未登录 HIV-1 Resistance to Islatravir/Tenofovir Combination Therapy in Wild-Type or NRTI-Resistant Strains of Diverse HIV-1 Subtypes Cilento, Maria E.; Wen, Xin; Reeve, Aaron B.; Ukah, Obiaara B.; Snyder, Alexa A.; Carrillo, Ciro M.; Smith, Cole P.; Edwards, Kristin; Wahoski, Claudia C.; Kitzler, Deborah R.; Kodama, Eiichi N.; Mitsuya, Hiroaki; Parniak, Michael A.; Tedbury, Philip R.; Sarafianos, Stefan G. 分享 收藏
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Pharmacophore-based design of novel 3-hydroxypyrimidine-2,4-dione subtypes as inhibitors of HIV reverse transcriptase-associated RNase H: Tolerance of a nonflexible linker Tang, Jing; Do, Ha T.; Huber, Andrew D.; Casey, Mary C.; Kirby, Karen A.; Wilson, Daniel J.; Kankanala, Jayakanth; Parniak, Michael A.; Sarafianos, Stefan G.; Wang, Zhengqiang 分享 收藏
6-Arylthio-3-hydroxypyrimidine-2,4-diones potently inhibited HIV reverse transcriptase-associated RNase H with antiviral activity 6-芳硫基-3-羟基嘧啶-2，4-二酮有效抑制具有抗病毒活性的HIV逆转录酶相关RNase H Wang, Lei; Tang, Jing; Huber, Andrew D.; Casey, Mary C.; Kirby, Karen A.; Wilson, Daniel J.; Kankanala, Jayakanth; Xie, Jiashu; Parniak, Michael A.; Sarafianos, Stefan G.; Wang, Zhengqiang 分享 收藏
6-Biphenylmethyl-3-hydroxypyrimidine-2,4-diones potently and selectively inhibited HIV reverse transcriptase-associated RNase H 6-联苯甲基-3-羟基嘧啶-2，4-二酮有效和选择性地抑制HIV逆转录酶相关的RNase H Wang, Lei; Tang, Jing; Huber, Andrew D.; Casey, Mary C.; Kirby, Karen A.; Wilson, Daniel J.; Kankanala, Jayakanth; Parniak, Michael A.; Sarafianos, Stefan G.; Wang, Zhengqiang 分享 收藏
A 2-Hydroxyisoquinoline-1,3-Dione Active-Site RNase H Inhibitor Binds in Multiple Modes to HIV-1 Reverse Transcriptase Kirby, Karen A.; Myshakina, Nataliya A.; Christen, Martin T.; Chen, Yue-Lei; Schmidt, Hilary A.; Huber, Andrew D.; Xi, Zhaoyong; Kim, Seongmi; Rao, Rohit K.; Kramer, Skyler T.; Yang, Qiongying; Singh, Kamalendra; Parniak, Michael A.; Wang, Zhengqiang; Ishima, Rieko; Sarafianos, Stefan G. 分享 收藏
Synthesis, biological evaluation and molecular modeling of 2-Hydroxyisoquinoline-1,3-dione analogues as inhibitors of HIV reverse transcriptase associated ribonuclease H and polymerase Tang, Jing; Vernekar, Sanjeev Kumar V.; Chen, Yue-Lei; Miller, Lena; Huber, Andrew D.; Myshakina, Nataliya; Sarafianos, Stefan G.; Parniak, Michael A.; Wang, Zhengqiang 分享 收藏
3-Hydroxypyrimidine-2,4-Diones as Novel Hepatitis B Virus Antivirals Targeting the Viral Ribonuclease H Huber, Andrew D.; Michailidis, Eleftherios; Tang, Jing; Puray-Chavez, Maritza N.; Boftsi, Maria; Wolf, Jennifer J.; Boschert, Kelsey N.; Sheridan, Megan A.; Leslie, Maxwell D.; Kirby, Karen A.; Singh, Kamalendra; Mitsuya, Hiroaki; Parniak, Michael A.; Wang, Zhengqiang; Sarafianos, Stefan G. 分享 收藏
Double-Winged 3-Hydroxypyrimidine-2,4-diones: Potent and Selective Inhibition against HIV-1 RNase H with Significant Antiviral Activity Vernekar, Sanjeev Kumar V.; Tang, Jing; Wu, Bulan; Huber, Andrew D.; Casey, Mary C.; Myshakina, Nataliya; Wilson, Daniel J.; Kankanala, Jayakanth; Kirby, Karen A.; Parniak, Michael A.; Sarafianos, Stefan G.; Wang, Zhengqiang 分享 收藏
Structural basis of HIV inhibition by translocation-defective RT inhibitor 4′-ethynyl-2-fluoro-2′-deoxyadenosine (EFdA) Salie, Zhe Li; Kirby, Karen A.; Michailidis, Eleftherios; Marchand, Bruno; Singh, Kamalendra; Rohan, Lisa C.; Kodama, Eiichi N.; Mitsuya, Hiroaki; Parniak, Michael A.; Sarafianos, Stefan G. 分享 收藏
