未登录Investigating the Roles of Active Site Residues in Mycobacterium tuberculosis Indole-3-glycerol Phosphate Synthase, a Potential Target for Antitubercular Agents
Konas, David W.; Cho, Sarah; Thomas, Oshane D.; Bhatti, Maryum M.; Hernandez, Katherine Leon; Moran, Cinthya; Booter, Hedda; Candela, Thomas; Lacap, Joseph; McFadden, Paige; van den Berg, Savannah; Welter, Alyssa M.; Peralta, Ashley; Janson, Cheryl A.; Catalano, Jaclyn; Goodey, Nina M. .png)
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收藏分享 收藏 Mutational analysis confirms the presence of distal inhibitor-selectivity determining residues in B. stearothermophilus dihydrofolate reductaseEck, Tyler; Patel, Seema; Candela, Thomas; Leon, Katherine H.; Little, Michael; Reis, Natalia E.; Liyanagunawardana, Uththara; Gubler, Ueli; Janson, Cheryl A.; Catalano, Jaclyn; Goodey, Nina M. 分享 收藏 Fragment-Based Drug Design of Novel Pyranopyridones as Cell Active and Orally Bioavailable Tankyrase Inhibitorsde Vicente, Javier; Tivitmahaisoon, Parcharee; Berry, Pamela; Bolin, David R.; Carvajal, Daisy; He, Wei; Huang, Kuo-Sen; Janson, Cheryl; Liang, Lena; Lukacs, Christine; Petersen, Ann; Qian, Hong; Yi, Lin; Zhuang, Yong; Hermann, Johannes C. 分享 收藏 Discovery of potent and selective spiroindolinone MDM2 inhibitor, RO8994, for cancer therapyZhang, Zhuming; Ding, Qingjie; Liu, Jin-Jun; Zhang, Jing; Jiang, Nan; Chu, Xin-Jie; Bartkovitz, David; Luk, Kin-Chun; Janson, Cheryl; Tovar, Christian; Filipovic, Zoran M.; Higgins, Brian; Glenn, Kelli; Packman, Kathryn; Vassilev, Lyubomir T.; Graves, Bradford 分享 收藏 Optimization of Benzodiazepinones as Selective Inhibitors of the X-Linked Inhibitor of Apoptosis Protein (XIAP) Second Baculovirus IAP Repeat (BIR2) DomainKester, Robert F.; Donnell, Andrew F.; Lou, Yan; Remiszewski, Stacy W.; Lombardo, Louis J.; Chen, Shaoqing; Le, Nam T.; Lo, Jennifer; Moliterni, John A.; Han, Xiaochun; Hogg, J. Heather; Liang, Weiling; Michoud, Christophe; Rupert, Kenneth C.; Mischke, Steven; Le, Kang; Weisel, Martin; Janson, Cheryl A.; Lukacs, Christine M.; Fretland, Adrian J.; Hong, Kyoungja; Polonskaia, Ann; Gao, Lin; Li, Shirley; Solis, Dave S.; Aguilar, Doug; Tardell, Christine; Dvorozniak, Mark; Tannu, Shahid; Lee, Edmund C.; Schutt, Andy D.; Goggin, Barry 分享 收藏 Benzazepinones and Benzoxazepinones as Antagonists of Inhibitor of Apoptosis Proteins (IAPs) Selective for the Second Baculovirus IAP Repeat (BIR2) DomainDonnell, Andrew F.; Michoud, Christophe; Rupert, Kenneth C.; Han, Xiaochun; Aguilar, Douglas; Frank, Karl B.; Fretland, Adrian J.; Gao, Lin; Goggin, Barry; Hogg, J. Heather; Hong, Kyoungja; Janson, Cheryl A.; Kester, Robert F.; Kong, Norman; Le, Kang; Li, Shirley; Liang, Weiling; Lombardo, Louis J.; Lou, Yan; Lukacs, Christine M.; Mischke, Steven; Moliterni, John A.; Polonskaia, Ann; Schutt, Andrew D.; Solis, Dave S.; Specian, Anthony; Taylor, Robert T.; Weisel, Martin; Remiszewski, Stacy W. 分享 收藏 Discovery of RG7388, a Potent and Selective p53-MDM2 Inhibitor in Clinical DevelopmentDing, Qingjie; Zhang, Zhuming; Liu, Jin-Jun; Jiang, Nan; Zhang, Jing; Ross, Tina M.; Chu, Xin-Jie; Bartkovitz, David; Podlaski, Frank; Janson, Cheryl; Tovar, Christian; Filipovic, Zoran M.; Higgins, Brian; Glenn, Kelli; Packman, Kathryn; Vassilev, Lyubomir T.; Graves, Bradford 分享 收藏 Deconstruction of a Nutlin: Dissecting the Binding Determinants of a Potent Protein-Protein Interaction InhibitorFry, David C.; Wartchow, Charles; Graves, Bradford; Janson, Cheryl; Lukacs, Christine; Kammlott, Ursula; Belunis, Charles; Palme, Stefan; Klein, Christian; Vu, Binh 分享 收藏 Identification of an Adamantyl Azaquinolone JNK Selective InhibitorHaynes, Nancy-Ellen; Scott, Nathan R.; Chen, Li C.; Janson, Cheryl A.; Li, Jia Kui; Lukacs, Christine M.; Railkar, Aruna; Tozzo, Effie; Whittard, Toni; Brown, Nicholas F.; Cheung, Adrian Wai-Hing 分享 收藏 Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerizationGraves, Bradford; Thompson, Thelma; Xia, Mingxuan; Janson, Cheryl; Lukacs, Christine; Deo, Dayanand; Di Lello, Paola; Fry, David; Garvie, Colin; Huang, Kuo-Sen; Gao, Lin; Tovar, Christian; Lovey, Allen; Wanner, Jutta; Vassilev, Lyubomir T. 