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Fiona Hackett

mrc national institute for medical research

35H指数
111论文数
5.1K被引数
收录论文 24
发表时间
Mixed alkyl/aryl phosphonates identify metabolic serine hydrolases as antimalarial targets
err2024-09-01
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errOAAI
errBennett, John M.; Narwal, Sunil K.; Kabeche, Stephanie; Abegg, Daniel; Thathy, Vandana; Hackett, Fiona; Yeo, Tomas; Li, Veronica L.; Muir, Ryan; Faucher, Franco; Lovell, Scott; Blackman, Michael J.; Adibekian, Alexander; Yeh, Ellen; Fidock, David A.; Bogyo, Matthew
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Peptidic Boronic Acid Plasmodium falciparum SUB1 Inhibitors with Improved Selectivity over Human Proteasome
err2024-07-25
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errWithers-Martinez, Chrislaine; Lidumniece, Elina; Hackett, Fiona; Collins, Christine R.; Taha, Zahie; Blackman, Michael J.; Jirgensons, Aigars
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Macrocyclic Peptidomimetic Plasmepsin X Inhibitors with Potent In Vitro and In Vivo Antimalarial Activity
err2023-07-28
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errKovada, Vadims; Withers-Martinez, Chrislaine; Bobrovs, Raitis; Cerule, Helena; Liepins, Edgars; Grinberga, Solveiga; Hackett, Fiona; Collins, Christine R. R.; Kreicberga, Agrita; Jimenez-Diaz, Maria Belen; Angulo-Barturen, Inigo; Rasina, Dace; Suna, Edgars; Jaudzems, Kristaps; Blackman, Michael J.; Jirgensons, Aigars
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A choline-releasing glycerophosphodiesterase essential for phosphatidylcholine biosynthesis and blood stage development in the malaria parasite
err2022-12-28
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errRamaprasad, Abhinay; Burda, Paul-Christian; Calvani, Enrica; Sait, Aaron J.; Palma-Duran, Susana Alejandra; Withers-Martinez, Chrislaine; Hackett, Fiona; Macrae, James; Collinson, Lucy; Gilberger, Tim Wolf; Blackman, Michael J.
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Subtilisin-like Serine Protease 1 (SUB1) as an Emerging Antimalarial Drug Target: Current Achievements in Inhibitor Discovery Miniperspective
err2022-09-22
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PREAI
errLidumniece, Elina; Withers-Martinez, Chrislaine; Hackett, Fiona; Blackman, Michael J.; Jirgensons, Aigars
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Peptidic boronic acids are potent cell-permeable inhibitors of the malaria parasite egress serine protease SUB1
err2021-05-11
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errLidumniece, Elina; Withers-Martinez, Chrislaine; Hackett, Fiona; Collins, Christine R.; Perrin, Abigail J.; Koussis, Konstantinos; Bisson, Claudine; Blackman, Michael J.; Jirgensons, Aigars
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Autocatalytic activation of a malarial egress protease is druggable and requires a protein cofactor
err2021-05-01
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errTan, Michele S. Y.; Koussis, Konstantinos; Withers-Martinez, Chrislaine; Howell, Steven A.; Thomas, James A.; Hackett, Fiona; Knuepfer, Ellen; Shen, Min; Hall, Matthew D.; Snijders, Ambrosius P.; Blackman, Michael J.
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The malaria parasite sheddase SUB2 governs host red blood cell membrane sealing at invasion
err2020-12-08
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errCollins, Christine R.; Hackett, Fiona; Howell, Steven A.; Snijders, Ambrosius P.; Russell, Matthew Rg; Collinson, Lucy M.; Blackman, Michael J.
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The Plasmodium falciparum pseudoprotease SERA5 regulates the kinetics and efficiency of malaria parasite egress from host erythrocytes
err2017-07-06
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errCollins, Christine R.; Hackett, Fiona; Atid, Jonathan; Tan, Michele Ser Ying; Blackman, Michael J.
