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K

Kouji Kobiyama

University of California San Diego
H指数:40
被引数:7,179

个人简介

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A poorly reactogenic lipid nanoparticle-mRNA vaccine unveils an innate immune pathway for adverse reactions

一种反应原性较差的脂质纳米颗粒-mRNA疫苗揭示不良免疫反应的固有免疫通路

npj Vaccines
IF6.5
2026-04-160
OAAI
Tomohiro Takano; Keigo Kumagai; Hitoshi Iuchi; Kazutaka Terahara; Aya Mizuike; Eita Sasaki; Yu Adachi; Ryutaro Kotaki; Saya Moriyama; Shinichiro Ota; Mizuki Fujisawa; Tomoharu Mizukami; Kyoko Saito; Masanori Isogawa; Kohei Soga; Haruyo Nakajima-Adachi; Satoshi Hachimura; Kouji Kobiyama; Ken J. Ishii; Michiaki Hamada; Masayoshi Fukasawa; Masaharu Shinkai; Takayuki Matsumura; Yoshimasa Takahashi
IL-1 delineates squalene-based adjuvant efficacy and reactogenicity in a cell-type-specific manner

IL-1以细胞类型特异性的方式界定了角鲨烯基佐剂的效能和反应原性。

npj Vaccines
IF6.5
2026-03-300
OAAI
Yuya Yoshioka; Anri Nishinaka-Yoshioka; Kouji Kobiyama; Tomoya Hayashi; Yujiro Kidani; Yosuke Yanagida; Junpei Kasahara; Kenichiro Tsujii; Yoshiji Asaoka; Norikazu Kuroda; Akira Kugimiya; Hiroaki Osawa; Akimasa Yoshimura; Motoyasu Onishi; Takayuki Nakagawa; Satoru Ishida; Shinya Omoto; Morio Nagira; Cevayir Coban; Ken J. Ishii
cGAS-IFN-I responses by extracting nuclear DNA from dying cells via nucleocytosis

通过核吞噬作用从死亡细胞中提取核DNA以引发cGAS-IFN-I反应

Nature Communications
IF15.7
2026-02-180
OAAI
Hideo Negishi; Yusuke Wada; Yoshitaka Shirasaki; Tomoya Hayashi; Yuji Kubota; Tomio Iwasaki; Mina Kurosawa; Tatsuma Ban; Daisuke Muto; Yusuke Suenaga; Taichi Kojima; Yuzuki Matsuda; Sean Lord Irish; Kosuke Dodo; Toru Suzuki; Mai Yamagishi; Burcu Temizoz; Atsushi Yoshimori; Chisato Kanai; Yoji Nagasaki; Masaki Ohmuraya; Tomohiko Tamura; Atsushi Iwama; Toshifumi Inada; Etsushi Kuroda; Kouji Kobiyama; Noriko Toyama-Sorimachi; Mutsuhiro Takekawa; Cevayir Coban; Ken J. Ishii
Long-term immunoprophylaxis by TLR9 ligand mediates macrophage-ILC cross-talk against respiratory viral infection

TLR9配体介导的长期免疫预防通过巨噬细胞-ILC相互作用抵抗呼吸道病毒感染

Science Advances
IF12.5
2026-01-010
PRE
Asuka Joy Tobuse; Kouji Kobiyama; Jun Tsuchida; Masamitsu N. Asaka; Daichi Utsumi; Mariana Silva Almeida; Yaeko Nakajima‐Takagi; Motohiko Oshima; Tomoya Hayashi; Burcu Temizoz; Etsushi Kuroda; Cevayir Coban; Yasuhiro Yasutomi; Atsushi Iwama; Ken J. Ishii
An adjuvant database for preclinical evaluation of vaccines and immunotherapeutics

用于疫苗和免疫治疗药物预临床评价的佐剂数据库

Cell Chemical Biology
IF7.2
2025-08-110
OAAI
Yayoi Natsume-Kitatani; Kouji Kobiyama; Yoshinobu Igarashi; Taiki Aoshi; Noriyuki Nakatsu; Lokesh P. Tripathi; Junichi Ito; Johan Nyström-Persson; Yuji Kosugi; Rodolfo S. Allendes Osorio; Chioko Nagao; Burcu Temizoz; Etsushi Kuroda; Daron M. Standley; Hiroshi Kiyono; Kenji Nakanishi; Satoshi Uematsu; Isao Hamaguchi; Yasuhiro Yasutomi; Jun Kunisawa; Sho Yamasaki; Cevayir Coban; Hiroshi Yamada; Kenji Mizuguchi; Ken J. Ishii
OTUD3 prevents ulcerative colitis by inhibiting microbiota-mediated STING activation

