未登录 Discovery of (S)-1-((2′,6-Bis(difluoromethyl)-[2,4′-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine (BMS-986176/LX-9211): AHighly Selective, CNS Penetrable, and Orally Active AdaptorProtein-2 Associated Kinase 1 Inhibitor in Clinical Trials for theTreatment of Neuropathic Pain Luo, Guanglin; Chen, Ling; Kostich, Walter A.; Hamman, Brian; Allen, Jason; Easton, Amy; Bourin, Clotilde; Gulianello, Michael; Lippy, Jonathan; Nara, Susheel; Maishal, Tarun Kumar; Thiyagarajan, Kamalraj; Jalagam, Prasadrao; Pattipati, Sreenivasulu Naidu; Dandapani, Kumaran; Dokania, Manoj; Vattikundala, Pradeep; Sharma, Vivek; Elavazhagan, Saravanan; Verma, Manoj Kumar; Das, Manish Lal; Wagh, Santosh; Balakrishnan, Anand; Johnson, Benjamin M.; Santone, Kenneth S.; Thalody, George; Denton, Rex; Saminathan, Hariharan; Holenarsipur, Vinay K.; Kumar, Anoop; Rao, Abhijith; Putlur, Siva Prasad; Sarvasiddhi, Sarat Kumar; Shankar, Ganesh; Louis, Justin, V; Ramarao, Manjunath; Conway, Charles M.; Li, Yu-Wen; Pieschl, Rick; Tian, Yuan; Hong, Yang; Ditta, Jonathan; Mathur, Arvind; Li, Jianqing; Smith, Daniel; Pawluczyk, Joseph; Sun, Dawn; Yip, Shiuhang; Wu, Dauh-Rurng; Vetrichelvan, Muthalagu; Gupta, Anuradha; Wilson, Alan; Gopinathan, Suma; Wason, Suman; Bristow, Linda; Albright, Charles F.; Bronson, Joanne J.; Macor, John E.; Dzierba, Carolyn D. 分享 收藏
Results of two Phase 1, Randomized, Double-blind, Placebo-controlled, Studies (Ascending Single-dose and Multiple-dose Studies) to Determine the Safety, Tolerability, and Pharmacokinetics of Orally Administered LX9211 in Healthy Participants 两项1期，随机，双盲，安慰剂对照研究 (递增单剂量和多剂量研究) 的结果，以确定健康参与者口服LX9211的安全性，耐受性和药代动力学 Bundrant, LuAnn; Hunt, Thomas L.; Banks, Phil; Gopinathan, Suma; Boehm, Kristi A.; Kassler-Taub, Kenneth; Tyle, Praveen; Wilson, Alan; Warner, Chris; Wason, Suman 分享 收藏
The Gut Microbiome and Xenobiotics: Identifying Knowledge Gaps 肠道微生物组和异生物: 识别知识差距 Sutherland, Vicki L.; McQueen, Charlene A.; Mendrick, Donna; Gulezian, Donna; Cerniglia, Carl; Foley, Steven; Forry, Sam; Khare, Sangeeta; Liang, Xue; Manautou, Jose E.; Tweedie, Donald; Young, Howard; Alekseyenko, Alexander, V; Burns, Frank; Dietert, Rod; Wilson, Alan; Chen, Connie 分享 收藏
LX2761, a Sodium/Glucose Cotransporter 1 Inhibitor Restricted to the Intestine, Improves Glycemic Control in Mice Powell, David R.; Smith, Melinda G.; Doree, Deon D.; Harris, Angela L.; Greer, Jennifer; DaCosta, Christopher M.; Thompson, Andrea; Jeter-Jones, Sabrina; Xiong, Wendy; Carson, Kenneth G.; Goodwin, Nicole C.; Harrison, Bryce A.; Rawlins, David B.; Strobel, Eric D.; Gopinathan, Suma; Wilson, Alan; Mseeh, Faika; Zambrowicz, Brian; Ding, Zhi-Ming 分享 收藏
Discovery of LX2761, a Sodium-Dependent Glucose Cotransporter 1 (SGLT1) Inhibitor Restricted to the Intestinal Lumen, for the Treatment of Diabetes Goodwin, Nicole C.; Ding, Zhi-Ming; Harrison, Bryce A.; Strobel, Eric D.; Harris, Angela L.; Smith, Melinda; Thompson, Andrea Y.; Xiong, Wendy; Mseeh, Faika; Bruce, Debra J.; Diaz, Damaris; Gopinathan, Suma; Li, Ling; O'Neill, Emily; Thiel, Mary; Wilson, Alan G. E.; Carson, Kenneth G.; Powell, David R.; Rawlins, David B. 分享 收藏
Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain Kostich, Walter; Hamman, Brian D.; Li, Yu-Wen; Naidu, Sreenivasulu; Dandapani, Kumaran; Feng, Jianlin; Easton, Amy; Bourin, Clotilde; Baker, Kevin; Allen, Jason; Savelieva, Katerina; Louis, Justin V.; Dokania, Manoj; Elavazhagan, Saravanan; Vattikundala, Pradeep; Sharma, Vivek; Das, Manish Lal; Shankar, Ganesh; Kumar, Anoop; Holenarsipur, Vinay K.; Gulianello, Michael; Molski, Ted; Brown, Jeffrey M.; Lewis, Martin; Huang, Yanling; Lu, Yifeng; Pieschl, Rick; O'Malley, Kevin; Lippy, Jonathan; Nouraldeen, Amr; Lanthorn, Thomas H.; Ye, Guilan; Wilson, Alan; Balakrishnan, Anand; Denton, Rex; Grace, James E.; Lentz, Kimberley A.; Santone, Kenneth S.; Bi, Yingzhi; Main, Alan; Swaffield, Jon; Carson, Ken; Mandlekar, Sandhya; Vikramadithyan, Reeba K.; Nara, Susheel J.; Dzierba, Carolyn; Bronson, Joanne; Macor, John E.; Zaczek, Robert; Westphal, Ryan; Kiss, Laszlo; Bristow, Linda; Conway, Charles M.; Zambrowicz, Brian; Albright, Charles F. 分享 收藏
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Discovery and Development of LX7101, a Dual LIM-Kinase and ROCK Inhibitor for the Treatment of Glaucoma Harrison, Bryce A.; Almstead, Zheng Y.; Burgoon, Hugh; Gardyan, Michael; Goodwin, Nicole C.; Healy, Jason; Liu, Ying; Mabon, Ross; Marinelli, Brett; Samala, Lakshman; Zhang, Yulian; Stouch, Terry R.; Whitlock, N. Andrew; Gopinathan, Suma; McKnight, Beth; Wang, Shuli; Patel, Nita; Wilson, Alan G. E.; Hamman, Brian D.; Rice, Dennis S.; Rawlins, David B. 分享 收藏
Effect of LX4211 on Glucose Homeostasis and Body Composition in Preclinical Models Powell, David R.; DaCosta, Christopher M.; Smith, Melinda; Doree, Deon; Harris, Angela; Buhring, Lindsey; Heydorn, William; Nouraldeen, Amr; Xiong, Wendy; Yalamanchili, Padmaja; Mseeh, Faika; Wilson, Alan; Shadoan, Melanie; Zambrowicz, Brian; Ding, Zhi-Ming 分享 收藏
LX4211, a Dual SGLT1/SGLT2 Inhibitor, Improved Glycemic Control in Patients With Type 2 Diabetes in a Randomized, Placebo-Controlled Trial Zambrowicz, B.; Freiman, J.; Brown, P. M.; Frazier, K. S.; Turnage, A.; Bronner, J.; Ruff, D.; Shadoan, M.; Banks, P.; Mseeh, F.; Rawlins, D. B.; Goodwin, N. C.; Mabon, R.; Harrison, B. A.; Wilson, A.; Sands, A.; Powell, D. R. 分享 收藏
Inhibition of Sphingosine 1-Phosphate Lyase for the Treatment of Rheumatoid Arthritis: Discovery of (E)-1-(4((1R,2S,3R)-1,2,3,4-Tetrahydroxybutyl)-1H-imidazol-2-yl)ethanone Oxime (LX2931) and (1R,2S,3R)-1-(2-(Isoxazol-3-yl)-1H-imidazol-4-yl)butane-1,2,3,4-tetraol (LX2932) Bagdanoff, Jeffrey T.; Donoviel, Michael S.; Nouraldeen, Amr; Carlsen, Marianne; Jessop, Theodore C.; Tarver, James; Aleem, Saadat; Dong, Li; Zhang, Haiming; Boteju, Lakmal; Hazelwood, Jill; Yan, Jack; Bednarz, Mark; Layek, Suman; Owusu, Iris B.; Gopinathan, Suma; Moran, Liam; Lai, Zhong; Kramer, Jeff; Kimball, S. David; Yalamanchili, Padmaja; Heydorn, William E.; Frazier, Kenny S.; Brooks, Barbara; Brown, Philip; Wilson, Alan; Sonnenburg, William K.; Main, Alan; Carson, Kenneth G.; Oravecz, Tamas; Augeri, David J. 分享 收藏
