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Stereospecific lasofoxifene derivatives reveal the interplay between estrogen receptor alpha stability and antagonistic activity in ESR1 mutant breast cancer cells Hosfield, David J.; Weber, Sandra; Li, Nan-Sheng; Suavage, Madline; Joiner, Carstyn F.; Hancock, Govinda R.; Sullivan, Emily A.; Ndukwe, Estelle; Han, Ross; Cush, Sydney; Laine, Muriel; Mader, Sylvie C.; Greene, Geoffrey L.; Fanning, Sean W. 分享 收藏
Discovery of CC-90011: A Potent and Selective Reversible Inhibitor of Lysine Specific Demethylase 1 (LSD1) Kanouni, Toufike; Severin, Christophe; Cho, Robert W.; Yuen, Natalie Y-Y; Xu, Jiangchun; Shi, Lihong; Lai, Chon; Del Rosario, Joselyn R.; Stansfield, Ryan K.; Lawton, Lee N.; Hosfield, David; O'Connell, Shawn; Kreilein, Matt M.; Tavares-Greco, Paula; Nie, Zhe; Kaldor, Stephen W.; Veal, James M.; Stafford, Jeffrey A.; Chen, Young K. 分享 收藏
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The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells Fanning, Sean W.; Jeselsohn, Rinath; Dharmarajan, Venkatasubramanian; Mayne, Christopher G.; Karimi, Mostafa; Buchwalter, Gilles; Houtman, Rene; Toy, Weiyi; Fowler, Colin E.; Han, Ross; Laine, Muriel; Carlson, Kathryn E.; Martin, Teresa A.; Nowak, Jason; Nwachukwu, Jerome C.; Hosfield, David J.; Chandarlapaty, Sarat; Tajkhorshid, Emad; Nettles, Kendall W.; Griffin, Patrick R.; Shen, Yang; Katzenellenbogen, John A.; Brown, Myles; Greene, Geoffrey L. 分享 收藏
Discovery of a Glucocorticoid Receptor (GR) Activity Signature Using Selective GR Antagonism in ER-Negative Breast Cancer West, Diana C.; Kocherginsky, Masha; Tonsing-Carter, Eva Y.; Dolcen, D. Nesli; Hosfield, David J.; Lastra, Ricardo R.; Sinnwell, Jason P.; Thompson, Kevin J.; Bowie, Kathleen R.; Harkless, Ryan V.; Skor, Maxwell N.; Pierce, Charles F.; Styke, Sarah C.; Kim, Caroline R.; de Wet, Larischa; Greene, Geoffrey L.; Boughey, Judy C.; Goetz, Matthew P.; Kalari, Krishna R.; Wang, Liewei; Fleming, Gini F.; Gyorffy, Balazs; Conzen, Suzanne D. 分享 收藏
Design of KDM4 Inhibitors with Antiproliferative Effects in Cancer Models 在癌症模型中设计具有抗增殖作用的KDM4抑制剂 Chen, Young K.; Bonaldi, Tiziana; Cuomo, Alessandro; Del Rosario, Joselyn R.; Hosfield, David J.; Kanouni, Toufike; Kao, Shih-chu; Lai, Chon; Lobo, Neethan A.; Matuszkiewicz, Jennifer; McGeehan, Andrew; O'Connell, Shawn M.; Shi, Lihong; Stafford, Jeffrey A.; Stansfield, Ryan K.; Veal, James M.; Weiss, Michael S.; Yuen, Natalie Y.; Wallace, Michael B. 分享 收藏
Bazedoxifene inhibits ESR1 somatic mutants with improved potency compared to tamoxifene and raloxifene Fanning, Sean W.; Dharmarajan, Venkat; Mayne, Christopher G.; Toy, Weiyi; Carlson, Kathryn E.; Martin, Teresa A.; Nowak, Jason; Nwachukwu, Jerome; Hosfield, David J.; Tajkhorshid, Emad; Chandarlapaty, Sarat; Griffin, Patrick; Shen, Yang; Katzenellenbogen, John A.; Greene, Geoffrey L. 分享 收藏
Overcoming mutation-based resistance to antiandrogens with rational drug design Balbas, Minna D.; Evans, Michael J.; Hosfield, David J.; Wongvipat, John; Arora, Vivek K.; Watson, Philip A.; Chen, Yu; Greene, Geoffrey L.; Shen, Yang; Sawyers, Charles L. 分享 收藏
Discovery and characterization of novel allosteric FAK inhibitors Iwatani, Misa; Iwata, Hidehisa; Okabe, Atsutoshi; Skene, Robert J.; Tomita, Naoki; Hayashi, Yoko; Aramaki, Yoshio; Hosfield, David J.; Hori, Akira; Baba, Atsuo; Miki, Hiroshi 分享 收藏
Conserved Structural Chemistry for Incision Activity in Structurally Non-homologous Apurinic/Apyrimidinic Endonuclease APE1 and Endonuclease IV DNA Repair Enzymes Tsutakawa, Susan E.; Shin, David S.; Mol, Clifford D.; Izumi, Tadahide; Arvai, Andrew S.; Mantha, Anil K.; Szczesny, Bartosz; Ivanov, Ivaylo N.; Hosfield, David J.; Maiti, Buddhadev; Pique, Mike E.; Frankel, Kenneth A.; Hitomi, Kenichi; Cunningham, Richard P.; Mitra, Sankar; Tainer, John A. 分享 收藏
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Structural insights into NOS regulatory mechanisms: What? where? how? Garcin-Hosfield, ED; Arvai, AS; Rosenfeld, RJ; Bonaventura, J; Scharber, MA; Bruns, CM; Hosfield, DJ; Lloyd, SJ; MacCoss, MJ; Yates, J; Tiso, M; Stuehr, DJ; Tainer, JA; Getzoff, ED 分享 收藏
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Crystal structure of Pasteurella haemolytica ferric ion-binding protein a reveals a novel class of bacterial iron-binding proteins Shouldice, SR; Dougan, DR; Williams, PA; Skene, RJ; Snell, G; Scheibe, D; Kirby, S; Hosfield, DJ; McRee, DE; Schryvers, AB; Tari, LW 分享 收藏
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Cloning, expression, and characterization of a nitric oxide synthase protein from Deinococcus radiodurans Adak, S; Bilwes, AM; Panda, K; Hosfield, D; Aulak, KS; McDonald, JF; Tainer, JA; Getzoff, ED; Crane, BR; Stuehr, DJ 分享 收藏
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