Development of novel high-throughput biochemical competition assays to identify ligands of human asialoglycoprotein receptor 1开发新型高通量生物化学竞争分析方法以鉴定人唾液酸糖蛋白受体1的配体SLAS DiscoveryIF2.72025-08-210OAAI
Accessing Therapeutically-Relevant Multifunctional Antisense Oligonucleotide Conjugates Using Native Chemical LigationANGEWANDTE CHEMIE-INTERNATIONAL EDITIONIF16.92024-10-310OAAI
Incorporation of Intracellular NanoSIMS Tracers to Oligonucleotide Conjugates via Strain Promoted Sydnone-Alkyne CycloadditionBIOCONJUGATE CHEMISTRYIF3.92024-06-111PRE
The effect of gem-difluorination on the conformation and properties of a model macrocyclic systemCHEMICAL SCIENCEIF7.42024-01-010OAAI
Late-Stage Functionalization with Cysteine Staples Generates Potent and Selective Melanocortin Receptor-1 AgonistsJOURNAL OF MEDICINAL CHEMISTRYIF6.82022-09-274PRE
A structure-specific small molecule inhibits a miRNA-200 family member precursor and reverses a type 2 diabetes phenotypeCELL CHEMICAL BIOLOGYIF7.22022-02-0119OAAI
Melanocortin 1 Receptor Agonists Based on a Bivalent, Bicyclic Peptide FrameworkJOURNAL OF MEDICINAL CHEMISTRYIF6.82021-07-019PREAI
Glucagon Like Peptide 1 Receptor Agonists for Targeted Delivery of Antisense Oligonucleotides to Pancreatic Beta CellJOURNAL OF THE AMERICAN CHEMICAL SOCIETYIF15.62021-02-2440PREAI
Invalidation of GSK3B in Pancreatic Beta Cell as a Therapeutic Target for T2DDIABETESIF7.52020-06-010PRE
Late-Stage Functionalization of Histidine in Unprotected PeptidesANGEWANDTE CHEMIE-INTERNATIONAL EDITIONIF16.92019-11-0751PREAI
Stereocontrolled Synthesis of Tetrafluoropentanols: Multivicinal Fluorinated Alkane Units for Drug DiscoveryORGANIC LETTERSIF52019-08-0923PREAI
Synthesis of Diverse α-Fluoroalkoxyaryl Derivatives and Their Use for the Generation of Fluorinated MacrocyclesCHEMISTRY-A EUROPEAN JOURNALIF3.72018-12-137PREAI
Iridium-Catalyzed Asymmetric Hydrogenation of N-Alkyl α-Aryl Furan-Containing Imines: an Efficient Route to Unnatural N-Alkyl Arylalanines and Related Derivatives.ADVANCED SYNTHESIS & CATALYSISIF42018-11-3014PREAI
Targeted delivery of antisense oligonucleotides to pancreatic β-cellsSCIENCE ADVANCESIF12.52018-10-05137OAAI
Discovery of a Series of Indole-2 Carboxamides as Selective Secreted Phospholipase A2 Type X (sPLA2-X) InhibitorsACS MEDICINAL CHEMISTRY LETTERSIF42018-06-239OAAI
Design of Selective sPLA2-X Inhibitor (-)-2-{2-[Carbamoyl-6-(trifluoromethoxy)-1H-indol-1-yl]pyridine-2-yl}propanoic AcidACS MEDICINAL CHEMISTRY LETTERSIF42018-06-235OAAI
The Conundrum of GSK3 Inhibitors: Is it the Dawn of a New Beginning?JOURNAL OF ALZHEIMERS DISEASEIF3.12018-06-1274PREAI
Development of Novel Melanocortin Receptor Agonists Based on the Cyclic Peptide Framework of Sunflower Trypsin Inhibitor-1JOURNAL OF MEDICINAL CHEMISTRYIF6.82018-03-3129OAAI
Exploring physicochemical space via a bioisostere of the trifluoromethyl and ethyl groups (BITE): attenuating lipophilicity in fluorinated analogues of Gilenya® for multiple sclerosisCHEMICAL COMMUNICATIONSIF4.22018-01-0132PREAI
Fluorine-Directed Glycosylation Enables the Stereocontrolled Synthesis of Selective SGLT2 Inhibitors for Type II DiabetesCHEMISTRY-A EUROPEAN JOURNALIF3.72017-12-2028PREAI