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C

Christopher J. Schofield

university of oxford

112H指数
1.3K论文数
6.3W被引数
收录论文 475
发表时间
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Human carbonic anhydrase II as a versatile biocatalyst for the synthesis of chiral aryl-1,2-diols人碳酐酶II作为合成手性芳基-1,2-二醇的多功能生物催化剂
errCommunications Chemistry
IF6.2
err2026-07-28
err0
errOAAI
errLaura Edit Barabás; Diana Maria Scrob; Monica Ioana Toşa; Jürgen Brem; László Poppe; Christopher J. Schofield; Csaba Paizs
err分享
err收藏
Substrate-Selective Inhibition of the SARS-CoV-2 Papain-Like Protease: Inhibition of Hydrolysis of Human Over Viral Substrates底物选择性抑制SARS-CoV-2木瓜蛋白酶样蛋白酶：抑制人源底物相对于病毒底物的水解
errChemistry – A European Journal
IF0
err2026-06-12
err0
errOAAI
errSakshi Sharma; Peter A. C. Wing; Wojtek Trede; Shyam Basak; Simeon D. Draganov; Taylah Andrews-Clark; Eidarus Salah; Petra Lukacik; Claire Strain-Damerell; Adán Pinto-Fernández; Martin A. Walsh; Fernanda Duarte; Christopher J. Schofield; Lennart Brewitz
err分享
err收藏
Beyond Histone Demethylation: Mechanisms of N-Alkyl Consecutive Oxidations by the Non-Heme Fe(II)/2-Oxoglutarate Oxygenase KDM6B超越组蛋白去甲基化：非血红素Fe(II)/2-酮戊二酸加氧酶KDM6B介导的N-烷基连续氧化机制
errJACS Au
IF8.7
err2026-06-06
err0
errOAAI
errSimahudeen Bathir Jaber Sathik Rifayee; Sudheesh Devadas; Midhun George Thomas; Bhargav Varada; Ethan Sommer; Cassandra Talaba; Christopher Schofield; Christo Z. Christov
err分享
err收藏
Evidence that SmTetX is not a tetracycline resistance determinant证据表明SmTetX并非四环素耐药决定因子
errMicrobiology Spectrum
IF3.8
err2026-06-02
err0
PREAI
errBeech, Matthew J.; Trush, Maria M.; Toma, Edmond C.; Farley, Alistair J. M.; Walsh, Timothy R.; Schofield, Christopher J.
err分享
err收藏
Development of Water-Trapping Pyrrole-2-carboxylic Acids as Broad-Spectrum Metallo-β-lactamase Inhibitors水捕获吡咯-2-羧酸类化合物的开发作为广谱金属β-内酰胺酶抑制剂
errJournal of Medicinal Chemistry
IF6.8
err2026-05-14
err0
errOAAI
errMonisha Singha; Liam A. Wilson; Elisabete C. C. M. Moura; Maria M. Trush; Karina Calvopina; Gurleen Kaur; Greta Zaborskytė; Toms Kalniņš; Tharindi Panduwawala; Matthew J. Bowen; Matthew J. Beech; Jürgen Brem; Peter J. McHugh; Edgars Suna; Timothy R. Walsh; Christopher J. Schofield; Alistair J. M. Farley
err分享
err收藏
Structure-guided optimisation of fenofibrate-derived oxidative phosphorylation inhibitors to modify tumour hypoxia基于结构的优化芬氟拉明衍生的氧化磷酸化抑制剂以修饰肿瘤缺氧
errrsc med. chem.
IF0
err2026-04-29
err0
errOAAI
errJames P. Holt-Martyn †; Nicole Machado †; James T. T. Coates; Rathi Puliyadi; Thomas Ashton; Elysia Traynor; Samina Aslam; Thomas K. Wise; Gonzalo Rodriguez-Berriguete; Christopher J. Schofield; Geoff S. Higgins
err分享
err收藏
β-Lactam antibiotics and β-lactamases: historical perspectives and a review of β-lactamase inhibitors derived from natural productsβ-内酰胺类抗生素和β-内酰胺酶：历史回顾及源自天然产物的β-内酰胺酶抑制剂的综述
