未登录 FGFR inhibition blocks NF-ĸB-dependent glucose metabolism and confers metabolic vulnerabilities in cholangiocarcinoma Zhen, Yuanli; Liu, Kai; Shi, Lei; Shah, Simran; Xu, Qin; Ellis, Haley; Balasooriya, Eranga R.; Kreuzer, Johannes; Morris, Robert; Baldwin, Albert S.; Juric, Dejan; Haas, Wilhelm; Bardeesy, Nabeel 分享 收藏
SULT1A1-dependent sulfonation of alkylators is a lineage-dependent vulnerability of liver cancers Shi, Lei; Shen, William; Davis, Mindy I.; Kong, Ke; Vu, Phuong; Saha, Supriya K.; Adil, Ramzi; Kreuzer, Johannes; Egan, Regina; Lee, Tobie D.; Greninger, Patricia; Shrimp, Jonathan H.; Zhao, Wei; Wei, Ting-Yu; Zhou, Mi; Eccleston, Jason; Sussman, Jonathan; Manocha, Ujjawal; Weerasekara, Vajira; Kondo, Hiroshi; Vijay, Vindhya; Wu, Meng-Ju; Kearney, Sara E.; Ho, Jeffrey; McClanaghan, Joseph; Murchie, Ellen; Crowther, Giovanna S.; Patnaik, Samarjit; Boxer, Matthew B.; Shen, Min; Ting, David T.; Kim, William Y.; Stanger, Ben Z.; Deshpande, Vikram; Ferrone, Cristina R.; Benes, Cyril H.; Haas, Wilhelm; Hall, Matthew D.; Bardeesy, Nabeel 分享 收藏
Scalable batch-correction approach for integrating large-scale single-cell transcriptomes Shen, Xilin; Shen, Hongru; Wu, Dan; Feng, Mengyao; Hu, Jiani; Liu, Jilei; Yang, Yichen; Yang, Meng; Li, Yang; Shi, Lei; Chen, Kexin; Li, Xiangchun 分享 收藏
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Mutant IDH Inhibits IFNγ-TET2 Signaling to Promote Immunoevasion and Tumor Maintenance in Cholangiocarcinoma Wu, Meng-Ju; Shi, Lei; Dubrot, Juan; Merritt, Joshua; Vijay, Vindhya; Wei, Ting-Yu; Kessler, Emily; Olander, Kira E.; Adil, Ramzi; Pankaj, Amaya; Tummala, Krishna Seshu; Weeresekara, Vajira; Zhen, Yuanli; Wu, Qibiao; Luo, Meiqi; Shen, William; Garcia-Beccaria, Maria; Fernandez-Vaquero, Mirian; Hudson, Christine; Ronseaux, Sebastien; Sun, Yi; Saad-Berreta, Rodrigo; Jenkins, Russell W.; Wang, Tong; Heikenwalder, Mathias; Ferrone, Cristina R.; Goyal, Lipika; Nicolay, Brandon; Deshpande, Vikram; Kohli, Rahul M.; Zheng, Hongwu; Manguso, Robert T.; Bardeesy, Nabeel 分享 收藏
EGFR Inhibition Potentiates FGFR Inhibitor Therapy and Overcomes Resistance in FGFR2 Fusion-Positive Cholangiocarcinoma Wu, Qibiao; Zhen, Yuanli; Shi, Lei; Vu, Phuong; Greninger, Patricia; Adil, Ramzi; Merritt, Joshua; Egan, Regina; Wu, Meng-Ju; Yin, Xunqin; Ferrone, Cristina R.; Deshpande, Vikram; Baiev, Islam; Pinto, Christopher J.; McLoughlin, Daniel E.; Walmsley, Charlotte S.; Stone, James R.; Gordan, John D.; Zhu, Andrew X.; Juric, Dejan; Goyal, Lipika; Benes, Cyril H.; Bardeesy, Nabeel 分享 收藏
FGFR2 Extracellular Domain In-Frame Deletions Are Therapeutically Targetable Genomic Alterations That Function as Oncogenic Drivers in Cholangiocarcinoma Cleary, James M.; Raghavan, Srivatsan; Wu, Qibiao; Li, Yvonne Y.; Spurr, Liam F.; Gupta, Hersh, V; Rubinson, Douglas A.; Fetter, Isobel J.; Hornick, Jason L.; Nowak, Jonathan A.; Siravegna, Giulia; Goyal, Lipika; Shi, Lei; Brais, Lauren K.; Loftus, Maureen; Shinagare, Atul B.; Abrams, Thomas A.; Clancy, Thomas E.; Wang, Jiping; Patel, Anuj K.; Brichory, Franck; Chessex, Anne Vaslin; Sullivan, Ryan J.; Keller, Rachel B.; Denning, Sarah; Hill, Emma R.; Shapiro, Geoffrey, I; Pokorska-Bocci, Anna; Zanna, Claudio; Ng, Kimmie; Schrag, Deborah; Janne, Pasi A.; Hahn, William C.; Cherniack, Andrew D.; Corcoran, Ryan B.; Meyerson, Matthew; Daina, Antoine; Zoete, Vincent; Bardeesy, Nabeel; Wolpin, Brian M. 分享 收藏
