Anmol Gulati

merck and co inc

H指数:8

被引数:444

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Discovery of Potent, Selective, CNS-Penetrant Macrocyclic LRRK2 Inhibitors for the Treatment of Parkinson's Disease (vol. 69, pg. 8548, 2026)

发现强效、选择性、中枢神经系统穿透性大环LRRK2抑制剂用于帕金森病的治疗（vol. 69, pg. 8548, 2026）

Journal of Medicinal Chemistry

IF6.8

2026-04-010

PRE

Discovery of Potent; Selective; CNS-Penetrant Macrocyclic LRRK2 Inhibitors for the Treatment of Parkinson’s Disease

发现强效、选择性、能穿透中枢神经系统的环状LRRK2抑制剂，用于帕金森病的治疗

Journal of Medicinal Chemistry

IF6.8

2026-03-290

PRE

Discovery of MK-1468: A Potent, Kinome-Selective, Brain-Penetrant Amidoisoquinoline LRRK2 Inhibitor for the Potential Treatment of Parkinson's Disease

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2023-10-205

PRE

Kattar, Solomon D.; Gulati, Anmol; Margrey, Kaila A.; Keylor, Mitchell H.; Ardolino, Michael; Yan, Xin; Johnson, Rebecca; Palte, Rachel L.; McMinn, Spencer E.; Nogle, Lisa; Su, Jing; Xiao, Dong; Piesvaux, Jennifer; Lee, Susi; Hegde, Laxminarayan G.; Woodhouse, Janice D.; Faltus, Robert; Moy, Lily Y.; Xiong, Tina; Ciaccio, Paul J.; Pearson, Kara; Patel, Mayankbhai; Otte, Karin M.; Leyns, Cheryl E. G.; Kennedy, Matthew E.; Bennett, David Jonathan; Dimauro, Erin F.; Fell, Matthew J.; Fuller, Peter H.

Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1-Heteroaryl-1H-Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson's Disease

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2022-12-0712

PRE

Candito, David A.; Simov, Vladimir; Gulati, Anmol; Kattar, Solomon; Chau, Ryan W.; Lapointe, Blair T.; Methot, Joey L.; DeMong, Duane E.; Graham, Thomas H.; Kurukulasuriya, Ravi; Keylor, Mitchell H.; Tong, Ling; Morriello, Gregori J.; Acton, John J.; Pio, Barbara; Liu, Weiguo; Scott, Jack D.; Ardolino, Michael J.; Martinot, Theodore A.; Maddess, Matthew L.; Yan, Xin; Gunaydin, Hakan; Palte, Rachel L.; McMinn, Spencer E.; Nogle, Lisa; Yu, Hongshi; Minnihan, Ellen C.; Lesburg, Charles A.; Liu, Ping; Su, Jing; Hegde, Laxminarayan G.; Moy, Lily Y.; Woodhouse, Janice D.; Faltus, Robert; Xiong, Tina; Ciaccio, Paul; Piesvaux, Jennifer A.; Otte, Karin M.; Kennedy, Matthew E.; Bennett, David Jonathan; DiMauro, Erin F.; Fell, Matthew J.; Neelamkavil, Santhosh; Wood, Harold B.; Fuller, Peter H.; Ellis, J. Michael

Structure-Guided Discovery of Aminoquinazolines as Brain-Penetrant and Selective LRRK2 Inhibitors

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2021-12-3027

PREAI

Keylor, Mitchell H.; Gulati, Anmol; Kattar, Solomon D.; Johnson, Rebecca E.; Chau, Ryan W.; Margrey, Kaila A.; Ardolino, Michael J.; Zarate, Cayetana; Poremba, Kelsey E.; Simov, Vladimir; Morriello, Gregori J.; Acton, John J.; Pio, Barbara; Yan, Xin; Palte, Rachel L.; McMinn, Spencer E.; Nogle, Lisa; Lesburg, Charles A.; Adpressa, Donovon; Lin, Shishi; Neelamkavil, Santhosh; Liu, Ping; Su, Jing; Hegde, Laxminarayan G.; Woodhouse, Janice D.; Faltus, Robert; Xiong, Tina; Ciaccio, Paul J.; Piesvaux, Jennifer; Otte, Karin M.; Wood, Harold B.; Kennedy, Matthew E.; Bennett, David Jonathan; DiMauro, Erin F.; Fell, Matthew J.; Fuller, Peter H.

Optimization of brain-penetrant picolinamide derived leucine-rich repeat kinase 2 (LRRK2) inhibitors

RSC MEDICINAL CHEMISTRY

IF3.6

2021-01-0113

OAAI

Gulati, Anmol; Yeung, Charles S.; Lapointe, Blair; Kattar, Solomon D.; Gunaydin, Hakan; Scott, Jack D.; Childers, Kaleen K.; Methot, Joey L.; Simov, Vladimir; Kurukulasuriya, Ravi; Pio, Barbara; Morriello, Greg J.; Liu, Ping; Tang, Haiqun; Neelamkavil, Santhosh; Wood, Harold B.; Rada, Vanessa L.; Ardolino, Michael J.; Yan, Xin Cindy; Palte, Rachel; Otte, Karin; Faltus, Robert; Woodhouse, Janice; Hegde, Laxminarayan G.; Ciaccio, Paul; Minnihan, Ellen C.; DiMauro, Erin F.; Fell, Matthew J.; Fuller, Peter H.; Ellis, J. Michael

Metal homeostasis in infectious disease: recent advances in bacterial metallophores and the human metal-withholding response

CURRENT OPINION IN CHEMICAL BIOLOGY

IF6.1

2017-04-0134

OAAI

Oxa, Thia, Heterocycle, and Carborane Analogues of SQ109: Bacterial and Protozoal Cell Growth Inhibitors

ACS INFECTIOUS DISEASES

IF3.8

2015-04-0933

OAAI

Multitarget Drug Discovery for Tuberculosis and Other Infectious Diseases

JOURNAL OF MEDICINAL CHEMISTRY