errnat. prod. rep.
IF0
err2026-04-23
err0
errOAAI
errPhanankosi Moyo †; Ikhane O. Albert †; Neo Hlungwani; Thulani Sibanda; Perfoy Lumu; Ndivhuwo Kevin Khorommbi; Gurleen Kaur; Karina Calvopina Tapia; George Siegwart; Nana Kwaku Buabeng; Cynthia A. Danquah; Lyndy J. McGaw; Sekelwa Cosa; Christopher J. Schofield; Vinesh J. Maharaj
err分享
err收藏
KDM3A catalyses the oxidation of acetyl-lysine to hydroxyacetyl-lysine on histone H3K9KDM3A催化组蛋白H3K9上的乙酰基-赖氨酸氧化为羟基乙酰基-赖氨酸
errNature Chemistry
IF20.2
err2026-04-15
err0
errOAAI
errRoman Belle; John-Paul Bukowski; Rachel Schiller; Ronald Cutler; Eidarus Salah; Robert S. Dawber; Anthony Tumber; Joanna Bonnici; Jessica D. Kindrick; Loane Serrano; Patrick Rabe; Catrine Johansson; Marie-Hélène Ruchaud; Richard J. Hopkinson; William D. Figg, Sr; Paul E. Brennan; David R. Mole; Simone Sidoli; Akane Kawamura; Christopher J. Schofield
err分享
err收藏
JmjC Histone Demethylases: Beyond Histone Lysine DemethylationJMjC组蛋白去甲基化酶：超越组蛋白赖氨酸去甲基化
errCHIMIA
IF1.6
err2026-03-01
err1
PREAI
errBonnici, Joanna; Schofield, Christopher J.; Kawamura, Akane
err分享
err收藏
Structural basis of the promiscuity of the unusual Fe(II) and 2-oxoglutarate dependent human aspartate/asparagine-β-hydroxylase非常规Fe(II)和2-氧戊二酸依赖性人天冬氨酸/天冬酰胺-β-羟化酶的底物不专一性的结构基础
errNature Communications
IF15.7
err2026-02-25
err0
errOAAI
errMariska de Munnik; Amelia Brasnett; Tiankun Zhou; William Myers; Yicheng Wang; Kuntal Chatterjee; Anthony Tumber; Stephen A. Marshall; Philipp S. Simon; Pierre Aller; Anastasiia Shilova; Danny Axford; Hiroki Makita; Daniel W. Paley; Vandana Tiwari; Alexander T. Stead; Sebastian Dehe; Humberto Sanchez; Daniel J. Rosenberg; Roberto Alonso-Mori; Asmit Bhowmick; Junko Yano; Vittal K. Yachandra; Jaehyun Park; Sehan Park; Allen M. Orville; Lennart Brewitz; Jan F. Kern; Christopher J. Schofield; Patrick Rabe
err分享
err收藏
Expanding the Alkene-Forming Capability of the Pseudomonas Savastanoi Ethylene-Forming Enzyme扩大假单胞菌乙烯形成酶的烯烃形成能力
errChemCatChem
IF3.9
err2026-01-14
err0
errOAAI
errSiddhant Dhingra; Yihong Sun; Zhihong Zhang; Christopher J. Schofield; Lennart Brewitz
err分享
err收藏
In Vitro and In Vivo Evaluation of Nitroxoline as an Effective Antimicrobial Alternative to Poultry Production体外和体内评估：将Nitroxoline作为家禽生产中有效的抗菌替代品
errAntibiotics
IF0
err2026-01-07
err0
errOAAI
errYuqing Zhou; Maria M. Trush; Lewis Ibbotson; Laura Espina; Aditya Kumar Lankapalli; Alistair J. M. Farley; Huangwei Song; Congming Wu; Xingyuan Cao; Xi Xia; Charlotte J. Gray-Hammerton; Alice Moorey; Amelie Delaitre; George Siegwart; Shaolin Wang; Yang Wang; Jianzhong Shen; Christopher J. Schofield; Timothy R. Walsh
err分享
err收藏
Structural and functional consequences of aspartate/asparagine-β-hydroxylase variants causing Traboulsi Syndrome导致Traboulsi综合征的天冬氨酸/天冬酰胺-β-羟化酶变异的结构和功能后果
