Rachel E. Simmonds - Publications, H-index & Citations

Rachel E. Simmonds

University of Surrey

27H指数

74论文数

5.2K被引数

收录论文 25

发表时间

Buruli ulcer 布鲁里溃疡

Nature Reviews Disease Primers

IF60.6

2025-12-18

PREAI

Rie R. Yotsu; Rachel E. Simmonds; Dziedzom K. de Souza; Richard Odame Phillips; Yaw Ampem Amoako; Shashikant Srivastava; Kingsley Asiedu; Sara Eyangoh; Paul D. R. Johnson; Gerd Pluschke

Patients Having Major Abdominal Cancer Surgery Exhibit Significant Acute Muscle Wasting 接受主要腹部癌症手术的患者表现出显著的急性肌肉减少

cachexia sarcopenia and muscle

IF0

2025-06-13

OAAI

Gabor Dudas; Ismita Chhetri; Martin Whyte; Margaret Rayman; Rachel Simmonds; Anthony Catchpole; Mark Griffiths; Ben Creagh-Brown

Micronutrient-deficient diets and possible environmental enteric dysfunction in Buruli ulcer endemic communities in Ghana: Lower dietary diversity and reduced serum zinc and vitamin C implicate micronutrient status a possible susceptibility factor

PLOS NEGLECTED TROPICAL DISEASES

IF3.4

2025-03-01

OAAI

Loglo, Aloysius Dzigbordi; Antwi, Philemon Boasiako; Abass, Kabiru Mohammed; Osei-Mireku, Samuel; Amofa, George; Ofori, Elizabeth; Adjei, Jonathan Kofi; Oppong, Michael Ntiamoah; Phillips, Richard Odame; Annan, Reginald; Engel, Barbara; Simmonds, Rachel E.

Editorial: Host-pathogen interactions in nontuberculous mycobacterial infections

FRONTIERS IN IMMUNOLOGY

IF5.9

2023-05-26

OAAI

Lore, Nicola Ivan; Yamasaki, Sho; Simmonds, Rachel E.; Jo, Eun-Kyeong

Equine Arteritis Virus in Monocytic Cells Suppresses Differentiation and Function of Dendritic Cells

VIRUSES-BASEL

IF3.5

2023-01-16

OAAI

Moyo, Nathifa A.; Westcott, Dave; Simmonds, Rachel; Steinbach, Falko

Synthesis, Biological Evaluation and Docking Studies of Ring-Opened Analogues of Ipomoeassin F

MOLECULES

IF4.6

2022-07-10

OAAI

O'Keefe, Sarah; Bhadra, Pratiti; Duah, Kwabena B.; Zong, Guanghui; Tenay, Levise; Andrews, Lauren; Schneider, Hayden; Anderson, Ashley; Hu, Zhijian; Aljewari, Hazim S.; Hall, Belinda S.; Simmonds, Rachel E.; Helms, Volkhard; High, Stephen; Shi, Wei Q.

Aberrant stromal tissue factor localisation and mycolactone-driven vascular dysfunction, exacerbated by IL-1β, are linked to fibrin formation in Buruli ulcer lesions

PLOS PATHOGENS

IF4.9

2022-01-31

OAAI

Hsieh, Louise Tzung-Harn; Dos Santos, Scott J.; Hall, Belinda S.; Ogbechi, Joy; Loglo, Aloysius D.; Salguero, Francisco Javier; Ruf, Marie-Therese; Pluschke, Gerd; Simmonds, Rachel E.

The One That Got Away: How Macrophage-Derived IL-1β Escapes the Mycolactone-Dependent Sec61 Blockade in Buruli Ulcer

FRONTIERS IN IMMUNOLOGY

IF5.9

2022-01-26

OAAI

Hall, Belinda S.; Hsieh, Louise Tzung-Harn; Sacre, Sandra; Simmonds, Rachel E.

Mycolactone enhances the Ca2+ leak from endoplasmic reticulum by trapping Sec61 translocons in a Ca2+ permeable state

BIOCHEMICAL JOURNAL

IF4.3

2021-11-23

OAAI

Bhadra, Pratiti; Dos Santos, Scott; Gamayun, Igor; Pick, Tillman; Neumann, Clarissa; Ogbechi, Joy; Hall, Belinda S.; Zimmermann, Richard; Helms, Volkhard; Simmonds, Rachel E.; Cavalie, Adolfo

Inhibition of the SEC61 translocon by mycolactone induces a protective autophagic response controlled by EIF2S1-dependent translation that does not require ULK1 activity

AUTOPHAGY

IF14.3

2021-08-23

OAAI

Hall, Belinda S.; Dos Santos, Scott J.; Hsieh, Louise Tzung-Harn; Manifava, Maria; Ruf, Marie-Therese; Pluschke, Gerd; Ktistakis, Nicholas; Simmonds, Rachel E.

