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P

Pamela J. Lein

university of iowa

65H指数
398论文数
1.3W被引数
收录论文 192
发表时间
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Neurodevelopmental outcomes relevant to autism in juvenile mice exposed to PCB 11 in the maternal diet throughout gestation and lactation孕期和哺乳期母体饮食暴露于PCB 11的幼年小鼠与自闭症相关的神经发育结局
errFrontiers in Toxicology
IF4.6
err2026-08-12
err0
errOAAI
errRJ Rebecca J. Wilson; HK Harmanpreet K. Panesar; ID Ilknur Dursun; RM Rosalia Mendieta; PM Peter M. Andrew; XL Xueshu Li; HL Hans-Joachim Lehmler; PJ Pamela J. Lein
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Cytochrome P450-Mediated Xenobiotic Metabolism in the Brain, Effects of 3,3'-Dichlorobiphenyl (PCB-11) Exposure, and Contributions to Naphthalene-Induced DNA Adducts细胞色素P450介导的脑内外源性物质代谢，3,3'-二氯联苯（PCB-11）暴露的影响，以及对萘诱导DNA加合物的贡献
errJournal of Pharmacology and Experimental Therapeutics
IF3.8
err2026-05-01
err0
PREAI
errManhas, Diksha; Han, Weiguo; Wu, Xiangmeng; Hannon, Sarrah; Hollon, Michelle; Li, Xueshu; Zhang, Qing-Yu; Lehmler, Hans-Joachim; Van Winkle, Laura; Lein, Pamela J.; Ding, Xinxin
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Sex and tissue resolved co-expression networks reveal a female placental–brain axis protective against prenatal PCB exposure性别和组织分辨的共表达网络揭示了女性胎盘-脑轴对产前PCB暴露的保护作用
errGenome Biology
IF9.4
err2026-04-07
err0
errOAAI
errKelly H. Chau; Kari Neier; Anthony E. Valenzuela; Rebecca J. Schmidt; Blythe Durbin-Johnson; Pamela J. Lein; Ian Korf; Janine M. LaSalle
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Spatial and spectral mapping of traffic-related nanoparticles in hippocampal subregions of an Alzheimer disease model阿尔茨海默病模型海马亚区中交通相关纳米颗粒的空间和光谱映射
errEnvironmental Pollution
IF7.3
err2026-01-27
err0
errOAAI
errHannah J. O'Toole; Anchaleena James; Nathifa Nasim; Dustin J. Hadley; Elizabeth J. Hale; Qing He; Keith J. Bein; Anthony Valenzuela; Tatu Rojalin; Brittany N. Dugger; Anthony S. Wexler; Pamela J. Lein; Randy P. Carney
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Microglial transcriptional profiles of a transgenic rat model closely model Alzheimer's disease转基因大鼠模型的微胶质细胞转录谱与阿尔茨海默病高度相似。
errJournal of Alzheimer’s Disease
IF0
err2026-01-05
err0
errOAAI
errCarrie J. Finno; Sharmila Ghosh; Veronika Rodriguez; Anthony Valenzuela; Peter Andrew; Heui Hye Park; Ana Cristina Grodzki; Nathifa Nasim; Kelsey Roberts; Blythe Durbin-Johnson; Ken A. Jackson; Patricia A. Pesavento; Pamela J. Lein
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Proposed Key Characteristics of Neurotoxic Chemicals提出的神经毒性化学品的关鍵特征
errNeuroToxicology
IF3.9
err2025-12-22
err0
errOAAI
errPamela J. Lein; Aaron B. Bowman; Zhengyu Cao; Monica Carson; Brenda Eskenazi; Ellen Fritsche; G. Jean Harry; Thomas Hartung; Isaac N. Pessah; William Slikker; Lauren Zeise; Martyn T. Smith
