Matthew G. Rees - Publications, H-index & Citations

Matthew G. Rees

broad institute of mit and harvard

34H指数

401论文数

1.1W被引数

收录论文 69

发表时间

A design approach for bitopic kinase inhibitors 双位点激酶抑制剂的构效关系设计方法

Nature

IF48.5

2026-09-23

OAAI

Jack W. Stevenson; Kevin Lou; Joshua A. Reynolds; Ian R. Outhwaite; Kenneth Huang; Ivan Sokirniy; Sky Y. J. Peterson; Amir Z. Munir; Celine D. Wang; Haider Inam; Emma L. Gebauer; Ariel Leyte-Vidal; Anastasiia Grynyova; Sydney M. Figueroa; Matthew G. Rees; Melissa M. Ronan; Fernando Salangsang; Yan Zeng; Veronica Steri; Jennifer A. Roth; Neil P. Shah; Ignacia Echeverria; Andrej Šali; Ziyang Zhang; Javid J. Moslehi; Markus A. Seeliger; Justin R. Pritchard; Kevan M. Shokat

Histone H4 lysine 20 tri-methylation safeguards breast cancer lineage fidelity and unfolded protein response 组蛋白H4赖氨酸20三甲基化保护乳腺癌谱系保真度和未折叠蛋白反应

Nature Communications

IF15.7

2026-08-22

OAAI

Zheqi Li; Amatullah Tawawalla; Pierre Foidart; Marco Seehawer; Jun Nishida; Ernesto Rojas Jimenez; Triet M. Bui; Xiao-Yun Huang; Matthew G. Rees; Melissa M. Ronan; Jennifer A. Roth; Laura E. Stevens; Miguel Munoz Gomez; Rong Li; Henry W. Long; Kornelia Polyak

Expanding the human proteome with microproteins and peptideins 通过微蛋白和肽蛋白扩展人类蛋白质组

Nature

IF48.5

2026-05-01

PREAI

Deutsch, Eric W.; Kok, Leron W.; Mudge, Jonathan M.; Valls, Cristian F.; Jungreis, Irwin; Ruiz-Orera, Jorge; Sun, Zhi; Kusebauch, Ulrike; Fierro-Monti, Ivo; Abelin, Jennifer G.; Alba, M. Mar; Aspden, Julie L.; Bandyopadhyay, Sreejan; Banerjee, Kaushik; Baranov, Pavel V.; Bazzini, Ariel A.; Bourassa, Francis; Bruford, Elspeth A.; Calviello, Lorenzo; Carr, Steven A.; Carvunis, Anne-Ruxandra; Chothani, Sonia; Clauwaert, Jim; Dean, Kellie; Faridi, Pouya; Frankish, Adam; Goodale, Amy; Green, Thomas; Hubner, Norbert; Ingolia, Nicholas T.; Kellis, Manolis; Magrane, Michele; Martin, Maria Jesus; Martinez, Thomas F.; Menschaert, Gerben; Ohler, Uwe; Orchard, Sandra; Potter, Alisa; Rackham, Owen J. L.; Rees, Matthew G.; Root, David E.; Roth, Jennifer A.; Roucou, Xavier; Sialana, Fernando J.; Slavoff, Sarah A.; Swirski, Michal I.; Tierney, Jack A. S.; Trifiro, Felix-Antoine; Valen, Eivind; Vasylieva, Valeriia; Wacholder, Aaron; Wang, Shengbo; Wang, Li; Weissman, Jonathan S.; Wu, Wei; Choudhary, Jyoti S.; Bassani-Sternberg, Michal; Vizcaino, Juan Antonio; Ternette, Nicola; Brunet, Marie A.; Moritz, Robert L.; Prensner, John R.; van Heesch, Sebastiaan

Improving Fellow Continuity Clinic With Multiple Subspecialties: A Quality Improvement Initiative 改善多亚专科背景下的同伴连续性诊所：一项质量改进计划

PEDIATRIC BLOOD & CANCER

IF2.3

2025-12-01

PREAI

Rees, Matthew; Bernstein, Rachel; Meredith, Carly; Aldridge, Sarah; Wade, Amy; Inaba, Hiroto; Bhatt, Nidhi

