Christoph Schächtele - Publications, H-index & Citations

Christoph Schächtele

proqinase

34H指数

137论文数

5.1K被引数

收录论文 31

发表时间

Novel Protein Kinase Inhibitors Related to Tau Pathology Modulate Tau Protein-Self Interaction Using a Luciferase Complementation Assay

MOLECULES

IF4.6

2018-09-12

OAAI

Holzer, Max; Schade, Nico; Opitz, Ansgar; Hilbrich, Isabel; Stieler, Jens; Vogel, Tim; Neukel, Valentina; Oberstadt, Moritz; Totzke, Frank; Schaechtele, Christoph; Sippl, Wolfgang; Hilgeroth, Andreas

Discovery of novel dual inhibitors of receptor tyrosine kinases EGFR and PDGFR-β related to anticancer drug resistance

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

IF5.4

2017-11-03

OAAI

Fischer, Tim; Najjar, Karim; Totzke, Frank; Schaechtele, Christoph; Sippl, Wolfgang; Ritter, Christoph; Hilgeroth, Andreas

Discovery of novel dual inhibitors of receptor tyrosine kinases EGFR and IGF-1R

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

IF5.4

2017-01-18

OAAI

Hempel, Cornelius; Totzke, Frank; Schaechtele, Christoph; Najjar, Abdulkarim; Sippl, Wolfgang; Ritter, Christoph; Hilgeroth, Andreas

Optimization of Potent DFG-in Inhibitors of Platelet Derived Growth Factor Receptorβ (PDGF-Rβ) Guided by Water Thermodynamics

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2014-07-21

PREAI

Horbert, Rebecca; Pinchuk, Boris; Johannes, Eugen; Schlosser, Joachim; Schmidt, Dorian; Cappel, Daniel; Totzke, Frank; Schaechtele, Christoph; Peifer, Christian

Development of First Lead Structures for Phosphoinositide 3-Kinase-C27γ Inhibitors

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2014-07-14

PREAI

Freitag, Anne; Prajwal, Prajwal; Shymanets, Aliaksei; Harteneck, Christian; Nuernberg, Bernd; Schaechtele, Christoph; Kubbutat, Michael; Totzke, Frank; Laufer, Stefan A.

Novel 2-chloro-4-anilino-quinazoline derivatives as EGFR and VEGFR-2 dual inhibitors

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2014-01-01

129

PREAI

de Castro Barbosa, Maria Leticia; Lima, Lidia Moreira; Tesch, Roberta; Sant'Anna, Carlos Mauricio R.; Totzke, Frank; Kubbutat, Michael H. G.; Schaechtele, Christoph; Laufer, Stefan A.; Barreiro, Eliezer J.

Assessing the Target Differentiation Potential of Imidazole-Based Protein Kinase Inhibitors

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2012-12-11

PREAI

Dimova, Dilyana; Iyer, Preeti; Vogt, Martin; Totzke, Frank; Kubbutat, Michael H. G.; Schaechtele, Christoph; Laufer, Stefan; Bajorath, Juergen

2-Anilino-4-(benzimidazol-2-yl)pyrimidines - A multikinase inhibitor scaffold with antiproliferative activity toward cancer cell lines

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2012-07-01

PREAI

Determann, Renate; Dreher, Jan; Baumann, Knut; Preu, Lutz; Jones, Peter G.; Totzke, Frank; Schaechtele, Christoph; Kubbutat, Michael H. G.; Kunick, Conrad

Development of bisphosphonate prodrugs of doxorubicin for targeting bone metastases that are cleaved pH dependently or by cathepsin B

CANCER RESEARCH

IF16.6

2012-04-01

PREAI

Hochdoerffer, Katrin; Schaefer-Obodozie, Cynthia; Schaechtele, Christoph; Kratz, Felix

Tri- and Tetrasubstituted Pyrazole Derivates: Regioisomerism Switches Activity from p38MAP Kinase to Important Cancer Kinases

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2012-01-17

PREAI

Abu Thaher, Bassam; Arnsmann, Martina; Totzke, Frank; Ehlert, Jan E.; Kubbutat, Michael H. G.; Schaechtele, Christoph; Zimmermann, Markus O.; Koch, Pierre; Boeckler, Frank M.; Laufer, Stefan A.

