未登录 Identification and Optimization of RNA-Splicing Modulators as Huntingtin Protein-Lowering Agents for the Treatment of Huntington's Disease Liu, Longbin; Malagu, Karine; Haughan, Alan F.; Khetarpal, Vinod; Stott, Andrew J.; Esmieu, William; Vater, Huw D.; Webster, Stephen J.; van de Poel, Amanda J.; Clissold, Cole; Cosgrove, Brett; Sutton, Benjamin; Spencer, Jonathan A.; Breccia, Perla; Gancia, Emanuela; Bonomo, Silvia; Ladduwahetty, Tammy; Lazari, Ovadia; Patel, Hiral; Atton, Helen C.; Clifton, Steve; Mota, Daniel M.; Magnani, Dario; O'Neill, Amy; Stebbeds, Marta; Macabuag, Natsuko; Todd, Daniel; Herva, Maria E.; Mitchell, Philip; Visser, Mijke; Compte Sancerni, Sara; Grand Moursel, Laure; da Silva, Marta; Kritikou, Eva; Heikkinen, Taneli T.; Bolkvadze, Tamuna; Fodale, Valentina; Spadafora, Debora; Daldin, Manuel; Bresciani, Alberto; Mangette, John E.; Doherty, Elizabeth M.; Lee, Matthew R.; Herbst, Todd; Monteagudo, Edith; Macdonald, Douglas; Plotnikov, Nikolay V.; Chambers, Mark; Mcallister, George; Munoz-Sanjuan, Ignacio; Dominguez, Celia 分享 收藏
Developing HDAC4-Selective Protein Degraders To Investigate the Role of HDAC4 in Huntington's Disease Pathology 开发HDAC4-Selective蛋白降解剂以研究HDAC4在亨廷顿病病理学中的作用 Macabuag, Natsuko; Esmieu, William; Breccia, Perla; Jarvis, Rebecca; Blackaby, Wesley; Lazari, Ovadia; Urbonas, Liudvikas; Eznarriaga, Maria; Williams, Rachel; Strijbosch, Annelieke; Van de Bospoort, Rhea; Matthews, Kim; Clissold, Cole; Ladduwahetty, Tammy; Vater, Huw; Heaphy, Patrick; Stafford, Douglas G.; Wang, Hong -Jun; Mangette, John E.; McAllister, George; Beaumont, Vahri; Vogt, Thomas F.; Wilkinson, Hilary A.; Doherty, Elizabeth M.; Dominguez, Celia 分享 收藏
A HUNTINGTON'S DISEASE EMBRYONIC STEM CELL PHENOTYPIC HTS TO IDENTIFY SMALL MOLECULE MODULATORS OF MUTANT HUNTINGTIN Todd, Daniel; Stebbeds, Marta; Thatcher, Emma; Barnard, Amy; Anton, Jeremy; Sienerth, Arnold; Visser, Mijke; Mitchell, Philip; Breccia, Perla; Smith, David; McAllister, George; Haque, Tasir; Liu, Longbin; Dominguez, Celia; Munoz-Sanjuan, Ignacio 分享 收藏
HAP40 is a conserved central regulator of Huntingtin and a potential modulator of Huntington's disease pathogenesis Xu, Shiyu; Li, Gang; Ye, Xin; Chen, Dongsheng; Chen, Zhihua; Xu, Zhen; Daniele, Moretti; Tambone, Sara; Ceccacci, Alessandra; Tomei, Licia; Ye, Lili; Yu, Yue; Solbach, Amanda; Farmer, Stephen M.; Stimming, Erin Furr; McAllister, George; Marchionini, Deanna M.; Zhang, Sheng 分享 收藏
