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Targeting Cytotoxic Agents through EGFR-Mediated Covalent Binding and Release Morese, Pasquale A.; Anthony, Nahoum; Bodnarchuk, Michael; Jennings, Claire; Martin, Mathew P.; Noble, Richard A.; Phillips, Nicole; Thomas, Huw D.; Wang, Lan Z.; Lister, Andrew; Noble, Martin E. M.; Ward, Richard A.; Wedge, Stephen R.; Stewart, Hannah L.; Waring, Michael J. 分享 收藏
Discovery of AZD4747, a Potent and Selective Inhibitor of Mutant GTPase KRASG12C with Demonstrable CNS Penetration AZD4747的发现，这是一种有效且选择性的突变体GTPase KRASG12C抑制剂，具有明显的中枢神经系统穿透性 Kettle, Jason G.; Bagal, Sharan K.; Barratt, Derek; Bodnarchuk, Michael S.; Boyd, Scott; Braybrooke, Erin; Breed, Jason; Cassar, Doyle J.; Cosulich, Sabina; Davies, Michael; Davies, Nichola L.; Deng, Chao; Eatherton, Andrew; Evans, Laura; Feron, Lyman J.; Fillery, Shaun; Gleave, Emma S.; Goldberg, Frederick W.; Gonzalez, Miguel A. Cortes; Guerot, Carine; Haider, Afreen; Harlfinger, Stephanie; Howells, Rachel; Jackson, Anne; Johnstrom, Peter; Kemmitt, Paul D.; Koers, Alex; Kondrashov, Mikhail; Lamont, Gillian M.; Lamont, Scott; Lewis, Hilary J.; Liu, Libin; Mylrea, Megan; Nash, Samuel; Niedbala, Michael J.; Peter, Alison; Phillips, Christopher; Pike, Kurt; Raubo, Piotr; Robb, Graeme R.; Ross, Sarah; Sanders, Matthew G.; Schou, Magnus; Simpson, Iain; Steward, Oliver 分享 收藏
Design of rigid protein-protein interaction inhibitors enables targeting of undruggable Mcl-1 刚性蛋白-蛋白相互作用抑制剂的设计使得靶向不可服用的Mcl-1成为可能 Hargreaves, David; Carbajo, Rodrigo J.; Bodnarchuk, Michael S.; Embrey, Kevin; Rawlins, Philip B.; Packer, Martin; Degorce, Sebastien L.; Hird, Alexander W.; Johannes, Jeffrey W.; Chiarparin, Elisabetta; Schade, Markus 分享 收藏
Virtual Screening in the Cloud Identifies Potent and Selective ROS1 Kinase Inhibitors Petrovic, Dusan; Scott, James S.; Bodnarchuk, Michael S.; Lorthioir, Olivier; Boyd, Scott; Hughes, George M.; Lane, Jordan; Wu, Allan; Hargreaves, David; Robinson, James; Sadowski, Jens 分享 收藏
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Discovery of AZD4625, a Covalent Allosteric Inhibitor of the MutantGTPase KRASG12C 突变gtpase KRASG12C的共价变构抑制剂AZD4625的发现 Kettle, Jason G.; Bagal, Sharan K.; Bickerton, Sue; Bodnarchuk, Michael S.; Boyd, Scott; Breed, Jason; Carbajo, Rodrigo J.; Cassar, Doyle J.; Chakraborty, Atanu; Cosulich, Sabina; Cumming, Iain; Davies, Michael; Davies, Nichola L.; Eatherton, Andrew; Evans, Laura; Feron, Lyman; Fillery, Shaun; Gleave, Emma S.; Goldberg, Frederick W.; Hanson, Lyndsey; Harlfinger, Stephanie; Howard, Martin; Howells, Rachel; Jackson, Anne; Kemmitt, Paul; Lamont, Gillian; Lamont, Scott; Lewis, Hilary J.; Liu, Libin; Niedbala, Michael J.; Phillips, Christopher; Polanski, Radek; Raubo, Piotr; Robb, Graeme; Robinson, David M.; Ross, Sarah; Sanders, Matthew G.; Tonge, Michael; Whiteley, Rebecca; Wilkinson, Stephen; Yang, Junsheng; Zhang, Wenman 分享 收藏
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Virtual Screening Approach to Identifying a Novel and Tractable Series of Pseudomonas aeruginosa Elastase Inhibitors Leiris, Simon; Davies, David T.; Sprynski, Nicolas; Castandet, Jerome; Beyria, Lilha; Bodnarchuk, Michael S.; Sutton, Jonathan M.; Mullins, Toby M. G.; Jones, Mark W.; Forrest, Andrew K.; Pallin, T. David; Karunakar, Paduri; Martha, Sathish Kumar; Parusharamulu, Battu; Ramula, Ramesh; Kotha, Venkatesh; Pottabathini, Narender; Pothukanuri, Srinivasu; Lemonnier, Marc; Everett, Martin 分享 收藏
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Alkynyl Benzoxazines and Dihydroquinazolines as Cysteine Targeting Covalent Warheads and Their Application in Identification of Selective Irreversible Kinase Inhibitors McAulay, Kirsten; Hoyt, Emily A.; Thomas, Morgan; Schimpl, Marianne; Bodnarchuk, Michael S.; Lewis, Hilary J.; Barratt, Derek; Bhavsar, Deepa; Robinson, David M.; Deery, Michael J.; Ogg, Derek J.; Bernardes, Goncalo J. L.; Ward, Richard A.; Waring, Michael J.; Kettle, Jason G. 分享 收藏
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Structure-Based Design and Pharmacokinetic Optimization of Covalent Allosteric Inhibitors of the Mutant GTPase KRASG12C Kettle, Jason G.; Bagal, Sharan K.; Bickerton, Sue; Bodnarchuk, Michael S.; Breed, Jason; Carbajo, Rodrigo J.; Cassar, Doyle J.; Chakraborty, Atanu; Cosulich, Sabina; Cumming, Iain; Davies, Michael; Eatherton, Andrew; Evans, Laura; Feron, Lyman; Fillery, Shaun; Gleave, Emma S.; Goldberg, Frederick W.; Harlfinger, Stephanie; Hanson, Lyndsey; Howard, Martin; Howells, Rachel; Jackson, Anne; Kemmitt, Paul; Kingston, Jennifer K.; Lamont, Scott; Lewis, Hilary J.; Li, Songlei; Liu, Libin; Ogg, Derek; Phillips, Christopher; Polanski, Radek; Robb, Graeme; Robinson, David; Ross, Sarah; Smith, James M.; Tonge, Michael; Whiteley, Rebecca; Yang, Junsheng; Zhang, Longfei; Zhao, Xiliang 分享 收藏
Heteroarylamide smoothened inhibitors: Discovery of N-[2,4-dimethyl-5-(1-methylimidazol-4-yl)phenyl]-4-(2-pyridylmethoxy)benzamide (AZD8542) and N-[5-(1H-imidazol-2-yl)-2,4-dimethyl-phenyl]-4-(2-pyridylmethoxy) benzamide (AZD7254) Yang, Bin; Hird, Alexander W.; Bodnarchuk, Michael S.; Zheng, Xiaolan; Dakin, Les; Su, Qibin; Daly, Kevin; Godin, Robert; Hattersley, Maureen M.; Brassil, Patrick; Redmond, Sean; Russell, Daniel John; Janetka, James W. 分享 收藏
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