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A

Andrew G. Stephen

national institutes of health (nih) - usa

40H指数
336论文数
5.3K被引数
收录论文 83
发表时间
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How KRAS Mutations Impair Intrinsic GTP Hydrolysis: Experimental and Computational InvestigationsKRAS突变如何抑制内在GTP水解：实验与计算研究
errJOURNAL OF CHEMICAL INFORMATION AND MODELING
IF5.3
err2025-11-01
err0
PREAI
errSong, Lin Frank; Rabara, Dana; Bali, Semiha K.; Pei, Jun; Lau, Edmond Y.; Kirshner, Dan; Lightstone, Felice C.; McCormick, Frank; Stephen, Andrew G.; Yang, Yue
err分享
err收藏
Dynamics and lipid membrane coupling of the RAS-RAF complex revealed via multiscale simulationsRAS-RAF复合物的动力学及与脂质膜的耦合关系通过多尺度模拟揭示
errBiophysical Journal
IF3.1
err2025-08-22
err0
errOAAI
errTimothy S. Carpenter; Fikret Aydin; Chris Neale; Que N. Van; Xiaohua Zhang; Harsh Bhatia; Jason W. Sidabras; Peter H. Frank; Konstantia Georgouli; Jeremy O.B. Tempkin; Violeta Burns Casamayor; Gulcin Gulten; Rebika Shrestha; Debanjan Goswami; Francesco Di Natale; Joseph R. Chavez; Adam Moody; Joseph Y. Moon; Tomas Oppelstrup; James N. Glosli; Gautham Dharuman; Sergio Wong; Shusen Liu; Nicolas W. Hengartner; Cesar A. López; Kien Nguyen; Christopher B. Stanley; Liam G. Stanton; Lara Patel; Tyler Reddy; Thomas J. Turbyville; Brian Van Essen; Peer-Timo Bremer; Felice C. Lightstone; Andrew G. Stephen; Sandrasegaram Gnanakaran; Frank McCormick; Dwight V. Nissley; Frederick H. Streitz; Helgi I. Ingólfsson
err分享
err收藏
Biophysical and structural analysis of KRAS switch-II pocket inhibitors reveals allele-specific binding constraintsKRAS开关-II口袋抑制剂的生物物理和结构分析揭示了等位基因特异性的结合限制
errJournal of Biological Chemistry
IF3.9
err2025-07-01
err0
errOAAI
errPatrick Alexander; Albert H. Chan; Dana Rabara; Monalisa Swain; Erik K. Larsen; Marcin Dyba; Oleg Chertov; Mariam Ashraf; Allison Champagne; Ken Lin; Anna Maciag; William K. Gillette; Dwight V. Nissley; Frank McCormick; Dhirendra K. Simanshu; Andrew G. Stephen
err分享
err收藏
BBO-10203 inhibits tumor growth without inducing hyperglycemia by blocking RAS-PI3Kα interactionBBO-10203通过阻断RAS-PI3Kα相互作用抑制肿瘤生长，而不诱导高血糖症
errScience
IF45.8
err2025-06-12
err0
PREAI
errDhirendra K. Simanshu; Rui Xu; James P. Stice; Daniel J. Czyzyk; Siyu Feng; John-Paul Denson; Erin Riegler; Yue Yang; Cathy Zhang; Sofia Donovan; Brian P. Smith; Maria Abreu-Blanco; Ming Chen; Cindy Feng; Lijuan Fu; Dana Rabara; Lucy C. Young; Marcin Dyba; Wupeng Yan; Ken Lin; Samar Ghorbanpoorvalukolaie; Erik K. Larsen; Wafa Malik; Allison Champagne; Katie Parker; Jin Hyun Ju; Stevan Jeknic; Dominic Esposito; David M. Turner; Felice C. Lightstone; Bin Wang; Paul M. Wehn; Keshi Wang; Andrew G. Stephen; Anna E. Maciag; Aaron N. Hata; Kerstin W. Sinkevicius; Dwight V. Nissley; Eli M. Wallace; Frank McCormick; Pedro J. Beltran
