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Brain microenvironment-remodeling nanomedicine improves cerebral glucose metabolism, mitochondrial activity and synaptic function in a mouse model of Alzheimer's disease 脑微环境重塑纳米药物改善了阿尔茨海默病小鼠模型中的脑葡萄糖代谢、线粒体活性及突触功能。 Park, Elliya; He, Chunsheng; Abbasi, Azhar Z.; Tian, Meng; Huang, Shudi; Wang, Liting; Georgiou, John; Collingridge, Graham L.; Fraser, Paul E.; Henderson, Jeffrey T.; Wu, Xiao Yu 分享 收藏
Genetic and pharmacologic enhancement of SUMO2 conjugation prevents and reverses cognitive impairment and synaptotoxicity in a preclinical model of Alzheimer's disease 遗传和药理学增强SUMO2连接作用可预防并逆转阿尔茨海默病前临床模型中的认知障碍和突触毒性。 Fioriti, L; Wijesekara, N; Argyrousi, EK; Matsuzaki, S; Takamura, H; Satoh, K; Han, K; Yamauchi, H; Staniszewski, A; Acquarone, E; Orsini, F; Martucci, A; Katayama, T; Arancio, O; Fraser, PE 分享 收藏
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Synthesis and Characterization of Click Chemical Probes for Single-Cell Resolution Detection of Epichaperomes in Neurodegenerative Disorders Bay, Sadik; Digwal, Chander S.; Martin, Ananda M. Rodilla; Sharma, Sahil; Stanisavljevic, Aleksandra; Rodina, Anna; Attaran, Anoosha; Roychowdhury, Tanaya; Parikh, Kamya; Toth, Eugene; Panchal, Palak; Rosiek, Eric; Pasala, Chiranjeevi; Arancio, Ottavio; Fraser, Paul E.; Alldred, Melissa J.; Prado, Marco A. M.; Ginsberg, Stephen D.; Chiosis, Gabriela 分享 收藏
Quantitative comparison of presenilin protein expression reveals greater activity of PS2-γ-secretase Eccles, Melissa K.; Main, Nathan; Carlessi, Rodrigo; Armstrong, Ayeisha Milligan; Sabale, Miheer; Roberts-Mok, Brigid; Tirnitz-Parker, Janina E. E.; Agostino, Mark; Groth, David; Fraser, Paul E.; Verdile, Giuseppe 分享 收藏
Alzheimer's disease brain-derived extracellular vesicles reveal altered synapse-related proteome and induce cognitive impairment in mice 阿尔茨海默病脑源性细胞外囊泡揭示突触相关蛋白质组改变并诱导小鼠认知障碍 Bodart-Santos, Victor; Pinheiro, Lisandra S.; da Silva-Junior, Almir J.; Froza, Rudimar L.; Ahrens, Rosemary; Goncalves, Rafaella A.; Andrade, Mayara M.; Chen, Yan; Alcantara, Carolina de Lima; Grinberg, Lea T.; Leite, Renata E. P.; Ferreira, Sergio T.; Fraser, Paul E.; De Felice, Fernanda G. 分享 收藏
Brain-Penetrating and Disease Site-Targeting Manganese Dioxide-Polymer-Lipid Hybrid Nanoparticles Remodel Microenvironment of Alzheimer's Disease by Regulating Multiple Pathological Pathways 脑穿透和疾病位点靶向二氧化锰-聚合物-脂质杂化纳米颗粒通过调节多种病理途径重塑阿尔茨海默病的微环境 Park, Elliya; Li, Lily Yi; He, Chunsheng; Abbasi, Azhar Z. Z.; Ahmed, Taksim; Foltz, Warren D. D.; O'Flaherty, Regan; Zain, Maham; Bonin, Robert P. P.; Rauth, Andrew M. M.; Fraser, Paul E. E.; Henderson, Jeffrey T. T.; Wu, Xiao Yu 分享 收藏
Viral alpha-synuclein knockdown prevents spreading synucleinopathy Menon, Sindhu; Kofoed, Rikke H.; Nabbouh, Fadl; Xhima, Kristiana; Al-Fahoum, Yasmeen; Langman, Tammy; Mount, Howard T. J.; Shihabuddin, Lamya S.; Sardi, S. Pablo; Fraser, Paul E.; Watts, Joel C.; Aubert, Isabelle; Tandon, Anurag 分享 收藏
Differential interaction with TREM2 modulates microglial uptake of modified Aβ species Joshi, Pranav; Riffel, Florian; Satoh, Kanayo; Enomoto, Masahiro; Qamar, Seema; Scheiblich, Hannah; Villacampa, Nadia; Kumar, Sathish; Theil, Sandra; Parhizkar, Samira; Haass, Christian; Heneka, Michael T.; Fraser, Paul E.; Walter, Jochen 分享 收藏