OTUD3通过抑制微生物介导的STING活化来预防溃疡性结肠炎

Science Immunology
IF16.3
2025-07-180
PRE
Bo Li; Taiki Sakaguchi; Haruka Tani; Takayoshi Ito; Mari Murakami; Ryu Okumura; Masao Kobayashi; Daisuke Okuzaki; Daisuke Motooka; Hiroki Ikeuchi; Takayuki Ogino; Tsunekazu Mizushima; Seiichi Hirota; Yuriko Otake-Kasamoto; Toshihiro Kishikawa; Shota Nakamura; Kouji Kobiyama; Ken J. Ishii; Takao Hashiguchi; Taro Kawai; Etsushi Kuroda; Shinichiro Shinzaki; Wataru Ise; Tomohiro Kurosaki; Akira Kikuchi; Yoshihiko Tomofuji; Yukinori Okada; Kiyoshi Takeda; Hisako Kayama
Microbial dysbiosis fuels STING-driven autoinflammation through cyclic dinucleotides

微生物群失调通过环状二核苷酸驱动STING介导的自身炎症。

JOURNAL OF AUTOIMMUNITY
IF7
2025-06-010
OA
Shibahara, Takayuki; Temizoz, Burcu; Egashira, Shiori; Hosomi, Koji; Park, Jonguk; Surucu, Naz; Bjork, Albin; Sag, Erdal; Doi, Takehiko; Ekinci, Rabia Miray Kisla; Balci, Sibel; Versnel, Marjan A.; Kunisawa, Jun; Yamamoto, Masahiro; Hayashi, Tomoya; Ito, Shuichi; Kamiyama, Yuji; Kobiyama, Kouji; Katsikis, Peter D.; Coban, Cevayir; Gursel, Mayda; Ozen, Seza; Nishida, Sumiyuki; Kumanogoh, Atsushi
Immunological analysis of LC16m8 vaccine: preclinical and early clinical insights into mpox

LC16m8疫苗的免疫学分析：对猴痘的预临床和早期临床见解

EBIOMEDICINE
IF10.8
2025-05-010
PRE
Kobiyama, Kouji; Utsumi, Daichi; Kaku, Yu; Sasaki, Eita; Yasui, Fumihiko; Okamura, Tomotaka; Onodera, Taishi; Tobuse, Asuka Joy; Sakkour, Areej; Amiry, Ahmad Faisal; Hayashi, Tomoya; Temizoz, Burcu; Liu, Kaiwen; Negishi, Hideo; Toyama-Sorimachi, Noriko; Kohara, Michinori; Sawasaki, Tatsuya; Takagi, Junichi; Sato, Kei; Takahashi, Yoshimasa; Yasutomi, Yasuhiro; Ishii, Ken J.
5,6-dimethylxanthenone-4-acetic acid (DMXAA), a partial STING agonist, competes for human STING activation

5，6-二甲基黄嘌呤酮-4-乙酸 (DMXAA)，一种部分STING激动剂，竞争人类STING激活

FRONTIERS IN IMMUNOLOGY
IF5.9
2024-03-126
OAAI
Temizoz, Burcu; Shibahara, Takayuki; Hioki, Kou; Hayashi, Tomoya; Kobiyama, Kouji; Lee, Michelle Sue Jann; Surucu, Naz; Sag, Erdal; Kumanogoh, Atsushi; Yamamoto, Masahiro; Gursel, Mayda; Ozen, Seza; Kuroda, Etsushi; Coban, Cevayir; Ishii, Ken J.
TLR9 plus STING Agonist Adjuvant Combination Induces Potent Neopeptide T Cell Immunity and Improves Immune Checkpoint Blockade Efficacy in a Tumor Model
JOURNAL OF IMMUNOLOGY
IF3.4
2023-12-083
OA
Eiro, Melisa D. Castro; Hioki, Kou; Li, Ling; Wilmsen, Merel E. P.; Kiernan, Caoimhe H.; Brouwers-Haspels, Inge; Meurs, Marjan van; Zhao, Manzhi; Wit, Harm de; Grashof, Dwin G. B.; Werken, Harmen J. G. van de; Mueller, Yvonne M.; Schliehe, Christopher; Temizoz, Burcu; Kobiyama, Kouji; Ishii, Ken J.; Katsikis, Peter D.

研究方向

暂未获取到该数据
K
Ken J. Ishii
H 指数:82论文数:482被引数:3.3万
C
Cevayir Coban
H 指数:49论文数:119被引数:1.3万
S
Shizuo Akira
H 指数:269论文数:1,478被引数:33.4万
T
Taiki Aoshi
H 指数:35论文数:88被引数:4,710
E
Etsushi Kuroda
H 指数:42论文数:144被引数:5,200
B
Burcu Temizoz
H 指数:14论文数:29被引数:850
K
Klaus Ley
H 指数:137论文数:972被引数:7.7万
T
Tomoya Hayashi
H 指数:19论文数:85被引数:1,397
F
Fumihiko Takeshita
H 指数:42论文数:93被引数:1.1万
Y
Yasuhiro Yasutomi
H 指数:38论文数:195被引数:5,542