err分享
err收藏
Blocking C-terminal processing of KRAS4b via a direct covalent attack on the CaaX-box cysteine通过直接共价攻击CaaX盒半胱氨酸来阻断KRAS4b的C末端加工
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2025-05-09
err0
errOAAI
errMaciag, Anna E.; Yang, Yue; Sharma, Alok K.; Turner, David M.; Dehart, Caroline J.; Abdelkarim, Hazem; Fan, Lixin; Smith, Brian P.; Kumari, Vandana; Dyba, Marcin; Rigby, Megan; Badillo, Jean A. Castillo; Adams, Lauren; Fornelli, Luca; Fox, Stephen; Brafman, Alla; Turbyville, Thomas; Gillette, William; Messing, Simon; Agamasu, Constance; Wolfe, Andrew L.; Gysin, Stephan; Chan, Albert H.; Simanshu, Dhirendra K.; Esposito, Dominic; Chertov, Oleg; Stephen, Andrew G.; Arkin, Michelle; Renslo, Adam; Kelleher, Neil L.; Gaponenko, Vadim; Lightstone, Felice C.; Nissley, Dwight, V; McCormick, Frank
err分享
err收藏
Two hearts beat as one: the debate over RAS dimers continues
errTRENDS IN BIOCHEMICAL SCIENCES
IF11
err2024-11-01
err0
errOAAI
errStephen, Andrew G.
err分享
err收藏
Beyond KRAS(G12C): Biochemical and Computational Characterization of Sotorasib and Adagrasib Binding Specificity and the Critical Role of H95 and Y96超越KRAS(G12C): Sotorasib和Adagrasib结合特异性的生化和计算表征以及H95和Y96的关键作用
errACS CHEMICAL BIOLOGY
IF3.8
err2024-09-16
err1
PREAI
errMahran, Randa; Kapp, Jonas N.; Valtonen, Salla; Champagne, Allison; Ning, Jinying; Gillette, William; Stephen, Andrew G.; Hao, Feng; Pluckthun, Andreas; Harma, Harri; Pantsar, Tatu; Kopra, Kari
err分享
err收藏
BBO-10203, a first-in-class, orally bioavailable, selective covalent small molecule that inhibits RAS- driven PI3Kalpha activity without affecting glucose metabolism
errCANCER RESEARCH
IF16.6
err2024-05-02
err1
PREAI
errBeltran, Pedro; Dhirendra, Simanshu; Xu, Rui; Chen, Ming; Czyzyk, Daniel; Donovan, Sofia; Feng, Siyu; Feng, Cindy; Fu, Lijuan; Lightstone, Felice; Lin, Ken; Maciag, Anna; Nissley, Dwight; Riegler, Erin; Sinkevicius, Kerstin; Stephen, Andrew; Stice, James; Turner, David; Wang, Bin; Wang, Keshi; Yang, Yue; Zhang, Cathy; McCormick, Frank; Wallace, Eli
err分享
err收藏
Membrane lipids drive formation of KRAS4b-RAF1 RBDCRD nanoclusters on the membrane (vol 7, 242 , 2024)
errCOMMUNICATIONS BIOLOGY
IF5.1
err2024-04-11
err0
errOAAI
errShrestha, Rebika; Carpenter, Timothy S.; Van, Que N.; Agamasu, Constance; Tonelli, Marco; Aydin, Fikret; Chen, De; Gulten, Gulcin; Glosli, James N.; Lopez, Cesar A.; Oppelstrup, Tomas; Neale, Chris; Gnanakaran, Sandrasegaram; Gillette, William K.; Ingolfsson, Helgi I.; Lightstone, Felice C.; Stephen, Andrew G.; Streitz, Frederick H.; Nissley, Dwight V.; Turbyville, Thomas J.