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3,3'-Dichlorobiphenyl (PCB 11) alters the hepatic expression of cytochrome P450 enzymes in the liver of mouse dams exposed orally during pregnancy and lactation3,3'-Dichlorobiphenyl (PCB 11)改变了孕期和哺乳期经口暴露的母鼠肝脏中细胞色素P450酶的肝表达。
errArchives of Toxicology
IF6.9
err2025-12-08
err0
errOAAI
errCrystal M. Roach; Nate R. Koester; Xueshu Li; Jeonghyeon Ahn; R. Marshall Pope; Rebecca J. Wilson; Rosalia Mendieta; Anthony Valenzuela; Weiguo Han; Xinxin Ding; Pamela J. Lein; Hans-Joachim Lehmler
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Single-cell transcriptomics showed that maternal PCB exposure dysregulated cell type-specific metabolic responses in the livers of female mouse offsprings单细胞转录组学显示，母体PCB暴露扰乱了雌性小鼠后代肝脏中细胞类型特异性的代谢反应。
errDrug Metabolism and Disposition
IF4
err2025-09-25
err0
PREAI
errJoe Jongpyo Lim; Youjun Suh; Xueshu Li; Rebecca J. Wilson; Hans-Joachim Lehmler; Pamela J. Lein; Julia Yue Cui
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Dantrolene Normalizes Heightened Ca2+ Influx in Activated T Cells from the Familial Alzheimer's Disease TgF344-AD Rats丹曲洛林使来自家族性阿尔茨海默病TgF344-AD大鼠的活化T细胞中升高的Ca2+内流正常化
errCell Calcium
IF4
err2025-08-27
err0
PREAI
errNavdeep K. Uppal; Anthony Valenzuela; Pamela J. Lein; Alla F. Fomina
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PCB 37 (3,4, 4’-trichlorobiphenyl) increased apoptosis and modulated neuronal morphogenesis in primary rat cortical neuron-glia cocultures in a concentration-, sex-, age-, and CREB-dependent mannerPCB 37 (3,4, 4’-trichlorobiphenyl) 以浓度依赖性、性别依赖性、年龄依赖性和CREB依赖性的方式增加了原代大鼠皮层神经元-胶质细胞共培养体系中的凋亡，并调节了神经元的形态发生。
errNeuroToxicology
IF3.9
err2025-08-19
err0
errOAAI
errJessie R. Badley; Peter M. Andrew; Hans-Joachim Lehmler; Pamela J. Lein
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Bile Acid Profile Differs Between Brain Regions in Rodents and Is Disrupted in a Rodent Model of Alzheimer's Disease胆汁酸谱在啮齿动物不同脑区存在差异，并在阿尔茨海默病啮齿动物模型中发生紊乱。
errComprehensive Physiology
IF5.2
err2025-08-04
err0
errOAAI
errMelanie A. Reuter; Rosalinda Moreno; Madelynn E. Agabao-Tucker; Rahaf Shishani; Jessica Miranda Bustamante; Zara Marfori; Taylor Richieri; Anthony E. Valenzuela; Ameer Y. Taha; Pamela J. Lein; Renu Nandakumar; Bethany P. Cummings
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Spatiotemporal perturbations of the plasminogen activation system in a rat model of acute organophosphate intoxication大鼠急性有机磷中毒模型中纤溶酶原激活系统的时空扰动
errACTA NEUROPATHOLOGICA COMMUNICATIONS
IF5.7
err2025-03-18
err0
errOAAI
errBlackmon, Thomas J.; Macmahon, Jeremy A.; Bernardino, Pedro N.; Hogans, Ryan E.; Cheng, Mei-Yun; Vu, Joan; Lee, Ruth Diana; Saito, Naomi H.; Grodzki, Ana Cristina; Bruun, Donald A.; Wulff, Heike; Woolard, Kevin D.; Brooks-Kayal, Amy; Harvey, Danielle J.; Gorin, Fredric A.; Lein, Pamela J.
