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J

Jacques Deguine

broad institute of mit and harvard
H指数:20
被引数:2,920

个人简介

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教育背景

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工作经历

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荣誉奖项

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Insights into early-onset colorectal cancer from a single-nucleus RNA-seq atlas of colorectal cancer across the age continuum

从跨越年龄连续体的结直肠癌单核RNA测序图谱中获得的关于早发性结直肠癌的见解

Nature Medicine
IF50
2026-10-290
OAAI
Caroline B. M. Porter; Shane P. Murphy; Jules Cazaubiel; Toni M. Delorey; Liat Amir-Zilberstein; Orr Ashenberg; Liubou Klindziuk; Elizabeth Andrews; William Tan; Kosuke Matsuda; Atsushi Kondo; Satoko Ugai; Tomotaka Ugai; Shuji Ogino; Emily Finan; Jacques Deguine; Ewa Sicinska; Lauren K. Brais; Jennifer S. Thalappillil; Marios Giannakis; Ramnik J. Xavier; Ana C. Anderson; Kimmie Ng
Multi-modal skin atlas identifies a multicellular immune-stromal community associated with disrupted cornification and specific T cell expansion in atopic dermatitis

多模态皮肤图谱识别出与角化紊乱和特定T细胞扩增相关的多细胞免疫-基质群落在特应性皮炎中

Nature Communications
IF15.7
2026-02-250
OAAI
Evgenij Fiskin; Gökcen Eraslan; Maria B. Alora-Palli; Tanvi Jain; Juan Manuel Leyva-Castillo; Sean Kim; Heather Choe; Caleb A. Lareau; Helena Lau; Emily P. Finan; Isabella Teixeira-Soldano; Brenna LaBere; Anne Chu; Brian Woods; Janet Chou; Michal Slyper; Julia Waldman; Sabina Islam; Lynda Schneider; Wanda Phipatanakul; Craig Platt; Orit Rozenblatt-Rosen; Toni M. Delorey; Orr Ashenberg; Jacques Deguine; Gideon P. Smith; Raif S. Geha; Aviv Regev; Ramnik J. Xavier
Spatial transcriptomics reveals altered communities and drivers of aberrant epithelia and pro-fibrotic fibroblasts in interstitial lung diseases
Cell Genomics
IF9
2026-01-220
OAAI
Alok Jaiswal; Tristan Kooistra; Vladislav Pokatayev; Hélder N. Bastos; Rita F. Santos; Tresa R. Sarraf; Åsa Segerstolpe; Crystal Lin; Liat Amir-Zilberstein; Shaina Twardus; Kevin Shannon; Shane P. Murphy; Rachel Knipe; Ingo K. Ganzleben; Katharine E. Black; Toni M. Delorey; Daniel B. Graham; Yin P. Hung; Lida P. Hariri; Jacques Deguine
Single-cell and spatial transcriptomics of stricturing Crohn’s disease highlights a fibrosis-associated network

限制克罗恩病的单细胞和空间转录组学突出了纤维化相关网络

Nature Genetics
IF0
2025-06-250
PRE
Lingjia Kong; Sathish Subramanian; Åsa Segerstolpe; Vy Tran; Angela R. Shih; Grace T. Carter; Hiroko Kunitake; Shaina W. Twardus; Jasmine Li; Shivam Gandhi; Marco E. Kaper; Christy Cauley; Eric J. Chen; Caroline B. M. Porter; Toni M. Delorey; Liliana Bordeianou; Rocco Ricciardi; Ashwin N. Ananthakrishnan; Helena Lau; Daniel B. Graham; Richard Hodin; Jacques Deguine; Christopher S. Smillie; Ramnik J. Xavier
Type 2 cytokines act on enteric sensory neurons to regulate neuropeptide-driven host defense

2型细胞因子作用于肠道感觉神经元，以调节神经肽驱动的宿主防御

Science
IF45.8
2025-05-220
PRE
Rocky M. Barilla; Clara Berard; Linyu Sun; Sumiti Sandhu; Sarah Zaghouani; Krishna S. Iyer; Gizem Altun; Chien-Wen Su; Jacques Deguine; Vasundhara Singh; Yu Hou; Kanupriya Kusumakar; Michael L. Rutlin; Meenakshi Rao; Habib Zaghouani; Hai Ning Shi; Ramnik J. Xavier; Vijay K. Kuchroo
An esophagus cell atlas reveals dynamic rewiring during active eosinophilic esophagitis and remission