Novel inhibitors of epidermal growth factor receptor: (4-(Arylamino)-7H-pyrrolo[2,3-d]pyrimidin-6-yl)(1H-indol-2-yl)methanones and (1H-indol-2-yl)(4-(phenylamino)thieno[2,3-d]pyrimidin-6-yl)methanones

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2012-01-01

PREAI

Beckers, Thomas; Sellmer, Andreas; Eichhorn, Emerich; Pongratz, Herwig; Schaechtele, Christoph; Totzke, Frank; Kelter, Gerhard; Krumbach, Rebekka; Fiebig, Heinz-Herbert; Boehmer, Frank-D.; Mahboobi, Siavosh

Dual IGF-1R/SRC inhibitors based on a N′-aroyl-2-(1H-indol-3-yl)-2-oxoacetohydrazide structure

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2011-07-01

PREAI

Schmidt, Stefanie; Preu, Lutz; Lemcke, Thomas; Totzke, Frank; Schaechtele, Christoph; Kubbutat, Michael H. G.; Kunick, Conrad

Discovery of 4-Benzylamino-Substituted α-Carbolines as a Novel Class of Receptor Tyrosine Kinase Inhibitors

CHEMMEDCHEM

IF3.4

2010-12-07

PREAI

Krug, Martin; Wichapong, Kanin; Erlenkamp, German; Sippl, Wolfgang; Schaechtele, Christoph; Totzke, Frank; Hilgeroth, Andreas

Identification of 2-Anilino-9-methoxy-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-ones as Dual PLK1/VEGF-R2 Kinase Inhibitor Chemotypes by Structure-Based Lead Generation

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2010-02-19

PREAI

Egert-Schmidt, Anne-Marie; Dreher, Jan; Dunkel, Ute; Kohfeld, Simone; Preu, Lutz; Weber, Holger; Ehlert, Jan E.; Mutschler, Bettina; Totzke, Frank; Schaechtele, Christoph; Kubbutat, Michael H. G.; Baumann, Knut; Kunick, Conrad

Substituted 2-arylbenzothiazoles as kinase inhibitors: Hit-to-lead optimization

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2009-09-01

PREAI

Tasler, Stefan; Mueller, Oliver; Wieber, Tanja; Herz, Thomas; Pegoraro, Stefano; Saeb, Wael; Lang, Martin; Krauss, Rolf; Totzke, Frank; Zirrgiebel, Ute; Ehlert, Jan E.; Kubbutat, Michael H. G.; Schaechtele, Christoph

Design, synthesis and characterization of N9/N7-substituted 6-aminopurines as VEGF-R and EGF-R inhibitors

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2009-04-01

PREAI

Peifer, Christian; Buehler, Stefanie; Hauser, Dominik; Kinkel, Katrin; Totzke, Frank; Schaechtele, Christoph; Laufer, Stefan

Bioactive Metabolites from the Endophytic Fungus Stemphylium globuliferum Isolated from Mentha pulegium

JOURNAL OF NATURAL PRODUCTS

IF3.6

2009-03-09

145

PREAI

Debbab, Abdessamad; Aly, Amal H.; Edrada-Ebel, RuAngelie; Wray, Victor; Mueller, Werner E. G.; Totzke, Frank; Zirrgiebel, Ute; Schaechtele, Christoph; Kubbutat, Michael H. G.; Lin, Wen Han; Mosaddak, Mahjouba; Hakiki, Abdelhak; Proksch, Peter; Ebel, Rainer

Search for Inhibitors of Bacterial and Human Protein Kinases among Derivatives of Diazepines[1,4] Annelated with Maleimide and Indole Cycles

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2008-12-03

PREAI

Danilenko, Valery N.; Simonov, Alexander Y.; Lakatosh, Sergey A.; Kubbutat, Michael H. G.; Totzke, Frank; Schaechtele, Christoph; Elizarov, Sergey M.; Bekker, Olga B.; Printsevskaya, Svetlana S.; Luzikov, Yuryi N.; Reznikova, Marina I.; Shtil, Alexander A.; Preobrazhenskaya, Maria N.

Design, synthesis, and biological evaluation of novel 3-aryl-4-(1H-indole-3yl)-1,5-dihydro-2H-pyrrole-2-ones as vascular endothelial growth factor receptor (VEGF-R) inhibitors

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2008-07-01

126

PREAI

Peifer, Christian; Selig, Roland; Kinkel, Katrin; Ott, Dimitri; Totzke, Frank; Schaechtele, Christoph; Heidenreich, Regina; Roecken, Martin; Schollmeyer, Dieter; Laufer, Stefan

Cytotoxic metabolites from the fungal endophyte Alternaria sp and their subsequent detection in its host plant Polygonum senegalense

JOURNAL OF NATURAL PRODUCTS

IF3.6

2008-05-22

250

PREAI

Aly, Amal H.; Edrada-Ebel, RuAngelie; Indriani, Ine Dewi; Wray, Victor; Mueller, Werner E. G.; Totzke, Frank; Zirrgiebel, Ute; Schaechtele, Christoph; Kubbutat, Michael H. G.; Lin, W. H.; Proksch, Peter; Ebel, Rainer

研究方向