logo
科言猫学术研究的AI总结
language
手机端手机端
  • Phone Feature微信小程序
简体中文简体中文
notice消息通知
博客博客
arrow
A

Alan Lau

AstraZeneca
H指数:37
被引数:9,978

个人简介

暂无内容

教育背景

暂无内容

工作经历

暂无内容

荣誉奖项

暂无内容

Phase 1 study of ceralasertib, an ATR kinase inhibitor, in combination with durvalumab in patients with recurrent or metastatic NSCLC or HNSCC

I期研究：评估ceralasertib（一种ATR激酶抑制剂）联合durvalumab治疗复发或转移性NSCLC或HNSCC患者的疗效。

British Journal of Cancer
IF6.8
2026-03-310
OAAI
Juanita S. Lopez; Kevin J. Harrington; Seock-Ah Im; Keun-Wook Lee; Sophie Postel-Vinay; Jacob S. Thomas; Natalia Lukashchuk; Sophie E. Willis; Itziar Irurzun-Arana; Benjamin Webb; Jyoti Nehra; Alan Lau; Arsène-Bienvenu Loembé; Emma Dean; Matthew G. Krebs
KEAP1 and STK11/LKB1 alterations enhance vulnerability to ATR inhibition in KRAS mutant non-small cell lung cancer

KEAP1和STK11/LKB1突变增强KRAS突变非小细胞肺癌对ATR抑制的易感性

Cancer Cell
IF44.5
2025-07-100
OAAI
Ana Galan-Cobo; Natalie I. Vokes; Yu Qian; David Molkentine; Kavya Ramkumar; Alvaro G. Paula; Marlese Pisegna; Daniel J. McGrail; Alissa Poteete; Sungnam Cho; Minh Truong Do; Amirali Karimi; Yifan Kong; Anisha Solanki; Ankur Karmokar; Nicolas Floc’h; Adina Hughes; Rebecca Sargeant; Lucy Young; Li Shen; Gozde Kar; Caezaan Keshvani; Claudio Arrechedera; Sharia Hernandez; Katharina Schlacher; Jing Wang; Sonia Iyer; James Conway; Mohamed Reda Keddar; Marta Milo; Ilario de Toma; Susan E. Critchlow; J. Carl Barrett; Jan Cosaert; Alan Lau; Viia Valge-Archer; Lauren A. Byers; Simon T. Barry; John V. Heymach
The ATR inhibitor ceralasertib potentiates cancer checkpoint immunotherapy by regulating the tumor microenvironment

ATR抑制剂ceralasertib通过调节肿瘤微环境来增强癌症检查点免疫治疗

NATURE COMMUNICATIONS
IF15.7
2024-02-248
OAAI
Hardaker, Elizabeth L.; Sanseviero, Emilio; Karmokar, Ankur; Taylor, Devon; Milo, Marta; Michaloglou, Chrysis; Hughes, Adina; Mai, Mimi; King, Matthew; Solanki, Anisha; Magiera, Lukasz; Miragaia, Ricardo; Kar, Gozde; Standifer, Nathan; Surace, Michael; Gill, Shaan; Peter, Alison; Talbot, Sara; Tohumeken, Sehmus; Fryer, Henderson; Mostafa, Ali; Mulgrew, Kathy; Lam, Carolyn; Hoffmann, Scott; Sutton, Daniel; Carnevalli, Larissa; Calero-Nieto, Fernando J.; Jones, Gemma N.; Pierce, Andrew J.; Wilson, Zena; Campbell, David; Nyoni, Lynet; Martins, Carla P.; Baker, Tamara; de Almeida, Gilberto Serrano; Ramlaoui, Zainab; Bidar, Abdel; Phillips, Benjamin; Boland, Joseph; Iyer, Sonia; Barrett, J. Carl; Loembe, Arsene-Bienvenu; Fuchs, Serge Y.; Duvvuri, Umamaheswar; Lou, Pei-Jen; Nance, Melonie A.; Gomez Roca, Carlos Alberto; Cadogan, Elaine; Critichlow, Susan E.; Fawell, Steven; Cobbold, Mark; Dean, Emma; Valge-Archer, Viia; Lau, Alan; Gabrilovich, Dmitry I.; Barry, Simon T.
Immunomodulatory effects of the ATR inhibitor ceralasertib in a window of opportunity biomarker trial in patients with head and neck squamous cell carcinoma
CANCER RESEARCH
IF16.6
2023-04-140
PRE
Jones, Gemma N.; Iyer, Sonia; Milo, Marta; Lou, Pei-Jen; Nance, Melonie A.; Gomez-Roca, Carlos A.; Standifer, Nathan; Marco-Casanova, Paola; Gill, Shaan; Surace, Michael; Bystry, Richard; Alexandrova, Maria; Willis, Sophie; Rodriguez-Canales, Jaime; Dannhorn, Andreas; Loembe, Bienvenu; Lau, Alan; Lukashchuk, Natalia; Harrington, Elizabeth A.; Sanai, Elhan; Dean, Emma; Duvvuri, Umamaheswar
Identification of a Molecularly-Defined Subset of Breast and Ovarian Cancer Models that Respond to WEE1 or ATR Inhibition, Overcoming PARP Inhibitor Resistance