Amyloid-β toxicity modulates tau phosphorylation through the PAX6 signalling pathway Zhang, Yalun; Zhang, Yi; Aman, Yahyah; Ng, Cheung Toa; Chau, Wing-Hin; Zhang, Zhigang; Yue, Ming; Bohm, Christopher; Jia, Yizhen; Li, Siwen; Yuan, Qiuju; Griffin, Jennifer; Chiu, Kin; Wong, Dana S. M.; Wang, Binbin; Jin, Dongyan; Rogaeva, Ekaterina; Fraser, Paul E.; Fang, Evandro F.; St George-Hyslop, Peter; Song, You-Qiang 分享 收藏
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Pancreatic β cell-selective zinc transporter 8 insufficiency accelerates diabetes associated with islet amyloidosis Xu, Jie; Wijesekara, Nadeeja; Regeenes, Romario; Al Rijjal, Dana; Piro, Anthony L.; Song, Youchen; Wu, Anne; Bhattacharjee, Alpana; Liu, Ying; Marzban, Lucy; Rocheleau, Jonathan, V; Fraser, Paul E.; Dai, Feihan F.; Hu, Cheng; Wheeler, Michael B. 分享 收藏
Aβ43 aggregates exhibit enhanced prion-like seeding activity in mice Ruiz-Riquelme, Alejandro; Mao, Alison; Barghash, Marim M.; Lau, Heather H. C.; Stuart, Erica; Kovacs, Gabor G.; Nilsson, K. Peter R.; Fraser, Paul E.; Schmitt-Ulms, Gerold; Watts, Joel C. 分享 收藏
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Pro-inflammatory interleukin-6 signaling links cognitive impairments and peripheral metabolic alterations in Alzheimer's disease Silva, Natalia M. Lyra e; Goncalves, Rafaella A.; Pascoal, Tharick A.; Lima-Filho, Ricardo A. S.; Resende, Elisa de Paula Franca; Vieira, Erica L. M.; Teixeira, Antonio L.; de Souza, Leonardo C.; Peny, Julyanna A.; Fortuna, Juliana T. S.; Furigo, Isadora C.; Hashiguchi, Debora; Miya-Coreixas, Vivian S.; Clarke, Julia R.; Abisambra, Jose F.; Longo, Beatriz M.; Donato, Jose, Jr.; Fraser, Paul E.; Rosa-Neto, Pedro; Caramelli, Paulo; Ferreira, Sergio T.; De Felice, Fernanda G. 分享 收藏
Mixed pathologies in pancreatic β cells from subjects with neurodegenerative diseases and their interaction with prion protein Martinez-Valbuena, Ivan; Valenti-Azcarate, Rafael; Amat-Villegas, Irene; Marcilla, Irene; Marti-Andres, Gloria; Caballero, Maria-Cristina; Riverol, Mario; Tunon, Maria-Teresa; Fraser, Paul E.; Luquin, Maria-Rosario 分享 收藏
Wild-type sTREM2 blocks Aβ aggregation and neurotoxicity, but the Alzheimer's R47H mutant increases Aβ aggregation Vilalta, Anna; Zhou, Ye; Sevalle, Jean; Griffin, Jennifer K.; Satoh, Kanayo; Allendorf, David H.; De, Suman; Puigdellivol, Mar; Bruzas, Arturas; Burguillos, Miguel A.; Dodd, Roger B.; Chen, Fusheng; Zhang, Yalun; Flagmeier, Patrick; Needham, Lisa-Maria; Enomoto, Masahiro; Qamar, Seema; Henderson, James; Walter, Jochen; Fraser, Paul E.; Klenerman, David; Lee, Steven F.; St George-Hyslop, Peter; Brown, Guy C. 分享 收藏
Discovery of sustainable drugs for Alzheimer's disease: cardanol-derived cholinesterase inhibitors with antioxidant and anti-amyloid properties de Andrade Ramos, Giselle; Souza de Oliveira, Andressa; Bartolini, Manuela; Naldi, Marina; Liparulo, Irene; Bergamini, Christian; Uliassi, Elisa; Wu, Ling; Fraser, Paul E.; Abreu, Monica; Kiametis, Alessandra Sofia; Gargano, Ricardo; Silveira, Edilberto Rocha; Brand, Guilherme D.; Prchal, Lukas; Soukup, Ondrej; Korabecny, Jan; Bolognesi, Maria Laura; Soares Romeiro, Luiz Antonio 分享 收藏
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