Tatum, Natalie J.; Wang, Lan-Zhen; Endicott, Jane A.; Noble, Martin E. M.; Martin, Mathew P.

Structure-based discovery of cyclin-dependent protein kinase inhibitors

STRUCTURE-BASED DRUG DESIGN: INSIGHTS FROM ACADEMIA AND INDUSTRY

IF0

2017-11-08

OAAI

Martin, Mathew P.; Endicott, Jane A.; Noble, Martin E. M.

Cyclin-Dependent Kinase (CDK) Inhibitors: Structure Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2017-02-14

OAAI

Coxon, Christopher R.; Anscombe, Elizabeth; Harnor, Suzannah J.; Martin, Mathew P.; Carbain, Benoit; Golding, Bernard T.; Hardcastle, Ian R.; Harlow, Lisa K.; Korolchuk, Svitlana; Matheson, Christopher J.; Newel, David R.; Noble, Martin E. M.; Sivaprakasam, Mangaleswaran; Tudhope, Susan J.; Turner, David M.; Wang, Lan Z.; Wedge, Stephen R.; Wong, Christopher; Griffin, Roger J.; Endicott, Jane A.; Cano, Celine

8-Substituted O6-Cyclohexylmethylguanine CDK2 Inhibitors: Using Structure-Based Inhibitor Design to Optimize an Alternative Binding Mode

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2013-12-23

PREAI

Carbain, Benoit; Paterson, David J.; Anscombe, Elizabeth; Campbell, Allyson J.; Cano, Celine; Echalier, Aude; Endicott, Jane A.; Golding, Bernard T.; Haggerty, Karen; Hardcastle, Ian R.; Jewsbury, Philip J.; Newell, David R.; Noble, Martin E. M.; Roche, Celine; Wang, Lan Z.; Griffin, Roger J.

EFFECTS OF LISDEXAMFETAMINE DIMESYLATE AUGMENTATION ON FUNCTIONAL OUTCOMES IN ADULTS WITH PARTIALLY OR FULLY REMITTED MAJOR DEPRESSIVE DISORDER

VALUE IN HEALTH

IF6

2012-06-01

OAAI

Supina, D.; Endicott, J.; Madhoo, M.; Keefe, R. S. E.; Trivedi, M.; Wu, J.; Scheckner, B.; Lasser, R.

DEVELOPMENT AND CONTENT VALIDITY OF A PATIENT REPORTED OUTCOMES MEASURE TO ASSESS SYMPTOMS OF MAJOR DEPRESSIVE DISORDER (MDD)

VALUE IN HEALTH

IF6

2011-11-01

OAAI

Hassan, M.; Lasch, K. E.; Piault-Louis, E.; Jernigan, K.; Hwang, S.; Fitz-randolph, M.; Pathak, S.; Locklear, J.; Endicott, J.

Analysis of Chemical Shift Changes Reveals the Binding Modes of Isoindolinone Inhibitors of the MDM2-p53 Interaction

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2008-10-30

114

PREAI

Riedinger, Christiane; Endicott, Jane A.; Kemp, Stuart J.; Smyth, Lynette A.; Watson, Anna; Valeur, Eric; Golding, Bernard T.; Griffin, Roger J.; Hardcastle, Ian R.; Noble, Martin E.; McDonnell, James M.

Meriolins (3-(pyrimidin-4-yl)-7-azaindoles): Synthesis, kinase inhibitory activity, cellular effects, and structure of a CDK2/cyclin A/meriolin complex

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2008-01-31

162

PREAI

Echalier, Aude; Bettayeb, Karima; Ferandin, Yoan; Lozach, Olivier; Clement, Monique; Valette, Annie; Liger, Franrcois; Marquet, Bernard; Morris, Jonathan C.; Endicott, Jane A.; Joseph, Benoit; Meijer, Laurent

研究方向