Harold Kohn - Publications, H-index & Citations

Chimeric Agents Derived from the Functionalized Amino Acid, Lacosamide, and the α-Aminoamide, Safinamide: Evaluation of Their Inhibitory Actions on Voltage-Gated Sodium Channels, and Antiseizure and Antinociception Activities and Comparison with Lacosamide and Safinamide

IF3

2015-07-01

OAAI

Torregrosa, Robert; Yang, Xiao-Fang; Dustrude, Erik T.; Cummins, Theodore R.; Khanna, Rajesh; Kohn, Harold

Substituted N-(Biphenyl-4′-yl)methyl (R)-2-Acetamido-3-methoxypropionamides: Potent Anticonvulsants That Affect Frequency (Use) Dependence and Slow Inactivation of Sodium Channels

IF3.9

2014-12-09

OAAI

Park, Ki Duk; Yang, Xiao-Fang; Dustrude, Erik T.; Wang, Yuying; Ripsch, Matthew S.; White, Fletcher A.; Khanna, Rajesh; Kohn, Harold

Benzyloxybenzylammonium chlorides: Simple amine salts that display anticonvulsant activity

IF6.8

2014-07-15

OAAI

Lee, Hyosung; Park, Ki Duk; Torregrosa, Robert; Yang, Xiao-Fang; Dustrude, Erik T.; Wang, Yuying; Wilson, Sarah M.; Barbosa, Cindy; Xiao, Yucheng; Cummins, Theodore R.; Khanna, Rajesh; Kohn, Harold

(Biphenyl-4-yl)methylammonium Chlorides: Potent Anticonvulsants That Modulate Na+ Currents

IF3

2013-12-01

PREAI

Lee, Hyosung; Gold, Alexander S.; Yang, Xiao-Fang; Khanna, Rajesh; Kohn, Harold

Discovery of Lacosamide Affinity Bait Agents That Exhibit Potent Voltage-Gated Sodium Channel Blocking Properties

IF6.8

2013-07-03

OAAI

Lee, Hyosung; Park, Ki Duk; Yang, Xiao-Fang; Dustrude, Erik T.; Wilson, Sarah M.; Khanna, Rajesh; Kohn, Harold

Identification of the Benzyloxyphenyl Pharmacophore: A Structural Unit That Promotes Sodium Channel Slow Inactivation

IF3.9

2013-01-16

OAAI

Park, Ki Duk; Yang, Xiao-Fang; Lee, Hyosung; Dustrude, Erik T.; Wang, Yuying; Khanna, Rajesh; Kohn, Harold

Synthesis, anticonvulsant activity, and neuropathic pain-attenuating activity of N-benzyl 2-amino-2-(hetero)aromatic acetamides

IF3.9

2012-10-04

OAAI

King, Amber M.; Yang, Xiao-Fang; Wang, Yuying; Dustrude, Erik T.; Barbosa, Cindy; Due, Michael R.; Piekarz, Andrew D.; Wilson, Sarah M.; White, Fletcher A.; Salome, Christophe; Cummins, Theodore R.; Khanna, Rajesh; Kohn, Harold

Primary Amino Acid Derivatives: Substitution of the 4′-N′-Benzylamide Site in (R)-N′-Benzyl 2-Amino-3-methylbutanamide, (R)-N′-Benzyl 2-Amino-3,3-dimethylbutanamide, and (R)-N′-Benzyl 2-Amino-3-methoxypropionamide Provides Potent Anticonvulsants with Pain-Attenuating Properties

IF3

2012-06-01

PREAI

Baruah, Pranjal K.; Dinsmore, Jason; King, Amber M.; Salome, Christophe; De Ryck, Marc; Kaminski, Rafal; Provins, Laurent; Kohn, Harold

Defining the Structural Parameters That Confer Anticonvulsant Activity by the Site-by-Site Modification of (R)-N′-Benzyl 2-Amino-3-methylbutanamide

IF6.8

2011-09-13

PREAI

King, Amber M.; Salome, Christophe; Salome-Grosjean, Elise; De Ryck, Marc; Kaminski, Rafal; Valade, Anne; Stables, James P.; Kohn, Harold

Identification of a Lacosamide Binding Protein Using an Affinity Bait and Chemical Reporter Strategy: 14-3-3 ζ

IF6.8

2011-09-13

OAAI

King, Amber M.; De Ryck, Marc; Kaminski, Rafal; Valade, Anne; Stables, James P.; Kohn, Harold

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2011-07-06

OAAI

Park, Ki Duk; Kim, Dongwook; Reamtong, Onrapak; Eyers, Claire; Gaskell, Simon J.; Liu, Rihe; Kohn, Harold

Primary Amino Acid Derivatives: Compounds with Anticonvulsant and Neuropathic Pain Protection Activities

Merging Structural Motifs of Functionalized Amino Acids and α-Aminoamides Results in Novel Anticonvulsant Compounds with Significant Effects on Slow and Fast Inactivation of Voltage-Gated Sodium Channels and in the Treatment of Neuropathic Pain

IF6.8

2011-06-15

PREAI

King, Amber M.; Salome, Christophe; Dinsmore, Jason; Salome-Grosjean, Elise; De Ryck, Marc; Kaminski, Rafal; Valade, Anne; Kohn, Harold

Development and Characterization of Novel Derivatives of the Antiepileptic Drug Lacosamide That Exhibit Far Greater Enhancement in Slow Inactivation of Voltage-Gated Sodium Channels

IF3.9

2011-04-22

OAAI

Wang, Yuying; Wilson, Sarah M.; Brittain, Joel M.; Ripsch, Matthew S.; Salome, Christophe; Park, Ki Duk; White, Fletcher A.; Khanna, Rajesh; Kohn, Harold

The Structure-Activity Relationship of the 3-Oxy Site in the Anticonvulsant (R)-N-Benzyl 2-Acetamido-3-methoxypropionamide

IF3.9

2010-11-24

OAAI

Wang, Yuying; Park, Ki Duk; Salome, Christophe; Wilson, Sarah M.; Stables, James P.; Liu, Rihe; Khanna, Rajesh; Kohn, Harold

Merging the Structural Motifs of Functionalized Amino Acids and α-Aminoamides: Compounds with Significant Anticonvulsant Activities

IF6.8

2010-07-08

OAAI

Morieux, Pierre; Salome, Christophe; Park, Ki Duk; Stables, James P.; Kohn, Harold

Lacosamide Isothiocyanate-Based Agents: Novel Agents To Target and Identify Lacosamide Receptors

IF6.8

2010-04-15

OAAI

Salome, Christophe; Salome-Grosjean, Elise; Stables, James P.; Kohna, Harold

A novel automated lazy learning QSAR (ALL-QSAR) approach: Method development, applications, and virtual screening of chemical databases using validated ALL-QSAR models

IF6.8

2009-10-01

OAAI

Park, Ki Duk; Morieux, Pierre; Salome, Christophe; Cotten, Steven W.; Reamtong, Onrapak; Eyers, Claire; Gaskell, Simon J.; Stables, James P.; Liu, Rihe; Kohn, Harold

JOURNAL OF CHEMICAL INFORMATION AND MODELING

IF5.3

2006-09-02

221

OAAI

Zhang, Shuxing; Golbraikh, Alexander; Oloff, Scott; Kohn, Harold; Tropsha, Alexander

N-substituted amino acid N′-benzylamides:: synthesis, anticonvulsant, and metabolic activities