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K

Kirsty S. Hewitson

University of Oxford

H指数:37

被引数:9,896

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Aspartate/asparagine-β-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern

NATURE COMMUNICATIONS

IF15.7

2019-10-2834

OAAI

Deregulated hepsin protease activity confers oncogenicity by concomitantly augmenting HGF/MET signalling and disrupting epithelial cohesion

IF7.3

2015-07-1341

PREAI

Molecular Cloning, Characterization, and Inhibition Studies of a β-Carbonic Anhydrase from Malassezia globosa, a Potential Antidandruff Target

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2012-03-2849

PREAI

Crystallographic and mass spectrometric analyses of a tandem GNAT protein from the clavulanic acid biosynthesis pathway

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

IF2.8

2009-12-1418

PREAI

Direct Analysis of Enzyme-Catalyzed DNA Demethylation

ANALYTICAL CHEMISTRY

IF6.7

2009-06-1121

PREAI

Evidence that two enzyme-derived histidine ligands are sufficient for iron binding and catalysis by factor inhibiting HIF (FIH)

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2008-09-0152

OAAI

Kinetic rationale for selectivity toward N- and C-terminal oxygen-dependent degradation domain substrates mediated by a loop region of hypoxia-inducible factor prolyl hydroxylases

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2008-02-0176

OAAI

Asparaginyl hydroxylation of the notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2007-08-01206

OAAI

Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2007-02-01212

OAAI

Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay

使用耗氧量测定法研究缺氧诱导因子羟化酶的活性

BIOCHEMICAL JOURNAL

IF4.3

2006-12-11198

OAAI

Posttranslational hydroxylation of ankyrin repeats in IκB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2006-10-03258

OAAI

Cellular oxygen sensing:: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2)

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2006-06-27359

OAAI

Purified recombinant hARD1 does not catalyse acetylation of Lys532 of HIF-1α fragments in vitro

IF3

2006-02-1745

PREAI

ORF17 from the clavulanic acid biosynthesis gene cluster catalyzes the ATP-dependent formation of N-glycyl-clavaminic acid

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2006-01-0142

OAAI

Selective inhibition of factor inhibiting hypoxia-inducible factor

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2005-05-07141

PREAI

Oxidation by 2-oxoglutarate oxygenases: non-haem iron systems in catalysis and signalling

2-氧代戊二酸加氧酶的氧化: 催化和信号传导中的非血红素铁系统

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES

IF3.7

2005-04-0765

PREAI

The inhibition of factor inhibiting hypoxia-inducible factor (FIH) by β-oxocarboxylic acids

CHEMICAL COMMUNICATIONS

IF4.2

2005-01-0138

PRE

Disruption of dimerization and substrate phosphorylation inhibit factor inhibiting hypoxia-inducible factor (FIH) activity

抑制缺氧诱导因子 (FIH) 活性的二聚化和底物磷酸化的破坏

BIOCHEMICAL JOURNAL

IF4.3

2004-10-2672

OAAI

Determination and comparison of specific activity of the HIF-prolyl hydroxylases

IF3

2004-09-1899

PREAI

The HIF pathway as a therapeutic target

DRUG DISCOVERY TODAY

IF7.5

2004-08-01151

PREAI