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Effect of Long-term Exposure to Traffic-related Air Pollution on the Gut Microbiome in a Transgenic Rat Model of Alzheimer's Disease长期接触交通相关空气污染对阿尔茨海默病转基因大鼠模型肠道微生物组的影响
errJOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
IF3.8
err2025-03-01
err0
PREAI
errVeloso, Kelly Portes; Syed, Zayan; Cataldo, Alexandra; Lee, Casandra; Mohr, Kaylen; Park, Heui Hye; Cheng, Mei-Yun; Valenzuela, Anthony E.; Bein, Keith; Lein, Pamela; Chandrasekaran, Vidya
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Allopregnanolone as an Adjunct Therapy to Midazolam is More Effective Than Midazolam Alone in Suppressing Soman-Induced Status Epilepticus in Male Rats阿洛普regnolone作为佐剂疗法用于咪达唑仑，比单独使用咪达唑仑更有效抑制雄性大鼠中索曼诱导的癫痫持续状态。
errCNS NEUROSCIENCE & THERAPEUTICS
IF5
err2025-02-28
err0
errOAAI
errAndrew, Peter M.; Macmahon, Jeremy A.; Liu, Xiuzhen; Saito, Naomi H.; Berger, Kyle E.; Morgan, Julia E.; Dhir, Ashish; Harvey, Danielle J.; Mccarren, Hilary S.; Rogawski, Michael A.; Lein, Pamela J.
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Acute and persistent changes in neural oscillatory activity predict development of epilepsy following acute organophosphate intoxication in adult rats
errEPILEPSIA
IF6.6
err2025-02-11
err0
errOAAI
errMacmahon, Jeremy A.; Andrew, Peter M.; Izadi, Ali; Bruun, Donald A.; Saito, Naomi H.; Tancredi, Daniel J.; Brooks-Kayal, Amy; Lein, Pamela J.; Gurkoff, Gene G.
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A primary rat neuron-astrocyte-microglia tri-culture model for studying mechanisms of neurotoxicity
errFRONTIERS IN TOXICOLOGY
IF4.6
err2025-01-10
err0
errOAAI
errBadley, Jessie R.; Bhusal, Aishwarya; Lein, Pamela J.
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Primary cortical cell tri-culture to study effects of amyloid-β on microglia function and neuroinflammatory response
errJOURNAL OF ALZHEIMERS DISEASE
IF3.1
err2024-11-05
err1
PREAI
errKim, Hyehyun; Le, Bryan; Goshi, Noah; Zhu, Kan; Grodzki, Ana Cristina; Lein, Pamela J.; Zhao, Min; Seker, Erkin
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Shifts in the spatiotemporal profile of inflammatory phenotypes of innate immune cells in the rat brain following acute intoxication with the organophosphate diisopropylfluorophosphate
errJOURNAL OF NEUROINFLAMMATION
IF10.1
err2024-11-04
err0
errOAAI
errAndrew, Peter M.; Macmahon, Jeremy A.; Bernardino, Pedro N.; Tsai, Yi-Hua; Hobson, Brad A.; Porter, Valerie A.; Huddleston, Sydney L.; Luo, Audrey S.; Bruun, Donald A.; Saito, Naomi H.; Harvey, Danielle J.; Brooks-Kayal, Amy; Chaudhari, Abhijit J.; Lein, Pamela J.
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Interactions of Polychlorinated Biphenyls and Their Metabolites with the Brain and Liver Transcriptome of Female Mice
errACS CHEMICAL NEUROSCIENCE
IF3.9
err2024-10-11
err0
errOAAI
errBullert, Amanda J.; Wang, Hui; Valenzuela, Anthony E.; Neier, Kari; Wilson, Rebecca J.; Badley, Jessie R.; Lasalle, Janine M.; Hu, Xin; Lein, Pamela J.; Lehmler, Hans-Joachim
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Significant metabolic alterations in mouse dams exposed to an environmental mixture of polychlorinated biphenyls (PCBs) during gestation and lactation: Insights into PCB and metabolite profiles
errENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
IF4.2
err2024-10-01
err0
PREAI
errLi, Xueshu; Suh, Youjun P.; Wilson, Rebecca J.; Lein, Pamela J.; Cui, Julia Y.; Lehmler, Hans-Joachim
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研究方向

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合作学者
合作期刊
C
Charles N. Serhan
H 指数: 175 · 论文数: 839
J
Joseph D. Buxbaum
H 指数: 140 · 论文数: 792
B
Bruce D. Hammock
H 指数: 124 · 论文数: 1.9K
P
Philippe Grandjean
H 指数: 112 · 论文数: 897
T
Thomas Härtung
H 指数: 102 · 论文数: 855
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