未登录 SIK2 selective inhibitors demonstrate dual anti-inflammatory and mucosal repair profiles in human ex vivo models of Ulcerative Colitis 丝苏氨酸激酶2选择性抑制剂在人类体外模型中的溃疡性结肠炎中显示出双重抗炎和黏膜修复特性 Daigle, S.; Collis, L.; Zhang, Y.; Elliott, G.; Kumar, S.; Zhu, X.; Kaila, N.; Basavapathruni, A.; Surapaneni, S.; Scaramozza, M.; Kumar, P.; Edmondson, S.; Loh, C.; Tummino, P. 分享 收藏
Preclinical characterization of NTX-452, a potent, selective and highly efficacious WRN inhibitor for the treatment of MSI-H tumors Boiko, S.; Li, D.; Toms, A.; Caravella, J.; Carreiro, S.; Bartels, F.; Sitnikov, N.; Browning, B.; Leit, S.; Jacques-O'Hagan, S.; Oh, H.; Florine, E.; Li, Z.; Scheuber, A.; Phadke, A.; Khong, Y. M.; Britt, S.; Alexander, J.; Tummino, P.; Svensson, R. 分享 收藏
Discovery of a Potent and Selective Tyrosine Kinase 2 Inhibitor: TAK-279 一种有效的选择性酪氨酸激酶2抑制剂的发现: TAK-279 Leit, Silvana; Greenwood, Jeremy; Carriero, Samantha; Mondal, Sayan; Abel, Robert; Ashwell, Mark; Blanchette, Heather; Boyles, Nicholas A. A.; Cartwright, Mark; Collis, Alan; Feng, Shulu; Ghanakota, Phani; Harriman, Geraldine C. C.; Hosagrahara, Vinayak; Kaila, Neelu; Kapeller, Rosanna; Rafi, Salma B. B.; Romero, Donna L. L.; Tarantino, Paul M. M.; Timaniya, Jignesh; Toms, Angela V. V.; Wester, Ronald T. T.; Westlin, William; Srivastava, Bhaskar; Miao, Wenyan; Tummino, Peter; McElwee, Joshua J. J.; Edmondson, Scott D. D.; Masse, Craig E. E. 分享 收藏
A HIGHLY SELECTIVE AND POTENT HPK1 INHIBITOR ENHANCES IMMUNE CELL ACTIVATION AND INDUCES ROBUST TUMOR GROWTH INHIBITION IN A MURINE SYNGENEIC TUMOR MODEL Ciccone, David; Lazari, Vad; Linney, Ian; Briggs, Michael; Carreiro, Samantha; McElwee, Joshua; Waddell, Ian; Hill, Chris; Loh, Christine; Tummino, Peter; Collis, Alan; Kaila, Neelu 分享 收藏
HPK1, hematopoietic progenitor kinase 1, is a promising therapeutic target for cancer immunotherapy Ciccone, David; Rocnik, Jennifer; Lazari, Vad; Linney, Ian; Briggs, Michael; Collis, Alan; Loh, Christine; Ashwell, Mark; Montana, John; Tummino, Peter; Kaila, Neelu 分享 收藏
MEK inhibitors overcome resistance to BET inhibition across a number of solid and hematologic cancers Wyce, Anastasia; Matteo, Jeanne J.; Foley, Shawn W.; Felitsky, Daniel J.; Rajapurkar, Satyajit R.; Zhang, Xi-Ping; Musso, Melissa C.; Korenchuk, Susan; Karpinich, Natalie O.; Keenan, Kathryn M.; Stern, Melissa; Mathew, Lijoy K.; McHugh, Charles F.; McCabe, Michael T.; Tummino, Peter J.; Kruger, Ryan G.; Carpenter, Christopher; Barbash, Olena 分享 收藏
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Broad activity for the combination of BET and MEK inhibitors across solid and hematologic cancers Wyce, Anastasia; Felitsky, Daniel J.; Zhang, Xi -Ping; Matteo, Jeanne J.; Korenchuk, Susan; Mathew, Lijoy K.; Musso, Melissa; Khaku, Sakina; Ortiz, Victoria; Keenan, Kathryn; Stern, Melissa; Degenhardt, Yan; Plant, Ramona; McHugh, Charles F.; Tummino, Peter J.; Carpenter, Christopher; Barbash, Olena 分享 收藏
Antitumor activity and sensitivity evaluation of novel BET inhibitors in neuroblastoma Healy, Jason R.; Schnepp, Robert W.; Hart, Lori S.; Raman, Pichai; Danielson, Laura; Russell, Michael; Khurana, Priya; Gagliardi, Maria; Kinsey, Ryan M.; Wyce, Anastasia; Barbash, Olena; Tummino, Peter J.; Chesler, Louis; Maris, John M. 分享 收藏
