未登录 The Apoptotic Mechanism of Action of the Sphingosine Kinase 1 Selective Inhibitor SKI-178 in Human Acute Myeloid Leukemia Cell Lines Dick, Taryn E.; Hengst, Jeremy A.; Fox, Todd E.; Colledge, Ashley L.; Kale, Vijay P.; Sung, Shen-Shu; Sharma, Arun; Amin, Shantu; Loughran, Thomas P., Jr.; Kester, Mark; Wang, Hong-Gang; Yun, Jong K. 分享 收藏
Pyoluteorin derivatives induce Mcl-1 degradation and apoptosis in hematological cancer cells Doi, Kenichiro; Gowda, Krishne; Liu, Qiang; Lin, Jyh-Ming; Sung, Shen-Shu; Dower, Christopher; Claxton, David; Loughran, Thomas P., Jr.; Amin, Shantu; Wang, Hong-Gang 分享 收藏
A novel selective multikinase inhibitor of ROCK and MRCK effectively blocks cancer cell migration and invasion Kale, Vijay Pralhad; Hengst, Jeremy A.; Desai, Dhimant H.; Dick, Taryn E.; Choe, Katherine N.; Colledge, Ashley L.; Takahashi, Yoshinori; Sung, Shen-Shu; Amin, Shantu G.; Yun, Jong K. 分享 收藏
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Pyridylthiazole-based ureas as inhibitors of Rho-associated protein kinases Pireddu, Roberta; Forinash, Kara; Sun, Nan N.; Martin, Mathew P.; Sung, Shen-Shu; Alexander, Brian; Zhu, Jin-Yi; Guida, Wayne C.; Schonbrunn, Ernst; Sebti, Said M.; Lawrence, Nicholas J. 分享 收藏
Discovery of Marinopyrrole A (Maritoclax) as a Selective Mcl-1 Antagonist that Overcomes ABT-737 Resistance by Binding to and Targeting Mcl-1 for Proteasomal Degradation Doi, Kenichiro; Li, Rongshi; Sung, Shen-Shu; Wu, Hongwei; Liu, Yan; Manieri, Wanda; Krishnegowda, Gowdahalli; Awwad, Andy; Dewey, Alden; Liu, Xin; Amin, Shantu; Cheng, Chunwei; Qin, Yong; Schonbrunn, Ernst; Daughdrill, Gary; Loughran, Thomas P., Jr.; Sebti, Said; Wang, Hong-Gang 分享 收藏
Fragment-Based and Structure-Guided Discovery and Optimization of Rho Kinase Inhibitors Li, Rongshi; Martin, Mathew P.; Liu, Yan; Wang, Binglin; Patel, Ronil A.; Zhu, Jin-Yi; Sun, Nan; Pireddu, Roberta; Lawrence, Nicholas J.; Li, Jiannong; Haura, Eric B.; Sung, Shen-Shu; Guida, Wayne C.; Schonbrunn, Ernst; Sebti, Said M. 分享 收藏
The BH3 α-Helical Mimic BH3-M6 Disrupts Bcl-XL, Bcl-2, and MCL-1 Protein-Protein Interactions with Bax, Bak, Bad, or Bim and Induces Apoptosis in a Bax- and Bim-dependent Manner Kazi, Aslamuzzaman; Sun, Jiazhi; Doi, Kenichiro; Sung, Shen-Shu; Takahashi, Yoshinori; Yin, Hang; Rodriguez, Johanna M.; Becerril, Jorge; Berndt, Norbert; Hamilton, Andrew D.; Wang, Hong-Gang; Sebti, Said M. 分享 收藏
Inhibition of cellular Shp2 activity by a methyl ester analog of SPI-112 Chen, Liwei; Pernazza, Daniele; Scott, Latanya M.; Lawrence, Harshani R.; Ren, Yuan; Luo, Yunting; Wu, Xin; Sung, Shen-Shu; Guida, Wayne C.; Sebti, Said M.; Lawrence, Nicholas J.; Wu, Jie 分享 收藏
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Targeting the Bcl-2/BH3 protein-protein interaction: Identification, design, and synthesis of new selective inhibitors of the Mcl-1/BH3 interaction Pernazza, Daniele; Lawrence, Harshani R.; Doi, Kenichiro; Sung, Shen-Shu; Guida, Wayne C.; Sebti, Said M.; Wang, Hong-Gang; Lawrence, Nicholas J. 分享 收藏
Inhibitors of Src homology-2 domain containing protein tyrosine phosphatase-2 (Shp2) based on oxindole scaffolds Lawrence, Harshani R.; Pireddu, Roberta; Chen, Liwei; Luo, Yunting; Sung, Shen-Shu; Szymanski, Ann Marie; Yip, M. L. Richard; Guida, Wayne C.; Sebti, Saed M.; Wu, Jie; Lawrence, Nicholas J. 分享 收藏
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