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Discovery of VTP-27999, an Alkyl Amine Renin Inhibitor with Potential for Clinical Utility Jia, Lanqi; Simpson, Robert D.; Yuan, Jing; Xu, Zhenrong; Zhao, Wei; Cacatian, Salvacion; Tice, Colin M.; Guo, Joan; Ishchenko, Alexey; Singh, Suresh B.; Wu, Zhongren; McKeever, Brian M.; Bukhtiyarov, Yuri; Johnson, Judith A.; Doe, Christopher P.; Harrison, Richard K.; McGeehan, Gerard M.; Dillard, Lawrence W.; Baldwin, John J.; Claremon, David A. 分享 收藏
Discovery of 2-hydroxy-N,N-dimethyl-3-{2-[[(R)-1-(5-methylfuran-2-yl)propyl]amino]-3,4-dioxocyclobut-1-enylamino}benzamide (SCH 527123):: A potent, orally bioavailable CXCR2/CXCR1 receptor antagonist Dwyer, Michael P.; Yu, Younong; Chao, Jianping; Aki, Cynthia; Chao, Jianhua; Biju, Purakkattle; Girijavallabhan, Viyyoor; Rindgen, Diane; Bond, Richard; Mayer-Ezel, Rosemary; Jakway, James; Hipkin, R. William; Fossetta, James; Gonsiorek, Waldemar; Bian, Hong; Fan, Xuedong; Terminelli, Carol; Fine, Jay; Lundell, Daniel; Merritt, J. Robert; Rokosz, Laura L.; Kaiser, Bernd; Li, Ge; Wang, Wei; Stauffer, Tara; Ozgur, Lynne; Baldwin, John; Taveras, Arthur G. 分享 收藏
Synthesis, biological evaluation, and pharmacokinetic study of prolyl-1-piperazinylacetic acid and prolyl-4-piperidinylacetic acid derivatives as VLA-4 antagonists Chiba, J; Takayama, G; Takashi, T; Yokoyama, M; Atsushi Nakayama, A; Baldwin, JJ; McDonald, E; Moriarty, KJ; Sarko, CR; Saionz, KW; Swanson, R; Hussain, Z; Wong, A; Machinaga, N 分享 收藏
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4-OXOSPIRO[BENZOPYRAN-2,4'-PIPERIDINES] AS CLASS-III ANTIARRHYTHMIC AGENTS - PHARMACOLOGICAL STUDIES ON 3,4-DIHYDRO-1'-[2-(BENZOFURAZAN-5-YL)-ETHYL]-6-METHANESULFONAMIDOSPIRO[(2H)-1-BENZOPYRAN-2,4'-PIPERIDIN]-4-ONE (L-691,121) ELLIOTT, JM; SELNICK, HG; CLAREMON, DA; BALDWIN, JJ; BUHROW, SA; BUTCHER, JW; HABECKER, CN; KING, SW; LYNCH, JJ; PHILLIPS, BT; PONTICELLO, GS; RADZILOWSKI, EM; REMY, DC; STEIN, RB; WHITE, JI; YOUNG, MB 分享 收藏
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Allosteric inhibitors of inducible nitric oxide synthase dimerization discovered via combinatorial chemistry McMillan, K; Adler, M; Auld, DS; Baldwin, JJ; Blasko, E; Browne, LJ; Chelsky, D; Davey, D; Dolle, RE; Eagen, KA; Erickson, S; Feldman, RI; Glaser, CB; Mallari, C; Morrissey, MM; Ohlmeyer, MHJ; Pan, CH; Parkinson, JF; Phillips, GB; Polokoff, MA; Sigal, NH; Vergona, R; Whitlow, M; Young, TA; Devlin, JJ 分享 收藏
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Class III antiarrhythmic activity in vivo by selective blockade of the slowly activating cardiac delayed rectifier potassium current I-Ks by (R)-2-(2,4-trifluoromethyl)-N-[2-oxo-5-phenyl-1-(2,2,2-trifluoroethyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]acetamide Selnick, HG; Liverton, NJ; Baldwin, JJ; Butcher, JW; Claremon, DA; Elliott, JM; Freidinger, RM; King, SA; Libby, BE; McIntyre, CJ; Pribush, DA; Remy, DC; Smith, GR; Tebben, AJ; Jurkiewicz, NK; Lynch, JJ; Salata, JJ; Sanguinetti, MC; Siegl, PKS; Slaughter, DE; Vyas, K 分享 收藏
Non-peptide glycoprotein IIb/IIIa inhibitors .17. Design and synthesis of orally active, long-acting non-peptide fibrinogen receptor antagonists Askew, BC; Bednar, RA; Bednar, B; Claremon, DA; Cook, JJ; McIntyre, CJ; Hunt, CA; Gould, RJ; Lynch, RJ; Lynch, JJ; Gaul, SL; Stranieri, MT; Sitko, GR; Holahan, MA; Glass, JD; Hamill, T; Gorham, LM; Prueksaritanont, T; Baldwin, JJ; Hartman, GD 分享 收藏
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