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Substrate reduction therapy for Krabbe disease and metachromatic leukodystrophy using a novel ceramide galactosyltransferase inhibitor Babcock, Michael C.; Mikulka, Christina R.; Wang, Bing; Chandriani, Sanjay; Chandra, Sundeep; Xu, Yue; Webster, Katherine; Feng, Ying; Nelvagal, Hemanth R.; Giaramita, Alex; Yip, Bryan K.; Lo, Melanie; Jiang, Xuntian; Chao, Qi; Woloszynek, Josh C.; Shen, Yuqiao; Bhagwat, Shripad; Sands, Mark S.; Crawford, Brett E. 分享 收藏
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CEP-32496: A Novel Orally Active BRAFV600E Inhibitor with Selective Cellular and In Vivo Antitumor Activity James, Joyce; Ruggeri, Bruce; Armstrong, Robert C.; Rowbottom, Martin W.; Jones-Bolin, Susan; Gunawardane, Ruwanthi N.; Dobrzanski, Pawel; Gardner, Michael F.; Zhao, Hugh; Cramer, Merryl D.; Hunter, Kathryn; Nepomuceno, Ronald R.; Cheng, Mangeng; Gitnick, Dana; Yazdanian, Mehran; Insko, Darren E.; Ator, Mark A.; Apuy, Julius L.; Faraoni, Raffaella; Dorsey, Bruce D.; Williams, Michael; Bhagwat, Shripad S.; Holladay, Mark W. 分享 收藏
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Identification of 1-(3-(6,7-Dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea Hydrochloride (CEP-32496), a Highly Potent and Orally Efficacious Inhibitor of V-RAF Murine Sarcoma Viral Oncogene Homologue B1 (BRAF) V600E Rowbottom, Martin W.; Faraoni, Raffaella; Chao, Qi; Campbell, Brian T.; Lai, Andiliy G.; Setti, Eduardo; Ezawa, Maiko; Sprankle, Kelly G.; Abraham, Sunny; Lan Tran; Struss, Brian; Gibney, Michael; Armstrong, Robert C.; Gunawardane, Ruwanthi N.; Nepomuceno, Ronald R.; Valenta, Ianina; Hua, Helen; Gardner, Michael F.; Cramer, Merry D.; Gitnick, Dana; Insko, Darren E.; Apuy, Julius L.; Jones-Bolin, Susan; Ghose, Arup K.; Herbertz, Torsten; Ator, Mark A.; Dorsey, Bruce D.; Ruggeri, Bruce; Williams, Michael; Bhagwat, Shripad; James, Joyce; Holladay, Mark W. 分享 收藏
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Identification of N-(5-tert-Butyl-isoxazol-3-yl)-N′-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea Dihydrochloride (AC220), a Uniquely Potent, Selective, and Efficacious FMS-Like Tyrosine Kinase-3 (FLT3) Inhibitor Chao, Qi; Sprankle, Kelly G.; Grotzfeld, Robert M.; Lai, Andiliy G.; Carter, Todd A.; Velasco, Anne Marie; Gunawardane, Ruwanthi N.; Cramer, Merryl D.; Gardner, Michael F.; James, Joyce; Zarrinkar, Patrick P.; Patel, Hitesh K.; Bhagwat, Shripad S. 分享 收藏
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4-amino-5-aryl-6-arylethynylpyrimidines: Structure-activity relationships of non-nucleoside adenosine kinase inhibitors 4-氨基-5-芳基-6-芳基乙炔基嘧啶: 非核苷腺苷激酶抑制剂的构效关系 Matulenko, Mark A.; Paight, Ernest S.; Frey, Robin R.; Gomtsyan, Arthur; DiDomenico, Stanley, Jr.; Jiang, Meiqun; Lee, Chih-Hung; Stewart, Andrew O.; Yu, Haixia; Kohlhaas, Kathy L.; Alexander, Karen M.; McGaraughty, Steve; Mikusa, Joseph; Marsh, Kennan C.; Muchmore, Steven W.; Jakob, Clarissa L.; Kowaluk, Elizabeth A.; Jarvis, Michael F.; Bhagwat, Shripad S. 分享 收藏
Crystal structures of human adenosine kinase inhibitor complexes reveal two distinct binding modes Muchmore, Steven W.; Smith, Richard A.; Stewart, Andrew O.; Cowart, Marlon D.; Gomtsyan, Arthur; Matulenko, Mark A.; Yu, Haixia; Severin, Jean M.; Bhagwat, Shripad S.; Lee, Chih-Hung; Kowaluk, Elizabeth A.; Jarvis, Michael F.; Jakob, Clarissa L. 分享 收藏
5-(3-bromophenyl)-7-(6-morpholin-4-ylpyridin-3-yl)pyrido-[2,3-d]pyrimidin-4-ylamine:: structure-activity relationships of 7-substituted heteroaryl analogs as non-nucleoside adenosine kinase inhibitors Matulenko, MA; Lee, CH; Jiang, M; Frey, RR; Cowart, MD; Bayburt, EK; DiDomenico, S; Gfesser, GA; Gomtsyan, A; Zheng, GZ; McKie, JA; Stewart, AO; Yu, HX; Kohlhaas, KL; Alexander, KM; McGaraughty, S; Wismer, CT; Mikusa, J; Marsh, KC; Snyder, RD; Diehl, MS; Kowaluk, EA; Jarvis, MF; Bhagwat, SS 分享 收藏
5,6,7-trisubstituted 4-aminopyrido[2,3-d]pyrimidines as novel inhibitors of adenosine kinase Perner, RJ; Gu, YG; Lee, CH; Bayburt, EK; McKie, J; Alexander, KM; Kohlhaas, KL; Wismer, CT; Mikusa, J; Jarvis, MF; Kowaluk, EA; Bhagwat, SS 分享 收藏
Synthesis and structure-activity relationships of 5-heteroatom-substituted pyridopyrimidines as adenosine kinase inhibitors Gfesser, GA; Bayburt, EK; Cowart, M; DiDomenico, S; Gomtsyan, A; Lee, CH; Stewart, AO; Jarvis, MF; Kowaluk, EA; Bhagwat, SS 分享 收藏
Design, synthesis, and structure-activity relationship of 6-alkynylpyrimidines as potent adenosine kinase inhibitors Gomtsyan, A; Didomenico, S; Lee, CH; Matulenko, MA; Kim, K; Kowaluk, EA; Wismer, CT; Mikusa, J; Yu, HX; Kohlhaas, K; Jarvis, MF; Bhagwat, SS 分享 收藏
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