Design, Synthesis, and Biological Evaluations of Hydroxypyridonecarboxylic Acids as Inhibitors of HIV Reverse Transcriptase Associated RNase H Kankanala, Jayakanth; Kirby, Karen A.; Liu, Feng; Miller, Lena; Nagy, Eva; Wilson, Daniel J.; Parniak, Michael A.; Sarafianos, Stefan G.; Wang, Zhengqiang 分享 收藏
3-Hydroxypyrimidine-2,4-diones as Selective Active Site Inhibitors of HIV Reverse Transcriptase-Associated RNase H: Design, Synthesis, and Biochemical Evaluations Tang, Jing; Liu, Feng; Nagy, Eva; Miller, Lena; Kirby, Karen A.; Wilson, Daniel J.; Wu, Bulan; Sarafianos, Stefan G.; Parniak, Michael A.; Wang, Zhengqiang 分享 收藏
Nucleotide Sugar Pucker Preference Mitigates Excision by HIV-1 RT Yamada, Ken; Wahba, Alexander S.; Bernatchez, Jean A.; Ilina, Tatiana; Martinez-Montero, Saul; Habibian, Maryam; Deleavey, Glen F.; Goette, Matthias; Parniak, Michael A.; Damha, Masad J. 分享 收藏
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Oral Administration of the Nucleoside EFdA (4′-Ethynyl-2-Fluoro-2′-Deoxyadenosine) Provides Rapid Suppression of HIV Viremia in Humanized Mice and Favorable Pharmacokinetic Properties in Mice and the Rhesus Macaque Stoddart, Cheryl A.; Galkina, Sofiya A.; Joshi, Pheroze; Kosikova, Galina; Moreno, Mary E.; Rivera, Jose M.; Sloan, Barbara; Reeve, Aaron B.; Sarafianos, Stefan G.; Murphey-Corb, Michael; Parniak, Michael A. 分享 收藏
Vaginal Microbicide Film Combinations of Two Reverse Transcriptase Inhibitors, EFdA and CSIC, for the Prevention of HIV-1 Sexual Transmission Zhang, Wei; Hu, Minlu; Shi, Yuan; Gong, Tiantian; Dezzutti, Charlene S.; Moncla, Bernard; Sarafianos, Stefan G.; Parniak, Michael A.; Rohan, Lisa C. 分享 收藏
Synthesis and Properties of 2′-Deoxy-2′,4′-difluoroarabinose-Modified Nucleic Acids Martinez-Montero, Saul; Deleavey, Glen F.; Dierker-Viik, Arden; Lindovska, Petra; Ilina, Tatiana; Portella, Guillem; Orozco, Modesto; Parniak, Michael A.; Gonzalez, Carlos; Damha, Masad J. 分享 收藏
Design, Synthesis, Biochemical, and Antiviral Evaluations of C6 Benzyl and C6 Biarylmethyl Substituted 2-Hydroxylisoquinoline-1,3-diones: Dual Inhibition against HIV Reverse Transcriptase-Associated RNase H and Polymerase with Antiviral Activities Vernekar, Sanjeev Kumar V.; Liu, Zheng; Nagy, Eva; Miller, Lena; Kirby, Karen A.; Wilson, Daniel J.; Kankanala, Jayakanth; Sarafianos, Stefan G.; Parniak, Michael A.; Wang, Zhengqiang 分享 收藏
Drug Resistance in Non-B Subtype HIV-1: Impact of HIV-1 Reverse Transcriptase Inhibitors Singh, Kamalendra; Flores, Jacqueline A.; Kirby, Karen A.; Neogi, Ujjwal; Sonnerborg, Anders; Hachiya, Atsuko; Das, Kalyan; Arnold, Eddy; McArthur, Carole; Parniak, Michael; Sarafianos, Stefan G. 分享 收藏
4′-Ethynyl-2-fluoro-2′-deoxyadenosine (EFdA) Inhibits HIV-1 Reverse Transcriptase with Multiple Mechanisms Michailidis, Eleftherios; Huber, Andrew D.; Ryan, Emily M.; Ong, Yee T.; Leslie, Maxwell D.; Matzek, Kayla B.; Singh, Kamalendra; Marchand, Bruno; Hagedorn, Ariel N.; Kirby, Karen A.; Rohan, Lisa C.; Kodama, Eiichi N.; Mitsuya, Hiroaki; Parniak, Michael A.; Sarafianos, Stefan G. 分享 收藏
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