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K

Kevin T. Chapman

Humboldt University of Berlin
H指数:40
被引数:1.1万
浏览量:0

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Hit-to-Lead Optimization and Discovery of 5-((5-([1,1′-Biphenyl]-4-yl)-6-chloro-1H-benzo[d]imidazol-2-yl)oxy)-2-methylbenzoic Acid (MK-3903): A Novel Class of Benzimidazole-Based Activators of AMP-Activated Protein Kinase
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2017-10-2523
PREAI
Lan, Ping; Romero, F. Anthony; Wodka, Dariusz; Kassick, Andrew J.; Dang, Qun; Gibson, Tony; Cashion, Daniel; Zhou, Gaochao; Chen, Yuli; Zhang, Xiaoping; Zhang, Aihua; Li, Ying; Trujillo, Maria E.; Shao, Qing; Wu, Margaret; Xu, Shiyao; He, Huaibing; MacKenna, Deidre; Staunton, Jocelyn; Chapman, Kevin T.; Weber, Ann; Sebhat, Iyassu K.; Makarat, Gergely M.
1,3,8-Triazaspiro[4.5]decane-2,4-diones as Efficacious Pan-Inhibitors of Hypoxia-Inducible Factor Prolyl Hydroxylase 1-3 (HIF PHD1-3) for the Treatment of Anemia
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2012-02-2773
PREAI
Vachal, Petr; Miao, Shouwu; Pierce, Joan M.; Guiadeen, Deodial; Colandrea, Vincent J.; Wyvratt, Matthew J.; Salowe, Scott P.; Sonatore, Lisa M.; Milligan, James A.; Hajdu, Richard; Gollapudi, Anantha; Keohane, Carol A.; Lingham, Russell B.; Mandala, Suzanne M.; DeMartino, Julie A.; Tong, Xinchun; Wolff, Michael; Steinhuebel, Dietrich; Kieczykowski, Gerard R.; Fleitz, Fred J.; Chapman, Kevin; Athanasopoulos, John; Adam, Gregory; Akyuz, Can D.; Jena, Dhirendra K.; Lusen, Jeffrey W.; Meng, Juncai; Stein, Benjamin D.; Xia, Lei; Sherer, Edward C.; Hale, Jeffrey J.
Design and Synthesis of Prolylcarboxypeptidase (PrCP) Inhibitors To Validate PrCP As A Potential Target for Obesity
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2010-09-2157
PREAI
Zhou, Changyou; Garcia-Calvo, Margareta; Pinto, Shirly; Lombardo, Matthew; Feng, Zhe; Bender, Kate; Pryor, KellyAnn D.; Bhatt, Urmi R.; Chabin, Renee M.; Geissler, Wavne M.; Shen, Zhu; Tong, Xinchun; Zhang, Zhoupeng; Wong, Kenny K.; Roy, Ranabir Sinha; Chapman, Kevin T.; Yang, Lihu; Xiong, Yusheng
Somatostatin receptor subtypes 2 and 5 mediate inhibition of egg yolk-induced gall bladder emptying in mice
NEUROGASTROENTEROLOGY AND MOTILITY
IF2.9
2010-02-018
PREAI
Kaczmarek, P.; Singh, V.; Cashen, D. E.; Yang, L.; Berk, S.; Pasternak, A.; Xiong, Y.; Shen, D. -M.; Hutchins, S. M.; Chapman, K.; Wiedenmann, B.; Schaeffer, J. M.; Strowski, M. Z.
Suppression of PC-1/ENPP-1 expression improves insulin sensitivity in vitro and in vivo
EUROPEAN JOURNAL OF PHARMACOLOGY
IF4.7
2009-08-0130
PREAI
Zhou, Heather H.; Chin, Chen-Ni; Wu, Margaret; Ni, Weihua; Quan, Shuo; Liu, Franklin; Dallas-Yang, Qing; Ellsworth, Kenneth; Ho, Thu; Zhang, Aiwu; Natasha, Tajneen; Li, Jing; Chapman, Kevin; Strohl, William; Li, Cai; Wang, I-Ming; Berger, Joel; An, Zhiqiang; Zhang, Bei B.; Jiang, Guoqiang
Application of Affinity Selection/Mass Spectrometry to Determine the Structural Isomer of Parnafungins Responsible for Binding Polyadenosine Polymerase
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
2008-11-1726
PREAI
Adam, Gregory C.; Parish, Craig A.; Wisniewski, Douglas; Meng, Juncai; Liu, Min; Calati, Kathleen; Stein, Benjamin D.; Athanasopoulos, John; Liberator, Paul; Roemer, Terry; Harris, Guy; Chapman, Kevin T.
The target of ezetimibe is Niemann-Pick Cl-Like 1 (NPC1L1)
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
2005-05-31701
OAAI
Garcia-Calvo, M; Lisnock, JM; Bull, HG; Hawes, BE; Burnett, DA; Braun, MP; Crona, JH; Davis, HR; Dean, DC; Detmers, PA; Graziano, MP; Hughes, M; MacIntyre, DE; Ogawa, A; O'Neill, KA; Iyer, SPN; Shevell, DE; Smith, MM; Tang, YS; Makarewicz, AM; Ujjainwalla, F; Altmann, SW; Chapman, KT; Thornberry, NA
Anthrax lethal factor inhibition
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
2005-05-23187
OAAI
Shoop, WL; Xiong, Y; Wiltsie, J; Woods, A; Guo, J; Pivnichny, JV; Felcetto, T; Michael, BF; Bansal, A; Cummings, RT; Cunningham, BR; Friedlander, AM; Douglas, CM; Patel, SB; Wisniewski, D; Scapin, G; Salowe, SP; Zaller, DM; Chapman, KT; Scolnick, EM; Schmatz, DM; Bartizal, K; MacCoss, M; Hermes, JD
