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E

Elaine Cadogan

oncology, r&d, astrazeneca, cambridge cb2 0aa, u.k.
H指数:26
被引数:2,860

个人简介

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教育背景

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工作经历

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荣誉奖项

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Discovery and Optimization of a Non-Nucleoside-Based Series of Inhibitors of 2′-Deoxynucleoside 5′-Monophosphate Glycosidase (DNPH1)

发现和优化一类非核苷类2′-脱氧核苷-5′-单磷酸糖苷酶（DNPH1）抑制剂

Journal of Medicinal Chemistry
IF6.8
2025-11-060
PRE
Bernard Barlaam; Luz Alonso-Crisostomo; Niall A. Anderson; Argyrides Argyrou; Peter C. Astles; Elaine B. Cadogan; Luca Carlino; Gavin W. Collie; Nichola L. Davies; James Hall; Linda Kitching; Xianxi Li; Filippos Michopoulos; Alexander G. Milbradt; Jenni Nikkilä; Sarah Northall; Mark J. O’Connor; Xiaohiu Pei; Joseph Shaw; Danial Slade; Harriet Southgate; Darren Stead; Christopher J. Stubbs; Benjamin C. Whitehurst; Bin Xing; Yihao Yuan; Jie Zhou
The ATR inhibitor ceralasertib potentiates cancer checkpoint immunotherapy by regulating the tumor microenvironment

