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F

Francis Gosselin

Genentech

31H指数
172论文数
3.2K被引数
收录论文 87
发表时间
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Data-driven construction of an imine reductase library capable of broad-scope reductive amination at equimolar substrate concentrations数据驱动的亚胺还原酶库构建：在等摩尔底物浓度下实现广谱还原胺化
errNature Communications
IF15.7
err2026-08-22
err0
errOAAI
errSarah A. Berger; Christopher Grimm; Marco Cespugli; Andreas Krassnigg; Tobias Schopper; Irene Marzuoli; Isabel Oroz-Guinea; Stephan Vrabl; Lukas Roemer; Melanie A. Weber; Fabian M. Kulier; Yuliya Orel; Bettina M. Nestl; Christian C. Gruber; Georg Steinkellner; Serena Bisagni; Francis Gosselin; Hans Iding; Kurt Puentener; Dennis Wetzl; Wolfgang Kroutil; Joerg H. Schrittwieser
err分享
err收藏
Development of a Second-Generation Stereoselective Manufacturing Process for a Key N-Hydroxyamidine Intermediate of GDC-6599 Enabled by Data Science and Mechanistic Understanding通过数据科学和机理理解开发GDC-6599关键N-羟基脒中间体的第二代立体选择性制造工艺
errORGANIC PROCESS RESEARCH & DEVELOPMENT
IF3.5
err2026-06-29
err0
PREAI
errJacob C. Timmerman; Allen Y. Hong; Kurt Püntener; Anna-Lena Glass; Sandro Tonazzi; Katarzyna A. Piechowicz; Maud Guillemot-Plass; José G. Napolitano; Breanna Conklin; Haiming Zhang; Francis Gosselin
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Assessment of Complementary Catalysts in an Uncharted Enantioselective Reaction of Sulfondiimines手性亚砜二亚胺中互补催化剂在未探索的手性选择性反应中的评估
errJournal of the American Chemical Society
IF15.6
err2026-05-04
err0
errOAAI
errEden Gaster; Hannah S. Slocumb; Zrinko Jurić; Tyler E. Myers; Ngiap-Kie Lim; Thomas C. Malig; F. Dean Toste; Francis Gosselin; Matthew S. Sigman; Scott J. Miller
err分享
err收藏
Data Science-Guided Development of Deoxyfluorination Reagents with Enhanced Reactivity; Practicality; and Safety数据科学指导下的高反应活性、实用性与安全性脱氧氟化试剂的开发
errJournal of the American Chemical Society
IF15.6
err2025-07-09
err0
PREAI
errMadeline E. Ruos; Natalie P. Romer; Julie A. Deichert; Lady Mae Alabanza; Shivaani S. Gandhi; Giselle Z. Brown; Richard C. Walroth; Karissa Cruz; Francis Gosselin; Allen Y. Hong; Matthew S. Sigman; Abigail G. Doyle
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Development of a Robust Pd-Catalyzed C-S Coupling for the Synthesis of Janus Kinase Inhibitor GDC-9918
errORGANIC PROCESS RESEARCH & DEVELOPMENT
IF3.5
err2024-09-20
err0
PREAI
errDalton, Derek M.; Siu, Juno Castillo; Varona-Ortiz, Marcelino; Sowell, C. Gregory; Gosselin, Francis
err分享
err收藏
Fit-for-Purpose Synthesis of a KRASG12C Covalent Inhibitor, via a Diastereoselective Hayashi Arylation通过非对映选择性Hayashi芳基化合成KRASG12C共价抑制剂
errORGANIC PROCESS RESEARCH & DEVELOPMENT
IF3.5
err2024-07-22
err0
PREAI
errMolinaro, Carmela; Wong, Nicholas; White, Nicholas A.; Sirois, Lauren E.; Bigler, Raphael; Bindschaedler, Quentin P.; Do, Steven; Malhotra, Sushant; Gosselin, Francis
