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H

Hilary Lewis

AstraZeneca
H指数:14
被引数:1,227

个人简介

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教育背景

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工作经历

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荣誉奖项

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Metabolism-driven in vitro/in vivo disconnect of an oral ERα VHL-PROTAC
COMMUNICATIONS BIOLOGY
IF5.1
2024-05-135
OAAI
Hayhow, Thomas G.; Williamson, Beth; Lawson, Mandy; Cureton, Natalie; Braybrooke, Erin L.; Campbell, Andrew; Carbajo, Rodrigo J.; Cheraghchi-Bashi, Azadeh; Chiarparin, Elisabetta; Diene, Coura R.; Fallan, Charlene; Fisher, David I.; Goldberg, Frederick W.; Hopcroft, Lorna; Hopcroft, Philip; Jackson, Anne; Kettle, Jason G.; Klinowska, Teresa; Kuenzel, Ulrike; Lamont, Gillian; Lewis, Hilary J.; Maglennon, Gareth; Martin, Scott; Gutierrez, Pablo Morentin; Morrow, Christopher J.; Nikolaou, Myria; Nissink, J. Willem M.; O'Shea, Patrick; Polanski, Radoslaw; Schade, Markus; Scott, James S.; Smith, Aaron; Weber, Judith; Wilson, Joanne; Yang, Bin; Crafter, Claire
The Next-Generation Oral Selective Estrogen Receptor Degrader Camizestrant (AZD9833) Suppresses ER+ Breast Cancer Growth and Overcomes Endocrine and CDK4/6 Inhibitor Resistance

下一代口服选择性雌激素受体降解剂Camizestrant (AZD9833) 抑制ER乳腺癌生长并克服内分泌和CDK4/6抑制剂抗性

CANCER RESEARCH
IF16.6
2023-09-1916
OAAI
Lawson, Mandy; Cureton, Natalie; Ros, Susana; Cheraghchi-Bashi, Azadeh; Urosevic, Jelena; D'Arcy, Sophie; Delpuech, Oona; Dupont, Michelle; Fisher, David I.; Gangl, Eric T.; Lewis, Hilary; Trueman, Dawn; Wali, Neha; Williamson, Stuart C.; Moss, Jennifer; Montaudon, Elodie; Derrien, Heloise; Marangoni, Elisabetta; Miragaia, Ricardo J.; Gagrica, Sladjana; Morentin-Gutierrez, Pablo; Moss, Thomas A.; Maglennon, Gareth; Sutton, Daniel; Polanski, Radoslaw; Rosen, Alan; Cairns, Jonathan; Zhang, Pei; Sanchez-Guixe, Monica; Serra, Violeta; Critchlow, Susan E.; Scott, James S.; Lindemann, Justin P. O.; Barry, Simon T.; Klinowska, Teresa; Morrow, Christopher J.; Carnevalli, Larissa
Discovery of AZD4747, a Potent and Selective Inhibitor of Mutant GTPase KRASG12C with Demonstrable CNS Penetration

AZD4747的发现，这是一种有效且选择性的突变体GTPase KRASG12C抑制剂，具有明显的中枢神经系统穿透性

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2023-07-0311
PRE
Kettle, Jason G.; Bagal, Sharan K.; Barratt, Derek; Bodnarchuk, Michael S.; Boyd, Scott; Braybrooke, Erin; Breed, Jason; Cassar, Doyle J.; Cosulich, Sabina; Davies, Michael; Davies, Nichola L.; Deng, Chao; Eatherton, Andrew; Evans, Laura; Feron, Lyman J.; Fillery, Shaun; Gleave, Emma S.; Goldberg, Frederick W.; Gonzalez, Miguel A. Cortes; Guerot, Carine; Haider, Afreen; Harlfinger, Stephanie; Howells, Rachel; Jackson, Anne; Johnstrom, Peter; Kemmitt, Paul D.; Koers, Alex; Kondrashov, Mikhail; Lamont, Gillian M.; Lamont, Scott; Lewis, Hilary J.; Liu, Libin; Mylrea, Megan; Nash, Samuel; Niedbala, Michael J.; Peter, Alison; Phillips, Christopher; Pike, Kurt; Raubo, Piotr; Robb, Graeme R.; Ross, Sarah; Sanders, Matthew G.; Schou, Magnus; Simpson, Iain; Steward, Oliver
AZD4625 is a Potent and Selective Inhibitor of KRASG12C
MOLECULAR CANCER THERAPEUTICS
IF5.5
2022-08-052
OAAI
Chakraborty, Atanu; Hanson, Lyndsey; Robinson, David; Lewis, Hilary; Bickerton, Sue; Davies, Michael; Polanski, Radoslaw; Whiteley, Rebecca; Koers, Alex; Atkinson, James; Baker, Tamara; Barrantes, Ivan del Barco; Ciotta, Giovanni; Kettle, Jason G.; Magiera, Lukasz; Martins, Carla P.; Peter, Alison; Wigmore, Eleanor; Underwood, Zoe; Cosulich, Sabina; Niedbala, Michael; Ross, Sarah
Discovery of AZD4625, a Covalent Allosteric Inhibitor of the MutantGTPase KRASG12C

