未登录 Optimization of Potent and Selective Cyclohexyl Acid ERAP1 Inhibitors Using Structure- and Property-Based Drug Design Hryczanek, Ross P.; Hackett, Andrew S.; Rowland, Paul; Chung, Chun-wa; Convery, Maire A.; Holmes, Duncan S.; Hutchinson, Jonathan P.; Kitchen, Semra; Korczynska, Justyna; Law, Robert P.; Lea, Jonathan D.; Liddle, John; Lonsdale, Richard; Neu, Margarete; Nickels, Leng; Phillipou, Alex; Rowedder, James E.; Schneck, Jessica L.; Scott-Stevens, Paul; Sheehan, Hester; Tayler, Chloe L.; Temponeras, Ioannis; Tinworth, Christopher P.; Walker, Ann L.; Wojno-Picon, Justyna; Young, Robert J.; Lindsay, David M.; Stratikos, Efstratios 分享 收藏
Investigation of Janus Kinase (JAK) Inhibitors for Lung Delivery and the Importance of Aldehyde Oxidase Metabolism Wellaway, Christopher R.; Baldwin, Ian R.; Bamborough, Paul; Barker, Daniel; Bartholomew, Michelle A.; Chung, Chun-wa; Dumpelfeld, Birgit; Evans, John P.; Fazakerley, Neal J.; Homes, Paul; Keeling, Steven P.; Lewell, Xiao Q.; McNab, Finlay W.; Morley, Joanne; Needham, Deborah; Neu, Margarete; van Oosterhout, Antoon J. M.; Pal, Anshu; Reinhard, Friedrich B. M.; Rianjongdee, Francesco; Robertson, Craig M.; Rowland, Paul; Shah, Rishi R.; Sherriff, Emma B.; Sloan, Lisa A.; Teague, Simon; Thomas, Daniel A.; Wellaway, Natalie; Wojno-Picon, Justyna; Woolven, James M.; Coe, Diane M. 分享 收藏
Targeting the Regulatory Site of ER Aminopeptidase 1 Leads to the Discovery of a Natural Product Modulator of Antigen Presentation Liddle, John; Hutchinson, Jonathan P.; Kitchen, Semra; Rowland, Paul; Neu, Margarete; Cecconie, Ted; Holmes, Duncan S.; Jones, Emma; Korczynska, Justyna; Koumantou, Despoina; Lea, Jonathan D.; Nickels, Leng; Pemberton, Michelle; Phillipou, Alex; Schneck, Jessica L.; Sheehan, Hester; Tinworth, Christopher P.; Uings, Iain; Wojno-Picon, Justyna; Young, Robert J.; Stratikos, Efstratios 分享 收藏
Mechanism for antigenic peptide selection by endoplasmic reticulum aminopeptidase 1 Giastas, Petros; Mpakali, Anastasia; Papakyriakou, Athanasios; Lelis, Aggelos; Kokkala, Paraskevi; Neu, Margarete; Rowland, Paul; Liddle, John; Georgiadis, Dimitris; Stratikos, Efstratios 分享 收藏
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Identification of KasA as the cellular target of an anti-tubercular scaffold Abrahams, Katherine A.; Chung, Chun-wa; Ghidelli-Disse, Sonja; Rullas, Joaquin; Jose Rebollo-Lopez, Maria; Gurcha, Sudagar S.; Cox, Jonathan A. G.; Mendoza, Alfonso; Jimenez-Navarro, Elena; Santos Martinez-Martinez, Maria; Neu, Margarete; Shillings, Anthony; Homes, Paul; Argyrou, Argyrides; Casanueva, Ruth; Loman, Nicholas J.; Moynihan, Patrick J.; Lelievre, Joel; Selenski, Carolyn; Axtman, Matthew; Kremer, Laurent; Bantscheff, Marcus; Angulo-Barturen, Inigo; Cacho Izquierdo, Monica; Cammack, Nicholas C.; Drewes, Gerard; Ballell, Lluis; Barros, David; Besra, Gurdyal S.; Bates, Robert H. 分享 收藏
New direct inhibitors of InhA with antimycobacterial activity based on a tetrahydropyran scaffold Pajk, Stane; Zivec, Matej; Sink, Roman; Sosic, Izidor; Neu, Margarete; Chung, Chun-wa; Martinez-Hoyos, Maria; Perez-Herran, Esther; Alvarez-Gomez, Daniel; Alvarez-Ruiz, Emilio; Mendoza-Losana, Alfonso; Castro-Pichel, Julia; Barros, David; Ballell-Pages, Lluis; Young, Robert J.; Convery, Maire A.; Encinas, Lourdes; Gobec, Stanislav 分享 收藏
Novel Interaction Mechanism of a Domain Antibody-based Inhibitor of Human Vascular Endothelial Growth Factor with Greater Potency than Ranibizumab and Bevacizumab and Improved Capacity over Aflibercept Walker, Adam; Chung, Chun-Wa; Neu, Margarete; Burman, Manish; Batuwangala, Thil; Jones, Gavin; Tang, Chi-Man; Steward, Michael; Mullin, Michael; Tournier, Nadia; Lewis, Alan; Korczynska, Justyna; Chung, Vicky; Catchpole, Ian 分享 收藏
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Encoded Library Technology as a Source of Hits for the Discovery and Lead Optimization of a Potent and Selective Class of Bactericidal Direct Inhibitors of Mycobacterium tuberculosis InhA Encinas, Lourdes; O'Keefe, Heather; Neu, Margarete; Remuinan, Modesto J.; Patel, Amish M.; Guardia, Ana; Davie, Christopher P.; Perez-Macias, Natalia; Yang, Hongfang; Convery, Maire A.; Messer, Jeff A.; Perez-Herran, Esther; Centrella, Paolo A.; Alvarez-Gomez, Daniel; Clark, Matthew A.; Huss, Sophie; O'Donovan, Gary K.; Ortega-Muro, Fatima; McDowell, William; Castaneda, Pablo; Arico-Muendel, Christopher C.; Pajk, Stane; Rullas, Joaquin; Angulo-Barturen, Inigo; Alvarez-Ruiz, Emilio; Mendoza-Losana, Alfonso; Pages, Lluis Ballell; Castro-Pichel, Julia; Evindar, Ghotas 分享 收藏
Identification of PDE4B Over 4D subtype-selective inhibitors revealing an unprecedented binding mode Kranz, Michael; Wall, Michael; Evans, Brian; Miah, Afjal; Ballantine, Stuart; Delves, Chris; Dombroski, Brian; Gross, Jeffrey; Schneck, Jessica; Villa, James P.; Neu, Margarete; Somers, Don O. 分享 收藏
X-ray crystal structure of human dopamine sulfotransferase, SULT1A3 - Molecular modeling and quantitative structure-activity relationship analysis demonstrate a molecular basis for sulfotransferase substrate specificity Dajani, R; Cleasby, A; Neu, M; Wonacott, AJ; Jhoti, H; Hood, AM; Modi, S; Hersey, A; Taskinen, J; Cooke, RM; Manchee, GR; Coughtrie, MWH 分享 收藏
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