Aymelt Itzen - Publications, H-index & Citations

Aymelt Itzen

university medical centre hamburg-eppendorf

33H指数

142论文数

3.7K被引数

收录论文 49

发表时间

The Shewanella oneidensis Fic enzyme SoFic targets the switch-I region of EF-Tu for AMPylation Shewanella oneidensis Fic酶SoFic靶向EF-Tu的开关I区域进行AMP化

FEBS Letters

IF3

2026-09-18

OAAI

Svenja Runge; Vivian Pogenberg; Alexander Baumgart; Bente Siebels; Hartmut Schlüter; Michael Hecht-Bucher; Aymelt Itzen

The DNA-binding induced (de)AMPylation activity of a Coxiella burnetii Fic enzyme targets Histone H3

COMMUNICATIONS BIOLOGY

IF5.1

2023-11-06

OAAI

Hoepfner, Dorothea; Cichy, Adam; Pogenberg, Vivian; Krisp, Christoph; Mezouar, Soraya; Bach, Nina C.; Grotheer, Jan; Zarza, Sandra Madariaga; Martinez, Eric; Bonazzi, Matteo; Feige, Matthias J.; Sieber, Stephan A.; Schlueter, Hartmut; Itzen, Aymelt

Dephosphocholination by Legionella effector Lem3 functions through remodelling of the switch II region of Rab1b

NATURE COMMUNICATIONS

IF15.7

2023-04-19

OAAI

Kaspers, Marietta S.; Pogenberg, Vivian; Pett, Christian; Ernst, Stefan; Ecker, Felix; Ochtrop, Philipp; Groll, Michael; Hedberg, Christian; Itzen, Aymelt

Revisiting AMPylation through the lens of Fic enzymes

TRENDS IN MICROBIOLOGY

IF14.9

2022-04-01

PREAI

Gulen, Burak; Itzen, Aymelt

Specificity of AMPylation of the human chaperone BiP is mediated by TPR motifs of FICD

NATURE COMMUNICATIONS

IF15.7

2021-04-23

OAAI

Fauser, Joel; Gulen, Burak; Pogenberg, Vivian; Pett, Christian; Pourjafar-Dehkordi, Danial; Krisp, Christoph; Hoepfner, Dorothea; Koenig, Gesa; Schlueter, Hartmut; Feige, Matthias J.; Zacharias, Martin; Hedberg, Christian; Itzen, Aymelt

Current Advances in Covalent Stabilization of Macromolecular Complexes for Structural Biology

BIOCONJUGATE CHEMISTRY

IF3.9

2021-04-16

PREAI

Fauser, Joel; Itzen, Aymelt; Gulen, Burak

Rab1-AMPylation by Legionella DrrA is allosterically activated by Rab1 军团菌DrrA的Rab1-AMPylation被Rab1变构激活

NATURE COMMUNICATIONS

IF15.7

2021-01-19

OAAI

Du, Jiqing; von Wrisberg, Marie-Kristin; Gulen, Burak; Stahl, Matthias; Pett, Christian; Hedberg, Christian; Lang, Kathrin; Schneider, Sabine; Itzen, Aymelt

Identification of targets of AMPylating Fic enzymes by co-substrate-mediated covalent capture

NATURE CHEMISTRY

IF20.2

2020-07-06

PREAI

Gulen, Burak; Rosselin, Marie; Fauser, Joel; Albers, Michael F.; Pett, Christian; Krisp, Christoph; Pogenberg, Vivian; Schlueter, Hartmut; Hedberg, Christian; Itzen, Aymelt

The trimer to monomer transition of Tumor Necrosis Factor-Alpha is a dynamic process that is significantly altered by therapeutic antibodies

SCIENTIFIC REPORTS

IF3.9

2020-06-09

OAAI

Daub, Herwin; Traxler, Lukas; Ismajli, Fjolla; Groitl, Bastian; Itzen, Aymelt; Rant, Ulrich

Legionella effector AnkX displaces the switch II region for Rab1b phosphocholination

SCIENCE ADVANCES

IF12.5

2020-05-15

OAAI

Ernst, Stefan; Ecker, Felix; Kaspers, Marietta S.; Ochtrop, Philipp; Hedberg, Christian; Groll, Michael; Itzen, Aymelt

PINK1-dependent phosphorylation of Serine111 within the SF3 motif of Rab GTPases impairs effector interactions and LRRK2-mediated phosphorylation at Threonine72

BIOCHEMICAL JOURNAL

IF4.3

2020-05-11

OAAI

Vieweg, Sophie; Mulholland, Katie; Braeuning, Bastian; Kachariya, Nitin; Lai, Yu-Chiang; Toth, Rachel; Singh, Pawan Kishor; Volpi, Ilaria; Sattler, Michael; Groll, Michael; Itzen, Aymelt; Muqit, Miratul M. K.

