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Pharmacokinetics, pharmacodynamics, and safety of a prostaglandin D2 receptor antagonist Lai, E.; Wenning, L. A.; Crumley, T. M.; De Lepeleire, I.; Liu, F.; de Hoon, J. N.; Van Hecken, A.; Depre, M.; Hilliard, D.; Greenberg, H.; O'Neill, G.; Metters, K.; Gottesdiener, K. G.; Wagner, J. A. 分享 收藏
Discovery of a potent and selective prostaglandin D2 receptor antagonist, [(3R)-4-(4-chlorobenzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]-acetic acid (MK-0524) Sturino, Claudio F.; O'Neill, Gary; Lachance, Nicolas; Boyd, Michael; Berthelette, Carl; Labelle, Marc; Li, Lianhai; Roy, Bruno; Scheigetz, John; Tsou, Nancy; Aubin, Yves; Bateman, Kevin P.; Chauret, Nathalie; Day, Stephen H.; Levesque, Jean-Francois; Seto, Carmai; Silva, Jose H.; Trimble, Laird A.; Carriere, Marie-Claude; Denis, Danielle; Greig, Gillian; Kargman, Stacia; Lamontagne, Sonia; Mathieu, Marie-Claude; Sawyer, Nicole; Slipetz, Deborah; Abraham, William M.; Jones, Tom; McAuliffe, Malia; Piechuta, Hana; Nicoll-Griffith, Deborah A.; Wang, Zhaoyin; Zamboni, Robert; Young, Robert N.; Metters, Kathleen M. 分享 收藏
Antagonism of the prostaglandin D2 receptor 1 suppresses nicotinic acid-induced vasodilation in mice and humans Cheng, K; Wu, TJ; Wu, KK; Sturino, C; Metters, K; Gottesdiener, K; Wright, SD; Wang, ZY; O'Neill, G; Lai, E; Waters, MG 分享 收藏
Selective modulation of chemokinesis, degranulation, and apoptosis in eosinophils through the PGD2 receptors CRTH2 and DP Gervais, FG; Cruz, RPG; Chateauneuf, A; Gale, S; Sawyer, N; Nantel, F; Metters, KM; O'Neill, GP 分享 收藏
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Structure-activity relationship of cinnamic acylsulfonamide analogues on the human EP3 prostanoid receptor Juteau, HN; Gareau, Y; Labelle, M; Sturino, CF; Sawyer, N; Tremblay, N; Lamontagne, S; Carrière, MC; Denis, D; Metters, KM 分享 收藏
Prostaglandin receptor EP4 mediates the bone anabolic effects of PGE2 Machwate, M; Harada, S; Leu, CT; Seedor, G; Labelle, M; Gallant, M; Hutchins, S; Lachance, N; Sawyer, N; Slipetz, D; Metters, KM; Rodan, SB; Young, R; Rodan, GA 分享 收藏
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γ-Aminobutyric acid type B receptors with specific heterodimer composition and postsynaptic actions in hippocampal neurons are targets of anticonvulsant gabapentin action Ng, GYK; Bertrand, S; Sullivan, R; Ethier, N; Wang, J; Yergey, J; Belley, M; Trimble, L; Bateman, K; Alder, L; Smith, A; McKernan, R; Metters, K; O'Neill, GP; Lacaille, JC; Hébert, TE 分享 收藏
Characterization of the human cysteinyl leukotriene 2 receptor Heise, CE; O'Dowd, BF; Figueroa, DJ; Sawyer, N; Nguyen, T; Im, DS; Stocco, R; Bellefeuille, JN; Abramovitz, M; Cheng, R; Williams, DL; Zeng, ZZ; Liu, QY; Ma, L; Clements, MK; Coulombe, N; Liu, Y; Austin, CP; George, SR; O'Neill, GP; Metters, KM; Lynch, KR; Evans, JF 分享 收藏
The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs Abramovitz, M; Adam, M; Boie, Y; Carrière, MC; Denis, D; Godbout, C; Lamontagne, S; Rochette, C; Sawyer, N; Tremblay, NM; Belley, M; Gallant, M; Dufresne, C; Gareau, Y; Ruel, R; Juteau, H; Labelle, M; Ouimet, N; Metters, KM 分享 收藏
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Characterization of the cloned guinea pig leukotriene B4 receptor:: comparison to its human orthologue Boie, Y; Stocco, R; Sawyer, N; Greig, GM; Kargman, S; Slipetz, DM; O'Neill, GP; Shimizu, T; Yokomizo, T; Metters, KM; Abramovitz, M 分享 收藏
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