errJournal of Biological Chemistry
IF3.9
err2025-12-05
err0
errOAAI
errCynthia X. Hou; Amelia Brasnett; Patrick Rabe; Christopher J. Schofield; Lennart Brewitz
err分享
err收藏
Cellular and functional insights into FIH-mediated hydroxylation of TRPA1细胞和功能层面的FIH介导的TRPA1羟基化机制研究
errJournal of Biological Chemistry
IF3.9
err2025-11-04
err0
errOAAI
errTao Guo; Dianne Marquez Lopez; Siyuan Wang; Liudi Yao; Xi Li; Elizabeth R. Davies; Mariana Vargas-Caballero; Nullin Divecha; Christopher J. Schofield; Katrin Deinhardt; Yihua Wang
err分享
err收藏
Small but powerful小巧但功能强大
errNature Reviews Chemistry
IF51.7
err2025-11-04
err0
PREAI
errAndrew V. Stachulski; Christopher J. Schofield
err分享
err收藏
Profiling Inhibitor Scaffolds for the Cancer Target Jumonji-C Domain-Containing Protein 6筛选靶向Jumonji-C结构域蛋白6的癌抑制剂骨架
errChemMedChem
IF3.4
err2025-10-31
err0
errOAAI
errThomas P. Corner; Eidarus Salah; Anthony Tumber; James P. Holt-Martyn; Lennart Brewitz; Christopher J. Schofield
err分享
err收藏
C6-Alkoxy substituted penicillins are potent non-covalently binding inhibitors of the SARS-CoV-2 main proteaseC6-烷氧基取代的青霉素是SARS-CoV-2主要蛋白酶的强效非共价结合抑制剂
errRSC Med. Chem.
IF3.6
err2025-10-27
err0
errOAAI
errDorian-Gabriel Muntean; Wojtek Treyde; Linda Kinena; Eidarus Saleh; Hani Choudhry; Fernanda Duarte; Lennart Brewitz; Christopher J Schofield
err分享
err收藏
Evidence human FTO catalyses hydroxylation of N6-methyladenosine without direct formation of a demethylated product contrasting with ALKBH5/2/3 and bacterial AlkB证据表明人类FTO催化N6-甲基腺苷的羟化作用，而不直接形成脱甲基产物，这与ALKBH5/2/3和细菌AlkB形成对比。
errNucleic Acids Research
IF13.1
err2025-08-28
err0
errOAAI
errSimranjeet Kaur; Pratheesh Maheswaran; Samanpreet Kaur; Yingqi Lai; Eidarus Salah; Dong Zhang; Shifali Shishodia; Christopher J Schofield; Wei Shen Aik
err分享
err收藏
Revealing the catalytic mechanism of the Fe(II)/2-oxoglutarate-dependent human epigenetic modifying enzyme ALKBH5揭示Fe(II)/2-oxoglutarate依赖性人类表观遗传修饰酶ALKBH5的催化机制
errCell Reports Physical Science
IF7.3
err2025-08-12
err0
errOAAI
errFathima Hameed Cherilakkudy; Midhun George Thomas; Ann Varghese; Sodiq O. Waheed; Anandhu Krishnan; Vincenzo Venditti; Christopher J. Schofield; Deyu Li; Christo Z. Christov; Tatyana G. Karabencheva-Christova
err分享
err收藏
Electrostatic interactions influence diazabicyclooctane inhibitor potency against OXA-48-like β-lactamases静电相互作用影响diaza bicyclooctane抑制剂的活性对OXA-48-like β-内酰胺酶的效力
errRSC Med. Chem.
IF3.6
err2025-08-09
err0
errOAAI
errJoseph Francis Hoff; Kirsty Elizabeth Goudar; Karina Calvopiña; Michael Beer; Philip Hinchliffe; John Shaw; Catherine Louise Tooke; Yuiko Takebayashi; Andrew Cadzow; Nicholas Harmer; Adrian John Mulholland; Christopher J Schofield; James Spencer
err分享
err收藏

研究方向

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