Spencer E. McMinn

Merck and Co.

H指数:9

被引数:302

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Discovery of Potent, Selective, CNS-Penetrant Macrocyclic LRRK2 Inhibitors for the Treatment of Parkinson's Disease (vol. 69, pg. 8548, 2026)

发现强效、选择性、中枢神经系统穿透性大环LRRK2抑制剂用于帕金森病的治疗（vol. 69, pg. 8548, 2026）

Journal of Medicinal Chemistry

IF6.8

2026-04-010

PRE

Discovery of Potent; Selective; CNS-Penetrant Macrocyclic LRRK2 Inhibitors for the Treatment of Parkinson’s Disease

发现强效、选择性、能穿透中枢神经系统的环状LRRK2抑制剂，用于帕金森病的治疗

Journal of Medicinal Chemistry

IF6.8

2026-03-290

PRE

Discovery and In Vivo Evaluation of Aryl Ether YAP1/TEAD Inhibitors for the Treatment of Hippo-Driven Malignancies

芳基醚YAP1/TEAD抑制剂的发现及其在活体内的评估：用于治疗Hippo通路驱动的恶性肿瘤

Journal of Medicinal Chemistry

IF6.8

2026-02-120

PRE

Synthesis of enantioenriched atropisomers by biocatalytic deracemization

生物催化消旋化合成对映富集的阿托帕异构体

Nature

IF48.5

2025-11-120

OAAI

Discovery and Optimization of N-Heteroaryl Indazole LRRK2 Inhibitors

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2024-09-040

PRE

Logan, Kaitlyn M.; Kaplan, Will; Simov, Vladimir; Zhou, Hua; Li, Derun; Torres, Luis; Morriello, Gregori J.; Acton, John J.; Pio, Barbara; Chen, Yi-Heng; Keylor, Mitchell H.; Johnson, Rebecca; Kattar, Solomon D.; Chau, Ryan; Yan, Xin; Ardolino, Michael; Zarate, Cayetana; Otte, Karin M.; Palte, Rachel L.; Xiong, Tina; McMinn, Spencer E.; Lin, Shishi; Neelamkavil, Santhosh F.; Liu, Ping; Su, Jing; Hegde, Laxminarayan G.; Woodhouse, Janice D.; Moy, Lily Y.; Ciaccio, Paul J.; Piesvaux, Jennifer; Zebisch, Matthias; Henry, Clare; Barker, John; Wood, Harold B.; Kennedy, Matthew E.; DiMauro, Erin F.; Fell, Matthew J.; Fuller, Peter H.

Discovery of MK-1468: A Potent, Kinome-Selective, Brain-Penetrant Amidoisoquinoline LRRK2 Inhibitor for the Potential Treatment of Parkinson's Disease

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2023-10-205

PRE

Kattar, Solomon D.; Gulati, Anmol; Margrey, Kaila A.; Keylor, Mitchell H.; Ardolino, Michael; Yan, Xin; Johnson, Rebecca; Palte, Rachel L.; McMinn, Spencer E.; Nogle, Lisa; Su, Jing; Xiao, Dong; Piesvaux, Jennifer; Lee, Susi; Hegde, Laxminarayan G.; Woodhouse, Janice D.; Faltus, Robert; Moy, Lily Y.; Xiong, Tina; Ciaccio, Paul J.; Pearson, Kara; Patel, Mayankbhai; Otte, Karin M.; Leyns, Cheryl E. G.; Kennedy, Matthew E.; Bennett, David Jonathan; Dimauro, Erin F.; Fell, Matthew J.; Fuller, Peter H.

Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1-Heteroaryl-1H-Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson's Disease

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2022-12-0712

PRE

Candito, David A.; Simov, Vladimir; Gulati, Anmol; Kattar, Solomon; Chau, Ryan W.; Lapointe, Blair T.; Methot, Joey L.; DeMong, Duane E.; Graham, Thomas H.; Kurukulasuriya, Ravi; Keylor, Mitchell H.; Tong, Ling; Morriello, Gregori J.; Acton, John J.; Pio, Barbara; Liu, Weiguo; Scott, Jack D.; Ardolino, Michael J.; Martinot, Theodore A.; Maddess, Matthew L.; Yan, Xin; Gunaydin, Hakan; Palte, Rachel L.; McMinn, Spencer E.; Nogle, Lisa; Yu, Hongshi; Minnihan, Ellen C.; Lesburg, Charles A.; Liu, Ping; Su, Jing; Hegde, Laxminarayan G.; Moy, Lily Y.; Woodhouse, Janice D.; Faltus, Robert; Xiong, Tina; Ciaccio, Paul; Piesvaux, Jennifer A.; Otte, Karin M.; Kennedy, Matthew E.; Bennett, David Jonathan; DiMauro, Erin F.; Fell, Matthew J.; Neelamkavil, Santhosh; Wood, Harold B.; Fuller, Peter H.; Ellis, J. Michael

Structure-Guided Discovery of Aminoquinazolines as Brain-Penetrant and Selective LRRK2 Inhibitors

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2021-12-3027

PREAI

Keylor, Mitchell H.; Gulati, Anmol; Kattar, Solomon D.; Johnson, Rebecca E.; Chau, Ryan W.; Margrey, Kaila A.; Ardolino, Michael J.; Zarate, Cayetana; Poremba, Kelsey E.; Simov, Vladimir; Morriello, Gregori J.; Acton, John J.; Pio, Barbara; Yan, Xin; Palte, Rachel L.; McMinn, Spencer E.; Nogle, Lisa; Lesburg, Charles A.; Adpressa, Donovon; Lin, Shishi; Neelamkavil, Santhosh; Liu, Ping; Su, Jing; Hegde, Laxminarayan G.; Woodhouse, Janice D.; Faltus, Robert; Xiong, Tina; Ciaccio, Paul J.; Piesvaux, Jennifer; Otte, Karin M.; Wood, Harold B.; Kennedy, Matthew E.; Bennett, David Jonathan; DiMauro, Erin F.; Fell, Matthew J.; Fuller, Peter H.

Comprehensive Strategies to Bicyclic Prolines: Applications in the Synthesis of Potent Arginase Inhibitors

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2021-10-139