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Xiaoteng Cui

Tianjin Medical University General Hospital
H指数:23
被引数:1,587

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Dual novel compounds destroy mitochondrial morphology and function to treat glioblastoma by promoting the p62-mediated protein degradation of mitochondrial respiratory chain complex

双新型化合物通过促进p62介导的线粒体呼吸链复合物的蛋白降解破坏线粒体形态和功能以治疗胶质母细胞瘤

2026-10-160
PRE
PEAKS activation by PROTAC EPIC-0726 potentiates temozolomide in glioblastoma via K63/K48 ubiquitination-dependent ERK/AKT suppression and p21 stabilization

PEAKS激活通过PROTAC EPIC-0726在胶质母细胞瘤中增强替莫唑胺的效果,其机制涉及K63/K48泛素化依赖的ERK/AKT抑制及p21稳定化。

2025-10-270
PRE