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D

Dominic J. Withers

imperial college london
H指数:60
被引数:1.9万

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OC5.4 - ECE_3532 - Constitutive active expression of ZFP36L1 in anterior pituitary SOX2+ stem cells results in pituitary hypoplasia and a failure of terminal differentiation via a non-cell autonomous mechanism

OC5.4 - ECE_3532 - ZFP36L1在前置垂体SOX2+干细胞中的组成性激活表达导致垂体发育不全，并通过非细胞自主机制导致终末分化失败

European Journal of Endocrinology
IF5.2
2026-08-100
OAAI
Olivia Sherwin; Saba Manshaei; Thea Willis; Hiba Hamdi; Yasmine Kemkem; Miriam Vazquez Segoviano; Bence Kover; James Kaufman-Cook; Shermin Mak; Dominic Withers; Jesus Gil; Juan Pedro Martínez-Barbera; Cynthia Andoniadou
In vivo functional profiling and structural characterization of the human GLP1R A316T variant
Science Advances
IF12.5
2026-02-040
OA
Liliane El Eid; Yusman Manchanda; Gregory Austin; Kieran Deane-Alder; Roxana-Maria Rujan; Zamara Mariam; Affiong I. Oqua; Matthew J. Belousoff; Jorge Bernardino de la Serna; Kyle W. Sloop; Guy A. Rutter; Alex Montoya; Dominic J. Withers; Steven J. Millership; Karim Bouzakri; Ben Jones; Christopher A. Reynolds; Patrick M. Sexton; Denise Wootten; Giuseppe Deganutti; Alejandra Tomas
GLP-1R associates with VAPB and SPHKAP at ERMCSs to regulate β-cell mitochondrial remodelling and function

GLP-1R在ERMCSs处与VAPB和SPHKAP相互作用，以调节β细胞线粒体重塑和功能。

Nature Communications
IF15.7
2025-12-100
OA
Gregory Austin; Affiong I. Oqua; Liliane El Eid; Mingli Zhu; Yusman Manchanda; Priyanka Peres; Helena Coyle; Yelyzaveta Poliakova; Zhanna Balkhiyarova; Karim Bouzakri; Alex Montoya; Dominic J. Withers; Michele Solimena; Ben Jones; Steven J. Millership; Steffen Burgold; David C. A. Gaboriau; Endre Majorovits; Evelyn Garlick; Maria Augusta do R. B. F. Lima; Inga Prokopenko; Jonathon Nixon-Abell; Andreas Müller; Alejandra Tomas
Growth of the maternal intestine during reproduction (vol 188, pg 2738, 2025)

繁殖期间母体肠道的生长（卷 188，页 2738，2025）

CELL
IF42.5
2025-05-010
OAAI
Ameku, Tomotsune; Laddach, Anna; Beckwith, Hannah; Milona, Alexandra; Rogers, Loranzie S.; Schwayer, Cornelia; Nye, Emma; Tough, Iain R.; Thoumas, Jean-Louis; Gautam, Umesh Kumar; Wang, Yi-Fang; Jha, Shreya; Castano-Medina, Alvaro; Amourda, Christopher; Vaelli, Patric M.; Gevers, Sira; Irvine, Elaine E.; Meyer, Leah; Andrew, Ivan; Choi, Ka Lok; Patel, Bhavik; Francis, Alice J.; Studd, Chris; Game, Laurence; Young, George; Murphy, Kevin G.; Owen, Bryn; Withers, Dominic J.; Rodriguez-Colman, Maria; Cox, Helen M.; Liberali, Prisca; Schwarzer, Martin; Leulier, Francois; Pachnis, Vassilis; Bellono, Nicholas W.; Miguel-Aliaga, Irene
Ribosomal S6 kinase 1 regulates inflammaging via the senescence secretome

核糖体S6激酶1通过衰老分泌组调节炎症

NATURE AGING
IF19.4
2024-08-291
OAAI
Gallage, Suchira; Irvine, Elaine E.; Barragan Avila, Jose Efren; Reen, Virinder; Pedroni, Silvia M. A.; Duran, Imanol; Ranvir, Vikas; Khadayate, Sanjay; Pombo, Joaquim; Brookes, Sharon; Heide, Danijela; Dharmalingham, Gopuraja; Choudhury, Agharul I.; Singh, Indrabahadur; Herranz, Nicolas; Vernia, Santiago; Heikenwalder, Mathias; Gil, Jesus; Withers, Dominic J.
mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype (vol 17, pg 1205, 2015)

mTOR调节MAPKAPK2翻译以控制衰老相关的分泌表型 (vol 17，pg 1205，2015)

NATURE CELL BIOLOGY
IF19.1
2024-05-221
OA
Herranz, Nicolas; Gallage, Suchira; Mellone, Massimiliano; Wuestefeld, Torsten; Klotz, Sabrina; Hanley, Christopher J.; Raguz, Selina; Acosta, Juan Carlos; Innes, Andrew J.; Banito, Ana; Georgilis, Athena; Montoya, Alex; Wolter, Katharina; Dharmalingam, Gopuraja; Faull, Peter; Carroll, Thomas; Martinez-Barbera, Juan Pedro; Cutillas, Pedro; Reisinger, Florian; Heikenwalder, Mathias; Miller, Richard A.; Withers, Dominic; Zender, Lars; Thomas, Gareth J.; Gil, Jesus
Differential CpG methylation at Nnat in the early establishment of beta cell heterogeneity

