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收藏分享 收藏 Discovery of ASTX295, a potent, next-generation small molecule antagonist of MDM2 with differentiated pharmacokinetic profile
Ahn, Maria; Bevan, Luke; Buck, Ildiko; Cano, Celine; Castro, Juan; Cons, Ben; Endicott, Jane; Fazal, Lynsey; Ferrari, Nicola; Hardcastle, Ian; Hearn, Keisha; Holvey, Rhian; Howard, Steven; Johnson, Chris; Jennings, Claire; Kucia-Tran, Justyna; Kyle, Suzanne; Lunec, John; Lyons, John; Miller, Duncan; Rees, David; Noble, Martin; Newell, David R.; Reeks, Judith; Saini, Harpreet; Denis, Jeffrey St.; Tamanini, Emiliano; Thomas, Huw; Thompson, Neil; Vinkovic, Mladen; Ward, George; Wallis, Nicola; Walton, Hugh; Wedge, Stephen; Williams, Pamela; Willmore, Elaine; Wilshire, Nicola; Zhao, Yan; Chessari, Gianni 分享 收藏 Development of a potent class of small molecule inhibitors of the MDM2-p53 protein-protein interactionFazal, Lynsey; Ahn, Maria; Bevan, Luke; Buck, Ildiko; Castro, Juan; Chessari, Gianni; Cons, Ben; Hearn, Keisha; Howard, Steven; Johnson, Chris; Reeks, Judith; Tamanini, Emiliano; Thompson, Neil; Walton, Hugh; Williams, Pamela; Bawn, Ruth H.; Blackburn, Tim J.; Cano, Celine; Cully, Sarah J.; Golding, Bernard; Griffin, Roger; Haggerty, Karen; Hardcastle, Ian; Newell, Herbie; Noble, Martin; Thomas, Huw; Willmore, Elaine; Zhao, Yan; Wedge, Steve 分享 收藏 JNJ-47117096, a selective small molecule inhibitor of the MELK oncogene decreases DNA damage tolerance in highly proliferating cancer cellsBeke, Lijs; Linders, Joannes T. M.; Kig, Cenk; Boeckx, An; van Heerde, Erika; Wuyts, Dirk; Parade, Marc; Meerpoel, Lieven; Johnson, Chris; Beullens, Monique; Bollen, Mathieu; Brehmer, Dirk 分享 收藏 Discovery of potent dual inhibitors of both XIAP and cIAP1 using fragment based drug discoveryChessari, Gianni; Buck, Ildiko; Chiarparin, Elisabetta; Day, James; Frederickson, Martyn; Hearn, Keisha; Heightman, Tom; Hillmann, Petra; Iqbal, Aman; Johnson, Chris; Lewis, Jon; Martins, Vanessa; Richardson, Caroline; Smythe, Tomoko; Tamanini, Emiliano; Thompson, Neil; Ward, George; Williams, Glyn; Williams, Pamela; Wilsher, Nicola; Wooford, Alison 分享 收藏 Pharmacodynamic and antitumor activity of fragment-derived inhibitors of MetAP2 in tumor xenograftsSmyth, Tomoko; Curry, Jayne; Wilsher, Nicola; Johnson, Chris; Berdini, Valerio; Richardson, Caroline; Massey, Frances; McMenamin, Rachel; Griffiths-Jones, Charlotte; Thompson, Neil; Wallis, Nicola G. 分享 收藏 
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