err分享
err收藏
BBO-8520, a first-in-class, direct inhibitor of KRASG12C (ON), locks GTP-bound KRASG12C in the state 1 conformation resulting in rapid and complete blockade of effector binding
errCANCER RESEARCH
IF16.6
err2024-04-05
err2
PREAI
errMaciag, Anna E.; Stice, James; Wang, Bin; Sharma, Alok; Chan, Albert; Lin, Ken; Singh, Devansh; Dyba, Marcin; Yang, Yue; Setoodeh, Saman; Smith, Brian P.; Rabara, Dana; Zhang, Zuhui; Larsen, Erik K.; Esposito, Dom; Denson, John Paul; Ranieri, Michela; Meynardie, Mary; Mehdizadeh, Sadaf; Alexander, Patrick; Blanco, Maria Abreu; Turner, David; Xu, Rui; Lightstone, Felice C.; Wong, Kwok Kin; Simanshu, Dhirendra; Wang, Keshi; Stephen, Andrew G.; Sinkevicius, Kerstin; Nissley, Dwight V.; Wallace, Eli; McCormick, Frank; Beltran, Pedro J.
err分享
err收藏
A Top-Down Proteomic Assay to Evaluate KRAS4B-Compound Engagement
errANALYTICAL CHEMISTRY
IF6.7
err2024-03-18
err2
errOAAI
errD'Ippolito, Robert A.; Rabara, Dana; Blanco, Maria Abreu; Alberico, Emily; Drew, Matthew R.; Ramakrishnan, Nitya; Sontan, Dara; Widmeyer, Stephanie R. T.; Scheidemantle, Grace M.; Messing, Simon; Turner, David; Arkin, Michelle; Maciag, Anna E.; Stephen, Andrew G.; Esposito, Dominic; Mccormick, Frank; Nissley, Dwight V.; Dehart, Caroline J.
err分享
err收藏
Membrane lipids drive formation of KRAS4b-RAF1 RBDCRD nanoclusters on the membrane膜脂驱动膜上KRAS4b-RAF1 RBDCRD纳米簇的形成
errCOMMUNICATIONS BIOLOGY
IF5.1
err2024-02-28
err8
errOAAI
errShrestha, Rebika; Carpenter, Timothy S.; Van, Que N.; Agamasu, Constance; Tonelli, Marco; Aydin, Fikret; Chen, De; Gulten, Gulcin; Glosli, James N.; Lopez, Cesar A.; Oppelstrup, Tomas; Neale, Chris; Gnanakaran, Sandrasegaram; Gillette, William K.; Ingolfsson, Helgi I.; Lightstone, Felice C.; Stephen, Andrew G.; Streitz, Frederick H.; Nissley, Dwight V.; Turbyville, Thomas J.
err分享
err收藏
Comparative analysis of KRAS4a and KRAS4b splice variants reveals distinctive structural and functional properties
errSCIENCE ADVANCES
IF12.5
err2024-02-16
err5
errOAAI
errWhitley, Matthew J.; Tran, Timothy H.; Rigby, Megan; Yi, Ming; Dharmaiah, Srisathiyanarayanan; Waybright, Timothy J.; Ramakrishnan, Nitya; Perkins, Shelley; Taylor, Troy; Messing, Simon; Esposito, Dominic; Nissley, Dwight V.; McCormick, Frank; Stephen, Andrew G.; Turbyville, Thomas; Cornilescu, Gabriel; Simanshu, Dhirendra K.
err分享
err收藏
Revealing the mechanism of action of a fi rst-in-class covalent inhibitor of KRASG12C (ON) and other functional properties of oncogenic KRAS by 31 P NMR通过31 p NMR揭示一类共价抑制剂KRASG12C (ON) 的作用机理和致癌KRAS的其他功能特性
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2024-02-01
err10
errOAAI
errSharma, Alok K.; Pei, Jun; Yang, Yue; Dyba, Marcin; Smith, Brian; Rabara, Dana; Larsen, Erik K.; Lightstone, Felice C.; Esposito, Dominic; Stephen, Andrew G.; Wang, Bin; Beltran, Pedro J.; Wallace, Eli; Nissley, Dwight V.; McCormick, Frank; Maciag, Anna E.