Nnat的差异CpG甲基化在 β 细胞异质性早期建立中的作用

DIABETOLOGIA
IF10.2
2024-03-211
OAAI
Yu, Vanessa; Yong, Fiona; Marta, Angellica; Khadayate, Sanjay; Osakwe, Adrien; Bhattacharya, Supriyo; Varghese, Sneha S.; Chabosseau, Pauline; Tabibi, Sayed M.; Chen, Keran; Georgiadou, Eleni; Parveen, Nazia; Suleiman, Mara; Stamoulis, Zoe; Marselli, Lorella; De Luca, Carmela; Tesi, Marta; Ostinelli, Giada; Delgadillo-Silva, Luis; Wu, Xiwei; Hatanaka, Yuki; Montoya, Alex; Elliott, James; Patel, Bhavik; Demchenko, Nikita; Whilding, Chad; Hajkova, Petra; Shliaha, Pavel; Kramer, Holger; Ali, Yusuf; Marchetti, Piero; Sladek, Robert; Dhawan, Sangeeta; Withers, Dominic J.; Rutter, Guy A.; Millership, Steven J.
COPI vesicle formation and N-myristoylation are targetable vulnerabilities of senescent cells

COPI囊泡形成和N-肉豆蔻酰化是衰老细胞的可靶向脆弱性

NATURE CELL BIOLOGY
IF19.1
2023-11-2712
OAAI
McHugh, Domhnall; Sun, Bin; Gutierrez-Munoz, Carmen; Hernandez-Gonzalez, Fernanda; Mellone, Massimiliano; Guiho, Romain; Duran, Imanol; Pombo, Joaquim; Pietrocola, Federico; Birch, Jodie; Kallemeijn, Wouter W.; Khadayate, Sanjay; Dharmalingam, Gopuraja; Vernia, Santiago; Tate, Edward W.; Martinez-Barbera, Juan Pedro; Withers, Dominic J.; Thomas, Gareth J.; Serrano, Manuel; Gil, Jesus
Platelet GPIb alpha is a mediator and potential interventional target for NASH and subsequent liver cancer (vol 25, pg 641, 2019)
NATURE MEDICINE
IF50
2022-02-184
OA
Malehmir, Mohsen; Pfister, Dominik; Gallage, Suchira; Szydlowska, Marta; Inverso, Donato; Kotsiliti, Elena; Leone, Valentina; Peiseler, Moritz; Surewaard, Bas G. J.; Rath, Dominik; Ali, Adnan; Wolf, Monika Julia; Drescher, Hannah; Healy, Marc E.; Dauch, Daniel; Kroy, Daniela; Krenkel, Oliver; Kohlhepp, Marlene; Engleitner, Thomas; Olkus, Alexander; Sijmonsma, Tjeerd; Volz, Julia; Deppermann, Carsten; Stegner, David; Helbling, Patrick; Nombela-Arrieta, Cesar; Rafiei, Anahita; Hinterleitner, Martina; Rall, Marcel; Baku, Florian; Borst, Oliver; Wilson, Caroline L.; Leslie, Jack; O'Connor, Tracy; Weston, Christopher J.; Chauhan, Abhishek; Adams, David H.; Sheriff, Lozan; Teijeiro, Ana; Prinz, Marco; Bogeska, Ruzhica; Anstee, Natasha; Bongers, Malte N.; Notohamiprodjo, Mike; Geisler, Tobias; Withers, Dominic J.; Ware, Jerry; Mann, Derek A.; Augustin, Hellmut G.; Vegiopoulos, Alexandros; Milsom, Michael D.; Rose, Adam J.; Lalor, Patricia F.; Llovet, Josep M.; Pinyol, Roser; Tacke, Frank; Rad, Roland; Matter, Matthias; Djouder, Nabil; Kubes, Paul; Knolle, Percy A.; Unger, Kristian; Zender, Lars; Nieswandt, Bernhard; Gawaz, Meinrad; Weber, Achim; Heikenwalder, Mathias
Sexually dimorphic roles for the type 2 diabetes-associated C2cd4b gene in murine glucose homeostasis

2型糖尿病相关的C2cd4b基因在小鼠葡萄糖稳态中的性双态作用

DIABETOLOGIA
IF10.2
2021-01-258
OAAI
Mousavy Gharavy, S. Neda; Owen, Bryn M.; Millership, Steven J.; Chabosseau, Pauline; Pizza, Grazia; Martinez-Sanchez, Aida; Tasoez, Emirhan; Georgiadou, Eleni; Hu, Ming; Fine, Nicholas H. F.; Jacobson, David A.; Dickerson, Matthew T.; Idevall-Hagren, Olof; Montoya, Alex; Kramer, Holger; Mehta, Zenobia; Withers, Dominic J.; Ninov, Nikolay; Gadue, Paul J.; Cardenas-Diaz, Fabian L.; Cruciani-Guglielmacci, Celine; Magnan, Christophe; Ibberson, Mark; Leclerc, Isabelle; Voz, Marianne; Rutter, Guy A.

研究方向

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C
Colin Selman
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A
Agharul I. Choudhury
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E
Elaine E. Irvine
H 指数:30论文数:73被引数:4,156
M
Mark A. Smith
H 指数:149论文数:1,061被引数:8.2万
R
Rachel L. Batterham
H 指数:78论文数:290被引数:3.6万
J
Jesús Gil
H 指数:72论文数:232被引数:2.9万
A
Alex Montoya
H 指数:22论文数:84被引数:1,984
M
Mathias Heikenwälder
H 指数:106论文数:648被引数:4.5万
S
Suchira Gallage
H 指数:18论文数:49被引数:2,846
S
Steven J. Millership
H 指数:16论文数:32被引数:1,645