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err收藏
Streamlined Synthesis of SHP2 Inhibitor GDC-1971 Enhanced by a Telescoped Schotten-Baumann SNAr and Reactive Crystallization Cascade
errORGANIC PROCESS RESEARCH & DEVELOPMENT
IF3.5
err2024-06-27
err0
PREAI
errSirois, Lauren E.; White, Nicholas A.; Shen, Jeff; Dalton, Derek M.; Zell, Daniel; St-Jean, Frederic; Gosselin, Francis
err分享
err收藏
Scalable Synthesis of 6-Chloro-1H-pyrazolo[3,4-b]pyrazine via a Continuous Flow Formylation/Hydrazine Cyclization Cascade
errORGANIC PROCESS RESEARCH & DEVELOPMENT
IF3.5
err2024-05-31
err2
PREAI
errBass, Thomas M.; Zell, Daniel; Kelly, Sean M.; Malig, Thomas C.; Napolitano, Jose G.; Sirois, Lauren E.; Han, Chong; Gosselin, Francis
err分享
err收藏
Development of a First-Generation Stereocontrolled Manufacturing Process of TRPA1 Inhibitor GDC-6599
errORGANIC PROCESS RESEARCH & DEVELOPMENT
IF3.5
err2024-05-24
err0
PREAI
errHong, Allen Y.; Piechowicz, Katarzyna A.; Timmerman, Jacob C.; Zhang, Haiming; Molinaro, Carmela; Gosselin, Francis
err分享
err收藏
Umpolung Flow Chemistry for the Synthesis of a 3-Oxo-3H-spiro[benzofuran-2,4′-piperidine] Building Block
errJOURNAL OF ORGANIC CHEMISTRY
IF3.6
err2024-05-20
err1
PREAI
errPompeo, Matthew M.; Kelly, Sean M.; St-Jean, Frederic; Bass, Thomas M.; Dalton, Derek M.; Zell, Daniel; Han, Chong; Sirois, Lauren E.; Gosselin, Francis
err分享
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Enantioselective Sulfonimidamide Acylation via a Cinchona Alkaloid-Catalyzed Desymmetrization: Scope, Data Science, and Mechanistic Investigation
errJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
err2024-03-13
err5
errOAAI
errHaas, Brittany C.; Lim, Ngiap-Kie; Jermaks, Janis; Gaster, Eden; Guo, Melody C.; Malig, Thomas C.; Werth, Jacob; Zhang, Haiming; Toste, F. Dean; Gosselin, Francis; Miller, Scott J.; Sigman, Matthew S.
err分享
err收藏
Data Science Guided Multiobjective Optimization of a Stereoconvergent Nickel-Catalyzed Reduction of Enol Tosylates to Access Trisubstituted Alkenes
errACS CATALYSIS
IF13.1
err2024-03-13
err2
PREAI
errRomer, Natalie P.; Min, Daniel S.; Wang, Jason Y.; Walroth, Richard C.; Mack, Kyle A.; Sirois, Lauren E.; Gosselin, Francis; Zell, Daniel; Doyle, Abigail G.; Sigman, Matthew S.
err分享
err收藏
Development of a Streamlined Manufacturing Process for the Highly Substituted Quinazoline Core Present in KRAS G12C Inhibitor Divarasib
errORGANIC PROCESS RESEARCH & DEVELOPMENT
IF3.5
err2024-01-09
err4
PREAI
errBurkhard, Johannes A.; Herold, Sebastian; Leitner, Christian; Zhang, Haiming; Angelaud, Remy; Tian, Qingping; Han, Chong; Gosselin, Francis
err分享
err收藏
Manufacturing Process for 6-Bromo-N,N-bis(4-methoxybenzyl)-4-methyl-5-(trifluoromethyl)pyridin-2-amine, a Key Intermediate in the Synthesis of KRAS G12C Inhibitor Divarasib合成KRAS G12C抑制剂Divarasib的关键中间体6-溴-N，N-双 (4-甲氧基苄基)-4-甲基-5-(三氟甲基) 吡啶-2-胺的制造工艺