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Novel Class of LIM-Kinase 2 Inhibitors for the Treatment of Ocular Hypertension and Associated Glaucoma Harrison, Bryce A.; Whitlock, N. Andrew; Voronkov, Michael V.; Almstead, Zheng Y.; Gu, Kun-jian; Mabon, Ross; Gardyan, Michael; Hamman, Brian D.; Allen, Jason; Gopinathan, Suma; McKnight, Beth; Crist, Mike; Zhang, Yulian; Liu, Ying; Courtney, Lawrence F.; Key, Billie; Zhou, Julia; Patel, Nita; Yates, Phil W.; Liu, Qingyun; Wilson, Alan G. E.; Kimball, S. David; Crosson, Craig E.; Rice, Dennis S.; Rawlins, David B. 分享 收藏
Novel L-Xylose Derivatives as Selective Sodium-Dependent Glucose Cotransporter 2 (SGLT2) Inhibitors for the Treatment of Type 2 Diabetes Goodwin, Nicole C.; Mabon, Ross; Harrison, Bryce A.; Shadoan, Melanie K.; Almstead, Zheng Y.; Xie, Yiling; Healy, Jason; Buhring, Lindsey M.; DaCosta, Christopher M.; Bardenhagen, Jennifer; Mseeh, Faika; Liu, Qingyun; Nouraldeen, Amr; Wilson, Alan G. E.; Kimball, S. David; Powell, David R.; Rawlins, David B. 分享 收藏
Inhibition of Sphingosine-1-Phosphate Lyase for the Treatment of Autoimmune Disorders 抑制Sphingosine-1-Phosphate裂解酶治疗自身免疫性疾病 Bagdanoff, Jeffrey T.; Donoviel, Michael S.; Nouraldeen, Amr; Tarver, James; Fu, Qinghong; Carlsen, Marianne; Jessop, Theodore C.; Zhang, Haiming; Hazelwood, Jill; Nguyen, Huy; Baugh, Simon D. P.; Gardyan, Michael; Terranova, Kristen M.; Barbosa, Joseph; Yan, Jack; Bednarz, Mark; Layek, Suman; Courtney, Lawrence F.; Taylor, Jerry; Digeorge-Foushee, Ann Marie; Gopinathan, Suma; Bruce, Debra; Smith, Traci; Moran, Liam; O'Neill, Emily; Kramer, Jeff; Lai, Zhong; Kimball, S. David; Liu, Qingyun; Sun, Weimei; Yu, Sean; Swaffield, Jonathan; Wilson, Alan; Main, Alan; Carson, Kenneth G.; Oravecz, Tamas; Augeri, David J. 分享 收藏
Modulation of peripheral serotonin levels by novel tryptophan hydroxylase inhibitors for the potential treatment of functional gastrointestinal disorders Shi, Zhi-Cai; Devasagayaraj, Arokiasamy; Gu, Kunjian; Jin, Hailiong; Marinelli, Brett; Samala, Lakshman; Scott, Sheldon; Stouch, Terry; Tunoori, Ashok; Wang, Ying; Zang, Yi; Zhang, Chengmin; Kmiball, S. David; Main, Alan J.; Sun, Weimei; Yang, Qi; Nouraldeen, Amr; Yu, Xiang-Qing; Buxton, Eric; Patel, Shiv; Nguyen, Nghi; Swaffield, Jon; Powell, David R.; Wilson, Alan; Liu, Qingyun 分享 收藏
Discovery and characterization of novel tryptophan hydroxylase inhibitors that selectively inhibit serotonin synthesis in the gastrointestinal tract Liu, Qingyun; Yang, Qi; Sun, Weimei; Vogel, Pete; Heydorn, William; Yu, Xiang-Qing; Hu, Zhixiang; Yu, Wangsheng; Jonas, Brandie; Pineda, Randy; Calderon-Gay, Valerie; Germann, Michael; O'Neill, Emily; Brommage, Robert; Cullinan, Emily; Platt, Ken; Wilson, Alan; Powell, Dave; Sands, Arthur; Zambrowicz, Brian; Shi, Zhi-Cai 分享 收藏
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