未登录 Optimization of a micro-scale air-liquid-interface model of human proximal airway epithelium for moderate throughput drug screening for SARS-CoV-2 针对SARS-CoV-2的中等通量药物筛选，对微尺度人近端气道上皮气液界面模型的优化 Sen, Chandani; Rickabaugh, Tammy M.; Jeyachandran, Arjit Vijey; Yuen, Constance; Ghannam, Maisam; Durra, Abdo; Aziz, Adam; Castillo, Kristen; Garcia, Gustavo; Purkayastha, Arunima; Han, Brandon; Boulton, Felix W.; Chekler, Eugene; Garces, Robert; Wolff, Karen C.; Riva, Laura; Kirkpatrick, Melanie G.; Gebara-Lamb, Amal; Mcnamara, Case W.; Betz, Ulrich A. K.; Arumugaswami, Vaithilingaraja; Damoiseaux, Robert; Gomperts, Brigitte N. 分享 收藏
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Discovery of quinazoline HPK1 inhibitors with high cellular potency Toure, Momar; Johnson, Theresa; Li, Bin; Schmidt, Ralf; Ma, Hong; Neagu, Constantin; Lopez, Andrea Unzue; Wang, Yanping; Guler, Satenig; Xiao, YuFang; Henkes, Renate; Ho, Kevin; Zhang, Susan; Chu, Chia Lin; Gundra, Uma Mahesh; Porichis, Filippos; Li, Long; Maurer, Christine Katharina; Fang, Zhizhou; Musil, Djordje; DiPoto, Maria; Friis, Emily; Jones, Reinaldo; Jones, Christopher; Cummings, James; Chekler, Eugene; Tanzer, Eva Maria; Huck, Bayard; Sherer, Brian 分享 收藏
Large-Scale Assessment of Binding Free Energy Calculations in Active Drug Discovery Projects 活性药物发现项目中结合自由能计算的大规模评估 Schindler, Christina E. M.; Baumann, Hannah; Blum, Andreas; Boese, Dietrich; Buchstaller, Hans-Peter; Burgdorf, Lars; Cappel, Daniel; Chekler, Eugene; Czodrowski, Paul; Dorsch, Dieter; Eguida, Merveille K., I; Follows, Bruce; Fuchss, Thomas; Graedler, Ulrich; Gunera, Jakub; Johnson, Theresa; Lebrun, Catherine Jorand; Karra, Srinivasa; Klein, Markus; Knehans, Tim; Koetzner, Lisa; Krier, Mireille; Leiendecker, Matthias; Leuthner, Birgitta; Li, Liwei; Mochalkin, Igor; Musil, Djordje; Neagu, Constantin; Rippmann, Friedrich; Schiemann, Kai; Schulz, Robert; Steinbrecher, Thomas; Tanzer, Eva-Maria; Lopez, Andrea Unzue; Follis, Ariele Viacava; Wegener, Ansgar; Kuhn, Daniel 分享 收藏
Structure-Based Approach To Identify 5-[4-Hydroxyphenyl]pyrrole-2-carbonitrile Derivatives as Potent and Tissue Selective Androgen Receptor Modulators Unwalla, Ray; Mousseau, James J.; Fadeyi, Olugbeminiyi O.; Choi, Chulho; Parris, Kevin; Hu, Baihua; Kenney, Thomas; Chippari, Susan; McNally, Christopher; Vishwanathan, Karthick; Kilbourne, Edward; Thompson, Catherine; Nagpal, Sunil; Wrobel, Jay; Yudt, Matthew; Morris, Carl A.; Powell, Dennis; Gilbert, Adam M.; Chekler, Eugene L. Piatnitski 分享 收藏
Structure-Based Design of Highly Selective Inhibitors of the CREB Binding Protein Bromodomain Denny, R. Aldrin; Flick, Andrew C.; Coe, Jotham; Langille, Jonathan; Basak, Arindrajit; Liu, Shenping; Stock, Ingrid; Sahasrabudhe, Parag; Bonin, Paul; Hay, Duncan A.; Brennan, Paul E.; Pletcher, Mathew; Jones, Lyn H.; Chekler, Eugene L. Piatnitski 分享 收藏
Reversal of neurobehavioral social deficits in dystrophic mice using inhibitors of phosphodiesterases PDE5A and PDE9A 使用磷酸二酯酶PDE5A和PDE9A抑制剂逆转营养不良小鼠的神经行为社会缺陷 Alexander, M. S.; Gasperini, M. J.; Tsai, P. T.; Gibbs, D. E.; Spinazzola, J. M.; Marshall, J. L.; Feyder, M. J.; Pletcher, M. T.; Chekler, E. L. P.; Morris, C. A.; Sahin, M.; Harms, J. F.; Schmidt, C. J.; Kleiman, R. J.; Kunkel, L. M. 分享 收藏
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Kiloscale Buchwald-Hartwig Amination: Optimized Coupling of Base-Sensitive 6-Bromoisoquinoline-1-carbonitrile with (S)-3-Amino-2-methylpropan-1-ol Sperry, Jeffrey B.; Wiglesworth, Kristin E. Price; Edmonds, Ian; Fiore, Phillip; Boyles, David C.; Damon, David B.; Dorow, Roberta L.; Chekler, Eugene L. Piatnitski; Langille, Jonathan; Coe, Jotham W. 分享 收藏
1-(2-Hydroxy-2-methyl-3-phenoxypropanoyl)indoline-4-carbonitrile Derivatives as Potent and Tissue Selective Androgen Receptor Modulators Chekler, Eugene L. Piatnitski; Unwalla, Rayomond; Khan, Taukeer A.; Tangirala, Raghuram S.; Johnson, Mark; St Andre, Michael; Anderson, James T.; Kenney, Thomas; Chiparri, Sue; McNally, Chris; Kilbourne, Edward; Thompson, Catherine; Nagpal, Sunil; Weber, Gregory; Schelling, Scott; Owens, Jane; Morris, Carl A.; Powell, Dennis; Verhoest, Patrick R.; Gilbert, Adam M. 分享 收藏
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Arylphthalazines as potent, and orally bioavailable inhibitors of VEGFR-2 芳基酞嗪作为VEGFR-2的有效和口服生物可利用的抑制剂 Duncton, Matthew A. J.; Chekler, Eugene L. Piatnitski; Katoch-Rouse, Reeti; Sherman, Dan; Wong, Wai C.; Smith, Leon M., II; Kawakami, Joel K.; Kiselyov, Alexander S.; Milligan, Daniel L.; Balagtas, Chris; Hadari, Yaron R.; Wang, Ying; Patel, Sheetal N.; Rolster, Robin L.; Tonra, James R.; Surguladze, David; Mitelman, Stan; Kussie, Paul; Bohlen, Peter; Doody, Jacqueline F. 分享 收藏
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