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J

James T. Brewster

University of Texas at Austin
H指数:19
被引数:1,496

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Kilo-Scale-Enabled Route toward PF-07907063, a Type II Brain Penetrant cMET Inhibitor

千吨级合成路线：PF-07907063，一种II型脑渗透性cMET抑制剂

ORGANIC PROCESS RESEARCH & DEVELOPMENT
IF3.5
2025-04-070
PRE
Mckenna, Grace; Cruz, Cole; Simmons, Bryon; Brewster, James T.; Benz-Weeden, Anna M.; Brandt, Thomas A.; Bumpers, Quinn A.; Cook, Adam; Elsayed, Mohamed Saad Abdullah; Golec, Daniel; Lewandowski, Nicholas; Nguyen, Phong; Pipal, Robert W.; Savechenkov, Pavel; Wong, Christina E.; Tarlton, Eugene; Gaudino, John J.; Hinklin, Ronald J.; Tang, Tony P.
Novel O-methylpyrimidine prodrugs of phenolic compounds bioactivated by aldehyde oxidase: Enhancing metabolic stability against first-pass conjugative metabolism in the intestine

新型O-甲基嘧啶酚类化合物前药，由醛氧化酶生物活化：增强对肠道首过共价代谢的代谢稳定性

DRUG METABOLISM AND DISPOSITION
IF4
2025-04-010
PRE
Kowalski, John P.; Baer, Brian R.; Randall, Samuel D.; Brown, Karin; Crooks, Amy; McCown, Joseph; McDonald, Matthew G.; Harrison, Jackie; Abuirqeba, Suomia; Dai, Donghua; Hilton, Michael; Brewster II, James T.; Kellum, Alex A.
Discovery of Pyrazolopyrazines as Selective, Potent, and Mutant-Active MET Inhibitors with Intracranial Efficacy
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2024-08-010
PRE
Bumpers, Quinn A.; Pipal, Robert W.; Benz-Weeden, Anna M.; Brewster II, James T.; Cook, Adam; Crooks, Amy L.; Cruz, Cole; Dwulet, Natalie C.; Gaudino, John J.; Golec, Daniel; Harrison, Jacqueline A.; Hartley, Dylan P.; Hassanien, Sherif H.; Hicken, Erik J.; Kahn, Dean; Laird, Ellen R.; Lemieux, Christine; Lewandowski, Nicholas; Mccown, Joseph; Mcdonald, Matthew G.; Mcnulty, Oren; Mou, Tung-Chung; Nguyen, Phong; Oko, Lauren; Opie, Lisa Pieti; Otten, Jennifer; Peck, Spencer C.; Polites, Viktor C.; Randall, Samuel D.; Rosen, Rachel Z.; Savechenkov, Pavel; Simpson, Helen; Singh, Anurag; Sparks, Drew; Wickersham, Kyle; Wollenberg, Lance; Wong, Christina E.; Wong, Jim; Wu, Wen-, I; Elsayed, Mohamed S. A.; Hinklin, Ronald J.; Tang, Tony P.

研究方向

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J
Jonathan L. Sessler
H 指数:135论文数:1,523被引数:7.6万
V
Vincent M. Lynch
H 指数:94论文数:1,191被引数:3.0万
A
Adam C. Sedgwick
H 指数:49论文数:306被引数:1.3万
H
Hadiqa Zafar
H 指数:9论文数:37被引数:290
H
Harrison D. Root
H 指数:8论文数:32被引数:289
G
Grégory Thiabaud
H 指数:14论文数:40被引数:668
D
Daniel N. Mangel
H 指数:10论文数:42被引数:411
T
Tony D. James
H 指数:98论文数:858被引数:4.2万
X
Xiao‐Peng He
H 指数:56论文数:296被引数:1.3万
田
田禾
H 指数:145论文数:1,331被引数:8.1万