Discovery of a Potent and Selective TEAD Degrader with Durable Degradation Activity 发现一种高效且特异性的TEAD降解剂，并具有持久的降解活性。

Advanced Science

IF14.1

2025-10-05

OAAI

Linhui Cao; Jing Yang; Yuhang Liu; Xiaotong Chen; Yufang Shi; Yunshuo Zhao; Yong Zhang; Jian Chen; Bowen Li; Wuqiang Wen; Lu Chen; Bo Peng; Lu Huang; Yanli Sun; Lixin Zhou; Matthew G Rees; Melissa M Ronan; Jennifer A Roth; Zhixiang Guo; Jing Xing; Guangya Zhu; Yazhou Wang; Baishan Jiang; Jing Lu; Kehao Zhao; Wenchao Lu

Targeting histone H2B acetylated enhanceosomes via p300/CBP degradation in prostate cancer 通过p300/CBP降解靶向前列腺癌中乙酰化的H2B组蛋白增强子复合物

Nature Genetics

IF29

2025-10-03

OAAI

Jie Luo; Zhixiang Chen; Yuanyuan Qiao; Jean Ching-Yi Tien; Eleanor Young; Rahul Mannan; Somnath Mahapatra; Rupam Bhattacharyya; Lanbo Xiao; Tongchen He; Sanjana Eyunni; Yuping Zhang; Yang Zheng; Fengyun Su; Xuhong Cao; Rui Wang; Yunhui Cheng; Rithvik Seri; James George; Miriam Shahine; Stephanie J. Miner; Matthew G. Rees; Melissa M. Ronan; Jennifer A. Roth; Ulka Vaishampayan; Mi Wang; Shaomeng Wang; Abhijit Parolia; Arul M. Chinnaiyan

CF10 Displayed Improved Activity Relative to 5-FU in a Mouse CRLM Model Under Conditions of Physiological Folate 在生理叶酸条件下，CF10在 mouse CRLM 模型中表现出相对于5-FU的改善的活性。

Cancers 2025, Vol. 17, Page 2739

IF4.4

2025-08-23

PREAI

Charles Chidi Okechukwu; Xue Ma; Wencheng Li; Ralph D’Agostino, Jr.; Matthew G. Rees; Melissa M. Ronan; Jennifer A. Roth; William H. Gmeiner

A neomorphic protein interface catalyzes covalent inhibition of RASG12D aspartic acid in tumors 一种新构型蛋白质界面催化肿瘤中RASG12D天冬氨酸的共价抑制

Science

IF45.8

2025-07-24

PREAI

Caroline Weller; G. Leslie Burnett; Lingyan Jiang; Sujata Chakraborty; Dongyu Zhang; Nicole A. Vita; Julien Dilly; Eejung Kim; Benjamin Maldonato; Kyle Seamon; Diane F. Eilerts; Anthony Milin; Abby Marquez; Jessica Spradlin; Ciara Helland; Andrea Gould; Tamar Bar Ziv; Phuong Dinh; Shelby L. Steele; Zhican Wang; Yunming Mu; Seema Chugh; Hanrong Feng; Conner Hennessey; Junning Wang; Jennifer Roth; Matthew Rees; Melissa Ronan; Brian M. Wolpin; William C. Hahn; Matthew Holderfield; Zhengping Wang; Elena S. Koltun; Mallika Singh; Adrian L. Gill; Jacqueline A. M. Smith; Andrew J. Aguirre; Jingjing Jiang; John E. Knox; David Wildes

Tegavivint triggers TECR-dependent nonapoptotic cancer cell death Tegavivint 触发 TECR 依赖性的非凋亡性癌细胞死亡

NATURE CHEMICAL BIOLOGY

IF13.7

2025-05-26

PREAI

Leak, Logan; Wang, Ziwei; Joseph, Alby J.; Johnson, Brianna; Chan, Alyssa A.; Decosto, Cassandra M.; Magtanong, Leslie; Ko, Pin-Joe; Lee, Weaverly Colleen; Ritho, Joan; Manukian, Sophia; Millner, Alec; Chitkara, Shweta; Salinas, Jennifer J.; Skouta, Rachid; Rees, Matthew G.; Ronan, Melissa M.; Roth, Jennifer A.; Myers, Chad L.; Moffat, Jason; Boone, Charles; Bensinger, Steven J.; Nathanson, David A.; Atilla-Gokcumen, G. Ekin; Moding, Everett J.

