未登录 Discovery and Characterization of Potent, Efficacious, Orally Available Antimalarial Plasmepsin X Inhibitors and Preclinical Safety Assessment of UCB7362 有效，有效，口服可用的抗疟血浆蛋白酶X抑制剂的发现和表征以及UCB7362的临床前安全性评估 Lowe, Martin A. .; Cardenas, Alvaro; Valentin, Jean-Pierre; Zhu, Zhaoning; Abendroth, Jan; Castro, Jose L.; Class, Reiner; Delaunois, Annie; Fleurance, Renaud; Gerets, Helga; Gryshkova, Vitalina; King, Lloyd; Lorimer, Donald D.; MacCoss, Malcolm; Rowley, Julian H.; Rosseels, Marie-Luce; Royer, Leandro; Taylor, Richard D.; Wong, Melanie; Zaccheo, Oliver; Chavan, Vishal P.; Ghule, Gokul A. .; Tapkir, Bapusaheb K.; Burrows, Jeremy N.; Duffey, Maelle; Rottmann, Matthias; Wittlin, Sergio; Angulo-Barturen, Inigo; Belen Jimenez-Diaz, Maria; Striepen, Josefine; Fairhurst, Kate J.; Yeo, Tomas; Fidock, David A. .; Cowman, Alan F.; Favuzza, Paola; Crespo-Fernandez, Benigno; Javier Gamo, Francisco; Goldberg, Daniel E.; Soldati-Favre, Dominique; Laleu, Benoit; de Haro, Teresa 分享 收藏
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Direct sulfonylation of anilines mediated by visible light Johnson, Tarn C.; Elbert, Bryony L.; Farley, Alistair J. M.; Gorman, Timothy W.; Genicot, Christophe; Lallemand, Benedicte; Pasau, Patrick; Flasz, Jakub; Castro, Jose L.; MacCoss, Malcolm; Dixon, Darren J.; Paton, Robert S.; Schofield, Christopher J.; Smith, Martin D.; Willis, Michael C. 分享 收藏
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C-H Cyanation of 6-Ring N-Containing Heteroaromatics Elbert, Bryony L.; Farley, Alistair J. M.; Gorman, Timothy W.; Johnson, Tarn C.; Genicot, Christophe; Lallemand, Benedicte; Pasau, Patrick; Flasz, Jakub; Castro, Jose L.; MacCoss, Malcolm; Paton, Robert S.; Schofield, Christopher J.; Smith, Martin D.; Willis, Michael C.; Dixon, Darren J. 分享 收藏
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Cyclic Hydroxyamidines as Amide Isosteres: Discovery of Oxadiazolines and Oxadiazines as Potent and Highly Efficacious γ-Secretase Modulators in Vivo Sun, Zhong-Yue; Asberom, Theodros; Bara, Thomas; Bennett, Chad; Burnett, Duane; Chu, Inhou; Clader, John; Cohen-Williams, Mary; Cole, David; Czarniecki, Michael; Durkin, James; Gallo, Gioconda; Greenlee, William; Josien, Hubert; Huang, Xianhai; Hyde, Lynn; Jones, Nicholas; Kazakevich, Irina; Li, Hongmei; Liu, Xiaoxiang; Lee, Julie; MacCoss, Malcolm; Mandal, Mihir B.; McCracken, Troy; Nomeir, Amin; Mazzola, Robert; Palani, Anandan; Parker, Eric M.; Pissarnitski, Dmitri A.; Qin, Jun; Song, Lixin; Terracina, Giuseppe; Vicarel, Monica; Voigt, Johannes; Xu, Ruo; Zhang, Lili; Zhang, Qi; Zhao, Zhiqiang; Zhu, Xiaohong; Zhu, Zhaoning 分享 收藏
Antiviral Efficacy upon Administration of a HepDirect Prodrug of 2′-C-Methylcytidine to Hepatitis C Virus-Infected Chimpanzees Carroll, Steven S.; Koeplinger, Kenneth; Vavrek, Marissa; Zhang, Nanyan Rena; Handt, Laurence; MacCoss, Malcolm; Olsen, David B.; Reddy, K. Raja; Sun, Zhili; van Poelje, Paul D.; Fujitaki, James M.; Boyer, Serge H.; Linemeyer, David L.; Hecker, Scott J.; Erion, Mark D. 分享 收藏
Sustained Viral Response in a Hepatitis C Virus-Infected Chimpanzee via a Combination of Direct-Acting Antiviral Agents Olsen, David B.; Davies, Mary-Ellen; Handt, Larry; Koeplinger, Kenneth; Zhang, Nanyan Rena; Ludmerer, Steven W.; Graham, Donald; Liverton, Nigel; MacCoss, Malcolm; Hazuda, Daria; Carroll, Steven S. 分享 收藏