ATR抑制剂ceralasertib通过调节肿瘤微环境来增强癌症检查点免疫治疗

NATURE COMMUNICATIONS
IF15.7
2024-02-248
OAAI
Hardaker, Elizabeth L.; Sanseviero, Emilio; Karmokar, Ankur; Taylor, Devon; Milo, Marta; Michaloglou, Chrysis; Hughes, Adina; Mai, Mimi; King, Matthew; Solanki, Anisha; Magiera, Lukasz; Miragaia, Ricardo; Kar, Gozde; Standifer, Nathan; Surace, Michael; Gill, Shaan; Peter, Alison; Talbot, Sara; Tohumeken, Sehmus; Fryer, Henderson; Mostafa, Ali; Mulgrew, Kathy; Lam, Carolyn; Hoffmann, Scott; Sutton, Daniel; Carnevalli, Larissa; Calero-Nieto, Fernando J.; Jones, Gemma N.; Pierce, Andrew J.; Wilson, Zena; Campbell, David; Nyoni, Lynet; Martins, Carla P.; Baker, Tamara; de Almeida, Gilberto Serrano; Ramlaoui, Zainab; Bidar, Abdel; Phillips, Benjamin; Boland, Joseph; Iyer, Sonia; Barrett, J. Carl; Loembe, Arsene-Bienvenu; Fuchs, Serge Y.; Duvvuri, Umamaheswar; Lou, Pei-Jen; Nance, Melonie A.; Gomez Roca, Carlos Alberto; Cadogan, Elaine; Critichlow, Susan E.; Fawell, Steven; Cobbold, Mark; Dean, Emma; Valge-Archer, Viia; Lau, Alan; Gabrilovich, Dmitry I.; Barry, Simon T.
Identification of Novel, Selective Ataxia-Telangiectasia Mutated Kinase Inhibitors with the Ability to Penetrate the Blood-Brain Barrier: The Discovery of AZD1390
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2024-02-024
PRE
Pike, Kurt G.; Hunt, Thomas A.; Barlaam, Bernard; Benstead, David; Cadogan, Elaine; Chen, Kan; Cook, Calum R.; Colclough, Nicola; Deng, Chao; Durant, Stephen T.; Eatherton, Andrew; Goldberg, Kristin; Johnstro''m, Peter; Liu, Libin; Liu, Zhaoqun; Nissink, J. Willem M.; Pang, Chengling; Pass, Martin; Robb, Graeme R.; Roberts, Caroline; Schou, Magnus; Steward, Oliver; Sykes, Andy; Yan, Yumei; Zhai, Baochang; Zheng, Li
Optimization of hERG and Pharmacokinetic Properties for Basic Dihydro-8H-purin-8-one Inhibitors of DNA-PK
ACS MEDICINAL CHEMISTRY LETTERS
IF4
2022-07-076
OA
Goldberg, Frederick W.; Ting, Attilla K. T.; Beattie, David; Lamont, Gillian M.; Fallan, Charlene; Finlay, M. Raymond, V; Williamson, Beth; Schimpl, Marianne; Harmer, Alexander R.; Adeyemi, Oladipupo B.; Nordell, Par; Cronin, Anna S.; Vazquez-Chantada, Mercedes; Barratt, Derek; Ramos-Montoya, Antonio; Cadogan, Elaine B.; Davies, Barry R.
Pharmacology of the ATM Inhibitor AZD0156: Potentiation of Irradiation and Olaparib Responses Preclinically
MOLECULAR CANCER THERAPEUTICS
IF5.5
2020-01-03123
OAAI
Riches, Lucy C.; Trinidad, Antonio G.; Hughes, Gareth; Jones, Gemma N.; Hughes, Adina M.; Thomason, Andrew G.; Gavine, Paul; Cui, Andy; Ling, Stephanie; Stott, Jonathan; Clark, Roger; Peel, Samantha; Gill, Pendeep; Goodwin, Louise M.; Smith, Aaron; Pike, Kurt G.; Barlaam, Bernard; Pass, Martin; O'Connor, Mark J.; Smith, Graeme; Cadogan, Elaine B.
The Discovery of 7-Methyl-2-[(7-methyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino]-9-(tetrahydro-2H-pyran-4-yl)-7,9-dihydro-8H-purin-8-one (AZD7648), a Potent and Selective DNA-Dependent Protein Kinase (DNA-PK) Inhibitor
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2019-12-1863
OAAI
Goldberg, Frederick W.; Finlay, M. Raymond, V; Ting, Attilla K. T.; Beattie, David; Lamont, Gillian M.; Fallan, Charlene; Wrigley, Gail L.; Schimpl, Marianne; Howard, Martin R.; Williamson, Beth; Vazquez-Chantada, Mercedes; Barratt, Derek G.; Davies, Barry R.; Cadogan, Elaine B.; Ramos-Montoya, Antonio; Dean, Emma
AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity
NATURE COMMUNICATIONS
IF15.7
2019-11-07237
OAAI
Fok, Jacqueline H. L.; Ramos-Montoya, Antonio; Vazquez-Chantada, Mercedes; Wijnhoven, Paul W. G.; Follia, Valeria; James, Neil; Farrington, Paul M.; Karmokar, Ankur; Willis, Sophie E.; Cairns, Jonathan; Nikkila, Jenni; Beattie, David; Lamont, Gillian M.; Finlay, M. Raymond, V; Wilson, Joanne; Smith, Aaron; O'Connor, Lenka Oplustil; Ling, Stephanie; Fawell, Stephen E.; O'Connor, Mark J.; Hollingsworth, Simon J.; Dean, Emma; Goldberg, Frederick W.; Davies, Barry R.; Cadogan, Elaine B.
Reversing PARP inhibitor resistance by targeting the replication stress response
CANCER RESEARCH
IF16.6
2019-07-010
PRE
O'Connor, Mark J.; Cruz, Cristina; Castroviejo-Bermejo, Marta; Polanska, Urszula M.; Jones, Gemma N.; Wang, Anderson; Lai, Zhongwu; Forment, Josep; Bulusu, Krishna; Llop-Guevara, Alba; Dougherty, Brian; Saura, Cristina; Brough, Rachel; Lord, Chris J.; Bruna, Alejandra; Caldas, Carlos; Fawell, Stephen; Barrett, J. Carl; Critchlow, Susan E.; Balmana, Judith; Cadogan, Elaine; Serra, Violeta

研究方向

暂未获取到该数据
A
Antonio Ramos‐Montoya
H 指数:28论文数:111被引数:3,481
K
Kurt G. Pike
H 指数:24论文数:94被引数:2,060
B
Bernard Barlaam
H 指数:24论文数:100被引数:1,893
S
Stephen T. Durant
H 指数:25论文数:109被引数:3,313
A
Alan Lau
H 指数:37论文数:108被引数:9,973
J
Joanne Wilson
H 指数:25论文数:203被引数:3,200
D
Dean, Emma
H 指数:0论文数:2被引数:0
M
Mercedes Vázquez–Chantada
H 指数:18论文数:60被引数:1,918
A
Aaron Smith
H 指数:41论文数:164被引数:6,733
U
Urszula M. Polanska
H 指数:21论文数:185被引数:2,065