食道细胞图谱揭示了活动性嗜酸性食管炎和缓解期间的动态重新布线

NATURE COMMUNICATIONS
IF15.7
2024-04-188
OAAI
Ding, Jiarui; Garber, John J.; Uchida, Amiko; Lefkovith, Ariel; Carter, Grace T.; Vimalathas, Praveen; Canha, Lauren; Dougan, Michael; Staller, Kyle; Yarze, Joseph; Delorey, Toni M.; Rozenblatt-Rosen, Orit; Ashenberg, Orr; Graham, Daniel B.; Deguine, Jacques; Regev, Aviv; Xavier, Ramnik J.
A distinct human cell type expressing MHCII and RORγt with dual characteristics of dendritic cells and type 3 innate lymphoid cells

一种表达MHCII和ror γ t的独特人类细胞类型，具有树突状细胞和3型固有淋巴样细胞的双重特征

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
2023-12-189
OAAI
Antonova, Alina Ulezko; Lonardi, Silvia; Monti, Matilde; Missale, Francesco; Fan, Changxu; Coates, Matthew L.; Bugatti, Mattia; Jaeger, Natalia; Rodrigues, Patrick Fernandes; Brioschi, Simone; Trsan, Tihana; Fachi, Jose L.; Nguyen, Khai M.; Nunley, Ryan M.; Moratto, Daniele; Zini, Stefania; Kong, Lingjia; Deguine, Jacques; Peeples, Mark E.; Xavier, Ramnik J.; Clatworthy, Menna R.; Wang, Ting; Cella, Marina; Vermi, William; Colonna, Marco
A human model of asthma exacerbation reveals transcriptional programs and cell circuits specific to allergic asthma
SCIENCE IMMUNOLOGY
IF16.3
2023-05-2643
OA
Alladina, Jehan; Smith, Neal P.; Kooistra, Tristan; Slowikowski, Kamil; Kernin, Isabela J.; Deguine, Jacques; Keen, Henry L.; Manakongtreecheep, Kasidet; Tantivit, Jessica; Rahimi, Rod A.; Sheng, Susan L.; Nguyen, Nhan D.; Haring, Alexis M.; Giacona, Francesca L.; Hariri, Lida P.; Xavier, Ramnik J.; Luster, Andrew D.; Villani, Alexandra-Chloe; Cho, Josalyn L.; Medoff, Benjamin D.
The landscape of immune dysregulation in Crohn?s disease revealed through single-cell transcriptomic profiling in the ileum and colon

通过回肠和结肠中的单细胞转录组分析揭示了克罗恩病的免疫失调景观

IMMUNITY
IF26.3
2023-02-0161
OA
Kong, Lingjia; Pokatayev, Vladislav; Lefkovith, Ariel; Carter, Grace T.; Creasey, Elizabeth A.; Krishna, Chirag; Subramanian, Sathish; Kochar, Bharati; Ashenberg, Orr; Lau, Helena; Ananthakrishnan, Ashwin N.; Graham, Daniel B.; Deguine, Jacques; Xavier, Ramnik J.

研究方向

暂未获取到该数据
R
Ramnik J. Xavier
H 指数:186论文数:1,025被引数:18.4万
T
Toni Delorey
H 指数:24论文数:75被引数:7,311
D
Daniel B. Graham
H 指数:47论文数:160被引数:1.1万
P
Philippe Bousso
H 指数:58论文数:173被引数:1.5万
L
Lingjia Kong
H 指数:19论文数:35被引数:1,368
A
Ashwin N. Ananthakrishnan
H 指数:99论文数:902被引数:4.5万
A
Ariel Lefkovith
H 指数:14论文数:49被引数:1,448
E
Elizabeth A. Creasey
H 指数:19论文数:29被引数:3,728
G
Grace T. Carter
H 指数:5论文数:5被引数:369
G
Gregory M. Barton
H 指数:45论文数:95被引数:1.6万