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K

Ken J. Ishii

the university of tokyo
H指数:82
被引数:3.3万

个人简介

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荣誉奖项

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A poorly reactogenic lipid nanoparticle-mRNA vaccine unveils an innate immune pathway for adverse reactions

一种反应原性较差的脂质纳米颗粒-mRNA疫苗揭示不良免疫反应的固有免疫通路

npj Vaccines
IF6.5
2026-04-160
OAAI
Tomohiro Takano; Keigo Kumagai; Hitoshi Iuchi; Kazutaka Terahara; Aya Mizuike; Eita Sasaki; Yu Adachi; Ryutaro Kotaki; Saya Moriyama; Shinichiro Ota; Mizuki Fujisawa; Tomoharu Mizukami; Kyoko Saito; Masanori Isogawa; Kohei Soga; Haruyo Nakajima-Adachi; Satoshi Hachimura; Kouji Kobiyama; Ken J. Ishii; Michiaki Hamada; Masayoshi Fukasawa; Masaharu Shinkai; Takayuki Matsumura; Yoshimasa Takahashi
IL-1 delineates squalene-based adjuvant efficacy and reactogenicity in a cell-type-specific manner

IL-1以细胞类型特异性的方式界定了角鲨烯基佐剂的效能和反应原性。

npj Vaccines
IF6.5
2026-03-300
OAAI
Yuya Yoshioka; Anri Nishinaka-Yoshioka; Kouji Kobiyama; Tomoya Hayashi; Yujiro Kidani; Yosuke Yanagida; Junpei Kasahara; Kenichiro Tsujii; Yoshiji Asaoka; Norikazu Kuroda; Akira Kugimiya; Hiroaki Osawa; Akimasa Yoshimura; Motoyasu Onishi; Takayuki Nakagawa; Satoru Ishida; Shinya Omoto; Morio Nagira; Cevayir Coban; Ken J. Ishii
cGAS-IFN-I responses by extracting nuclear DNA from dying cells via nucleocytosis

通过核吞噬作用从死亡细胞中提取核DNA以引发cGAS-IFN-I反应

Nature Communications
IF15.7
2026-02-180
OAAI
Hideo Negishi; Yusuke Wada; Yoshitaka Shirasaki; Tomoya Hayashi; Yuji Kubota; Tomio Iwasaki; Mina Kurosawa; Tatsuma Ban; Daisuke Muto; Yusuke Suenaga; Taichi Kojima; Yuzuki Matsuda; Sean Lord Irish; Kosuke Dodo; Toru Suzuki; Mai Yamagishi; Burcu Temizoz; Atsushi Yoshimori; Chisato Kanai; Yoji Nagasaki; Masaki Ohmuraya; Tomohiko Tamura; Atsushi Iwama; Toshifumi Inada; Etsushi Kuroda; Kouji Kobiyama; Noriko Toyama-Sorimachi; Mutsuhiro Takekawa; Cevayir Coban; Ken J. Ishii
Identification of Histone Deacetylase Inhibitor Targeting Type I Interferon and B Cell Abnormalities in Systemic Lupus Erythematosus

系统性红斑狼疮中靶向I型干扰素和B细胞异常的组蛋白去乙酰化酶抑制剂的鉴定

Arthritis & Rheumatology
IF10.9
2026-02-010
OAAI
Hirayama, Takehiro; Konaka, Hachiro; Kato, Yasuhiro; Shibahara, Takayuki; Nishizawa, Chisato; Tsujimoto, Kohei; Park, Jeonghoon; Itotagawa, Eri; Jo, Tatsunori; Nishide, Masayuki; Nishida, Sumiyuki; Shima, Yoshihito; Narazaki, Masashi; Aoki, Wataru; Ishii, Ken J.; Takamatsu, Hyota; Kumanogoh, Atsushi
Long-term immunoprophylaxis by TLR9 ligand mediates macrophage-ILC cross-talk against respiratory viral infection

TLR9配体介导的长期免疫预防通过巨噬细胞-ILC相互作用抵抗呼吸道病毒感染

Science Advances
IF12.5
2026-01-010
PRE
Asuka Joy Tobuse; Kouji Kobiyama; Jun Tsuchida; Masamitsu N. Asaka; Daichi Utsumi; Mariana Silva Almeida; Yaeko Nakajima‐Takagi; Motohiko Oshima; Tomoya Hayashi; Burcu Temizoz; Etsushi Kuroda; Cevayir Coban; Yasuhiro Yasutomi; Atsushi Iwama; Ken J. Ishii
Resident alveolar macrophages are highly susceptible to the induction of RIPK1/RIPK3-mediated necroptosis which promote efficient pulmonary immune response

定居肺泡巨噬细胞极易受到RIPK1/RIPK3介导的坏死性凋亡的诱导，这促进了高效的肺部免疫反应。

Cell Death & Disease
IF9.6
2025-12-220
OAAI
Takumi Adachi; Kazufumi Matsushita; Koubun Yasuda; Masakiyo Nakahira; Mai Imasaka; Michihiko Sugimoto; Zhuohao Yang; Kouji Kobiyama; Tomoya Hayashi; Ken J. Ishii; Yasuo Yoshioka; Masaki Ohmuraya; Yoshitaka Shirasaki; Etsushi Kuroda
NOX2-Dependent Phagocyte Signaling Mediates Silica-Induced Murine Lung Injury via Macrophage-Neutrophil Interactions

