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D

Donovon A. Adpressa

merck and co inc
H指数:16
被引数:863

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Discovery of Potent, Selective, CNS-Penetrant Macrocyclic LRRK2 Inhibitors for the Treatment of Parkinson's Disease (vol. 69, pg. 8548, 2026)

发现强效、选择性、中枢神经系统穿透性大环LRRK2抑制剂用于帕金森病的治疗（vol. 69, pg. 8548, 2026）

Journal of Medicinal Chemistry
IF6.8
2026-04-010
PRE
Yu, Elsie C.; Zhou, Hua; Yan, Xin; Logan, Kaitlyn M.; Li, Derun; Gulati, Anmol; Poremba, Kelsey E.; Ardolino, Michael J.; Su, Jing; Xiao, Dong; Palte, Rachel L.; McMinn, Spencer E.; Nogle, Lisa M.; Adpressa, Donovon A.; Burgess, Samantha A.; Xiong, Tina; Otte, Karin M.; Chobanian, Harry R.; Bass, Alan; Lee, Susi; Pearson, Kara; Messina, Eric; Parisi, Michael; Barnum, John; Sobol, Zhanna; Ciaccio, Paul J.; DiMauro, Erin F.; Fell, Matthew J.; Fuller, Peter H.
Discovery of Potent; Selective; CNS-Penetrant Macrocyclic LRRK2 Inhibitors for the Treatment of Parkinson’s Disease

发现强效、选择性、能穿透中枢神经系统的环状LRRK2抑制剂，用于帕金森病的治疗

Journal of Medicinal Chemistry
IF6.8
2026-03-290
PRE
Elsie C. Yu; Hua Zhou; Xin Yan; Kaitlyn M. Logan; Derun Li; Anmol Gulati; Kelsey E. Poremba; Michael J. Ardolino; Jing Su; Dong Xiao; Rachel L. Palte; Spencer E. McMinn; Lisa M. Nogle; Donovon A. Adpressa; Samantha A. Burgess; Tina Xiong; Karin M. Otte; Harry R. Chobanian; Alan Bass; Susi Lee; Kara Pearson; Eric Messina; Michael Parisi; John Barnum; Zhanna Sobol; Paul J. Ciaccio; Erin F. DiMauro; Matthew J. Fell; Peter H. Fuller
Structure-Guided Discovery of Aminoquinazolines as Brain-Penetrant and Selective LRRK2 Inhibitors
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2021-12-3027
PREAI
Keylor, Mitchell H.; Gulati, Anmol; Kattar, Solomon D.; Johnson, Rebecca E.; Chau, Ryan W.; Margrey, Kaila A.; Ardolino, Michael J.; Zarate, Cayetana; Poremba, Kelsey E.; Simov, Vladimir; Morriello, Gregori J.; Acton, John J.; Pio, Barbara; Yan, Xin; Palte, Rachel L.; McMinn, Spencer E.; Nogle, Lisa; Lesburg, Charles A.; Adpressa, Donovon; Lin, Shishi; Neelamkavil, Santhosh; Liu, Ping; Su, Jing; Hegde, Laxminarayan G.; Woodhouse, Janice D.; Faltus, Robert; Xiong, Tina; Ciaccio, Paul J.; Piesvaux, Jennifer; Otte, Karin M.; Wood, Harold B.; Kennedy, Matthew E.; Bennett, David Jonathan; DiMauro, Erin F.; Fell, Matthew J.; Fuller, Peter H.
Comprehensive Strategies to Bicyclic Prolines: Applications in the Synthesis of Potent Arginase Inhibitors
ACS MEDICINAL CHEMISTRY LETTERS
IF4
2021-10-139
OA
Li, Derun; Zhang, Hongjun; Lyons, Thomas W.; Lu, Min; Achab, Abdelghani; Pu, Qinglin; Childers, Matthew; Mitcheltree, Matthew J.; Wang, Jialiang; Martinot, Theodore A.; McMinn, Spencer E.; Sloman, David L.; Palani, Anandan; Beard, Adam; Nogle, Lisa; Gathiaka, Symon; Sauri, Josep; Kim, Hai-Young; Adpressa, Donovon; Spacciapoli, Peter; Miller, J. Richard; Palte, Rachel L.; Lesburg, Charles A.; Cumming, Jared; Fischer, Christian

研究方向

暂未获取到该数据
S
Sandra Loesgen
H 指数:25论文数:78被引数:1,903
S
Spencer E. McMinn
H 指数:9论文数:19被引数:301
R
R.L. Palte
H 指数:10论文数:43被引数:305
J
Josep Saurí
H 指数:22论文数:93被引数:1,471
E
Erin F. DiMauro
H 指数:28论文数:113被引数:2,142
A
Anmol Gulati
H 指数:8论文数:14被引数:443
R
Richmond Sarpong
H 指数:1论文数:5被引数:75
C
Charles S. Yeung
H 指数:29论文数:127被引数:7,899
M
Michael J. Ardolino
H 指数:12论文数:24被引数:569
J
Justin Jurczyk
H 指数:10论文数:22被引数:1,015