err分享
err收藏
Use of the natural nucleotide, GTP, is essential for the identification of potent, active-state KRASG12C inhibitors that bind in the switch II pocket
errMOLECULAR CANCER THERAPEUTICS
IF5.5
err2023-12-01
err0
PREAI
errWang, Bin; Sharma, Alok; Stice, James; Smith, Brian; Dyba, Marcin; Singh, Devansh; Denson, John-Paul; Rabara, Dana; Larsen, Erik; Yang, Yue; Lightstone, Felice C.; Stephen, Andrew; Nissley, Dwight; McCormick, Frank; Wallace, Eli; Maciag, Anna E.; Beltran, Pedro J.
err分享
err收藏
Direct Modulators of K-Ras-Membrane Interactions
errACS CHEMICAL BIOLOGY
IF3.8
err2023-08-14
err7
errOAAI
errMorstein, Johannes; Shrestha, Rebika; Van, Que N.; Lopez, Cesar A.; Arora, Neha; Tonelli, Marco; Liang, Hong; Chen, De; Zhou, Yong; Hancock, John F.; Stephen, Andrew G.; Turbyville, Thomas J.; Shokat, Kevan M.
err分享
err收藏
Allosteric Regulation of Switch-II Domain Controls KRAS Oncogenicity
errCANCER RESEARCH
IF16.6
err2023-08-09
err4
PREAI
errYang, Moon Hee; Tran, Timothy H.; Hunt, Bethany; Agnor, Rebecca; Johnson, Christian W.; Shui, Bing; Waybright, Timothy J.; Nowak, Jonathan A.; Stephen, Andrew G.; Simanshu, Dhirendra K.; Haigis, Kevin M.
err分享
err收藏
RAS-dependent RAF-MAPK hyperactivation by pathogenic RIT1 is a therapeutic target in Noonan syndrome-associated cardiac hypertrophy
errSCIENCE ADVANCES
IF12.5
err2023-07-14
err8
errOAAI
errCuevas-Navarro, Antonio; Wagner, Morgan; Van, Richard; Swain, Monalisa; Mo, Stephanie; Columbus, John; Allison, Madeline R.; Cheng, Alice; Messing, Simon; Turbyville, Thomas J.; Simanshu, Dhirendra K.; Sale, Matthew J.; McCormick, Frank; Stephen, Andrew G.; Castel, Pau
err分享
err收藏
Germline RASopathy mutations provide insights into the differential regulation of RAF family kinases
errMOLECULAR CANCER RESEARCH
IF4.7
err2023-05-01
err0
PREAI
errSpencer-Smith, Russell; Terrell, Elizabeth M.; Insinna, Christine; Agamasu, Constance; Wagner, Morgan E.; Ritt, Daniel A.; Stauffer, Jim; Stephen, Andrew G.; Morrison, Deborah K.
err分享
err收藏
Machine Learning-Driven Multiscale Modeling: Bridging the Scales with a Next-Generation Simulation Infrastructure机器学习驱动的多尺度建模: 用下一代仿真基础设施桥接尺度
errJOURNAL OF CHEMICAL THEORY AND COMPUTATION
IF5.5
err2023-04-19
err18
errOAAI
errIngolfsson, Helgi I.; Bhatia, Harsh; Aydin, Fikret; Oppelstrup, Tomas; Lopez, Cesar A.; Stanton, Liam G.; Carpenter, Timothy S.; Wong, Sergio; Di Natale, Francesco; Zhang, Xiaohua; Moon, Joseph Y.; Stanley, Christopher B.; Chavez, Joseph R.; Nguyen, Kien; Dharuman, Gautham; Burns, Violetta; Shrestha, Rebika; Goswami, Debanjan; Gulten, Gulcin; Van, Que N.; Ramanathan, Arvind; Van Essen, Brian; Hengartner, Nicolas W.; Stephen, Andrew G.; Turbyville, Thomas; Bremer, Peer-Timo; Gnanakaran, S.; Glosli, James N.; Lightstone, Felice C.; Nissley, Dwight V.; Streitz, Frederick H.
err分享
err收藏

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