Structure of the Inhibited State of the Sec Translocon

MOLECULAR CELL

IF16.6

2020-08-01

OAAI

Gerard, Samuel F.; Hall, Belinda S.; Zaki, Afroditi M.; Corfield, Katherine A.; Mayerhofer, Peter U.; Costa, Catia; Whelligan, Daniel K.; Biggin, Philip C.; Simmonds, Rachel E.; Higgins, Matthew K.

Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2019-05-06

OAAI

Zong, Guanghui; Hu, Zhijian; O'Keefe, Sarah; Tranter, Dale; Iannotti, Michael J.; Baron, Ludivine; Hall, Belinda; Corfield, Katherine; Paatero, Anja O.; Henderson, Mark J.; Roboti, Peristera; Zhou, Jianhong; Sun, Xianwei; Govindarajan, Mugunthan; Rohde, Jason M.; Blanchard, Nicolas; Simmonds, Rachel; Inglese, James; Du, Yuchun; Demangel, Caroline; High, Stephen; Paavilainen, Ville O.; Shi, Wei Q.

Inhibition of Sec61-dependent translocation by mycolactone uncouples the integrated stress response from ER stress, driving cytotoxicity via translational activation of ATF4

CELL DEATH & DISEASE

IF9.6

2018-03-14

OAAI

Ogbechi, Joy; Hall, Belinda S.; Sbarrato, Thomas; Taunton, Jack; Willis, Anne E.; Wek, Ronald C.; Simmonds, Rachel E.

Haemostatic genetic risk factors in arterial thrombosis 动脉血栓形成的止血遗传危险因素

THROMBOSIS AND HAEMOSTASIS

IF4.3

2017-12-12

PREAI

Simmonds, RE; Hermida, J; Rezende, SM; Lane, DA

Effect of vitamin D supplementation on the induction of pro-inflammatory cytokines (il-8) from hepatocytes

PROCEEDINGS OF THE NUTRITION SOCIETY

IF4.5

2017-12-11

OAAI

Akinyemi, O. A.; Mendis, J.; Lanham-New, S.; Simmonds, R.

Mycolactone reveals the substrate-driven complexity of Sec61-dependent transmembrane protein biogenesis Mycolactone揭示了Sec61-dependent跨膜蛋白生物发生的底物驱动的复杂性

JOURNAL OF CELL SCIENCE

IF3.6

2017-04-01

OAAI

McKenna, Michael; Simmonds, Rachel E.; High, Stephen

Mechanistic insights into the inhibition of Sec61-dependent co- and post-translational translocation by mycolactone

JOURNAL OF CELL SCIENCE

IF3.6

2016-04-01

OAAI

McKenna, Michael; Simmonds, Rachel E.; High, Stephen

Mycolactone-Dependent Depletion of Endothelial Cell Thrombomodulin Is Strongly Associated with Fibrin Deposition in Buruli Ulcer Lesions

PLOS PATHOGENS

IF4.9

2015-07-16

OAAI

Ogbechi, Joy; Ruf, Marie-Therese; Hall, Belinda S.; Bodman-Smith, Katherine; Vogel, Moritz; Wu, Hua-Lin; Stainer, Alexander; Esmon, Charles T.; Ahnstroem, Josefin; Pluschke, Gerd; Simmonds, Rachel E.

The Pathogenic mechanism of the mycobacterium ulcerans virulence factor, mycolactone, deends on blockade of protein translocation intot he ER

PLOS PATHOGENS

IF4.9

2014-04-03

126

OAAI

Hall, Belinda S.; Hill, Kirsti; McKenna, Michael; Ogbechi, Joy; High, Stephen; Willis, Anne E.; Simmonds, Rachel E.

Pleiotropic molecular effects of the Mycobacterium ulcerans virulence factor mycolactone underlying the cell death and immunosuppression seen in Buruli ulcer

BIOCHEMICAL SOCIETY TRANSACTIONS

IF4.3

2014-01-23

OAAI

Hall, Belinda; Simmonds, Rachel

研究方向