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B

Brian S. J. Blagg

university of notre dame

59H指数
388论文数
1.0W被引数
收录论文 188
发表时间
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AHA1 Regulates Aβ Production via Modulation of APP Abundance and γ-Secretase AssemblyAHA1通过调节APP丰度和γ-分泌酶组装来调控Aβ的产生
errJournal of Neurochemistry
IF4
err2026-09-03
err0
errOAAI
errArshad Ali Noorani; Sadequl Islam; Emma Filip; Kevin Catalfano; Shravan Paswan; Vaishnavi Nagarajan; Heather M. Wilkins; Brian S. J. Blagg; Kun Zou; Michael S. Wolfe
err分享
err收藏
Attempts to Achieve Targeted Covalent Inhibition of Hsp90β靶向共价抑制Hsp90β的尝试
errChemical Biology & Drug Design
IF3.3
err2026-04-12
err0
errOAAI
errTerin D'Amico; Tyelor S. Reynolds; Michael A. Serwetnyk; Brian S. J. Blagg
err分享
err收藏
Small Molecules to Elevate Rab7-GTPase Activity and Lower Cholesterol Accumulation in Niemann-Pick Type C Disease小分子提升Rab7-GTPase活性并降低Niemann-Pick Type C病中胆固醇积累
errPharmaceutical Research
IF4.3
err2026-03-03
err0
errOAAI
errMai K. L. Nguyen; Maya R. Nikenich; Kim Seifert; Céline Pinkenburg; Felcia Lai; Hanna-Loisa Walther; Martje Hartmann; Aleksandra Szulc; Eric Sparkes; Shihui Chen; Ravi Wikramanayake; Marc Bernaus-Esqué; Yangjing Liu; Francesc Tebar; Michael Serwetnyk; Anna Wenninger; Christopher Patzke; Brian S. J. Blagg; Brandon L. Ashfeld; Paul W. Groundwater; David E. Hibbs; Andrew J. Hoy; Carles Rentero; Carlos Enrich; Ann-Na Cho; Jonathan J. Du; Thomas Grewal
err分享
err收藏
Cell-Impermeable Hsp90α-Selective Inhibitor NDNA4 Inhibits Cancer Cell Migration and Targets Extracellular Hsp90α's Critical F-5 Fragment细胞不可渗透的Hsp90α选择性抑制剂NDNA4抑制癌细胞迁移并靶向细胞外Hsp90α的关键F-5片段
errACS Chemical Biology
IF3.8
err2026-03-01
err0
PREAI
errReynolds, Tyelor S.; Mersich, Ian; Blagg, Brian S. J.
err分享
err收藏
Optimization of triazole-based small molecule disruptors of the Aha1/Hsp90 complex that manifest potent activities
errEuropean Journal of Medicinal Chemistry
IF5.9
err2026-02-02
err0
errOAAI
errKevin C. Catalfano; Margaret H. Rakonick; Brian S.J. Blagg
err分享
err收藏
Multi-omic integration identifies broad drug resistance mechanisms and strategies to therapeutically reprogram cancer cells
errISCIENCE
IF4.1
err2026-01-16
err0
errOAAI
errErsich, Ian M.; Blagg, Brian S. J.; Ali, Aktar
err分享
err收藏
Synergistic Disruption of Survival and Metastatic Potential in Esophageal Adenocarcinoma Cells Through Combined Inhibition of HIF1α and CD73通过联合抑制HIF1α和CD73协同破坏食管腺癌细胞系的生存和转移潜能
errCancers 2025, Vol. 17, Page 4016
IF4.4
err2025-12-17
err0
errOAAI
errIan Mersich; Alexander Malmberg; Eahsanul Anik; Md Sazzad Hassan; Urs von Holzen; Brian S. J. Blagg; Aktar Ali
err分享
err收藏
Design, Synthesis, and Biological Properties Exhibited by 1,2,3-Triazole Based Grp94-selective Inhibitors基于1,2,3-三唑的Grp94选择性抑制剂的制备、合成及其生物学特性
errEuropean Journal of Medicinal Chemistry
IF5.9
err2025-11-29
err0
PREAI
errHao Xu; Dustin J.E. Huard; Elijah Dunn; Lucas A. Chalfoun; Felix Adulley; Raquel L. Lieberman; Brian S.J. Blagg
err分享
err收藏
Optimization of Hsp90/Aha1 Small-Molecule Disruptors Via the Evaluation of Amide Bioisosteres通过评价酰胺生物电子等排体优化Hsp90/Aha1小分子破坏剂
errACS Medicinal Chemistry Letters
IF4
err2025-11-07
err0
PREAI
errKevin C. Catalfano; Bradley M. Keegan; Brian S. J. Blagg
err分享
err收藏
Hsp90β-Selective Inhibitors: Probing the Solvent-Accessible FrontierHsp90β选择性抑制剂：探查溶剂可及前沿
errCHEMMEDCHEM
IF3.4
err2025-11-01
err0
errOAAI
errD'Amico, Terin; Serwetnyk, Michael A.; Dou, Xiaozheng; Mersich, Ian; Barlow, Deborah; Houseknecht, Karen L.; Streicher, John M.; Ali, Aktar; Blagg, Brian S. J.