The mutant IDH1 inhibitor ivosidenib promotes tumor cell differentiation and anti-tumor immunity in intrahepatic cholangiocarcinoma Wu, Meng-Ju; Shi, Lei; Dubrot, Juan; Hudson, Christine; Merritt, Joshua; Adil, Ramzi; Wu, Qibiao; Ronseaux, Sebastien; Narayanaswamy, Rohini; Manguso, Robert; Nicolay, Brandon; Bardeesy, Nabeel 分享 收藏
FGFR2 in-frame indels: A novel targetable alteration in intrahepatic cholangiocarcinoma Li, Yvonne Y.; Cleary, James M.; Raghavan, Srivatsan; Spurr, Liam F.; Wu, Qibiao; Shi, Lei; Brais, Lauren K.; Loftus, Maureen; Goyal, Lipika; Patel, Anuj K.; Shinagare, Atul B.; Clancy, Thomas E.; Shapiro, Geoffrey; Cerami, Ethan; Sellers, William R.; Hahn, William C.; Meyerson, Matthew; Bardeesy, Nabeel; Cherniack, Andrew D.; Wolpin, Brian M. 分享 收藏
Comparative performance of the BGI and Illumina sequencing technology for single-cell RNA-sequencing Senabouth, Anne; Andersen, Stacey; Shi, Qianyu; Shi, Lei; Jiang, Feng; Zhang, Wenwei; Wing, Kristof; Daniszewski, Maciej; Lukowski, Samuel W.; Hung, Sandy S. C.; Nguyen, Quan; Fink, Lynn; Beckhouse, Anthony; Pebay, Alice; Hewitt, Alex W.; Powell, Joseph E. 分享 收藏
TAS-120 Overcomes Resistance to ATP-Compartitive FGFR Inhibitors in Patients with FGFR2 Fusion-Positive Intrahepatic Cholanjiocarcinoma Goyal, Lipika; Shi, Lei; Liu, Leah Y.; de la Cruz, Ferran Fece; Lennerz, Jochen K.; Raghavan, Srivatsan; Leschiner, Ignaty; Elagina, Liudmila; Siravegna, Giulia; Ng, Raymond W. S.; Phuong Vu; Patra, Krushna C.; Saha, Supriya K.; Uppot, Raul N.; Arellano, Ron; Reyes, Stephanie; Sagara, Takeshi; Otsuki, Sachie; Nadres, Brandon; Shahzade, Heather A.; DeyGuha, Ipsita; Fetter, Isobel J.; Baiev, Islam; Van Seventer, Emily E.; Murphy, Janet E.; Ferrone, Cristina R.; Tanabe, Kenneth K.; Deshpande, Vikram; Harding, James J.; Yaeger, Rona; Kelley, Robin K.; Bardelli, Alberto; Iafrate, A. John; Hahn, William C.; Benes, Cyril H.; Ting, David T.; Hirai, Hiroshi; Getz, Gad; Juric, Dejan; Zhu, Andrew X.; Corcoran, Ryan B.; Bardeesy, Nabeel 分享 收藏
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Hypoxia-induced upregulation of BMX kinase mediates therapeutic resistance in acute myeloid leukemia 缺氧诱导的BMX激酶上调介导急性髓系白血病治疗耐药 van Oosterwijk, Jolieke G.; Buelow, Daelynn R.; Drenberg, Christina D.; Vasilyeva, Aksana; Li, Lie; Shi, Lei; Wang, Yong-Dong; Finkelstein, David; Shurtleff, Sheila A.; Janke, Laura J.; Pounds, Stanley; Rubnitz, Jeffrey E.; Inaba, Hiroto; Pabla, Navjotsingh; Baker, Sharyn D. 分享 收藏
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Isocitrate Dehydrogenase Mutations Confer Dasatinib Hypersensitivity and SRC Dependence in Intrahepatic Cholangiocarcinoma Saha, Supriya K.; Gordan, John D.; Kleinstiver, Benjamin P.; Vu, Phuong; Najem, Mortada S.; Yeo, Jia-Chi; Shi, Lei; Kato, Yasutaka; Levin, Rebecca S.; Webber, James T.; Damon, Leah J.; Egan, Regina K.; Greninger, Patricia; McDermott, Ultan; Garnett, Mathew J.; Jenkins, Roger L.; Rieger-Christ, Kimberly M.; Sullivan, Travis B.; Hezel, Aram F.; Liss, Andrew S.; Mizukami, Yusuke; Goyal, Lipika; Ferrone, Cristina R.; Zhu, Andrew X.; Joung, J. Keith; Shokat, Kevan M.; Benes, Cyril H.; Bardeesy, Nabeel 分享 收藏
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