突变gtpase KRASG12C的共价变构抑制剂AZD4625的发现

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2022-04-2637
PRE
Kettle, Jason G.; Bagal, Sharan K.; Bickerton, Sue; Bodnarchuk, Michael S.; Boyd, Scott; Breed, Jason; Carbajo, Rodrigo J.; Cassar, Doyle J.; Chakraborty, Atanu; Cosulich, Sabina; Cumming, Iain; Davies, Michael; Davies, Nichola L.; Eatherton, Andrew; Evans, Laura; Feron, Lyman; Fillery, Shaun; Gleave, Emma S.; Goldberg, Frederick W.; Hanson, Lyndsey; Harlfinger, Stephanie; Howard, Martin; Howells, Rachel; Jackson, Anne; Kemmitt, Paul; Lamont, Gillian; Lamont, Scott; Lewis, Hilary J.; Liu, Libin; Niedbala, Michael J.; Phillips, Christopher; Polanski, Radek; Raubo, Piotr; Robb, Graeme; Robinson, David M.; Ross, Sarah; Sanders, Matthew G.; Tonge, Michael; Whiteley, Rebecca; Wilkinson, Stephen; Yang, Junsheng; Zhang, Wenman
Resolution of NASH and hepatic fibrosis by the GLP-1R and GCGR dual-agonist cotadutide via modulating mitochondrial function and lipogenesis

GLP-1R和GCGR双激动剂可通过调节线粒体功能和脂肪生成来解决NASH和肝纤维化

NATURE METABOLISM
IF20.8
2020-05-21170
OAAI
Boland, Michelle L.; Laker, Rhianna C.; Mather, Karly; Nawrocki, Arkadiusz; Oldham, Stephanie; Boland, Brandon B.; Lewis, Hilary; Conway, James; Naylor, Jacqueline; Guionaud, Silvia; Feigh, Michael; Veidal, Sanne S.; Lantier, Louise; McGuinness, Owen P.; Grimsby, Joseph; Rondinone, Cristina M.; Jermutus, Lutz; Larsen, Martin R.; Trevaskis, James L.; Rhodes, Christopher J.
Alkynyl Benzoxazines and Dihydroquinazolines as Cysteine Targeting Covalent Warheads and Their Application in Identification of Selective Irreversible Kinase Inhibitors
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
2020-05-1552
OAAI
McAulay, Kirsten; Hoyt, Emily A.; Thomas, Morgan; Schimpl, Marianne; Bodnarchuk, Michael S.; Lewis, Hilary J.; Barratt, Derek; Bhavsar, Deepa; Robinson, David M.; Deery, Michael J.; Ogg, Derek J.; Bernardes, Goncalo J. L.; Ward, Richard A.; Waring, Michael J.; Kettle, Jason G.
Structure-Based Design and Pharmacokinetic Optimization of Covalent Allosteric Inhibitors of the Mutant GTPase KRASG12C
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2020-02-0560
PREAI
Kettle, Jason G.; Bagal, Sharan K.; Bickerton, Sue; Bodnarchuk, Michael S.; Breed, Jason; Carbajo, Rodrigo J.; Cassar, Doyle J.; Chakraborty, Atanu; Cosulich, Sabina; Cumming, Iain; Davies, Michael; Eatherton, Andrew; Evans, Laura; Feron, Lyman; Fillery, Shaun; Gleave, Emma S.; Goldberg, Frederick W.; Harlfinger, Stephanie; Hanson, Lyndsey; Howard, Martin; Howells, Rachel; Jackson, Anne; Kemmitt, Paul; Kingston, Jennifer K.; Lamont, Scott; Lewis, Hilary J.; Li, Songlei; Liu, Libin; Ogg, Derek; Phillips, Christopher; Polanski, Radek; Robb, Graeme; Robinson, David; Ross, Sarah; Smith, James M.; Tonge, Michael; Whiteley, Rebecca; Yang, Junsheng; Zhang, Longfei; Zhao, Xiliang
Structure-Based Design of Potent and Selective Inhibitors of the Metabolic Kinase PFKFB3
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2015-04-1382
PREAI
Boyd, Scott; Brookfield, Joanna L.; Critchlow, Susan E.; Cumming, Iain A.; Curtis, Nicola J.; Debreczeni, Judit; Degorce, Sebastien L.; Donald, Craig; Evans, Nicola J.; Groombridge, Sam; Hopcroft, Philip; Jones, Neil P.; Kettle, Jason G.; Lamont, Scott; Lewis, Hilary J.; MacFaull, Philip; McLoughlin, Sheila B.; Rigoreau, Laurent J. M.; Smith, James M.; St-Gallay, Steve; Stock, Julie K.; Turnbull, Andrew P.; Wheatley, Edward R.; Winter, Jon; Wingfield, Jonathan

研究方向

暂未获取到该数据
J
Jason G. Kettle
H 指数:31论文数:163被引数:3,394
D
David M. Robinson
H 指数:21论文数:86被引数:1,819
M
Michael S. Bodnarchuk
H 指数:16论文数:40被引数:1,018
F
Frederick W. Goldberg
H 指数:20论文数:71被引数:1,711
S
Sarah J. Ross
H 指数:28论文数:163被引数:5,956
R
Radosław Polański
H 指数:17论文数:80被引数:1,901
S
Sabina Cosulich
H 指数:36论文数:293被引数:5,846
A
Anne Jackson
H 指数:7论文数:15被引数:304
C
Christopher Phillips
H 指数:66论文数:317被引数:1.3万
L
Libin Liu
H 指数:26论文数:85被引数:3,430