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Parasitophorous vacuole poration precedes its rupture and rapid host erythrocyte cytoskeleton collapse in Plasmodium falciparum egress
err2017-03-14
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errHale, Victoria L.; Watermeyer, Jean M.; Hackett, Fiona; Vizcay-Barrena, Gema; van Ooij, Christiaan; Thomas, James A.; Spink, Matthew C.; Harkiolaki, Maria; Duke, Elizabeth; Fleck, Roland A.; Blackman, Michael J.; Saibil, Helen R.
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The malaria parasite egress protease SUB1 is a calcium-dependent redox switch subtilisin (vol 5, 3726, 2014)
err2014-05-28
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errWithers-Martinez, Chrislaine; Strath, Malcolm; Hackett, Fiona; Haire, Lesley F.; Howell, Steven A.; Walker, Philip A.; Christodoulou, Evangelos; Dodson, Guy G.; Blackman, Michael J.
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The malaria parasite egress protease SUB1 is a calcium-dependent redox switch subtilisin
err2014-05-02
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errWithers-Martinez, Chrislaine; Strath, Malcolm; Hackett, Fiona; Haire, Lesley F.; Howell, Steven A.; Walker, Philip A.; Christodoulou, Evangelos; Dodson, Guy G.; Blackman, Michael J.
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Malaria Parasite cGMP-dependent Protein Kinase Regulates Blood Stage Merozoite Secretory Organelle Discharge and Egress
err2013-05-09
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errCollins, Christine R.; Hackett, Fiona; Strath, Malcolm; Penzo, Maria; Withers-Martinez, Chrislaine; Baker, David A.; Blackman, Michael J.
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Proteolytic Activation of the Essential Parasitophorous Vacuole Cysteine Protease SERA6 Accompanies Malaria Parasite Egress from Its Host Erythrocyte
err2012-11-01
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errRuecker, Andrea; Shea, Michael; Hackett, Fiona; Suarez, Catherine; Hirst, Elizabeth M. A.; Milutinovic, Katarina; Withers-Martinez, Chrislaine; Blackman, Michael J.
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Plasmodium subtilisin-like protease 1 (SUB1): Insights into the active-site structure, specificity and function of a pan-malaria drug target
err2012-05-01
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errWithers-Martinez, Chrislaine; Suarez, Catherine; Fulle, Simone; Kher, Samir; Penzo, Maria; Ebejer, Jean-Paul; Koussis, Kostas; Hackett, Fiona; Jirgensons, Aigars; Finn, Paul; Blackman, Michael J.
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Juxtamembrane Shedding of Plasmodium falciparum AMA1 Is Sequence Independent and Essential, and Helps Evade Invasion-Inhibitory Antibodies
err2011-12-15
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errOlivieri, Anna; Collins, Christine R.; Hackett, Fiona; Withers-Martinez, Chrislaine; Marshall, Joshua; Flynn, Helen R.; Skehel, J. Mark; Blackman, Michael J.
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A multifunctional serine protease primes the malaria parasite for red blood cell invasion
err2009-02-12
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errKoussis, Konstantinos; Withers-Martinez, Chrislaine; Yeoh, Sharon; Child, Matthew; Hackett, Fiona; Knuepfer, Ellen; Juliano, Luiz; Woehlbier, Ute; Bujard, Hermann; Blackman, Michael J.
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An Inhibitory Antibody Blocks Interactions between Components of the Malarial Invasion Machinery
err2009-01-23
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errCollins, Christine R.; Withers-Martinez, Chrislaine; Hackett, Fiona; Blackman, Michael J.
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Intramembrane proteolysis mediates shedding of a key adhesin during erythrocyte invasion by the malaria parasite
err2006-09-21
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errO'Donnell, Rebecca A.; Hackett, Fiona; Howell, Steven A.; Treeck, Moritz; Struck, Nicole; Krnajski, Zita; Withers-Martinez, Chrislaine; Gilberger, Tim W.; Blackman, Michael J.
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Molecular identification of a malaria merozoite surface sheddase
err2005-11-25
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errHarris, Philippa K.; Yeoh, Sharon; Dluzewski, Anton R.; O'Donnell, Rebecca A.; Withers-Martinez, Chrislaine; Hackett, Fiona; Bannister, Lawrence H.; Mitchell, Graham H.; Blackman, Michael J.
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