确定对WEE1或ATR抑制有反应的乳腺癌和卵巢癌模型的分子定义子集，克服PARP抑制剂耐药性

CLINICAL CANCER RESEARCH
IF10.2
2022-08-0327
OAAI
Serra, Violeta; Wang, Anderson T.; Castroviejo-Bermejo, Marta; Polanska, Urszula M.; Palafox, Marta; Herencia-Ropero, Andrea; Jones, Gemma N.; Lai, Zhongwu; Armenia, Joshua; Michopoulos, Filippos; Llop-Guevara, Alba; Brough, Rachel; Gulati, Aditi; Pettitt, Stephen J.; Bulusu, Krishna C.; Nikkila, Jenni; Wilson, Zena; Hughes, Adina; Wijnhoven, Paul W. G.; Ahmed, Ambar; Bruna, Alejandra; Gris-Oliver, Albert; Guzman, Marta; Rodriguez, Olga; Grueso, Judit; Arribas, Joaquin; Cortes, Javier; Saura, Cristina; Lau, Alan; Critchlow, Susan; Dougherty, Brian; Caldas, Carlos; Mills, Gordon B.; Barrett, J. Carl; Forment, Josep V.; Cadogan, Elaine; Lord, Christopher J.; Cruz, Cristina; Balmana, Judith; O'Connor, Mark J.
ATR Inhibitor AZD6738 (Ceralasertib) Exerts Antitumor Activity as a Monotherapy and in Combination with Chemotherapy and the PARP Inhibitor Olaparib

ATR抑制剂AZD6738 (Ceralasertib) 作为单一疗法以及与化疗和PARP抑制剂Olaparib联合使用具有抗肿瘤活性

CANCER RESEARCH
IF16.6
2022-03-1566
OAAI
Wilson, Zena; Odedra, Rajesh; Wallez, Yann; Wijnhoven, Paul W. G.; Hughes, Adina M.; Gerrard, Joe; Jones, Gemma N.; Bargh-Dawson, Hannah; Brown, Elaine; Young, Lucy A.; O'Connor, Mark J.; Lau, Alan
Method To Visualize the Intratumor Distribution and Impact of Gemcitabine in Pancreatic Ductal Adenocarcinoma by Multimodal Imaging
ANALYTICAL CHEMISTRY
IF6.7
2022-01-1024
PRE
Strittmatter, Nicole; Richards, Frances M.; Race, Alan M.; Ling, Stephanie; Sutton, Daniel; Nilsson, Anna; Wallez, Yann; Barnes, Jennifer; Maglennon, Gareth; Gopinathan, Aarthi; Brais, Rebecca; Wong, Edmond; Serra, Maria Paola; Atkinson, James; Smith, Aaron; Wilson, Joanne; Hamm, Gregory; Johnson, Timothy, I; Dunlop, Charles R.; Kaistha, Brajesh P.; Bunch, Josephine; Sansom, Owen J.; Takats, Zoltan; Andren, Per E.; Lau, Alan; Barry, Simon T.; Goodwin, Richard J. A.; Jodrell, Duncan, I
Ceralasertib (AZD6738), an Oral ATR Kinase Inhibitor, in Combination with Carboplatin in Patients with Advanced Solid Tumors: A Phase I Study
CLINICAL CANCER RESEARCH
IF10.2
2021-07-2260
OAAI
Yap, Timothy A.; Krebs, Matthew G.; Postel-Vinay, Sophie; El-Khouiery, Anthony; Soria, Jean-Charles; Lopez, Juanita; Berges, Alienor; Cheung, S. Y. Amy; Irurzun-Arana, Itziar; Goldwin, Andrew; Felicetti, Brunella; Jones, Gemma N.; Lau, Alan; Frewer, Paul; Pierce, Andrew J.; Clack, Glen; Stephens, Christine; Smith, Simon A.; Dean, Emma; Hollingsworth, Simon J.

研究方向

暂未获取到该数据
M
Mark J. O’Connor
H 指数:69论文数:435被引数:2.1万
N
Niall M.B. Martin
H 指数:33论文数:127被引数:1.3万
E
Elaine Cadogan
H 指数:26论文数:128被引数:2,864
Z
Zena Wilson
H 指数:17论文数:90被引数:2,358
Y
Yann Wallez
H 指数:18论文数:66被引数:1,671
A
Aaron Cranston
H 指数:19论文数:88被引数:3,733
M
Mark J. O’Connor
H 指数:17论文数:120被引数:1,694
D
Dean, Emma
H 指数:0论文数:2被引数:14
G
Gemma N. Jones
H 指数:19论文数:62被引数:2,618
R
Rajesh Odedra
H 指数:29论文数:187被引数:3,315