Divergent Evolution of Legionella RCC1 Repeat Effectors Defines the Range of Ran GTPase Cycle Targets

MBIO

IF4.7

2020-04-28

OAAI

Swart, A. Leoni; Steiner, Bernhard; Gomez-Valero, Laura; Schuetz, Sabina; Hannemann, Mandy; Janning, Petra; Irminger, Michael; Rothmeier, Eva; Buchrieser, Carmen; Itzen, Aymelt; Panse, Vikram Govind; Hilbi, Hubert

Conformational control of small GTPases by AMPylation 通过AMPylation控制小gtp酶的构象

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2020-03-02

OAAI

Barthelmes, Katja; Ramcke, Evelyn; Kang, Hyun-Seo; Sattler, Michael; Itzen, Aymelt

Nucleotide exchange factor Rab3GEP requires DENN and non- DENN elements for activation and targeting of Rab27a

JOURNAL OF CELL SCIENCE

IF3.6

2019-04-30

OAAI

Sanza, Paolo; Evans, Richard D.; Briggs, Deborah A.; Cantero, Marta; Montoliu, Lluis; Patel, Shyamal; Sviderskaya, Elena V.; Itzen, Aymelt; Figueiredo, Ana C.; Seabra, Miguel C.; Hume, Alistair N.

The protease GtgE from Salmonella exclusively targets inactive Rab GTPases

NATURE COMMUNICATIONS

IF15.7

2018-01-03

OAAI

Wachtel, Rudolf; Braeuning, Bastian; Mader, Sophie L.; Ecker, Felix; Kaila, Ville R. I.; Groll, Michael; Itzen, Aymelt

Proximity-Triggered Covalent Stabilization of Low-Affinity Protein Complexes In Vitro and In Vivo 体外和体内低亲和力蛋白复合物的邻近触发共价稳定

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

IF16.9

2017-11-09

PREAI

Cigler, Marko; Mueller, Thorsten G.; Horn-Ghetko, Daniel; von Wrisberg, Marie-Kristin; Fottner, Maximilian; Goody, Roger S.; Itzen, Aymelt; Mueller, Matthias P.; Lang, Kathrin

bMERB domains are bivalent Rab8 family effectors evolved by gene duplication

ELIFE

IF0

2016-08-23

OAAI

Rai, Amrita; Oprisko, Anastasia; Campos, Jeremy; Fu, Yangxue; Friese, Timon; Itzen, Aymelt; Goody, Roger S.; Gazdag, Emerich Mihai; Mueller, Matthias P.

Adenylylation of Tyr77 stabilizes Rab1b GTPase in an active state: A molecular dynamics simulation analysis

SCIENTIFIC REPORTS

IF3.9

2016-01-28

OAAI

Luitz, Manuel P.; Bomblies, Rainer; Ramcke, Evelyn; Itzen, Aymelt; Zacharias, Martin

Phosphoproteomic screening identifies Rab GTPases as novel downstream targets of PINK1

EMBO JOURNAL

IF8.3

2015-10-16

148

OAAI

Lai, Yu-Chiang; Kondapalli, Chandana; Lehneck, Ronny; Procter, James B.; Dill, Brian D.; Woodroof, Helen I.; Gourlay, Robert; Peggie, Mark; Macartney, Thomas J.; Corti, Olga; Corvol, Jean-Christophe; Campbell, David G.; Itzen, Aymelt; Trost, Matthias; Muqit, Miratul M. K.

Locking GTPases covalently in their functional states

NATURE COMMUNICATIONS

IF15.7

2015-07-16

OAAI

Wiegandt, David; Vieweg, Sophie; Hofmann, Frank; Koch, Daniel; Li, Fu; Wu, Yao-Wen; Itzen, Aymelt; Mueller, Matthias P.; Goody, Roger S.

研究方向