John Denis Fryer - Publications, H-index & Citations

John Denis Fryer

mayo clinic

66H指数

388论文数

1.4W被引数

收录论文 97

发表时间

Sex-specific APOE4-dependent innate immunity regulates meningeal lymphatics, brain lipids, neuroinflammation, and cognition APOE4依赖性的性别特异性固有免疫调控硬脑膜淋巴管、脑脂质、神经炎症和认知功能。

Neuron

IF15

2026-03-26

OAAI

Nickoleta Delivanoglou; Kennedi T. Todd; Francisco Almeida; Shanon Rego; Amogh Changavi; Myriam Spajer; Virginia Estades Ayuso; Liliana M. Pinho-Correia; Guadalupe Sanchez; Sofia P. das Neves; Megan J. Barber; Racquelle Schrader; Patricia Sacilotto; Yuka A. Martens; Michael G. Heckman; Guojun Bu; Rudolph E. Tanzi; Jean-Leon Thomas; John D. Fryer; Tiago Gil Oliveira

Laboratory mice exposed naturally to multiple pathogens show profound sex- and organ-dependent immunological phenotypes

JOURNAL OF IMMUNOLOGY

IF3.4

2025-11-01

PREAI

Brooksby, Jared Joseph; Roscoe, Donna Mae; Iijima, Koji; Fryer, John D.; Kita, Hirohito

Conditional ablation of MHC class I antigen presentation on microglia reduces CD8 T cell accumulation in the CNS in a novel tauopathy animal model

JOURNAL OF IMMUNOLOGY

IF3.4

2025-11-01

PREAI

Lewis, Cody Lynn; Maynes, Mark Andrew; Seady, Marina; Hassani, Asma; Thelwell, Javonte; Owens, Carley; Hansen, Michael J.; Jin, Fang; Fryer, John; Johnson, Aaron J.

An Alzheimer's neuroinflammatory microenvironment resists glioblastoma immune hijacking 阿尔茨海默病神经炎症微环境抵抗胶质母细胞瘤免疫劫持

NEURO-ONCOLOGY

IF13.4

2025-11-01

PREAI

Nascari, David; Eghlimi, Ryan; Beniwal, Angad; Bouchal, Samantha; Grief, Dustin; Haug, Katelin; Alton, Drake; Fryer, John; Tran, Nhan

Sex-dependent responses in mice to a natural microbial environment

JOURNAL OF IMMUNOLOGY

IF3.4

2025-11-01

PREAI

Roscoe, Donna Mae; Fryer, John D.; Tallant, Lauren Tallant

A glial circadian gene expression atlas reveals cell-type and disease-specific reprogramming in response to amyloid pathology or aging 胶质细胞昼夜节律基因表达图谱揭示了在淀粉样蛋白病理或衰老刺激下，细胞类型和疾病特异性的重编程。

Nature Neuroscience

IF20

2025-10-23

OAAI

Patrick W. Sheehan; Stuart B. Fass; Darshan Sapkota; Sylvia Kang; Henry C. Hollis; Jennifer H. Lawrence; Sohui Park; Ashish Sharma; Dorothy P. Schafer; Ron C. Anafi; Joseph D. Dougherty; John D. Fryer; Erik S. Musiek

Intrahippocampally Injected Human Recombinant Clusterin Reduces Amyloid-β Aggregate Size in Cerebral Arteriole Walls of Clusterin Knockout Mice 海马内注射的人重组clusterin可减少clusterin基因敲除小鼠脑 arteriole 壁中Amyloid-β聚集物的大小

Neuropathology and Applied Neurobiology

IF3.4

2025-09-08

OAAI

Alexandru Laslo; Tudor-Gabriel Boghițoiu; Laura Chinezu; Doina Manu; Adrian Dumitru Ivanescu; Bogdan Andrei Cordoș; Mark R. Wilson; Claudia Banescu; John D. Fryer; Ajay Verma; Jennifer M. Dewing; Roxana-Octavia Carare

Research models to study lewy body dementia 研究路易体痴呆的研究模型

MOLECULAR NEURODEGENERATION

IF17.5

2025-04-23

OAAI

Boschen, Suelen Lucio; A. Mukerjee, Aarushi; H. Faroqi, Ayman; E. Rabichow, Ben; Fryer, John

Distinct transcriptional alterations distinguish Lewy body disease from Alzheimer's disease

BRAIN

IF11.7

2024-06-25

OAAI

Olney, Kimberly C.; Rabichow, Benjamin E.; Wojtas, Aleksandra M.; Deture, Michael; Mclean, Pamela J.; Dickson, Dennis W.; Chang, Rui; Ross, Owen A.; Fryer, John D.

Mapping medically relevant RNA isoform diversity in the aged human frontal cortex with deep long-read RNA-seq

NATURE BIOTECHNOLOGY

IF41.7

2024-05-22

OAAI

Aguzzoli Heberle, Bernardo; Brandon, J. Anthony; Page, Madeline L.; Nations, Kayla A.; Dikobe, Ketsile I.; White, Brendan J.; Gordon, Lacey A.; Fox, Grant A.; Wadsworth, Mark E.; Doyle, Patricia H.; Williams, Brittney A.; Fox, Edward J.; Shantaraman, Anantharaman; Ryten, Mina; Goodwin, Sara; Ghiban, Elena; Wappel, Robert; Mavruk-Eskipehlivan, Senem; Miller, Justin B.; Seyfried, Nicholas T.; Nelson, Peter T.; Fryer, John D.; Ebbert, Mark T. W.