Inhibition of BET bromodomain proteins as a therapeutic approach in small cell lung cancer Wyce, Anastasia; Le, BaoChau; Bai, Yuchen; Soong, David; Zhang, Xi-Ping; Matteo, Jeanne J.; Korenchuk, Susan; Butticello, Michael F.; Plant, Ramona; Bleam, Maureen R.; Degenhardt, Yan; McHugh, Charles F.; Carpenter, Christopher; Tummino, Peter J.; Barbash, Olena 分享 收藏
SMYD3 links methylation of MAP3K2 to Ras-driven tumors Mazur, Pawel K.; Reynoird, Nicolas; Khatri, Purvesh; Butte, Atul J.; Wilkinson, Alex; Garcia, Benjamin; Liu, Shichong; Vermeulen, Michiel; Jansen, Pascal W. T. C.; Tummino, Peter J.; Kruger, Ryan G.; Van Aller, Glenn S.; Barbash, Olena; Huddleston, Michael; Gozani, Or; Sage, Julien 分享 收藏
A687V EZH2 Is a Driver of Histone H3 Lysine 27 ( H3K27) Hypertrimethylation Ott, Heidi M.; Graves, Alan P.; Pappalardi, Melissa B.; Huddleston, Michael; Halsey, Wendy S.; Hughes, Ashley M.; Groy, Arthur; Dul, Edward; Jiang, Yong; Bai, Yuchen; Annan, Roland; Verma, Sharad K.; Knight, Steven D.; Kruger, Ryan G.; Dhanak, Dashyant; Schwartz, Benjamin; Tummino, Peter J.; Creasy, Caretha L.; McCabe, Michael T. 分享 收藏
Defining the antitumor activity and sensitivity profiles of BET inhibitors in neuroblastoma Schnepp, Robert; Hart, Lori; Raman, Pichai; Danielson, Laura; Gagliardi, Maria; Kinsey, Ryan; Wyce, Anastasia; Barbash, Olena; Tummino, Peter; Chesler, Louis; Maris, John 分享 收藏
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Inhibition of BET bromodomain proteins as a therapeutic approach in prostate cancer Wyce, Anastasia; Degenhardt, Yan; Bai, Yuchen; Le, BaoChau; Korenchuk, Susan; Crouthamel, Ming-Chih; McHugh, Charles F.; Vessella, Robert; Creasy, Caretha L.; Tummino, Peter J.; Barbash, Olena 分享 收藏
Control of NF-kB activity in human melanoma by bromodomain and extra-terminal protein inhibitor I-BET151 Gallagher, Stuart J.; Mijatov, Branka; Gunatilake, Dilini; Gowrishankar, Kavitha; Tiffen, Jessamy; James, Wilmott; Jin, Lei; Pupo, Gulietta; Cullinane, Carleen; McArthur, Grant A.; Tummino, Peter J.; Rizos, Helen; Hersey, Peter 分享 收藏
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Long Residence Time Inhibition of EZH2 in Activated Polycomb Repressive Complex 2 Van Aller, Glenn S.; Pappalardi, Melissa Baker; Ott, Heidi M.; Diaz, Elsie; Brandt, Martin; Schwartz, Benjamin J.; Miller, William H.; Dhanak, Dashyant; McCabe, Michael T.; Verma, Sharad K.; Creasy, Caretha L.; Tummino, Peter J.; Kruger, Ryan G. 分享 收藏
Identification of Potent, Selective, Cell-Active Inhibitors of the Histone Lysine Methyltransferase EZH2 鉴定组蛋白赖氨酸甲基转移酶EZH2的有效，选择性，细胞活性抑制剂 Verma, Sharad K.; Tian, Xinrong; LaFrance, Louis V.; Duquenne, Celine; Suarez, Dominic P.; Newlander, Kenneth A.; Romeril, Stuart P.; Burgess, Joelle L.; Grant, Seth W.; Brackley, James A.; Graves, Alan P.; Scherzer, Daryl A.; Shu, Art; Thompson, Christine; Ott, Heidi M.; Van Aller, Glenn S.; Machutta, Carl A.; Diaz, Elsie; Jiang, Yong; Johnson, Neil W.; Knight, Steven D.; Kruger, Ryan G.; McCabe, Michael T.; Dhanak, Dashyant; Tummino, Peter J.; Creasy, Caretha L.; Miller, William H. 分享 收藏
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