Identification of a Potent, Selective, and Brain-Penetrant Rho Kinase Inhibitor and its Activity in a Mouse Model of Huntington's Disease Ladduwahetty, Tammy; Lee, Matthew R.; Maillard, Michel C.; Cachope, Roger; Todd, Daniel; Barnes, Michael; Beaumont, Vahri; Chauhan, Alka; Gallati, Caroline; Haughan, Alan F.; Kempf, Georg; Luckhurst, Christopher A.; Matthews, Kim; McAllister, George; Mitchell, Philip; Patel, Hiral; Rose, Mark; Saville-Stones, Elizabeth; Steinbacher, Stefan; Stott, Andrew J.; Thatcher, Emma; Tierney, Jason; Urbonas, Liudvikas; Munoz-Sanjuan, Ignacio; Dominguez, Celia 分享 收藏
Structure-Based Exploration of Selectivity for ATM Inhibitors in Huntington's Disease Van de Poel, Amanda; Toledo-Sherman, Leticia; Breccia, Perla; Cachope, Roger; Bate, Jennifer R.; Angulo-Herrera, Ivan; Wishart, Grant; Matthews, Kim L.; Martin, Sarah L.; Peacock, Marcus; Barnard, Amy; Cox, Helen C.; Jones, Graham; McAllister, George; Vater, Huw; Esmieu, William; Clissold, Cole; Lamers, Marieke; Leonard, Philip; Jarvis, Rebecca E.; Blackaby, Wesley; Eznarriaga, Maria; Lazari, Ovadia; Yates, Dawn; Rose, Mark; Jang, Sung-Wook; Munoz-Sanjuan, Ignacio; Dominguez, Celia 分享 收藏
Evaluation of 5-(Trifluoromethyl)-1,2,4-oxadiazole-Based Class Ila HDAC Inhibitors for Huntington's Disease Stott, Andrew J.; Maillard, Michel C.; Beaumont, Vahri; Allcock, David; Aziz, Omar; Borchers, Alexander H.; Blackaby, Wesley; Breccia, Perla; Creighton-Gutteridge, Gillian; Haughan, Alan F.; Jarvis, Rebecca E.; Luckhurst, Christopher A.; Matthews, Kim L.; McAllister, George; Pollack, Scott; Saville-Stones, Elizabeth; Van de Poel, Amanda J.; Vater, Huw D.; Vann, Julie; Williams, Rachel; Yates, Dawn; Munoz-Sanjuan, Ignacio; Dominguez, Celia 分享 收藏
Optimization of Potent and Selective Ataxia Telangiectasia-Mutated Inhibitors Suitable for a Proof-of-Concept Study in Huntington's Disease Models Toledo-Sherman, Leticia; Breccia, Perla; Cachope, Roger; Bate, Jennifer R.; Angulo-Herrera, Ivan; Wishart, Grant; Matthews, Kim L.; Martin, Sarah L.; Cox, Helen C.; McAllister, George; Penrose, Stephen D.; Vater, Huw; Esmieu, William; Van de Poel, Amanda; Van de Bospoort, Rhea; Strijbosch, Annelieke; Lamers, Marieke; Leonard, Philip; Jarvis, Rebecca E.; Blackaby, Wesley; Barnes, Karen; Eznarriaga, Maria; Dowler, Simon; Smith, Graham D.; Fischer, David F.; Lazari, Ovadia; Yates, Dawn; Rose, Mark; Jang, Sung-Wook; Munoz-Sanjuan, Ignacio; Dominguez, Celia 分享 收藏
OPTIMISATION OF POTENT, SELECTIVE AND BRAIN PENETRANT ATM INHIBITORS AS POTENTIAL THERAPEUTIC AGENTS FOR HD Toledo-Sherman, Leticia; Chachope, Roger; Rose, Mark; Munoz-Sanjuan, Ignacio; Breccia, L. Perla; Bate, Jennipher; Matthews, Kimberly L.; Wilshart, Grant; Vater, Hugh; Jarvis, Rebecca; Lazari, Vad; Barnes, Kate; Martin, Steve; Blackaby, Wesley; McAllister, George; Yates, Dawn; Fischer, David; Dominguez, Celia 分享 收藏