Effects of coding variants in the glucokinase regulatory protein gene on hepatic glucose and triglyceride metabolism suggest a gene regulatory function of glucokinase

METABOLISM-CLINICAL AND EXPERIMENTAL

IF11.9

2025-05-01

PREAI

Langer, Sara; Jagdhuhn, David; Waterstradt, Rica; Gromoll, Jessica; Mueller, Michael; Rees, Matthew G.; Gloyn, Anna L.; Baltrusch, Simone

Article Targeted degradation of CDK9 potently disrupts the network 题目：靶向降解CDK9能显著破坏网络

CELL CHEMICAL BIOLOGY

IF7.2

2025-04-01

OAAI

Toure, Mohammed A.; Motoyama, Keisuke; Xiang, Yichen; Urgiles, Julie; Kabinger, Florian; Koglin, Ann-Sophie; Iyer, Ramya S.; Gagnon, Kaitlyn; Kumar, Amruth; Ojeda, Samuel; Harrison, Drew A.; Rees, Matthew G.; Roth, Jennifer A.; Ott, Christopher J.; Schiavoni, Richard; Whittaker, Charles A.; Levine, Stuart S.; White, Forest M.; Calo, Eliezer; Richters, Andre; Koehler, Angela N.

KRASmulti inhibitor BI 3706674 shows efficacy in KRAS-driven preclinical models of cancer that supports clinical testing in patients with tumors harboring KRASG12V mutations and KRAS wild-type amplifications

EUROPEAN JOURNAL OF CANCER

IF7.1

2024-10-01

PREAI

Tedeschi, A.; Peng, D. H.; Schischlik-Siegl, F.; Schaaf, O.; Gerlach, D.; Rocchetti, F.; Popow, J.; Broeker, J.; Wunberg, T.; Boghossian, A. S.; Rees, M. G.; Ronan, M. M.; Roth, J. A.; Williams, M.; Vellano, C.; Marszalek, J. R.; Heffernan, T. P.; Pearson, M.; Kraut, N.; Dorothea, R.

Mechanism of Action of KL-50, a Candidate Imidazotetrazine for the Treatment of Drug-Resistant Brain Cancers

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2024-05-30

PREAI

Huseman, Eric D.; Lo, Anna; Fedorova, Olga; Elia, James L.; Gueble, Susan E.; Lin, Kingson; Sundaram, Ranjini K.; Oh, Joonseok; Liu, Jinchan; Menges, Fabian; Rees, Matthew G.; Ronan, Melissa M.; Roth, Jennifer A.; Batista, Victor S.; Crawford, Jason M.; Pyle, Anna M.; Bindra, Ranjit S.; Herzon, Seth B.

Genetic dependencies associated with transcription factor activities in human cancer cell lines

CELL REPORTS

IF6.9

2024-05-01

OAAI

Thatikonda, Venu; Supper, Verena; Wachter, Johannes; Kaya, Onur; Kombara, Anju; Bilgilier, Ceren; Ravichandran, Madhwesh C.; Lipp, Jesse J.; Sharma, Rahul; Badertscher, Lukas; Boghossian, Andrew S.; Rees, Matthew G.; Ronan, Melissa M.; Roth, Jennifer A.; Grosche, Sarah; Ller, Ralph A. Neumu euro; Mauri, Barbara Mair Federico; Popa, Alexandra

Group 3 medulloblastoma transcriptional networks collapse under domain specific EP300/CBP inhibition

NATURE COMMUNICATIONS

IF15.7

2024-04-25

OAAI

Shendy, Noha A. M.; Bikowitz, Melissa; Sigua, Logan H.; Zhang, Yang; Mercier, Audrey; Khashana, Yousef; Nance, Stephanie; Liu, Qi; Delahunty, Ian M.; Robinson, Sarah; Goel, Vanshita; Rees, Matthew G.; Ronan, Melissa A.; Wang, Tingjian; Kocak, Mustafa; Roth, Jennifer A.; Wang, Yingzhe; Freeman, Burgess B.; Orr, Brent A.; Abraham, Brian J.; Roussel, Martine F.; Schonbrunn, Ernst; Qi, Jun; Durbin, Adam D.