Altered tumor microenvironment in animal model of concomitant GBM and Alzheimer's pathology

CANCER RESEARCH

IF16.6

2024-03-22

PREAI

Nascari, David; Eghlimi, Ryan; Beniwal, Angad; Alton, Drake; Fryer, John; Tran, Nhan L.

Aducanumab anti-amyloid immunotherapy induces sustained microglial and immune alterations

JOURNAL OF EXPERIMENTAL MEDICINE

IF10.6

2024-01-16

OAAI

Cadiz, Mika P.; Gibson, Katelin A.; Todd, Kennedi T.; Nascari, David G.; Massa, Nashali; Lilley, Meredith T.; Olney, Kimberly C.; Al-Amin, Md Mamun; Jiang, Hong; Holtzman, David M.; Fryer, John D.

Commonly disrupted pathways in brain and kidney in a pig model of systemic endotoxemia

JOURNAL OF NEUROINFLAMMATION

IF10.1

2024-01-04

OAAI

Olney, Kimberly C.; de avila, Camila; Todd, Kennedi T.; Tallant, Lauren E.; Barnett, J. Hudson; Gibson, Katelin A.; Hota, Piyush; Pandiane, Adithya Shyamala; Durgun, Pinar Cay; Serhan, Michael; Wang, Ran; Lind, Mary Laura; Forzani, Erica; Gades, Naomi M.; Thomas, Leslie F.; Fryer, John D.

Investigating the Pathogenic Interplay of Alpha-Synuclein, Tau, and Amyloid Beta in Lewy Body Dementia: Insights from Viral-Mediated Overexpression in Transgenic Mouse Models

BIOMEDICINES

IF3.9

2023-10-22

OAAI

Lim, Melina J.; Boschen, Suelen L.; Kurti, Aishe; Castanedes Casey, Monica; Phillips, Virginia R.; Fryer, John D.; Dickson, Dennis; Jansen-West, Karen R.; Petrucelli, Leonard; Delenclos, Marion; Mclean, Pamela J.

Cell-autonomous effects of APOE4 in restricting microglial response in brain homeostasis and Alzheimer's disease

NATURE IMMUNOLOGY

IF27.6

2023-10-19

PREAI

Liu, Chia-Chen; Wang, Na; Chen, Yuanxin; Inoue, Yasuteru; Shue, Francis; Ren, Yingxue; Wang, Minghui; Qiao, Wenhui; Ikezu, Tadafumi C.; Li, Zonghua; Zhao, Jing; Martens, Yuka; Doss, Sydney V.; Rosenberg, Cassandra L.; Jeevaratnam, Suren; Jia, Lin; Raulin, Ana-Caroline; Qi, Fangfang; Zhu, Yiyang; Alnobani, Alla; Knight, Joshua; Chen, Yixing; Linares, Cynthia; Kurti, Aishe; Fryer, John D.; Zhang, Bin; Wu, Long-Jun; Kim, Betty Y. S.; Bu, Guojun

Trem2 H157Y increases soluble TREM2 production and reduces amyloid pathology (vol 18, 8, 2023)

MOLECULAR NEURODEGENERATION

IF17.5

2023-04-28

OAAI

Qiao, Wenhui; Chen, Yixing; Zhong, Jun; Madden, Benjamin J.; Charlesworth, Cristine M.; Martens, Yuka A.; Liu, Chia-Chen; Knight, Joshua; Ikezu, Tadafumi C.; Aishe, Kurti; Zhu, Yiyang; Meneses, Axel; Rosenberg, Cassandra L.; Kuchenbecker, Lindsey A.; Vanmaele, Lucy K.; Li, Fuyao; Chen, Kai; Shue, Francis; Dacquel, Maxwell V.; Fryer, John; Pandey, Akhilesh; Zhao, Na; Bu, Guojun

Biomaterial mediated simultaneous delivery of spermine and alpha ketoglutarate modulate metabolism and innate immune cell phenotype in sepsis mouse models

BIOMATERIALS

IF12.9

2023-02-01

OAAI

Inamdar, Sahil; Tylek, Tina; Thumsi, Abhirami; Suresh, Abhirami P.; Jaggarapu, Madhan Mohan Chandra Sekhar; Halim, Michelle; Mantri, Shivani; Esrafili, Arezoo; Ng, Nathan D.; Schmitzer, Elizabeth; Lintecum, Kelly; de Avila, Camila; Fryer, John D.; Xu, Ying; Spiller, Kara L.; Acharya, Abhinav P.

Trem2 H157Y increases soluble TREM2 production and reduces amyloid pathology Trem2 H157Y增加可溶性TREM2的产生并减少淀粉样蛋白病理

MOLECULAR NEURODEGENERATION

IF17.5

2023-01-31

OAAI

Culture shock: microglial heterogeneity, activation, and disrupted single-cell microglial networks in vitro

MOLECULAR NEURODEGENERATION

IF17.5

2022-03-28

OAAI

Cadiz, Mika P.; Jensen, Tanner D.; Sens, Jonathon P.; Zhu, Kuixi; Song, Won-Min; Zhang, Bin; Ebbert, Mark; Chang, Rui; Fryer, John D.

Widespread choroid plexus contamination in sampling and profiling of brain tissue

MOLECULAR PSYCHIATRY

IF10.1

2022-01-05

OAAI

Olney, Kimberly C.; Todd, Kennedi T.; Pallegar, Praveen N.; Jensen, Tanner D.; Cadiz, Mika P.; Gibson, Katelin A.; Barnett, Joseph H.; de Avila, Camila; Bouchal, Samantha M.; Rabichow, Benjamin E.; Ding, Zonghui; Wojtas, Aleksandra M.; Wilson, Melissa A.; Fryer, John D.

研究方向