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K

Kaja Kostyrko

Boehringer Ingelheim
H指数:14
被引数:1,089

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SOS1 inhibitor BI-3406 shows in vivo antitumor activity akin to genetic ablation and synergizes with a KRASG12D inhibitor in KRAS LUAD

SOS1抑制剂BI-3406显示出类似基因敲除的在体抗肿瘤活性，并能与KRASG12D抑制剂协同作用，用于KRAS LUAD。

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
2025-03-120
OA
Baltanas, Fernando C.; Kramer-Drauberg, Maximilian; Garcia-Navas, Rosula; Patrucco, Enrico; Petrini, Ettore; Arnhof, Heribert; Olarte-SanJuan, Andrea; Rodriguez-Ramos, Pablo; Borrajo, Javier; Calzada, Nuria; Castellano, Esther; Mair, Barbara; Kostyrko, Kaja; Hofmann, Marco H.
Co-targeting SOS1 enhances the antitumor effects of KRASG12C inhibitors by addressing intrinsic and acquired resistance

共靶向SOS1通过解决内在和获得性耐药增强KRASG12C抑制剂的抗肿瘤作用

NATURE CANCER
IF28.5
2024-08-051
OA
Thatikonda, Venu; Lyu, Hengyu; Jurado, Sabine; Kostyrko, Kaja; Bristow, Christopher A.; Albrecht, Christoph; Alpar, Donat; Arnhof, Heribert; Bergner, Oliver; Bosch, Karin; Feng, Ningping; Gao, Sisi; Gerlach, Daniel; Gmachl, Michael; Hinkel, Melanie; Lieb, Simone; Jeschko, Astrid; Machado, Annette A.; Madensky, Thomas; Marszalek, Ethan D.; Mahendra, Mikhila; Melo-Zainzinger, Gabriella; Molkentine, Jessica M.; Jaeger, Philipp A.; Peng, David H.; Schenk, Robyn L.; Sorokin, Alexey; Strauss, Sandra; Trapani, Francesca; Kopetz, Scott; Vellano, Christopher P.; Petronczki, Mark; Kraut, Norbert; Heffernan, Timothy P.; Marszalek, Joseph R.; Pearson, Mark; Waizenegger, Irene C.; Hofmann, Marco H.
The Mir181ab1 cluster promotes KRAS-driven oncogenesis and progression in lung and pancreas
JOURNAL OF CLINICAL INVESTIGATION
IF13.6
2020-03-0928
OAAI
Valencia, Karmele; Erice, Oihane; Kostyrko, Kaja; Hausmann, Simone; Guruceaga, Elizabeth; Tathireddy, Anuradha; Flores, Natasha M.; Sayles, Leanne C.; Lee, Alex G.; Fragoso, Rita; Sun, Tian-Qiang; Vallejo, Adrian; Roman, Marta; Entrialgo-Cadierno, Rodrigo; Migueliz, Itziar; Razquin, Nerea; Fortes, Puri; Lecanda, Fernando; Lu, Jun; Ponz-Sarvise, Mariano; Chen, Chang-Zheng; Mazur, Pawel K.; Sweet-Cordero, E. Alejandro; Vicent, Silvestre
Inhibition of activin signaling in lung adenocarcinoma increases the therapeutic index of platinum chemotherapy
SCIENCE TRANSLATIONAL MEDICINE
IF14.6
2018-07-2535
OAAI
Marini, Kieren D.; Croucher, David R.; McCloy, Rachael A.; Vaghjiani, Vijesh; Gonzalez-Rajal, Alvaro; Hastings, Jordan F.; Chin, Venessa; Szczepny, Anette; Kostyrko, Kaja; Marquez, Cesar; Jayasekara, W. Samantha N.; Alamgeer, Muhammad; Boolell, Vishal; Han, Jeremy Z. R.; Waugh, Todd; Lee, Hong Ching; Oakes, Samantha R.; Kumar, Beena; Harrison, Craig A.; Hedger, Mark P.; Lorensuhewa, Nirmal; Kita, Badia; Barrow, Ross; Robinson, Bruce W.; de Kretser, David M.; Wu, Jianmin; Ganju, Vinod; Sweet-Cordero, E. Alejandro; Burgess, Andrew; Martelotto, Luciano G.; Rossello, Fernando J.; Cain, Jason E.; Watkins, D. Neil

研究方向

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E
E. Alejandro Sweet‐Cordero
H 指数:42论文数:340被引数:1.7万
P
Peter K. Jackson
H 指数:81论文数:490被引数:2.8万
M
Marco H. Hofmann
H 指数:18论文数:209被引数:2,239
M
Michael C. Bassik
H 指数:69论文数:307被引数:2.4万
M
Marcus R. Kelly
H 指数:13论文数:57被引数:1,159
R
Robyn L. Schenk
H 指数:12论文数:26被引数:773
M
Melanie Hinkel
H 指数:4论文数:59被引数:279
E
Edwin E. Jeng
H 指数:11论文数:66被引数:1,781
D
Daniel Gerlach
H 指数:33论文数:177被引数:9,051
K
Kyuho Han
H 指数:17论文数:132被引数:2,962