Potent, Selective, and CNS-Penetrant Tetrasubstituted Cyclopropane Class Ila Histone Deacetylase (HDAC) Inhibitors Luckhurst, Christopher A.; Breccia, Perla; Stott, Andrew J.; Aziz, Omar; Birch, Helen L.; Buerli, Roland W.; Hughes, Samantha J.; Jarvis, Rebecca E.; Lamers, Marieke; Leonard, Philip M.; Matthews, Kim L.; McAllister, George; Pollack, Scott; Saville-Stones, Elizabeth; Wishart, Grant; Yates, Dawn; Dominguez, Celia 分享 收藏
Design, Synthesis, and Biological Evaluation of Potent and Selective Class IIa Histone Deacetylase (HDAC) Inhibitors as a Potential Therapy for Huntington's Disease Buerli, Roland W.; Luckhurst, Christopher A.; Aziz, Omar; Matthews, Kim L.; Yates, Dawn; Lyons, Kathy. A.; Beconi, Maria; McAllister, George; Breccia, Perla; Stott, Andrew J.; Penrose, Stephen D.; Wall, Michael; Lamers, Marieke; Leonard, Philip; Mueller, Ilka; Richardson, Christine M.; Jarvis, Rebecca; Stones, Liz; Hughes, Samantha; Wishart, Grant; Haughan, Alan F.; O'Connell, Catherine; Mead, Tania; McNeil, Hannah; Vann, Julie; Mangette, John; Maillard, Michel; Beaumont, Vahri; Munoz-Sanjuan, Ignacio; Dominguez, Celia 分享 收藏
Identification of a biological signature for schizophrenia in serum Schwarz, E.; Guest, P. C.; Rahmoune, H.; Harris, L. W.; Wang, L.; Leweke, F. M.; Rothermundt, M.; Bogerts, B.; Koethe, D.; Kranaster, L.; Ohrmann, P.; Suslow, T.; McAllister, G.; Spain, M.; Barnes, A.; van Beveren, N. J. M.; Baron-Cohen, S.; Steiner, J.; Torrey, F. E.; Yolken, R. H.; Bahn, S. 分享 收藏
Increased levels of circulating insulin-related peptides in first-onset, antipsychotic naive schizophrenia patients Guest, P. C.; Wang, L.; Harris, L. W.; Burling, K.; Levin, Y.; Ernst, A.; Wayland, M. T.; Umrania, Y.; Herberth, M.; Koethe, D.; van Beveren, J. M.; Rothermundt, M.; McAllister, G.; Leweke, F. M.; Steiner, J.; Bahn, S. 分享 收藏
Behavioral and neurochemical alterations in mice deficient in anaplastic lymphoma kinase suggest therapeutic potential for psychiatric indications Bilsland, James G.; Wheeldon, Alan; Mead, Andrew; Znamenskiy, Petr; Almond, Sarah; Waters, Kerry A.; Thakur, Matthew; Beaumont, Vahri; Bonnert, Timothy P.; Heavens, Robert; Whiting, Paul; McAllister, George; Munoz-Sanjuan, Ignacio 分享 收藏
分享 收藏
分享 收藏
N-arylsulfonylindole derivatives as serotonin 5-HT6 receptor ligands Russell, MGN; Baker, RJ; Barden, L; Beer, MS; Bristow, L; Broughton, HB; Knowles, M; McAllister, G; Patel, S; Castro, JL 分享 收藏
分享 收藏
Characterization of a novel sphingosine 1-phosphate receptor, Edg-8 Im, DS; Heise, CE; Ancellin, N; O'Dowd, BF; Shei, GJ; Heavens, RP; Rigby, MR; Hla, T; Mandala, S; McAllister, G; George, SR; Lynch, KR 分享 收藏
分享 收藏
.png){kind=icon}
未登录.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
