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Microprotein-encoding RNA regulation in cells treated with pro-inflammatory and pro-fibrotic stimuli Pai, Victor J.; Lau, Calvin J.; Garcia-Ruiz, Almudena; Donaldson, Cynthia; Vaughan, Joan M.; Miller, Brendan; De Souza, Eduardo V.; Pinto, Antonio M.; Diedrich, Jolene; Gavva, Narender R.; Yu, Shan; DeBoever, Christopher; Horman, Shane R.; Saghatelian, Alan 分享 收藏
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Discovery of Selective Pituitary Adenylate Cyclase 1 Receptor (PAC1R) Antagonist Peptides Potent in a Maxadilan/PACAP38-Induced Increase in Blood Flow Pharmacodynamic Model Hu, Essa; Hong, Fang-Tsao; Aral, Jennifer; Long, Jason; Piper, Derek E.; Poppe, Leszek; Andrews, Kristin L.; Hager, Todd; Davis, Carl; Li, Hongyan; Wong, Philip; Gavva, Narender; Shi, Licheng; Zhu, Dawn X. D.; Lehto, Sonya G.; Xu, Cen; Miranda, Les P. 分享 收藏
Reduced TRPM8 expression underpins reduced migraine risk and attenuated cold pain sensation in humans Gavva, Narender R.; Sandrock, Robert; Arnold, Gregory E.; Davis, Michael; Lamas, Edwin; Lindvay, Chris; Li, Chi-Ming; Smith, Brian; Backonja, Miroslav; Gabriel, Kristin; Vargas, Gabriel 分享 收藏
Discovery of TRPM8 Antagonist (S)-6-(((3-Fluoro-4-(trifluoromethoxy)phenyl)(3-fluoropyridin-2-yl)methyl)carbamoyl)nicotinic Acid (AMG 333), a Clinical Candidate for the Treatment of Migraine Horne, Daniel B.; Biswas, Kaustav; Brown, James; Bartberger, Michael D.; Clarine, Jeffrey; Davis, Carl D.; Gore, Vijay K.; Harried, Scott; Horner, Michelle; Kaller, Matthew R.; Lehto, Sonya G.; Liu, Qingyian; Ma, Vu V.; Monenschein, Holger; Nguyen, Thomas T.; Yuan, Chester C.; Youngblood, Beth D.; Zhang, Maosheng; Zhong, Wenge; Allen, Jennifer R.; Chen, Jian Jeffrey; Gavva, Narender R. 分享 收藏
TRPV1 antagonists that cause hypothermia, instead of hyperthermia, in rodents: Compounds' pharmacological profiles, invivo targets, thermoeffectors recruited and implications for drug development Garami, A.; Pakai, E.; McDonald, H. A.; Reilly, R. M.; Gomtsyan, A.; Corrigan, J. J.; Pinter, E.; Zhu, D. X. D.; Lehto, S. G.; Gavva, N. R.; Kym, P. R.; Romanovsky, A. A. 分享 收藏
Optimization of a Novel Quinazolinone-Based Series of Transient Receptor Potential A1 (TRPA1) Antagonists Demonstrating Potent in Vivo Activity Schenkel, Laurie B.; Olivieri, Philip R.; Boezio, Alessandro A.; Deak, Holly L.; Emkey, Renee; Graceffa, Russell F.; Gunaydin, Hakan; Guzman-Perez, Angel; Lee, Josie H.; Teffera, Yohannes; Wang, Weiya; Youngblood, Beth D.; Yu, Violeta L.; Zhang, Maosheng; Gavva, Narender R.; Lehto, Sonya G.; Geuns-Meyer, Stephanie 分享 收藏
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AMG2850, a potent and selective TRPM8 antagonist, is not effective in rat models of inflammatory mechanical hypersensitivity and neuropathic tactile allodynia Lehto, Sonya G.; Weyer, Andy D.; Zhang, Maosheng; Youngblood, Beth D.; Wang, Judy; Wang, Weiya; Kerstein, Patrick C.; Davis, Carl; Wild, Kenneth D.; Stucky, Cheryl L.; Gavva, Narender R. 分享 收藏