errORGANIC PROCESS RESEARCH & DEVELOPMENT
IF3.5
err2023-12-29
err5
PREAI
errShen, Jeff; White, Nicholas A.; Tian, Qingping; Sirois, Lauren E.; Zhang, Haiming; Gosselin, Francis
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Asymmetric Synthesis of N-Alkyl Amino Acids through a Biocatalytic Dynamic Kinetic Resolution of PEGylated N-Alkyl Amino Esters
errORGANIC LETTERS
IF5
err2023-12-05
err1
PREAI
errMolinaro, Carmela; Kelly, Sean; Tang, Allison; Iding, Hans; Stocker, Patrik; Xin, Linghu; Gosselin, Francis
err分享
err收藏
Data Science-Enabled Palladium-Catalyzed Enantioselective Aryl-Carbonylation of Sulfonimidamides
errJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
err2023-09-01
err19
PREAI
errvan Dijk, Lucy; Haas, Brittany C.; Lim, Ngiap-Kie; Clagg, Kyle; Dotson, Jordan J.; Treacy, Sean M.; Piechowicz, Katarzyna A.; Roytman, Vladislav A.; Zhang, Haiming; Toste, F. Dean; Miller, Scott J.; Gosselin, Francis; Sigman, Matthew S.
err分享
err收藏
Synthesis of a Highly Functionalized Quinazoline Organozinc toward KRAS G12C Inhibitor Divarasib (GDC-6036), Enabled through Continuous Flow Chemistry
errORGANIC PROCESS RESEARCH & DEVELOPMENT
IF3.5
err2023-08-24
err7
PREAI
errKelly, Sean M.; Lebl, Rene; Malig, Thomas C.; Bass, Thomas M.; Kummli, Dominique; Kaldre, Dainis; Orcel, Ugo; Trondlin, Lars; Linder, David; Sedelmeier, Joerg; Bachmann, Stephan; Han, Chong; Zhang, Haiming; Gosselin, Francis
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Practical Synthesis of Reactive Immuno-PET Linker-Chelator (1R,2R)-RESCA-TFP
errORGANIC PROCESS RESEARCH & DEVELOPMENT
IF3.5
err2023-06-28
err2
PREAI
errWong, Nicholas; Zhao, Eileen; Bao, Jiangyin; Koenig, Stefan G.; Molinaro, Carmela; Timmerman, Jacob C.; Zhang, Haiming; Sowell, C. Gregory; Gosselin, Francis
err分享
err收藏
Second-Generation Atroposelective Synthesis of KRAS G12C Covalent Inhibitor GDC-6036第二代KRAS G12C共价抑制剂GDC-6036的选择性合成
errORGANIC LETTERS
IF5
err2023-05-10
err12
PREAI
errXu, Jie; Lim, Ngiap-Kie; Timmerman, Jacob C.; Shen, Jeff; Clagg, Kyle; Orcel, Ugo; Bigler, Raphael; Trachsel, Etienne; Meier, Roland; White, Nicholas A.; Burkhard, Johannes A.; Sirois, Lauren E.; Tian, Qingping; Angelaud, Remy; Bachmann, Stephan; Zhang, Haiming; Gosselin, Francis
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A Convergent Synthesis of HPK1 Inhibitor GNE-6893 via Palladium- Catalyzed Functionalization of a Tetrasubstituted Isoquinoline
errORGANIC PROCESS RESEARCH & DEVELOPMENT
IF3.5
err2023-02-27
err6
PREAI
errStumpf, Andreas; Xu, Di; Ranjan, Rohit; Angelaud, Remy; Gosselin, Francis
err分享
err收藏

研究方向

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合作学者
合作期刊
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