未登录YES1 Is a Targetable Oncogene in Cancers Harboring YES1 Gene Amplification
Hamanaka, Natsuki; Nakanishi, Yoshito; Mizuno, Takakazu; Horiguchi-Takei, Kana; Akiyama, Nukinori; Tanimura, Hiromi; Hasegawa, Masami; Satoh, Yasuko; Tachibana, Yukako; Fujii, Toshihiko; Sakata, Kiyoaki; Ogasawara, Kiyomoto; Ebiike, Hirosato; Koyano, Hiroshi; Sato, Haruhiko; Ishii, Nobuya; Mio, Toshiyuki .png)
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收藏Molecular screening of patients with FGFR alterations for phase 1 (ph1) study with the selective FGFR inhibitor Debio 1347Iafrate, Anthony J.; Borger, Darrell R.; Vivancos, Ana; Voss, Martin; Cleary, James; Meric-Bernstam, Funda; Tabernero, Josep; Flaherty, Keith; Ishii, Nobuya; Brichory, Franck; Tanaka, Hiroaki; Pokorska-Bocci, Anna; Baselga, Jose; Nuciforo, Paolo 分享 收藏 A Phase I, Open-Label, Multicenter, Dose-escalation Study of the Oral Selective FGFR Inhibitor Debio 1347 in Patients with Advanced Solid Tumors Harboring FGFR Gene Alterations口服选择性FGFR抑制剂Debio 1347在患有FGFR基因改变的晚期实体瘤患者中的I期，开放标签，多中心，剂量递增研究Voss, Martin H.; Hierro, Cinta; Heist, Rebecca S.; Cleary, James M.; Meric-Bernstam, Funda; Tabernero, Josep; Janku, Filip; Gandhi, Leena; Iafrate, A. John; Borger, Darrell R.; Ishii, Nobuya; Hu, Youyou; Kirpicheva, Yulia; Nicolas-Metral, Valerie; Pokorska-Bocci, Anna; Chessex, Anne Vaslin; Zanna, Claudio; Flaherty, Keith T.; Baselga, Jose 分享 收藏 Acquired JHDM1D-BRAF Fusion Confers Resistance to FGFR Inhibition in FGFR2-Amplified Gastric CancerSase, Hitoshi; Nakanishi, Yoshito; Aida, Satoshi; Horiguchi-Takei, Kana; Akiyama, Nukinori; Fujii, Toshihiko; Sakata, Kiyoaki; Mio, Toshiyuki; Aoki, Masahiro; Ishii, Nobuya 分享 收藏 Discovery of [5-Amino-1-(2-methyl-3H-benzimidazol-5-yl)pyrazol-4-yl]-(1H-indol-2-yl)methanone (CH5183284/Debio 1347), An Orally Available and Selective Fibroblast Growth Factor Receptor (FGFR) InhibitorEbiike, Hirosato; Taka, Naoki; Matsushita, Masayuki; Ohmori, Masayuki; Takami, Kyoko; Hyohdoh, Ikumi; Kohchi, Masami; Hayase, Tadakatsu; Nishii, Hiroki; Morikami, Kenji; Nakanishi, Yoshito; Akiyama, Nukinori; Shindoh, Hidetoshi; Ishii, Nobuya; Isobe, Takehito; Matsuoka, Hiroharu 分享 收藏 Sustained ERK inhibition maximizes responses of BrafV600E thyroid cancers to radioiodineNagarajah, James; Le, Mina; Knauf, Jeffrey A.; Ferrandino, Giuseppe; Montero-Conde, Cristina; Pillarsetty, Nagavarakishore; Bolaender, Alexander; Irwin, Christopher; Krishnamoorthy, Gnana Prakasam; Saqcena, Mahesh; Larson, Steven M.; Ho, Alan L.; Seshan, Venkatraman; Ishii, Nobuya; Carrasco, Nancy; Rosen, Neal; Weber, Wolfgang A.; Fagin, James A. 分享 收藏 ERK signal suppression and sensitivity to CH5183284/Debio 1347, a selective FGFR inhibitorNakanishi, Yoshito; Mizuno, Hideaki; Sase, Hitoshi; Fujii, Toshihiko; Sakata, Kiyoaki; Akiyama, Nukinori; Aoki, Yuko; Aoki, Masahiro; Ishii, Nobuya 分享 收藏 ERK Signal Suppression and Sensitivity to CH5183284/Debio 1347, a Selective FGFR InhibitorNakanishi, Yoshito; Mizuno, Hideaki; Sase, Hitoshi; Fujii, Toshihiko; Sakata, Kiyoaki; Akiyama, Nukinori; Aoki, Yuko; Aoki, Masahiro; Ishii, Nobuya 分享 收藏 Formulation switch and pharmacokinetics/pharmacodynamics of Debio 1347 (CH5183284), a novel FGFR inhibitor, in a first-in-human dose escalation trial in solid tumors patientsNicolas-Metral, Valerie; Vaslin, Anne; Supko, Jeffrey G.; Nakai, Kiyohiko; Ishii, Nobuya; Menetrey, Annick; Roubaudi-Fraschini, Marie-Claude; Marfurt, Judith; Chabaud, Sebastien; Layer, Andreas; Purcea, Daniela; Douchain, Jerome; Zanna, Claudio 