Akira Hiratsuka - Publications, H-index & Citations

Selective antagonization of activated Nrf2 and inhibition of cancer cell proliferation by procyanidins from Cinnamomi Cortex extract

IF3

2017-12-01

PREAI

Ohnuma, Tomokazu; Sakamoto, Kazuya; Shinoda, Asumi; Takagi, Chiaki; Ohno, Shoko; Nishiyama, Takahito; Ogura, Kenichiro; Hiratsuka, Akira

Activation of the Nrf2/ARE pathway via S-alkylation of cysteine 151 in the chemopreventive agent-sensor Keap1 protein by falcarindiol, a conjugated diacetylene compound

IF3

2015-11-01

PREAI

Ohnuma, Tomokazu; Anzai, Eri; Suzuki, Yohei; Shimoda, Mai; Saito, Shin; Nishiyama, Takahito; Ogura, Kenichiro; Hiratsuka, Akira

TOXICOLOGY AND APPLIED PHARMACOLOGY

IF3.4

2010-04-01

PREAI

Ohnuma, Tomokazu; Nakayama, Shinji; Anan, Eisaburo; Nishiyama, Takahito; Ogura, Kenichiro; Hiratsuka, Akira

Induction of antioxidant and phase 2 drug-metabolizing enzymes by falcarindiol isolated from Notopterygium incisum extract, which activates the Nrf2/ARE pathway, leads to cytoprotection against oxidative and electrophilic stress

Redox cycling of 9,10-phenanthraquinone to cause oxidative stress is terminated through its monoglucuronide conjugation in human pulmonary epithelial A549 cells

IF3

2009-08-01

PREAI

Ohnuma, Tomokazu; Komatsu, Takao; Nakayama, Shinji; Nishiyama, Takahito; Ogura, Kenichiro; Hiratsuka, Akira

Identification of human UDP-glucuronosyltransferase isoform(s) responsible for the C-glucuronidation of phenylbutazone

IF8.2

2008-04-01

PREAI

Taguchi, Keiko; Shimada, Megumi; Fujii, Sayako; Sumi, Daigo; Pan, Xiaoqing; Yamano, Shigeru; Nishiyama, Takahito; Hiratsuka, Akira; Yamamoto, Masayuki; Cho, Arthur K.; Froines, John R.; Kumagai, Yoshito

Quaternary ammonium-linked glucuronidation of trans-4-hydroxytamoxifen, an active metabolite of tamoxifen, by human liver microsomes and UDP-glucuronosyltransferase 1A4

IF3

2006-10-01

PREAI

Nishiyama, Takahito; Kobori, Tomihiro; Arai, Kouji; Ogura, Kenichiro; Ohnuma, Tomokazu; Ishii, Kazuo; Hayashi, Kenichiro; Hiratsuka, Akira

Inhibitory effects of various beverages on ritodrine sulfation by recombinant human sulfotransferase isoforms SULT1A1 and SULT1A3

IF5.6

2006-04-01

PREAI

Ogura, K; Ishikawa, Y; Kaku, T; Nishiyama, T; Ohnuma, T; Muro, K; Hiratsuka, A

PHARMACEUTICAL RESEARCH

IF4.3

2005-08-03

PREAI

Nishimuta, H; Tsujimoto, M; Ogura, K; Hiratsuka, A; Ohtani, H; Sawada, Y

Dihydropyrimidine dehydrogenase activity in 150 healthy Japanese volunteers and identification of novel mutations

CLINICAL CANCER RESEARCH

IF10.2

2005-07-20

PREAI

Ogura, K; Ohnuma, T; Minamide, Y; Mizuno, A; Nishiyama, T; Nagashima, S; Kanamaru, M; Hiratsuka, A; Watabe, T; Uematsu, T

Sesquiterpenes and flavonol glycosides from Zingiber aromaticum and their CYP3A4 and CYP2D6 inhibitory activities

JOURNAL OF NATURAL PRODUCTS

IF3.6

2004-06-17

PREAI

Usia, T; Iwata, H; Hiratsuka, A; Watabe, T; Kadota, S; Tezuka, Y

Quaternary ammonium-linked glucuronidation of tamoxifen by human liver microsomes and UDP-glucuronosyltransferase 1A4

Reverse geometrical selectivity in glucuronidation and sulfation of cis- and trans-4-hydroxytamoxifens by human liver UDP-glucuronosyltransferases and sulfotransferases

IF5.6

2004-06-01

PREAI

Kaku, T; Ogura, K; Nishiyama, T; Ohnuma, T; Muro, K; Hiratsuka, A

(S)-Preferential detoxification of 4-hydroxy-2(E)-nonenal enantiomers by hepatic glutathione S-transferase isoforms in guinea-pigs and rats

IF5.6

2002-05-01

PREAI

Nishiyama, T; Ogura, K; Nakano, H; Ohnuma, T; Kaku, T; Hiratsuka, A; Muro, K; Watabe, T

BIOCHEMICAL JOURNAL

IF4.3

2001-04-01

OAAI

Hiratsuka, A; Tobita, K; Saito, H; Sakamoto, Y; Nakano, H; Ogura, K; Nishiyama, T; Watabe, T

4-Hydroxy-2(E)-nonenal enantiomers:: (S)-selective inactivation of glyceraldehyde-3-phosphate dehydrogenase and detoxification by rat glutathione S-transferase A4-4

BIOCHEMICAL JOURNAL

IF4.3

2000-07-25

OAAI

Hiratsuka, A; Hirose, K; Saito, H; Watabe, T

Cholesterol 7-hydroperoxides in rat skin as a marker for lipid peroxidation

Photogeneration of 3β-hydroxy-5α-cholest-6-ene-5-hydroperoxide in rat skin:: Evidence for occurrence of singlet oxygen in vivo 大鼠皮肤中3β-hydroxy-5α-cholest-6-ene-5-hydroperoxide的光生:: 体内单线态氧发生的证据

IF5.6

1999-11-01

PREAI

Yamazaki, S; Ozawa, N; Hiratsuka, A; Watabe, T

Quantitative determination of cholesterol 5α-, 7α-, and 7β-hydroperoxides in rat skin

IF8.2

1999-08-01

PREAI

Yamazaki, S; Ozawa, N; Hiratsuka, A; Watabe, T

Increases in cholesterol 7-hydroperoxides in lipids of human skin by sunlight exposure

IF8.2

1999-07-01

PREAI

Yamazaki, S; Ozawa, N; Hiratsuka, A; Watanabe, T

Guinea pig liver Mu-class glutathione S-transferase M1-2 cross-reacts with antibodies to both rat Mu- and Theta-class glutathione S-transferases 豚鼠肝脏Mu类谷胱甘肽S-转移酶M1-2与大鼠Mu类和Theta类谷胱甘肽S-转移酶的抗体交叉反应

IF8.2

1999-05-01

PREAI

Yamazaki, S; Ozawa, N; Hiratsuka, A; Watabe, T