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Optimization of Potency and Pharmacokinetic Properties of Tetrahydroisoquinoline Transient Receptor Potential Melastatin 8 (TRPM8) Antagonists Horne, Daniel B.; Tamayo, Nuria A.; Bartberger, Michael D.; Bo, Yunxin; Clarine, Jeffrey; Davis, Carl D.; Gore, Vijay K.; Kaller, Matthew R.; Lehto, Sonya G.; Ma, Vu V.; Nishimura, Nobuko; Nguyen, Thomas T.; Tang, Phi; Wang, Weiya; Youngblood, Beth D.; Zhang, Maosheng; Gavva, Narender R.; Monenschein, Holger; Norman, Mark H. 分享 收藏
Fused Piperidines as a Novel Class of Potent and Orally Available Transient Receptor Potential Melastatin Type 8 (TRPM8) Antagonists Tamayo, Nuria A.; Bo, Yunxin; Gore, Vijay; Ma, Vu; Nishimura, Nobuko; Tang, Phi; Deng, Hong; Klionsky, Lana; Lehto, Sonya G.; Wang, Weiya; Youngblood, Brad; Chen, Jiyun; Correll, Tiffany L.; Bartberger, Michael D.; Gavva, Narender R.; Norman, Mark H. 分享 收藏
Antihyperalgesic effects of (R,E)-N-(2-hydroxy-2,3-dihydro-1H-inden-4-yl)-3-(2-(piperidin-1-yl)-4-(trifluoromethyl)phenyl)acrylamide (AMG8562), a novel transient receptor potential vanilloid type 1 modulator that does not cause hyperthermia in rats Lehto, Sonya G.; Tamir, Rami; Deng, Hong; Klionsky, Lana; Kuang, Rongzhen; Le, April; Lee, Doo; Louis, Jean-Claude; Magal, Ella; Manning, Barton H.; Rubino, John; Surapaneni, Sekhar; Tamayo, Nuria; Wang, Tingrong; Wang, Judy; Wang, Jue; Wang, Weiya; Youngblood, Brad; Zhang, Maosheng; Zhu, Dawn; Norman, Mark H.; Gavva, Narender R. 分享 收藏
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Pharmacological blockade of the vanilloid receptor TRPV1 elicits marked hyperthermia in humans Gavva, Narender R.; Treanor, James J. S.; Garami, Andras; Fang, Liang; Surapaneni, Sekhar; Akrami, Anna; Alvarez, Francisco; Bak, Annette; Darling, Mary; Gore, Anu; Jang, Graham R.; Kesslak, James P.; Ni, Liyun; Norman, Mark H.; Palluconi, Gabrielle; Rose, Mark J.; Salfi, Margaret; Tan, Edward; Romanovsky, Andrej A.; Banfield, Christopher; Davar, Gudarz 分享 收藏
Design and synthesis of peripherally restricted transient receptor potential vanilloid 1 (TRPV1) antagonists Tamayo, Nuria; Liao, Hongyu; Stec, Markian M.; Wang, Xianghong; Chakrabarti, Partha; Retz, Dan; Doherty, Elizabeth M.; Surapaneni, Sekhar; Tamir, Rami; Bannon, Anthony W.; Gavva, Narender R.; Norman, Mark H. 分享 收藏
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Repeated administration of vanilloid receptor TRPV1 antagonists attenuates hyperthermia elicited by TRPV1 blockade Gavva, Narender R.; Bannon, Anthony W.; Hovland, David N., Jr.; Lehto, Sonya G.; Klionsky, Lana; Surapaneni, Sekhar; Immke, David C.; Henley, Charles; Arik, Leyla; Bak, Annette; Davis, James; Ernst, Nadia; Hever, Gal; Kuang, Rongzhen; Shi, Licheng; Tamir, Rami; Wang, Jue; Wang, Weiya; Zajic, Gary; Zhu, Dawn; Norman, Mark H.; Louis, Jean-Claude; Magal, Ella; Treanor, James J. S. 分享 收藏
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