NOX2依赖的吞噬细胞信号介导二氧化硅诱导的小鼠肺损伤，通过巨噬细胞-中性粒细胞相互作用。

Inflammation
IF5
2025-12-170
OAAI
Masahiro Kusaka; Koji Sakamoto; Yoshiki Ikeyama; Yuki Kondo; Tomoya Hayashi; Akira Ando; Yuta Mori; Tomonori Sato; Miyoko Matsushima; Atsushi Suzuki; Saeka Fujita; Yukihiro Shiraki; Tsutomu Kawabe; Atsushi Enomoto; Ken J. Ishii; Naozumi Hashimoto; Makoto Ishii
An adjuvant database for preclinical evaluation of vaccines and immunotherapeutics

用于疫苗和免疫治疗药物预临床评价的佐剂数据库

Cell Chemical Biology
IF7.2
2025-08-110
OAAI
Yayoi Natsume-Kitatani; Kouji Kobiyama; Yoshinobu Igarashi; Taiki Aoshi; Noriyuki Nakatsu; Lokesh P. Tripathi; Junichi Ito; Johan Nyström-Persson; Yuji Kosugi; Rodolfo S. Allendes Osorio; Chioko Nagao; Burcu Temizoz; Etsushi Kuroda; Daron M. Standley; Hiroshi Kiyono; Kenji Nakanishi; Satoshi Uematsu; Isao Hamaguchi; Yasuhiro Yasutomi; Jun Kunisawa; Sho Yamasaki; Cevayir Coban; Hiroshi Yamada; Kenji Mizuguchi; Ken J. Ishii
OTUD3 prevents ulcerative colitis by inhibiting microbiota-mediated STING activation

OTUD3通过抑制微生物介导的STING活化来预防溃疡性结肠炎

Science Immunology
IF16.3
2025-07-180
PRE
Bo Li; Taiki Sakaguchi; Haruka Tani; Takayoshi Ito; Mari Murakami; Ryu Okumura; Masao Kobayashi; Daisuke Okuzaki; Daisuke Motooka; Hiroki Ikeuchi; Takayuki Ogino; Tsunekazu Mizushima; Seiichi Hirota; Yuriko Otake-Kasamoto; Toshihiro Kishikawa; Shota Nakamura; Kouji Kobiyama; Ken J. Ishii; Takao Hashiguchi; Taro Kawai; Etsushi Kuroda; Shinichiro Shinzaki; Wataru Ise; Tomohiro Kurosaki; Akira Kikuchi; Yoshihiko Tomofuji; Yukinori Okada; Kiyoshi Takeda; Hisako Kayama
Immunological analysis of LC16m8 vaccine: preclinical and early clinical insights into mpox

LC16m8疫苗的免疫学分析：对猴痘的预临床和早期临床见解

EBIOMEDICINE
IF10.8
2025-05-010
PRE
Kobiyama, Kouji; Utsumi, Daichi; Kaku, Yu; Sasaki, Eita; Yasui, Fumihiko; Okamura, Tomotaka; Onodera, Taishi; Tobuse, Asuka Joy; Sakkour, Areej; Amiry, Ahmad Faisal; Hayashi, Tomoya; Temizoz, Burcu; Liu, Kaiwen; Negishi, Hideo; Toyama-Sorimachi, Noriko; Kohara, Michinori; Sawasaki, Tatsuya; Takagi, Junichi; Sato, Kei; Takahashi, Yoshimasa; Yasutomi, Yasuhiro; Ishii, Ken J.
Immunogenicity, safety, and tolerability of a β-glucan-CpG-adjuvanted respiratory syncytial virus vaccine in Japanese healthy participants aged 60 to 80 years: A phase 2, randomized, double-blind, dose-finding study

在60至80岁的日本健康参与者中，β-葡聚糖-CpG佐剂呼吸道合胞病毒疫苗的免疫原性，安全性和耐受性: 一项2期，随机，双盲，剂量发现研究

HUMAN VACCINES & IMMUNOTHERAPEUTICS
IF3.5
2025-04-210
OA
Tetsuo Nakayama; Makoto Iwanami; Sachiko Sakakibara; Ryuta Mukasa; Aisaku Ota; Kei Furihata; Yuko Honda; Ken J. Ishii

研究方向

暂未获取到该数据
S
Shizuo Akira
H 指数:269论文数:1,478被引数:33.4万
K
Kouji Kobiyama
H 指数:40论文数:119被引数:7,179
C
Cevayir Coban
H 指数:49论文数:119被引数:1.3万
T
Taro Kawai
H 指数:89论文数:248被引数:8.3万
E
Etsushi Kuroda
H 指数:42论文数:144被引数:5,200
F
Fumihiko Takeshita
H 指数:42论文数:93被引数:1.1万
S
Satoshi Uematsu
H 指数:85论文数:290被引数:4.7万
T
Taiki Aoshi
H 指数:35论文数:88被引数:4,710
D
Dennis M. Klinman
H 指数:85论文数:372被引数:2.8万
S
Shintaro Sato
H 指数:66论文数:152被引数:4.4万