Phosphoramidate Prodrugs of 2′-C-Methylcytidine for Therapy of Hepatitis C Virus Infection Gardelli, Cristina; Attenni, Barbara; Donghi, Monica; Meppen, Malte; Pacini, Barbara; Harper, Steven; Di Marco, Annalise; Fiore, Fabrizio; Giuliano, Claudio; Pucci, Vincenzo; Laufer, Ralph; Gennari, Nadia; Marcucci, Isabella; Leone, Joseph F.; Olsen, David B.; MacCoss, Malcolm; Rowley, Michael; Narjes, Frank 分享 收藏
Discovery of N-{N-[(3-Cyanophenyl)sulfonyl]-4(R)-cyclobutylamino-(L)-prolyl}-4-[(3′,5′-dichloroisonicotinoyl)amino]-(L)-phenylalanine (MK-0668), an Extremely Potent and Orally Active Antagonist of Very Late Antigen-4 Lin, Linus S.; Lanza, Thomas, Jr.; Jewell, James P.; Liu, Ping; Jones, Carrie; Kieczykowski, Gerard R.; Treonze, Kelly; Si, Qian; Manior, Salony; Koo, Gloria; Tong, Xinchun; Wang, Junying; Schuelke, Anne; Pivnichny, James; Wang, Regina; Raab, Conrad; Vincent, Stella; Davies, Philip; MacCoss, Malcolm; Mumford, Richard A.; Hagmann, William K. 分享 收藏
Robust Antiviral Efficacy upon Administration of a Nucleoside Analog to Hepatitis C Virus-Infected Chimpanzees Carroll, Steven S.; Ludmerer, Steven; Handt, Larry; Koeplinger, Kenneth; Zhang, Nanyan Rena; Graham, Donald; Davies, Mary-Ellen; MacCoss, Malcolm; Hazuda, Daria; Olsen, David B. 分享 收藏
Synthesis and HCV inhibitory properties of 9-deaza- and 7,9-dideaza-7-oxa-2′-C-methyladenosine Butora, Gabor; Olsen, David B.; Carroll, Steven S.; McMasters, Daniel R.; Schmitt, Christoph; Leone, Joseph F.; Stahlhut, Mark; Burlein, Christine; MacCoss, Malcolm 分享 收藏
Liver-targeted prodrugs of 2′-C-methyladenosine for therapy of hepatitis C virus infection Hecker, Scott J.; Reddy, K. Raja; van Poelje, Paul D.; Sun, Zhili; Huang, Wenjian; Varkhedkar, Vaibhav; Reddy, M. Venkat; Fujitaki, James M.; Olsen, David B.; Koeplinger, Kenneth A.; Boyer, Serge H.; Linemeyer, David L.; MacCoss, Malcolm; Erion, Mark D. 分享 收藏
Discovery of 3-piperidinyl-1-cyclopentanecarboxamide as a novel scaffold for highly potent CC chemokine receptor 2 antagonists Yang, Lihu; Butora, Gabor; Jiao, Richard X.; Pasternak, Alex; Zhou, Changyou; Parsons, William H.; Mills, Sander G.; Vicario, Pasquale P.; Ayala, Julia M.; Cascieri, Margaret A.; MacCoss, Malcolm 分享 收藏
Novel, orally bioavailable γ-aminoamide CC chemokine receptor 2 (CCR2) antagonists Pasternak, Alexander; Marino, Dominick; Vicario, Pasquale P.; Ayala, Julia Marie; Cascierri, Margaret A.; Parsons, William; Mills, Sander G.; MacCoss, Malcolm; Yang, Lihu 分享 收藏
Synthesis and study of alendronate derivatives as potential prodrugs of alendronate sodium for the treatment of low bone density and osteoporosis Vachal, Petr; Hale, Jeffrey J.; Lu, Zhe; Streckfuss, Eric C.; Mills, Sander G.; MacCoss, Malcolm; Yin, Daniel H.; Algayer, Kimberly; Manser, Kimberly; Kesisoglou, Filippos; Ghosh, Soumojeet; Alani, Laman L. 分享 收藏
Anthrax lethal factor inhibition Shoop, WL; Xiong, Y; Wiltsie, J; Woods, A; Guo, J; Pivnichny, JV; Felcetto, T; Michael, BF; Bansal, A; Cummings, RT; Cunningham, BR; Friedlander, AM; Douglas, CM; Patel, SB; Wisniewski, D; Scapin, G; Salowe, SP; Zaller, DM; Chapman, KT; Scolnick, EM; Schmatz, DM; Bartizal, K; MacCoss, M; Hermes, JD 分享 收藏
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