KRASmulti inhibitor BI 3706674 shows efficacy in KRAS-driven preclinical models of cancer that supports clinical testing in patients with tumors harbouring KRASG12V mutations and KRAS wild-type amplifications

CANCER RESEARCH

IF16.6

2024-03-22

PREAI

Tedeschi, Antonio; Peng, David H.; Schischlik, Fiorella; Herdeis, Lorenz; Schaaf, Otmar; Santoro, Valeria; Gerlach, Daniel; Savarese, Fabio; Lipp, Jesse; Haslinger, Christian; Rocchetti, Francesca; Popow, Johannes; Huber, Heinrich J.; Wilding, Birgit; Treu, Matthias; Fuchs, Julian; Broeker, Joachim; Wunber, Tobias; Gmachl, Michael; Rumpel, Klaus; Rees, Matthew; Ron, Melissa; Roth, Jennifer; Williams, Mariah; Deckard, Charles; Ramamoorthy, Vandhana; Daniele, Joseph R.; Ajani, Jaffer A.; Meric-Bernstam, Funda; Kopetz, Scott; Kim, Michael; Gibbons, Don L.; Vellano, Christopher P.; Marszalek, Joseph R.; Heffernan, Timothy P.; McConnell, Darryl; Pearson, Mark; Kraut, Norbert; Rudolph, Dorothea

Novel WRN helicase inhibitors selectively target microsatellite unstable cancer cells

CANCER RESEARCH

IF16.6

2024-03-22

PREAI

Picco, Gabriele; Rao, Yanhua; Al Saedi, Angham; Vieira, Sara F.; Lee, Yang; Shenje, Ray; Bhosle, Shriram; Walker, Samantha; May, Kieron; Herranz-Ors, Carmen; Dicer, Cansu; Gibson, Freddy; Banerjee, Ruby; Werner, Thilo; Cottom, Josh; Peng, Yang; Deng, Nanhua; Landis, Phil; Angel, Thomas; Bush, Jacob; Rees, Matthew G.; Ronan, Melissa M.; Roth, Jennifer A.; Lightfoot, Howard; Zappacosta, Francesca; Pettinger, Jonathan; Barthorpe, Syd; Eberl, Chris; Jones, Brian; Schneck, Jess; Murphy, Dennis; Taygerly, Josh; DeMartino, Mike; Coelho, Matthew; Houseley, Jon; Schwartz, Benjamin; Garnett, Mathew J.

Assessing cancer drug combination efficacy across 900+PRISM cell lines in a multiplexed screening assay

CANCER RESEARCH

IF16.6

2024-03-22

PREAI

George, Ashish Bino; Nair, Shiker; Kocak, Mustafa; Nguyen, Ellen; Kalathungal, Alvin; Fazio, Anthony; Ponsi, Cole; Golabi, Aydin; Ronan, Melissa A.; Rees, Matthew G.; Roth, Jennifer A.

Optimizing 500 pooled PRISM cell lines for a 10-day assay to elucidate viability effects and mechanism of action for slower-acting therapeutics

CANCER RESEARCH

IF16.6

2024-03-22

PREAI

Ronan, Melissa; Ip, Blanche C.; Nguyen, Ellen; Widocki, Ursula; Sangpo, Tenzin; Kalathungal, Alvin; Diaz-Gallegos, Nashielli; Fazio, Anthony; Golabi, Aydin; Naim, Maha; George, Ashish Bino; Liu, YuhJong; Kocak, Mustafa; Puram, Rishi; Rees, Matthew G.; Roth, Jennifer

Creating a living public oncology drug resource using PRISM cell line viability screening

CANCER RESEARCH

IF16.6

2024-03-22

PREAI

Rees, Matthew G.; Kocak, Mustafa; Mapa, Claudine; Frederick, Dennie; Nguyen, Ellen; Kalathungal, Alvin; Fazio, Anthony; Davis, John F.; Reeves, Emily; Tucci, Ariah; Barry, Rachael; Harrington, Colleen; Eskra, Jillian; Ronan, Melissa M.; Sellers, William R.; Roth, Jennifer A.

研究方向