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E

Eric Metzger

klinikum der albert-ludwigs-universität freiburg
H指数:36
被引数:6,720

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荣誉奖项

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KMT9 drives T cell exclusion and dysfunction by promoting PMN-MDSCs infiltration and ARG1 expression in prostate cancer

KMT9通过促进PMN-MDSCs浸润和ARG1表达，驱动T细胞排斥和功能障碍在前列腺癌中的作用

Molecular Cancer
IF33.9
2026-09-170
OAAI
Jon Peñarando; Dominica Willmann; Manuela Sum; Yanhan Jia; Christopher Berlin; Lukas M. Braun; Zihao Chen; Sylvia Urban; Manfred Jung; Delphine Duteil; Daniel Metzger; Christian Gratzke; Robert Zeiser; Holger Greschik; Roland Schüle; Eric Metzger
Menin-inhibition enhances graft-versus-leukemia effects by T-cell activation and endogenous retrovirus induction in AML

Menin抑制通过T细胞活化及内源性逆转录病毒诱导增强移植物抗白血病效应（AML）

Blood
IF23.1
2025-10-300
PRE
Viktor Fetsch; Lennard Schwöbel; Ezgi Ozyerli-Goknar; Anna-Verena Stell; Marco Punta; Thomas Plenge; Tabea Klaus; Manoj K. Gupta; Geoffroy Andrieux; Khalid Shoumariyeh; Sophie Pfeiffer; Eyleen Corrales; Lina Schlenke; Hosna Baniadam; Simon M. Brandl; Massimo Andreis; Michal Remen; Alina Hartmann; Kathleen Grueter; Melissa Zwick; Natalie Köhler; Monika Kuban; Eric Metzger; Christoph Rummelt; Justus Duyster; Melanie Boerries; Maike Hofmann; Julian Färber; Lukas Braun; Alexander J. Zähringer; Michael Lübbert; Cristina Toffalori; Luca Vago; Florian H. Heidel; Susana Minguet; Petya Apostolova; Tobias Feuchtinger; Kristina Maas-Bauer; Franziska Blaeschke; Michael W.M. Kühn; H.Th.Marc Timmers; Tobias Wertheimer; Florian Perner; Robert Zeiser
Lysine-specific demethylase 1 regulates hematopoietic stem cell expansion and myeloid cell differentiation

赖氨酸特异性去甲基化酶1调控造血干细胞扩增和髓系细胞分化

Cell Death & Disease
IF9.6
2025-08-150
OA
Hans Felix Staehle; Christoph Koellerer; Anne Marie Staehle; Jana Schulze; Philipp Eble; Anja Müller; Franziska Zell; Judith M. Müller; Florian Perner; Aya Attia; Jan-Philipp Mallm; Olga Pozdnyakova; Karsten Rippe; Benedikt Brors; Lars Feuerbach; Charles D. Imbusch; Eric Metzger; Roland Schüle; Heike L. Pahl; Jonas S. Jutzi
Structure-Guided Design of a KMT9 Inhibitor Prodrug with Cellular Activity