分享 收藏 分享 收藏 Unique pattern of copy number changes including chromothripsis in pulmonary adenocarcinoma with EML4-ALK fusionNinomiya, Hironori; Kato, Motohiro; Ogawa, Seishi; Motoi, Noriko; Takeuchi, Kengo; Kodama, Tatsushi; Sakamoto, Hiroshi; Ishii, Nobuya; Fujiwara, Mutsunori; Ishikawa, Yuichi 分享 收藏 分享 收藏 The Fibroblast Growth Factor Receptor Genetic Status as a Potential Predictor of the Sensitivity to CH5183284/Debio 1347, a Novel Selective FGFR InhibitorNakanishi, Yoshito; Akiyama, Nukinori; Tsukaguchi, Toshiyuki; Fujii, Toshihiko; Sakata, Kiyoaki; Sase, Hitoshi; Isobe, Takehito; Morikami, Kenji; Shindoh, Hidetoshi; Mio, Toshiyuki; Ebiike, Hirosato; Taka, Naoki; Aoki, Yuko; Ishii, Nobuya 分享 收藏 Design and preclinical profile of CH5183284/Debio 1347, a novel orally available and selective FGFR inhibitor acting on a gatekeeper mutant of FGFR2Ebiike, Hirosato; Taka, Naoki; Nakanishi, Yoshito; Akiyama, Nukinori; Sawamura, Fumie; Morikami, Kenji; Matsushita, Masayuki; Ohmori, Masayuki; Takami, Kyouko; Hyohdoh, Ikumi; Kohchi, Masami; Hayase, Tadakatsu; Nishii, Hiroki; Ishii, Nobuya; Matsuoka, Hiroharu 分享 收藏 Disruption of CRAF-mediated MEK activation is required for effective MEK inhibition in KRAS mutant tumorsLito, Piro; Saborowski, Anna; Yue, Jingyin; Solomon, Martha; Joseph, Eric; Fellman, Christof; Ohara, Kazuhiro; Morikami, Kenji; Miura, Takaaki; Lucas, Christine; Ishii, Nobuya; Lowe, Scott; Rosen, Neal 分享 收藏 FGFR genetic alterations as a potential predictor of the sensitivity to CH5183284/Debio 1347, a selective FGFR inhibitor with a novel chemical scaffoldNakanishi, Yoshito; Akiyama, Nukinori; Tsukaguchi, Toshiyuki; Tachibana-Kondo, Yukako; Fujii, Toshihiko; Sakata, Kiyoaki; Sase, Hitoshi; Isobe, Takehito; Sato, Yasuko; Morikami, Kenji; Shindoh, Hidetoshi; Mio, Toshiyuki; Ebiike, Hirosato; Taka, Naoki; Aoki, Yuko; Ishii, Nobuya 分享 收藏 Inhibition of FGFR3-BAIAP2L1 fusion kinase oncogenic potential by CH5183284/Debio 1347, a compound that inhibits FGFR3 kinase activity constitutively activated by BAIAP2L1 BAR domain dimerizationAkiyama, Nukinori; Nakanishi, Yoshito; Tsukaguchi, Toshiyuki; Satoh, Yasuko; Nagata, Yasue; Takahashi, Tsutomu; Nishito, Yukari; Ashihara, Motoki; Ishii, Nobuya; Aoki, Masahiro 分享 收藏 Evaluation of efficacy of a new MEK inhibitor, RO4987655, in human tumor xenografts by [18F] FDG-PET imaging combined with proteomic approachesTegnebratt, Tetyana; Ruge, Elisabeth; Bader, Sabine; Ishii, Nobuya; Aida, Satoshi; Yoshimura, Yasushi; Ooi, Chia-Huey; Lu, Li; Mitsios, Nicholas; Meresse, Valerie; Mulder, Jan; Pawlak, Michael; Venturi, Miro; Tessier, Jean; Stone-Elander, Sharon 分享 收藏 Pre-clinical investigation of predictive biomarkers for drug candidates using a molecularly profiled large cancer cell line panel.Aida, Satoshi; Mizuno, Hideaki; Sakamoto, Hiroshi; Nakanishi, Yoshito; Mutoh, Hironori; Cai, James; Burtscher, Helmut; Aoki, Masahiro; Aoki, Yuko; Ishii, Nobuya 分享 收藏 Enhanced Inhibition of ERK Signaling by a Novel Allosteric MEK Inhibitor, CH5126766, That Suppresses Feedback Reactivation of RAF ActivityIshii, Nobuya; Harada, Naoki; Joseph, Eric W.; Ohara, Kazuhiro; Miura, Takaaki; Sakamoto, Hiroshi; Matsuda, Yutaka; Tomii, Yasushi; Tachibana-Kondo, Yukako; Iikura, Hitoshi; Aoki, Toshihiro; Shimma, Nobuo; Arisawa, Mikio; Sowa, Yoshihiro; Poulikakos, Poulikos I.; Rosen, Neal; Aoki, Yuko; Sakai, Toshiyuki 分享 收藏 
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