分享 收藏 Crystal Structures of IL-2-inducible T cell Kinase Complexed with Inhibitors: Insights into Rational Drug Design and Activity Regulation与抑制剂复合的IL-2-inducible T细胞激酶的晶体结构: 对合理药物设计和活性调节的见解Kutach, Alan K.; Villasenor, Armando G.; Lam, Diana; Belunis, Charles; Janson, Cheryl; Lok, Stephen; Hong, Li-Na; Liu, Chao-Min; Deval, Jerome; Novak, Thomas J.; Barnett, Jim W.; Chu, Wei; Shaw, David; Kuglstatter, Andreas 分享 收藏 Highly potent inhibitors of methionine aminopeptidase-2 based on a 1,2,4-triazole pharmacophoreMarino, Joseph P., Jr.; Fisher, Paul W.; Hofmann, Glenn A.; Kirkpatrick, Robert B.; Janson, Cheryl A.; Johnson, Randall K.; Ma, Chun; Mattern, Michael; Meek, Thomas D.; Ryan, M. Dominic; Schulz, Christina; Smith, Ward W.; Tew, David G.; Tomazek, Thaddeus A., Jr.; Veber, Daniel F.; Xiong, Wenfang C.; Yamamoto, Yuuichi; Yamashita, Keizo; Yang, Guang; Thompson, Scott K. 分享 收藏 Structure activity relationships of 5-, 6-, and 7-methyl -substituted azepan-3-one cathepsin K inhibitorsYamashita, DS; Marquis, RW; Xie, R; Nidamarthy, SD; Oh, HJ; Jeong, JU; Erhard, KF; Ward, KW; Roethke, TJ; Smith, BR; Cheng, HY; Geng, XL; Lin, F; Offen, PH; Wang, B; Nevins, N; Head, MS; Haltiwanger, RC; Sarjeant, AAN; Liable-Sands, LM; Zhao, BG; Smith, WW; Janson, CA; Gao, E; Tomaszek, T; McQueney, M; Jarnes, IE; Gress, CJ; Zembryki, DL; Lark, MW; Veber, DF 分享 收藏 4-Aryl-1,2,3-triazole: A novel template for a reversible methionine aminopeptidase 2 inhibitor, optimized to inhibit angiogenesis in vivoKallander, LS; Lu, Q; Chen, WF; Tomaszek, T; Yang, G; Tew, D; Meek, TD; Hofmann, GA; Schulz-Pritchard, CK; Smith, WW; Janson, CA; Ryan, MD; Zhang, GF; Johanson, KO; Kirkpatrick, RB; Ho, TF; Fisher, PW; Mattern, MR; Johnson, RK; Hansbury, MJ; Winkler, JD; Ward, KW; Veber, DF; Thompson, SK 分享 收藏 Identification of 1,5-naphthyridine derivatives as a novel series of potent and selective TGF-β type I receptor inhibitorsGellibert, FO; Woolven, J; Fouchet, MH; Mathews, N; Goodland, H; Lovegrove, V; Laroze, A; Nguyen, VL; Sautet, S; Wang, RL; Janson, C; Smith, W; Krysa, G; Boullay, V; de Gouville, AC; Huet, S; Hartley, D 分享 收藏 Indole naphthyridinones as inhibitors of bacterial enoyl-ACP reductases FabI and FabKSeefeld, MA; Miller, WH; Newlander, KA; Burgess, WJ; DeWolf, WE; Elkins, PA; Head, MS; Jakas, DR; Janson, CA; Keller, PM; Manley, PJ; Moore, TD; Payne, DJ; Pearson, S; Polizzi, BJ; Qiu, XY; Rittenhouse, SF; Uzinskas, IN; Wallis, NG; Huffmann, WF 分享 收藏 First X-ray cocrystal structure of a bacterial FabH condensing enzyme and a small molecule inhibitor achieved using rational design and homology modelingDaines, RA; Pendrak, I; Sham, K; Van Aller, GS; Konstantinidis, AK; Lonsdale, JT; Janson, CA; Qiu, XY; Brandt, M; Khandekar, SS; Silverman, C; Head, MS 分享 收藏 Discovery of a novel and potent class of fabI-directed antibacterial agentsPayne, DJ; Miller, WH; Berry, V; Brosky, J; Burgess, WJ; Chen, E; DeWolf, WE; Fosberry, AP; Greenwood, R; Head, MS; Heerding, DA; Janson, CA; Jaworski, DD; Keller, PM; Manley, PJ; Moore, TD; Newlander, KA; Pearson, S; Polizzi, BJ; Qiu, XY; Rittenhouse, SF; Slater-Radosti, C; Salyers, KL; Seefeld, MA; Smyth, MG; Takata, DT; Uzinskas, IN; Vaidya, K; Wallis, NG; Winram, SB; Yuan, CCK; Huffman, WF 分享 收藏 Discovery of aminopyridine-based inhibitors of bacterial enoyl-ACP reductase (FabI)Miller, WH; Seefeld, MA; Newlander, KA; Uzinskas, IN; Burgess, WJ; Heerding, DA; Yuan, CCK; Head, MS; Payne, DJ; Rittenhouse, SF; Moore, TD; Pearson, SC; Berry, V; DeWolf, WE; Keller, PM; Polizzi, BJ; Qiu, XY; Janson, CA; Huffman, WF 分享 收藏 
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