err分享
err收藏
Integrative Multi-Omics Analyses Reveal Mechanisms of Resistance to Hsp90β-Selective Inhibition整合多组学分析揭示了Hsp90β选择性抑制的耐药机制
errCancers 2025, Vol. 17, Page 3488
IF4.4
err2025-10-30
err0
errOAAI
errIan Mersich; Eahsanul Anik; Aktar Ali; Brian S. J. Blagg
err分享
err收藏
[11C]HSP990 PET as a translational tool to investigate the role of Hsp90 in tumours and support the development of Hsp90 therapeutics[11C]HSP990 PET作为一种转化工具，用于研究Hsp90在肿瘤中的作用并支持Hsp90治疗药物的开发。
errEJNMMI Radiopharmacy and Chemistry
IF3.3
err2025-09-26
err0
errOAAI
errRomy Cools; Valeria Narykina; Koen Vermeulen; Sanket J. Mishra; Brian S. J. Blagg; Marleen Derweduwe; Frederik De Smet; Aaron Ziani-Zeryouh; Matteo Riva; An Coosemans; Frederic Rousseau; Joost Schymkowitz; Guy Bormans
err分享
err收藏
TRAP1 and its therapeutic potentialTRAP1及其治疗潜力
errBioorganic & Medicinal Chemistry Letters
IF2.2
err2025-09-05
err0
errOAAI
errAndrew Gutierrez; Jason Archdeacon; Brian S.J. Blagg
err分享
err收藏
Proteomic Analysis of Hsp90β-selective Inhibitors Against Triple-negative Breast Cancer (TNBC) to Gain a Mechanistic InsightHsp90β选择性抑制剂对三阴性乳腺癌（TNBC）的蛋白质组学分析，以获得机制性见解
errMolecular & Cellular Proteomics
IF5.5
err2025-07-24
err0
errOAAI
errTyelor S. Reynolds; Daniel D. Hu; Simon D. Weaver; Emma C. Ronck; Sanket J. Mishra; Matthew M. Champion; Brian S.J. Blagg
err分享
err收藏
Biotinylated Hsp90β-selective inhibitors生物素标记的Hsp90β选择性抑制剂
errBioorganic & Medicinal Chemistry Letters
IF2.2
err2025-07-01
err0
errOAAI
errChaitanya Kondam; Nitin Sharma; Gaya K. Amarasinge; Brian S.J. Blagg
err分享
err收藏
Optimization of an Hsp90β-selective inhibitor via exploration of the Hsp90 N-terminal ATP-binding pocket通过探索Hsp90 N端ATP结合口袋优化Hsp90β选择性抑制剂
errEuropean Journal of Medicinal Chemistry
IF5.9
err2025-06-30
err0
errOAAI
errMichael A. Serwetnyk; Taddäus Strunden; Ian Mersich; Deborah Barlow; Terin D'Amico; Sanket J. Mishra; Karen L. Houseknecht; John M. Streicher; Brian S.J. Blagg
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err收藏
Glucose-regulated protein 94 (Grp94/gp96) in viral pathogenesis: Insights into its role and therapeutic potentials葡萄糖调节蛋白94 (Grp94/gp96) 在病毒致病中的作用：对其功能及治疗潜力的见解
errEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
err2025-05-10
err0
errOAAI
errXu, Hao; Blagg, Brian S. J.
err分享
err收藏
The Hsp90β Isoform: An Attractive Target for Drug DevelopmentHsp90β异构体：药物开发中的一个有吸引力的靶点
errMedicinal Research Reviews
IF11.6
err2025-04-28
err0
errOAAI
errSubhabrata Chaudhury; Terin D'Amico; Brian S. J. Blagg
err分享
err收藏
5,7-Dimethoxychroman-3-yl 4-methoxybenzoate Has a Unique Effect upon the Modulation of Mutant Cardiac Muscle Thin Filament Function and Dynamics due to Phosphorylation of Troponin I5,7-二甲氧基色烷-3-基 4-甲氧基苯甲酸酯由于肌钙蛋白I的磷酸化，对突变心肌肌薄丝功能与动力学的调节具有独特效应
errACS PHARMACOLOGY & TRANSLATIONAL SCIENCE
IF3.7
err2025-04-15
err0
errOAAI
errYang, ZY; Sheehan, AM; Papadaki, M; Messer, AE; Blagg, BSJ; Gould, IR; Marston, SB
err分享
err收藏
C-Terminal Hsp90 Inhibitors Overcome MEK and BRAF Inhibitor Resistance in MelanomaC-末端Hsp90抑制剂克服黑色素瘤中MEK和BRAF抑制剂的耐药性
errJOURNAL OF CELLULAR AND MOLECULAR MEDICINE
IF4.2
err2025-03-26
err0
errOAAI
errSubramanian, Chitra; Hohenberger, Katie K.; Zuo, Ang; Cousineau, Eric; Blagg, Brian; Cohen, Mark
err分享
err收藏

研究方向

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合作学者
合作期刊
H
Hugh Watkins
H 指数: 144 · 论文数: 914
J
John A. Tainer
H 指数: 123 · 论文数: 807
A
Alan D. D’Andrea
H 指数: 120 · 论文数: 710
K
Kenneth A. Jacobson
H 指数: 117 · 论文数: 1.3K
G
Geoffrey I. Shapiro
H 指数: 115 · 论文数: 2.0K
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