A novel glucagon receptor antagonist inhibits glucagon-mediated biological effects
DIABETES
IF7.5
2004-12-01103
OAAI
Qureshi, SA; Candelore, MR; Xie, D; Yang, XD; Tota, LM; Ding, VDH; Li, ZH; Bansal, A; Miller, C; Cohen, SM; Jiang, GQ; Brady, E; Saperstein, R; Duffy, JL; Tata, JR; Chapman, KT; Moller, DE; Zhang, BB
CCR5 antagonists: 3-(pyrrolidin-1-yl)propionic acid analogues with potent anti-HIV activity
ORGANIC LETTERS
IF5
2003-06-1120
PREAI
Lynch, CL; Hale, JJ; Budhu, RJ; Gentry, AL; Finke, PE; Caldwell, CG; Mills, SG; MacCoss, M; Shen, DM; Chapman, KT; Malkowitz, L; Springer, MS; Gould, SL; DeMartino, JA; Siciliano, SJ; Cascieri, MA; Carella, A; Carver, G; Karen, H; Schleif, WA; Danzeisen, R; Hazuda, D; Kessler, J; Lineberger, J; Miller, M; Emini, E
DIRECTED REDUCTION OF BETA-HYDROXY KETONES EMPLOYING TETRAMETHYLAMMONIUM TRIACETOXYBOROHYDRIDE
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
2002-05-011.2K
PREAI
EVANS, DA; CHAPMAN, KT; CARREIRA, EM
INHIBITION OF MATRIX METALLOPROTEINASES BY N-CARBOXYALKYL PEPTIDES
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2002-05-0194
PREAI
CHAPMAN, KT; KOPKA, IE; DURETTE, PL; ESSER, CK; LANZA, TJ; IZQUIERDOMARTIN, M; NIEDZWIECKI, L; CHANG, B; HARRISON, RK; KUO, DW; LIN, TY; STEIN, RL; HAGMANN, WK
Mass spectrometry screening of combinatorial mixtures, correlation of measured and predicted electrospray ionization spectra
ANALYTICAL CHEMISTRY
IF6.7
2001-05-3021
PREAI
Yates, N; Wislocki, D; Roberts, A; Berk, S; Klatt, T; Shen, DM; Willoughby, C; Rosauer, K; Chapman, K; Griffin, P
Versatile and efficient solid-phase syntheses of pyrazoles and isoxazoles
ORGANIC LETTERS
IF5
2000-08-0469
PREAI
Shen, DM; Shu, M; Chapman, KT
Synthesis and biological activities of potent peptidomimetics selective for somatostatin receptor subtype 2
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
1998-09-01136
OAAI
Yang, LH; Berk, SC; Rohrer, SP; Mosley, RT; Guo, LQ; Underwood, DJ; Arison, BH; Birzin, ET; Hayes, EC; Mitra, SW; Parmar, RM; Cheng, K; Wu, TJ; Butler, BS; Foor, F; Pasternak, A; Pan, YP; Silva, M; Freidinger, RM; Smith, RG; Chapman, K; Schaeffer, JM; Patchett, AA
A combinatorial approach defines specificities of members of the caspase family and granzyme B - Functional, relationships established for key mediators of apoptosis
JOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
1997-07-012.1K
OAAI
Thornberry, NA; Ranon, TA; Pieterson, EP; Rasper, DM; Timkey, T; GarciaCalvo, M; Houtzager, VM; Nordstrom, PA; Roy, S; Vaillancourt, JP; Chapman, KT; Nicholson, DW
Inhibition of stromelysin-1 (MMP-3) by P-1'-biphenylylethyl carboxyalkyl dipeptides
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
1997-03-1469
PREAI
Esser, CK; Bugianesi, RL; Caldwell, CG; Chapman, KT; Durette, PL; Girotra, NN; Kopka, IE; Lanza, TJ; Levorse, DA; MacCoss, M; Owens, KA; Ponpipom, MM; Simeone, JP; Harrison, RK; Niedzwiecki, L; Becker, JW; Marcy, AI; Axel, MG; Christen, AJ; McDonnell, J; Moore, VL; Olszewski, JM; Saphos, C; Visco, DM; Shen, F; Colletti, A; Krieter, PA; Hagmann, WK
Dendrimer-supported combinatorial chemistry
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
1996-09-1790
OAAI
Kim, RM; Manna, M; Hutchins, SM; Griffin, PR; Yates, NA; Bernick, AM; Chapman, KT
Two new criteria for choosing sample size in combinatorial chemistry
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
1996-01-1916
PREAI
Zhao, PL; Nachbar, RB; Bolognese, JA; Chapman, K

研究方向

暂未获取到该数据
D
Dong‐Ming Shen
H 指数:19论文数:56被引数:1,464
S
Scott C. Berk
H 指数:20论文数:55被引数:2,616
M
Malcolm MacCoss
H 指数:48论文数:252被引数:1.0万
G
Guoqiang Jiang
H 指数:40论文数:128被引数:6,602
B
Benjamin D. Stein
H 指数:11论文数:67被引数:956
N
Nancy A. Thornberry
H 指数:73论文数:151被引数:4.0万
G
Gregory C. Adam
H 指数:19论文数:51被引数:2,504
A
Alexander Pasternak
H 指数:36论文数:172被引数:4,272
P
Patrick R. Griffin
H 指数:91论文数:638被引数:3.6万
R
Richard K. Harrison
H 指数:30论文数:133被引数:3,712