结构导向的KMT9抑制剂前药设计及其细胞活性

Journal of Medicinal Chemistry
IF6.8
2025-06-170
OA
Sheng Wang; Nicolas P. F. Barthes; Sylvia Urban; Viktor I. Hazai; Sebastian O. Klein; Tabea Pappert; Paul Kümmel; Nicolas Heller; Johannes Bacher; Maximilian Staudt; Jan Ruprecht; Ling Peng; Manuela Sum; Christopher Berlin; Daad Sarraf; Pierre Regenass; Robin Warstat; Johannes Walz; Pankaj Mishra; Lin Zhang; Oliver Einsle; Stefan Günther; Bernhard Breit; Eric Metzger; Manfred Jung; Roland Schüle
Structure-guided design of a selective inhibitor of the methyltransferase KMT9 with cellular activity
NATURE COMMUNICATIONS
IF15.7
2024-01-022
OAAI
Wang, Sheng; Klein, Sebastian O.; Urban, Sylvia; Staudt, Maximilian; Barthes, Nicolas P. F.; Willmann, Dominica; Bacher, Johannes; Sum, Manuela; Bauer, Helena; Peng, Ling; Rennar, Georg A.; Gratzke, Christian; Schuele, Katrin M.; Zhang, Lin; Einsle, Oliver; Greschik, Holger; Macleod, Calum; Thomson, Christopher G.; Jung, Manfred; Metzger, Eric; Schuele, Roland
KDM4A promotes NEPC progression through regulation of MYC expression
CANCER RESEARCH
IF16.6
2023-04-040
PRE
Mak, Celia Sze Ling; Zhu, Ming; Liang, Xin; Wang, Feng; Hoang, Anh G.; Song, Xinzhi; Shepherd, Peter; Liang, Derek; Suh, Jessica; Park, Jiwon; Zhang, Miao; Metzger, Eric; Schule, Roland; Jain, Abhinav K.; Karasik, Ellen; Foster, Barbara A.; Lee, Min Gyu; Corn, Paul; Logothetis, Christopher J.; Aparicio, Ana; Navone, Nora; Troncoso, Patricia; Zhang, Jianhua; Lin, Sue-Hwa; Wang, Guocan
KMT9 monomethylates histone H4 lysine 12 and controls proliferation of prostate cancer cells
NATURE STRUCTURAL & MOLECULAR BIOLOGY
IF10.1
2019-05-0663
PREAI
Metzger, Eric; Wang, Sheng; Urban, Sylvia; Willmann, Dominica; Schmidt, Andreas; Offermann, Anne; Allen, Anita; Sum, Manuela; Obier, Nadine; Cottard, Felicie; Ulferts, Svenja; Preca, Bogdan-Tiberius; Hermann, Bianca; Maurer, Jochen; Greschik, Holger; Hornung, Veit; Einsle, Oliver; Perner, Sven; Imhof, Axel; Jung, Manfred; Schuele, Roland
LSD1 inhibition by tranylcypromine derivatives interferes with GFI1-mediated repression of PU.1 target genes and induces differentiation in AML (vol 33, pg 1411, 2019)
LEUKEMIA
IF13.4
2019-03-052
OAAI
Barth, Jessica; Abou-El-Ardat, Khalil; Dalic, Denis; Kurrle, Nina; Maier, Anna-Maria; Mohr, Sebastian; Schuette, Judith; Vassen, Lothar; Greve, Gabriele; Schulz-Fincke, Johannes; Schmitt, Martin; Tosic, Milica; Metzger, Eric; Bug, Gesine; Khandanpour, Cyrus; Wagner, Sebastian A.; Luebbert, Michael; Jung, Manfred; Serve, Hubert; Schuele, Roland; Berg, Tobias
LSD1 inhibition by tranylcypromine derivatives interferes with GFI1-mediated repression of PU.1 target genes and induces differentiation in AML
LEUKEMIA
IF13.4
2019-01-2449
PREAI
Barth, Jessica; Abou-El-Ardat, Khalil; Dalic, Denis; Kurrle, Nina; Maier, Anna-Maria; Mohr, Sebastian; Schuette, Judith; Vassen, Lothar; Greve, Gabriele; Schulz-Fincke, Johannes; Schmitt, Martin; Tosic, Milica; Metzger, Eric; Bug, Gesine; Khandanpour, Cyrus; Wagner, Sebastian A.; Luebbert, Michael; Jung, Manfred; Serve, Hubert; Schuele, Roland; Berg, Tobias

研究方向

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R
Roland Schüle
H 指数:60论文数:331被引数:1.5万
M
Manfred Jung
H 指数:65论文数:469被引数:1.3万
D
Dominica Willmann
H 指数:17论文数:59被引数:1,583
W
Wolfgang Sippl
H 指数:64论文数:504被引数:1.3万
R
Reinhard Buettner
H 指数:77论文数:707被引数:2.4万
O
Oliver Einsle
H 指数:56论文数:430被引数:1.4万
M
Manuela Sum
H 指数:5论文数:21被引数:192
H
Holger Greschik
H 指数:20论文数:54被引数:2,274
S
Sylvia Urban
H 指数:8论文数:30被引数:635
A
Axel Imhof
H 指数:71论文数:342被引数:2.0万